CN206518724U - Citrate anticoagulation device - Google Patents
Citrate anticoagulation device Download PDFInfo
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- CN206518724U CN206518724U CN201620997643.2U CN201620997643U CN206518724U CN 206518724 U CN206518724 U CN 206518724U CN 201620997643 U CN201620997643 U CN 201620997643U CN 206518724 U CN206518724 U CN 206518724U
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
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Abstract
The utility model provides a kind of citrate anticoagulation device, and the citrate anticoagulation device at least includes：Control device, the first peristaltic pump and the second peristaltic pump, the control device includes wriggling pump control module, display module and input module, the input module connects wriggling pump control module, the wriggling pump control module connects the first peristaltic pump and the second peristaltic pump, first peristaltic pump is citric acid pump, and second peristaltic pump is calcium pump.The Automated condtrol of citric acid pump and calcium pump can be realized using the utility model, manpower is saved, while more accurate.
Description
Technical field
The utility model is related to a kind of citrate anticoagulation device.
Background technology
Such as Fig. 1, shown external anti-freezing is the key that blood purification is smoothed out.Regional Citrate Anticoagulation (regional
Citrate anticoagulation, RCA) because with anticoagulant effect, definitely, hemorrhage complication is few, the service life of dialyzer 30
The advantages of extension, the ideal chose as current highly accomplished cardiopulmonary bypass in patients anti-freezing.But, due to potential metabolism
Complication, operates complex, the problems such as during which needing frequently monitoring, limits it in clinical application.
Traditional Regional Citrate Anticoagulation technology is to circulate arterial end in vitro, is transfused according to VPV with certain proportion
Liquor sodii citratis (is placed in citric acid fluid reservoir 10), while mending calcium chloride in vein end (before blood is returned in patient's body)
(being placed in calcium chloride holding vessel 20), so as to ensure that ionized calcium level is normal in patient's body.Regional Citrate Anticoagulation-CRRT principles：
Citric acid is transfused from arterial end, and the ionized calcium level in extracorporeal circulation pipeline is down to 0.2-0.4mM/L, is played external anti-freezing and is made
With while supplementing calcium chloride from vein end, internal ionized calcium level remains normal, without influenceing internal blood coagulation system.
In Fig. 1,4% sodium citrate is inputted from vein end, extracorporal circulatory system ionized calcium is down to 0.2-0.4mmol/L, is reached
Anticoagulant effect, while supplementing calcium chloride from vein end, makes internal ionized calcium level recover to 1.0-1.2mmol/L.
According to the experience in existing literature report and real work, traditional RCA is below clinical application generally existing
Railway Project：
(1) extra two precision transfusion pumps of increase on the basis of original apparatus for purifying blood are needed to be used for citric acid soln
With the infusion of calcium solution, it is cumbersome；
(2) citric acid infusion pump and infusion pump of replenishing the calcium are two independent pumps, when treatment Parameters variation or dialysis machine because
The reason artery pump terminations of pumping such as alarm, replacing displacement liquid/dialyzate, it is necessary to which the nurse that dialyses suspends/started the two pumps manually, if
Operation is lack of standardization, is likely to result in iatrogenic citric acid infusion excessively or hypercalcinemia causes extracorporal circulatory system anti-freezing to fail；
(3) " trial-and-error method " that traditional citrate anticoagulation scheme is mainly monitored again using monitoring-adjustment-, i.e., rule of thumb
An initial speed of replenishing the calcium first is set, then speed of replenishing the calcium is adjusted by frequently monitoring circulation ionized calcium level in vivo and in vitro,
As a result find that internal ionized calcium level fluctuation is larger, and because the change of calcium lags behind the adjustment of calcium, it is difficult to accurate assurance is replenished the calcium
Amount；
(4) manpower input during RCA (at least needs one by the hemodialysis nurse of strict training and is familiar with citrate anticoagulation
The doctor of technology is on the scene), material resources (needing every 2-4 hours monitoring ionized calcium, 150 yuan of expense is determined every time) cost input is huge.
Utility model content
The shortcoming of prior art in view of the above, the purpose of this utility model is to provide one kind being capable of adjust automatically speed
The citrate anticoagulation device of degree, without artificial trial and error, realizes automation mechanized operation.
