CN206508943U - Porous light particle preparation facilities - Google Patents
Porous light particle preparation facilities Download PDFInfo
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- CN206508943U CN206508943U CN201720025046.8U CN201720025046U CN206508943U CN 206508943 U CN206508943 U CN 206508943U CN 201720025046 U CN201720025046 U CN 201720025046U CN 206508943 U CN206508943 U CN 206508943U
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- preparation facilities
- porous light
- diaphragm
- light particle
- particle preparation
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Abstract
The utility model provides a kind of porous light particle preparation facilities, and it includes atomization portion 10, is configured to fluid sample 123 being atomized into multiple droplets；Frozen part 20, if being configured to multiple droplets being cooled to dry ice pellet；With drying section 30, if being configured to dry ice pellet being dried to multiple porous granules, to obtain the solid powder formed by multiple porous granule set.The porous light particle preparation facilities is by atomization portion 10 by the uniform atomizing of fluid sample 123 into the equal micron order droplet of countless particle diameters, droplet is frozen into several ice pellets by frozen part 20, by drying section 30 by ice pellets low temperature drying into porous light particle, so can be directly by thermal sensitivity, consistence, active material and the high fluid sample 123 of sugar content are prepared into by the molecular powder of porous light grain, the original biological and chemical characteristic of sample can be not only set to keep constant, and particle specific surface area is big, good fluidity, with fine aerosol dynamics characteristic, suction preparation is suitably made to use, it can also be applied to other field.
Description
Technical field
The utility model is related to particle preparing technical field, more particularly to a kind of porous light particle preparation facilities.
Background technology
Vaccine and medicine are the new hair of reply and the popular effective means of deadly infectious disease, and current research direction is vaccine
Or the fluid sample of medicine is prepared into solid powder, powdered vaccine directly nasal membrane can both be immunized, can also lung suction
Treatment can be directly sucked in by entering immune, powdered medicine, injected after can also dissolving, broken away from cold chain transportation and Cord blood
Link.Existing particle preparation method mainly has spray drying process and vacuum freeze-drying method, and both approaches exist certain
Defect.Temperature or pressure in spray-drying process may influence the bioactivity of vaccine, although vacuum freeze drying can be most
Limits protect original activity of sample, but generally yield after drying is pie or bulk product, is needed by crushing again
Grinding could obtain powder product.
Utility model content
The utility model is intended to overcome at least one defect of existing powdered vaccine or medicine preparation, and there is provided one kind is porous
Lightweight particle preparation facilities, thermal sensitivity, consistence, active material and the high fluid sample of sugar content directly can be prepared into by many by it
The molecular powder of hole lightweight grain, can not only make the original biological and chemical characteristic of sample keep constant, and particle compares surface
Product is big, good fluidity, with fine aerosol dynamics characteristic, suitably makees suction preparation and uses.
Therefore, the utility model provides a kind of porous light particle preparation facilities, it includes：
Atomization portion, is configured to fluid sample being atomized into multiple droplets；
Frozen part, if being configured to multiple droplets being cooled to dry ice pellet；With
Drying section, is configured to some ice pellets being dried to multiple porous granules, to obtain by the multiple porous grain
The solid powder of subclass formation.
Further, the frozen part has the cooling space for being used for receiving multiple droplets；
If the drying section has the dry place for receiving the dry ice pellet.
Further, the atomization portion is vibration hole sizer atomizer, with horizontally disposed diaphragm and the drive diaphragm
The vibrating device of vibration；And
It is provided with the diaphragm on the upside of multiple holes, and the diaphragm and is configured to hold the fluid sample；
The vibrating device drives the fluid sample vibration on the upside of the diaphragm and the diaphragm, so that the film
The fluid sample on the upside of piece forms multiple droplets in the downside of the diaphragm through multiple described holes.
Further, the diameter range of each described hole is 1 to 100 microns.
Further, the cooling space is configured to receive the liquid nitrogen for being used for freezing multiple droplets；And
The frozen part also includes agitating device, and the agitating device is configured to the institute that stirring is located in the cooling space
Droplet and the liquid nitrogen are stated, so that the two is sufficiently mixed.
Further, the frozen part also includes limiting the cooling space in cooling tank, the cooling tank；
The agitating device is magnetic stirring apparatus, and it includes the stirring rotator being located in the cooling space and positioned at described
Guide device below refrigerated cylinder.