In order to achieve the above objects and other related objects, the invention provides a kind of citrate anticoagulation device, the citron
Sour anti-coagulation device at least includes：First peristaltic pump, the second peristaltic pump, and control device, the control device include peristaltic pump
Control module, display module and input module, the input module connect wriggling pump control module, the wriggling pump control module
The first peristaltic pump and the second peristaltic pump are connected, first peristaltic pump is citric acid pump, and second peristaltic pump is calcium pump.
Preferably, the wriggling pump control module includes：
The first peristaltic pump speed control submodule for controlling citric acid infusion velocity, with the first peristaltic pump phase
Even；
Second peristaltic pump speed control submodule of speed of being replenished the calcium for control, is connected with second peristaltic pump.
Preferably, the first peristaltic pump speed control submodule includes：
Citric acid infusion velocity computing unit for calculating citric acid infusion velocity, is connected with the input module；
The first peristaltic pump rate signal output unit for sending the instruction of the first peristaltic pump infusion velocity, with the citron
Sour infusion velocity computing unit and the first peristaltic pump are connected.
Preferably, the second peristaltic pump speed control submodule includes：
For the second peristaltic pump first stage speed of the calcium amount and accumulation calcium amount sum in vivo that calculate extracorporal dialysis removing
Computing unit, is connected with the input module and citric acid infusion velocity computing unit；
For the second peristaltic pump second stage speed computing unit of the calcium amount for calculating extracorporal dialysis removing, with the input
Module and citric acid infusion velocity computing unit are connected.
The second peristaltic velocity signal output unit for sending the second wriggling pump speed, with second peristaltic pump first
Stage speed computing unit, the second peristaltic pump second stage speed computing unit and the second peristaltic pump are connected.
Replenish the calcium in the present invention and be divided into two stages, process is as follows：
Citric acid accumulation in body when its core concept is Regional Citrate Anticoagulation, the citric acid of accumulation is main with calcium salt
Form is present, according to citric acid pharmacokinetic parameter, and accumulation typically reaches stable state in 3 hours or so after treatment starts, for example
The report such as Kramer was without citric acid half-life period average out in hepatic sclerosis critical patient body 36 minutes, according to pharmacokinetic theory,
Vivo medicine concentration reaches Css after 5 half-life period, therefore internal citron acid concentration is three hours after RCA-CRRT starts
Up to Css, RCA-CRRT is started latter 3rd hour as speed adjustment of replenishing the calcium time point (Kramer L, Bauer E,
Joukhadar C,et al.Crit Care Med,2003,31：2450-2455.).Therefore, Regional Citrate Anticoagulation is replenished the calcium
It is also required to be divided into two stages, the first stage requires supplementation with accumulation calcium in vivo and calcium is removed in extracorporal circulatory system, and second stage is only needed to
Supplement extracorporal circulatory system and remove calcium.
It should be noted that the two benches that the present apparatus is proposed are replenished the calcium, mathematical modeling is applied to the presence of the low clear of citric acid accumulation
Except efficiency blood purification pattern, such as CRRT.And for high elimination efficiency blood purification pattern (as conventional intermittence blood is saturating
Analysis etc.), it can be ignored due to accumulating or accumulating in the absence of citric acid, the special case of above-mentioned model can be regarded as, i.e., directly entered
Enter second stage to replenish the calcium, without supplementing accumulation calcium part.
Preferably, the second peristaltic pump rate signal output unit includes：
Switching time subelement for storing or setting the second peristaltic pump first stage and second stage switching time；
Signal output subelement for sending the second peristaltic pump velocity output signal according to switching time, with switching time
Subelement, the second peristaltic pump first stage speed computing unit, the second peristaltic pump second stage speed computing unit and second are compacted
Dynamic pump is connected.
Preferably, the citrate anticoagulation device also includes bubble detection module, and the wriggling pump control module also includes：
Receive bubble detection module signal and send the module of pause peristaltic pump instruction, be connected with the bubble detection module.
Preferably, the bubble detection module includes bubble detection piece and warning part.
Preferably, the bubble detection piece is supersonic detector, and the warning part includes the instruction of a variety of different colours
Lamp.
Supersonic detector can use prior art, and the supersonic detector passes through the peristaltic pump of ultrasound examination first
With the bubble in the woven hose on the second peristaltic pump, principle is as follows：I.e. when ultrasonic wave is propagated in media as well, acoustic impedance is run into not
Same interface can produce scatter reflections, so as to can cause the decay of ultrasonic wave.When there is no bubble in woven hose, ultrasonic reflections
Coefficient very little, does not almost decay；When having bubble, because the acoustic impedance difference of air and water is larger, ultrasonic wave has very big
Reflectance factor, now ultrasonic attenuation is serious.
Preferably, external infusion pipe is connected when the citrate anticoagulation device is used, the wriggling pump control module is also wrapped
Include for controlling the preliminary filling unit to woven hose preliminary filling, with the first peristaltic pump speed control submodule and the second wriggling pump speed control
System module is connected.
Preferably, the display module is connected with input module and is selectively connected with wriggling pump control module.
Preferably, whether the parameter that the control device also includes being used to detect input module input meets parameter preset model
The self-detection module enclosed, the self-detection module is connected with input module.
As described above, citrate anticoagulation device of the present utility model, has the advantages that：
The present invention has advantages below compared with prior art：The present apparatus aims at RCA anti-freezings design, by citric acid pump and calcium pump
Integrate, the double pump system can link with dialysis machine artery pump again, while embedded in citric acid, calcium infusion mathematical modeling, control two
The speed of individual pump, multioperation is crossed without medical personnel.Need every 2-4 hours monitoring in vivo during conventional RCA and pipeline ion
Calcium, 24 hours CRRT need frequently monitoring 6~8 times, and the speed of replenishing the calcium calculated by software is replenished the calcium, the extension of monitoring interval, and 24
Hour treatment only needs detection 2~3 times.The work load of medical personnel is alleviated to a certain extent, while improving security.Carry
High critical acute injury of kidney patient, especially merges high-risk bleeding risk patient, the salvage success rate of blood purification treatment.This hair
Bright one side alleviates the labor intensity of staff, on the other hand reduces medical expense.So that Regional Citrate Anticoagulation into
For a kind of easy anticoagulation, it is promoted in clinical application.
Brief description of the drawings
Fig. 1 is the structural representation of prior art；
Fig. 2 is the first embodiment structural representation of the present invention；
Fig. 3 is second of embodiment structural representation of the present invention；
Fig. 4 is the third embodiment structural representation of the present invention；
Fig. 5 is the 4th kind of embodiment structural representation of the present invention；
Fig. 6 is the 5th kind of embodiment structural representation of the present invention；
Fig. 7 be the present embodiment two benches replenish the calcium model long-time CVVH treatment in application effect schematic diagram.
1 first peristaltic pump
2 second peristaltic pumps
3 control devices
100 wriggling pump control modules
110 first peristaltic pump speed control submodules
111 citric acid speed calculation modules
112 first peristaltic pump rate signal output units
120 second peristaltic pump speed control submodules
121 second peristaltic pump first stage speed computing units
122 second peristaltic pump second stage speed computing units
123 second peristaltic pump rate signal output units
1231 switching time subelements
1232 signal output subelements
200 display modules
300 input modules
400 self-detection modules
4 bubble detection modules
401 bubble detection pieces
402 warning parts
10 citric acid fluid reservoirs
20 sodium chloride storage tanks
30 dialyzers
Embodiment
Embodiment of the present utility model is illustrated by particular specific embodiment below, those skilled in the art can be by this
Content disclosed by specification understands other advantages of the present utility model and effect easily.
Fig. 1 is referred to Fig. 7.It should be clear that structure, ratio, size depicted in this specification institute accompanying drawings etc., is only used to
Coordinate the content disclosed in specification, so that those skilled in the art is understood with reading, be not limited to the utility model
Enforceable qualifications, therefore do not have technical essential meaning, the modification of any structure, the change of proportionate relationship or size
Adjustment, in the case where not influenceing the utility model effect that can be generated and the purpose that can reach, all should still fall in the utility model
Disclosed technology contents are obtained in the range of covering.Meanwhile, in this specification it is cited as " on ", " under ", " left side ",
The term on " right side ", " centre " and " one " etc., is merely convenient to understanding for narration, and it is enforceable to be not used to restriction the utility model
Scope, being altered or modified for its relativeness is enforceable when being also considered as the utility model under without essence change technology contents
Category.
As shown in Fig. 2 the utility model provides a kind of citrate anticoagulation device, including the first peristaltic pump 1, the second peristaltic pump
2, and control device 3, the control device includes wriggling pump control module 100, display module 200 and input module 300, institute
The connection wriggling of input module 300 pump control module 100 is stated, the wriggling pump control module 100 connects the first peristaltic pump 1 and second
Peristaltic pump 2, first peristaltic pump 1 is citric acid pump, and second peristaltic pump 2 is calcium pump.