Further, the drying section is freeze drier.
Further, the atomization portion, which has, is used for the droplet outlet that the multiple droplet flows out, with the cooling space
Connection.
Porous light particle preparation facilities of the present utility model is by atomization portion by fluid sample uniform atomizing into countless
The equal micron order droplet of particle diameter, is frozen into several ice pellets by droplet by frozen part, does ice pellets low temperature by drying section
Thermal sensitivity, consistence, active material and the high fluid sample of sugar content, directly can so be prepared into by the dry particle into porous light
By the molecular powder of porous light grain, the original biological and chemical characteristic of sample can be not only set to keep constant, and particle ratio
Surface area is big, good fluidity, with fine aerosol dynamics characteristic, suitably makees suction preparation and uses, can also be applied to other necks
Domain.
Brief description of the drawings
It is described in detail by way of example, and not by way of limitation with reference to the accompanying drawings hereinafter more of the present utility model specific real
Apply example.Identical reference denotes same or similar part or part in accompanying drawing.It should be appreciated by those skilled in the art that
What these accompanying drawings were not necessarily drawn to scale.In accompanying drawing：
Fig. 1 is the schematic diagram of the porous light particle preparation facilities according to the utility model one embodiment.
Fig. 2 is the powder prepared by porous light particle preparation facilities of the present utility model.
Fig. 3 is the stereoscan photograph of gained powder.
Embodiment
To make the purpose, technical scheme and advantage of the utility model embodiment clearer, below in conjunction with accompanying drawing to tool
Body embodiment is described in detail.
Fig. 1 is the schematic diagram of the porous light particle preparation facilities according to the utility model one embodiment.Such as
Shown in Fig. 1, the utility model embodiment provides a kind of porous light particle preparation facilities.The porous light particle preparation facilities
It may include atomization portion 10, frozen part 20 and drying section 30.Atomization portion 10 is configured to the fluid sample mist such as vaccine, medicine and albumen
Be melted into multiple tiny droplets, if frozen part 20 is configured to multiple droplets being cooled to dry ice pellet, if drying section 30 be configured to by
Dry ice pellet is dried to multiple porous granules, to obtain the solid powder formed by multiple porous granule set.So can directly by
Thermal sensitivity, consistence, active material and the high fluid sample of sugar content are prepared into by the molecular powder of porous light grain, not only may be used
The original biological and chemical characteristic of sample is set to keep constant, and particle specific surface area is big, good fluidity, with fine aerosol
Dynamics, suitably makees suction preparation and uses.
Further, in some embodiments of the present utility model, frozen part 20, which has, to be used to receive multiple fine mists
Cooling space 210, if drying section 30 have receive dry ice pellet dry place.In some embodiments of the present utility model,
Atomization portion 10, which also has, to be used to the droplet outlet that multiple droplets flow out, connect with cooling space 210.It is of the present utility model porous light
When in use, atomization portion 10 is by fluid sample uniform atomizing into countless fine mists, and small droplet enters for the sub- preparation facilities of plasmid
Frozen part 20, is cooled into ice pellets, and the ice pellets formed enters drying section 30, is finally dried to by consolidating that porous granule is constituted
Body powder.
In some embodiments of the present utility model, atomization portion 10 is vibration hole sizer atomizer 12, and the atomizer has water
The flat diaphragm 121 set and the vibrating device 122 vibrated with dynamic diaphragm 121.Multiple equal-sized holes are provided with diaphragm 121
Hole, the diameter range of each hole is 1 to 100 microns.The upside of diaphragm 121 is configured to hold fluid sample 123.Vibrating device
122 fluid samples 123 with dynamic diaphragm 121 and the upside of diaphragm 121 vibrate, so that the fluid sample 123 of the upside of diaphragm 121 is saturating
Cross multiple holes and form multiple droplets in the downside of diaphragm 121.Vibrating device 122 is vibrated by Piezoelectric Driving, band dynamic diaphragm 121,
It is per second to produce million micron-sized droplets.
In some embodiments of the present utility model, frozen part 20 also includes limiting in cooling tank 220, cooling tank 220
Space 210 is cooled down, cooling space 210 can receive the liquid nitrogen for freezing multiple droplets.For example, can be set on cooling tank 220
There are multiple openings 230, the liquid nitrogen being stored in liquid nitrogen container enters cooling tank 220, the nitrogen of volatilization by one or more openings
Pass through remaining opening discharge cooling tank 220.