For further optimizing design scheme, display module 200 can also be connected with input module 300, peristaltic pump control
Module 100 is also connected with display module 200, and display module can show the speed of peristaltic pump.
Control device can utilize computer in the present invention, and the first peristaltic pump and the are sent a signal to by RS485 buses
Two peristaltic pumps.Display module and input module form human-computer interaction to provide a dialog box on calculator display organization
Interface, user can use computer keyboard or tangible formula display screen input parameter and/or instruction.Described first wriggles
Pump and the second peristaltic pump are conventional peristaltic pump, and those skilled in the art can buy from market.
Preferred embodiment is as shown in figure 3, the control device 3 also includes self-detection module 400, to detect input mould
Whether the input parameter of block 300 meets the self-detection module of preset parameter range, is connected with input module 300 and display module 200.
I.e. after the input parameter of input module 300, self-detection module 400 will the parameter of automatic decision arrange parameter or input whether close
Reason, if unreasonable will show prompt message through display module 200, prevents the maloperation during doctor's input parameter.Close
In rational parameter area, professional standard in the art can be used.For example, the general range man of packed cell volume：0.40
~0.50, female：0.35~0.45, the packed cell volume that such as user inputs is 0.8, then display module meeting pop-up dialogue box, is carried
Show that mistake occurs in user.
For further optimizing design scheme, wriggling pump control module 100 is including for controlling citric acid defeated as described in Figure 4
Note the first peristaltic pump speed control submodule 110 of speed, for controlling the second peristaltic pump speed control submodule of speed of replenishing the calcium
Block 120, controls the first peristaltic pump 1, the speed of the second peristaltic pump 2 respectively.In order to which further optimizing design scheme, described first is wriggled
Pump speed control submodule 110 can control 4% citrate anticoagulation speed or ACDC anti-freezing speed.Second peristaltic pump
Speed is denoted as QCaCl respectively2, the speed that second peristaltic pump is replenished the calcium is divided into two stages, respectively first stage and second
In the stage, the first stage is between the 0~3h that replenishes the calcium, the second stage starts for the 4th hour of replenishing the calcium.
As shown in figure 5, the first peristaltic pump speed control submodule 110, including for calculating citric acid infusion velocity
Citric acid infusion velocity computing unit 111, be connected with the input module, further calculated and obtained by the parameter value of input
Obtain citric acid infusion velocity；The first peristaltic pump rate signal output unit for sending the instruction of the first peristaltic pump infusion velocity
112, it is connected with the citric acid infusion velocity computing unit and the first peristaltic pump 1, it is compacted that rate signal instruction is sent into first
Dynamic pump 1.
Citric acid infusion velocity mathematical formulae can use prior art, it would however also be possible to employ following method is calculated：
Qcit=Qb × (1-Hct) × C0mmol/Csolution；
C0：3~5mmol/L；
Qcit：Citric acid infusion velocity L/h,
Hct：Packed cell volume,
Qb：Blood flow velocity (L/h)
Csolution：Amount mmol containing citric acid in 1L citric acid solns,
Above-mentioned parameter Hct, Qb can be measured before dialysis starts using prior art, and user is defeated using input module
Enter, C0It is predeterminable.
Such as Fig. 5, the second peristaltic pump speed control submodule 120 includes：Calcium amount for calculating extracorporal dialysis removing
The second peristaltic pump first stage speed computing unit 121 with accumulating calcium amount sum in vivo, with the input module and citric acid
Infusion velocity computing unit is connected；Second peristaltic pump second stage speed of the calcium amount for calculating extracorporal dialysis removing calculates single
Member 122, is connected with the input module and citric acid infusion velocity computing unit；Second for sending the second wriggling pump speed
Peristaltic velocity signal output unit 123, with the second peristaltic pump first stage speed computing unit, the second peristaltic pump second-order
Duan Sudu computing units and the second peristaltic pump 2 are connected.Therefore the second peristaltic velocity signal output unit 123 can will be compacted from second
Dynamic pump first stage speed computing unit 121 and the second peristaltic velocity signal output unit 122 of the second wriggling pump speed are obtained
The second peristaltic pump needed for rate signal be sent to the second peristaltic pump 2.
Such as Fig. 5, for further optimizing design scheme, the second peristaltic pump rate signal output unit 123 includes：With
In the switching time subelement 1231 for storing or setting the second peristaltic pump first stage and second stage switching time；For foundation
Switching time sends the signal output subelement 1232 of the second peristaltic pump velocity output signal, with switching time subelement, second
Peristaltic pump first stage speed computing unit, the second peristaltic pump second stage speed computing unit and the second peristaltic pump are connected.Make
User can set the switching time point of first stage and second stage by input module, such as after 3 hours of dialysing, the
Two peristaltic pumps directly enter second stage from the first stage, and in the dialysis period of 0-3 hours, signal output unit will be from second
The rate signal of the acquisition of peristaltic pump first stage speed computing unit is transferred to the second peristaltic pump, after the 4th hour starts,
Signal output unit will be transferred to the second wriggling from the rate signal obtained of the second peristaltic pump second stage speed computing unit
Pump.
The second peristaltic pump first stage speed computing unit and the second peristaltic pump second stage speed computing unit can
To use prior art, it would however also be possible to employ equation below, which is calculated, to be obtained：
First stage calculation formula：
QCaCl2=Qca/0.34
Second stage calculation formula：
Or：
Qca (phaseII)=Qeffluent × Cca_effluent
QCaCl2=Qca/0.34
Wherein, Qca：The calcium amount mmol/h that unit interval should supplement,
QCaCl2：The calcium chloride solution infusion velocity ml/h of unit interval 5%,
Qca(phaseⅠ)：The first stage unit time amount of replenishing the calcium mmol/h,
Qca(phaseⅡ)：The second stage unit interval amount of replenishing the calcium mmol/h,
CcaT(art)：The total calcium concentration of arterial end, equivalent to internal total calcium concentration mmol/L,
Qpw：Blood plasma water speed L/h,
Quf：Ultrafiltrate speed L/h,
Qsub：Displacement liquid speed L/h,
WT：Body weight kg,
Css(t)：Internal citric acid Css mmol/L,
Qeffluent：Efflux speed L/h,
Cca_effluent：The total calcium concentration mmol/L of efflux.
Qcit：Citric acid infusion velocity L/h,
Above-mentioned parameter CcaT (art), Qpw, Quf, Qsub, WT, Css (t), Qeffluent, Cca_effluent etc. can be with
Measured before dialysis starts using prior art, user is inputted using input module.
Wherein, Css (t) is internal citric acid Css (mmol/L), can use following citric acid pharmacokinetic
Immunologing mathematics model prediction concrete mathematical model derive (referring to Zheng Yin, Xu Zhongye, it is burnt just etc., Chinese holly during continuous renal replacementtherapy
The structure of rafter acid pharmacokinetics mathematical modeling.Chinese Journal of Nephrology 2010；26(6)：432-437.) citric acid medicine generation
Dynamics mathematical model checking referring to：Yin Zheng,Zhongye Xu,Qiuyu Zhu,Junfeng Liu,Jing Qian,
Huaizhou You,Yong Gu,Chuanming Hao,Zheng Jiao,Feng Ding.Citrate
Pharmacokinetics in Critically Ill Patients with Acute Kidney Injury。PLoS ONE
2013,8(6)：E65992. (the citric acid pharmacokinetics of critical patients with acute renal failure)；(internal citron acidemia medicine is dense by Csys
Degree mmol/L) 3 hours or so general citric acids can reach stable state, concentration no longer changes, you can obtain, now as Css
(t)。
C(0)：Basic citron acid concentration mmol/L；
CLf：External citron acid dialysis clearance rate L/h；
CLb：Internal citric acid clearance rate L/h；
t：Citric acid Infusion Time h；
V：Citric acid apparent volume L；
G：Unit interval enters internal citric acid amount mmol.
G=Qp × Cinf × (1-Ecit),
Cinf：Citric acid amount mmol/L is added in every liter of blood plasma,
Ecit：Citric acid filtration frasction,
Qp：Plasmaflux L/h.
Css (t) is obtained to calculate after C (0), CLf, CLb, V, Cinf, Ecit, Qp using prior art and obtained.
As described in Figure 7, the application (n=10) in CVVH treatments.CVVH treatment times are longer than 24 hours, the number of display
According to 24 hours.First stage replenishes the calcium speed for 6.24 ± 0.43mmol/h, and second stage is reduced to 5.10 ± 0.22mmol/h.
Patient's body is interior and dialysis pipeline intermediate ion calcium concentration is smoothly controlled in the ideal range.