To ensure that it is sufficiently cool that droplet is obtained, in some embodiments of the present utility model, frozen part 20 also includes stirring
Device 240, is configured to droplet and liquid nitrogen that stirring is located in cooling space 210, so that the two is sufficiently mixed.Agitating device 240
Magnetic stirring apparatus can be used, it includes the stirring rotator 241 being located in cooling space 210 and the guiding dress below refrigerated cylinder
Put 242.
In some embodiments of the present utility model, drying section 30 is freeze drier, and it can be in low temperature and vacuum environment
Under ice pellets is dried, vaccine or the original bioactivity of medicine can be retained.Specifically, have in freeze drier and dry sky
Between, and sample disc is provided with dry place, ice pellets to be dried is positioned in sample disc.Freeze drier can make dry place
Interior holding low temperature environment (i.e. -10 DEG C~-60 DEG C of temperature environments) and vacuum environment, under the low temperature environment and vacuum environment,
The moisture biochemistry of solid in ice pellets is into gaseous state, so that ice pellets is dried, becomes loose porous particle, many such grains
Son just constitutes a pile powder.These powder are exactly the drug powder or vaccine powder that are used to suck preparation etc. obtained, finally
The powder of acquisition is as shown in Fig. 2 the stereoscan photograph of powder as described in Figure 3, shows that gained powder is by the micro- of porous light
Meter level particle is constituted.
Described above is only preferred embodiment of the present utility model, it is noted that for the common skill of the art
For art personnel, on the premise of the utility model principle is not departed from, any improvements and modifications made also should be regarded as this reality
With new protection domain.
Claims (8)
1. a kind of porous light particle preparation facilities, it is characterised in that including：
Atomization portion, is configured to fluid sample being atomized into multiple droplets；
Frozen part, if being configured to multiple droplets being cooled to dry ice pellet；With
Drying section, is configured to some ice pellets being dried to multiple porous granules, to obtain by the multiple porous granule collection
Close the solid powder formed.
2. porous light particle preparation facilities according to claim 1, it is characterised in that
The frozen part has the cooling space for being used for receiving multiple droplets；
If the drying section has the dry place for receiving the dry ice pellet.
3. porous light particle preparation facilities according to claim 1 or 2, it is characterised in that
The atomization portion is vibration hole sizer atomizer, the vibration dress with horizontally disposed diaphragm and the drive diaphragm vibration
Put；And
It is provided with the diaphragm on the upside of multiple holes, and the diaphragm and is configured to hold the fluid sample；
The vibrating device drives the fluid sample vibration on the upside of the diaphragm and the diaphragm, so that on the diaphragm
The fluid sample of side forms multiple droplets in the downside of the diaphragm through multiple described holes.
4. porous light particle preparation facilities according to claim 3, it is characterised in that
The diameter (span) of each described hole is 1 to 100 microns.
5. porous light particle preparation facilities according to claim 2, it is characterised in that
The cooling space is configured to receive the liquid nitrogen for being used for freezing multiple droplets；And
The frozen part also includes agitating device, and the agitating device is configured to the mist that stirring is located in the cooling space
Drop and the liquid nitrogen, so that the two is sufficiently mixed.
6. porous light particle preparation facilities according to claim 5, it is characterised in that
The frozen part also includes limiting the cooling space in cooling tank, the cooling tank；
The agitating device is magnetic stirring apparatus, and it includes the stirring rotator being located in the cooling space and positioned at the freezing
Guide device below tank.
7. porous light particle preparation facilities according to claim 2, it is characterised in that
The drying section is freeze drier.
8. porous light particle preparation facilities according to claim 2, it is characterised in that
The atomization portion, which has, to be used to the droplet outlet that the multiple droplet flows out, connect with the cooling space.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201720025046.8U CN206508943U (en) | 2017-01-10 | 2017-01-10 | Porous light particle preparation facilities |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201720025046.8U CN206508943U (en) | 2017-01-10 | 2017-01-10 | Porous light particle preparation facilities |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN206508943U true CN206508943U (en) | 2017-09-22 |
Family
ID=59864606
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201720025046.8U Active CN206508943U (en) | 2017-01-10 | 2017-01-10 | Porous light particle preparation facilities |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN206508943U (en) |
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2017
- 2017-01-10 CN CN201720025046.8U patent/CN206508943U/en active Active
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