As shown in fig. 6, for further optimizing design scheme, citrate anticoagulation device also includes bubble and examined in the present embodiment
Module 4 is surveyed, the bubble detection module 4 connects wriggling pump control module 100, and the bubble detection module 4 includes bubble and detected
Part 401 and warning part 402, the bubble detection piece is supersonic detector (in the market is bought), and the warning part includes 3 kinds not
With the indicator lamp (red, yellow, and green) of color.
Bubble detection module includes I/O control units in another embodiment, and I/O control units are multi-channel mode,
Data interaction, indicator lamp and the bubble detection of three colors of major control are carried out by RS-485 communication modes and control device
Part.Multichannel I/O units can control the open and close of three lamps, at the same also it is readable go out bubble detection piece state, and should
State is sent to wriggling pump control module 100 in time.
External infusion pipe, if there is bubble in woven hose, supersonic detector are connected when citrate anticoagulation device is used
The bubble will be detected, and wriggling pump control module 100 is sent to by RS485 buses, will also be wrapped in wriggling pump control module 100
The module for receiving bubble detection module signal and sending pause peristaltic pump instruction is included, is connected with the bubble detection module 4, when connecing
The signal sent by bubble detection module, for example, point out alveolate signal, then receive and send signal so that first wriggles
The peristaltic pump 2 of pump 1 and second shuts down.When system runs well, indicator lamp green light；Having in infusion process will report during bubble
Alert, indicator lamp when red, two pumps shut down simultaneously.
For further optimizing design scheme, the wriggling pump control module also includes preliminary filling unit, the preliminary filling unit
It is connected with the first peristaltic pump speed control submodule and the second peristaltic pump speed control submodule, control is passed through using preceding user
Preliminary filling unit is respectively adopted the first peristaltic pump and the second peristaltic pump and carries out preliminary filling to woven hose, and indicator lamp is lighted.
Those skilled in the art understand, and obtains the first peristaltic pump rate signal calculating process, sends the as described above
The process of one peristaltic pump rate signal, the second peristaltic pump rate signal calculating process, send the mistake of the second peristaltic pump rate signal
Journey, self-detection module judges parameter calculating process, can utilize computer of the prior art, integrated circuit modules, can compile
Journey logical device, other hardware or existing software module are realized.
Citrate anticoagulation device of the present utility model provides two kinds of modes of operation：Automatic control mode and manual controlling party
Formula.Automatic control mode refers to that user's (majority is doctor) inputs the parameter needed in anti-coagulation process, example by input module
Such as：Total calcium concentration CcaT_art (mmol/L), displacement liquid speed Qsub (L/h), citric acid infusion velocity Qcit (L/h), ultrafiltration
Liquid speed degree Quf (L/h), packed cell volume (Hct), total protein concentration TP (g/L), patient body weight WT (kg), through peristaltic pump control
Module and then the rotating speed for calculating two peristaltic pumps, and rate signal is transferred to peristaltic pump.
Equipment possesses adjust automatically and replenished the calcium speed function under automatic control mode, that is, speed of replenishing the calcium point two-part.RCA starts
3 as a child after, system, which can be pointed out to enter second stage, replenishes the calcium, and related parameter can be carried out resetting with flow velocity.
Once setting successfully, system automatic can directly change the exploitation speed of two pumps according to second stage parameter, without the cumbersome behaviour of doctor
Make.
Manual control mode refers to using by input module that the rate signal of the first peristaltic pump and the second peristaltic pump is defeated
The first peristaltic pump rate signal outflow unit and the second wriggling pump speed entered to give in wriggling pump control module, wriggling pump control module
Rate signal is transmitted to the first peristaltic pump and the second peristaltic pump by degree signal outflow unit respectively.
So, the utility model effectively overcomes various shortcoming of the prior art and has high industrial utilization.
Above-described embodiment only illustrative principle of the present utility model and its effect are new not for this practicality is limited
Type.Any person skilled in the art can all be carried out without prejudice under spirit and scope of the present utility model to above-described embodiment
Modifications and changes.Therefore, such as those of ordinary skill in the art without departing from the essence disclosed in the utility model
God and all equivalent modifications completed under technological thought or change, should be covered by claim of the present utility model.
Claims (8)
1. a kind of citrate anticoagulation device, it is characterised in that the citrate anticoagulation device at least includes：First peristaltic pump,
Two peristaltic pumps, and control device, the control device include wriggling pump control module, display module and input module, described
Input module connects wriggling pump control module, and the wriggling pump control module connects the first peristaltic pump and the second peristaltic pump, described
First peristaltic pump is citric acid pump, and second peristaltic pump is calcium pump.
2. citrate anticoagulation device according to claim 1, it is characterised in that：The wriggling pump control module includes：
The first peristaltic pump speed control submodule for controlling citric acid infusion velocity, is connected with first peristaltic pump；
Second peristaltic pump speed control submodule of speed of being replenished the calcium for control, is connected with second peristaltic pump.
3. citrate anticoagulation device according to claim 1, it is characterised in that：The citrate anticoagulation device also includes gas
Detection module is steeped, the wriggling pump control module also includes：
Receive bubble detection module signal and send the module of pause peristaltic pump instruction, be connected with the bubble detection module.
4. citrate anticoagulation device according to claim 3, it is characterised in that：The bubble detection module is examined including bubble
Survey part and warning part.
5. citrate anticoagulation device according to claim 4, it is characterised in that：The bubble detection piece is ultrasound examination
Device, the warning part includes the indicator lamp of a variety of different colours.
6. citrate anticoagulation device according to claim 1, it is characterised in that：The citrate anticoagulation device connects when using
External infusion pipe is connect, the wriggling pump control module also includes being used to control the preliminary filling unit to woven hose preliminary filling, compacted with first
Dynamic pump speed control submodule is connected with the second peristaltic pump speed control submodule.
7. citrate anticoagulation device according to claim 1, it is characterised in that：The display module is connected with input module
And be selectively connected with wriggling pump control module.
8. citrate anticoagulation device according to claim 1, it is characterised in that：The control device also includes being used to detect
Whether input module input parameter meets the self-detection module of preset parameter range, the self-detection module and input module and aobvious
Show that module is connected.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201620997643.2U CN206518724U (en) | 2016-08-30 | 2016-08-30 | Citrate anticoagulation device |
| PCT/CN2016/107678 WO2018040324A1 (en) | 2016-08-30 | 2016-11-29 | Citrate anticoagulation device and application thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201620997643.2U CN206518724U (en) | 2016-08-30 | 2016-08-30 | Citrate anticoagulation device |
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| Publication Number | Publication Date |
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| CN206518724U true CN206518724U (en) | 2017-09-26 |
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| CN201620997643.2U Active CN206518724U (en) | 2016-08-30 | 2016-08-30 | Citrate anticoagulation device |
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| CN (1) | CN206518724U (en) |
| WO (1) | WO2018040324A1 (en) |
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| BR112021011191A2 (en) * | 2018-12-11 | 2021-08-24 | Gambro Lundia Ab | Monitoring the performance of anticoagulation with regional citrate |
| CN111004707A (en) * | 2019-12-23 | 2020-04-14 | 深圳赛动生物自动化有限公司 | Stem cell collection control system and control method thereof |
| CN113018546B (en) * | 2021-03-17 | 2023-03-21 | 上海溯湃医疗科技有限公司 | Regional citric acid anticoagulation infusion system, control method, system and medium |
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| US7029456B2 (en) * | 2003-10-15 | 2006-04-18 | Baxter International Inc. | Medical fluid therapy flow balancing and synchronization system |
| US8372025B2 (en) * | 2005-09-22 | 2013-02-12 | Baxter International Inc. | Automation and optimization of CRRT treatment using regional citrate anticoagulation |
| CN202336108U (en) * | 2011-11-14 | 2012-07-18 | 赵红梅 | Trace infusion pump control system |
| CN102768653B (en) * | 2012-07-12 | 2016-03-02 | 广东省人民医院 | A kind of CRRT replacement liquid prescription counter |
| CN103830788B (en) * | 2012-11-27 | 2016-02-24 | 深圳先进技术研究院 | Liquid-supplying system of hemodialysis center |
| CN203139210U (en) * | 2013-04-12 | 2013-08-21 | 孟宇 | Portable system for monitoring infusion of extracorporeal circulation sodium citrate anticoagulant |
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Effective date of registration: 20201203 Address after: Room 508, building 11, No.1, Xinjie Road, Songjiang District, Shanghai, 201600 Patentee after: Shanghai shupai Medical Technology Co., Ltd Address before: Room f2967, building 1, 5500 Yuanjiang Road, Minhang District, Shanghai 201100 Patentee before: Shanghai Ailan Industrial Equipment Co., Ltd |