CN206508590U - A kind of high speed centrifugation atomization combines the alcohol sink device of continuous alcohol precipitation - Google Patents
A kind of high speed centrifugation atomization combines the alcohol sink device of continuous alcohol precipitation Download PDFInfo
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Abstract
A kind of high speed centrifugation atomization combines the alcohol sink device of continuous alcohol precipitation, it is characterized in that the alcohol sink device includes the water extracted immersing paste delivery pump, ethanol delivery pump, centrifugal turntable, spray chamber, atomized liquid delivery pump, stirred tank, liquid level limiter and sensor, the centrifugal turntable can carry out centrifugal atomizing respectively to two-way liquid material simultaneously, the outlet of the water extracted immersing paste delivery pump and ethanol delivery pump is connected with the different feeds mouthful of centrifugal turntable respectively, described spray chamber bottom conveys pump intake by pipeline and atomized liquid and is connected, atomized liquid conveying pump discharge is connected by pipeline with the charging aperture of stirred tank, the liquid level limiter is arranged on spray chamber side wall, the sensor is connected with liquid level limiter.
Description
Technical field
The utility model belongs to Chinese medicine separating and purifying technology and apparatus field, and more particularly to a kind of high speed centrifugation atomization is combined
The alcohol precipitation of continuous alcohol precipitation.
Background technology
Aqueous extraction-alcohol precipitation technology is widely used in Chinese medicine preparation, and because ethanol price is relatively cheap, non-toxic, operation letter
Just, alcohol precipitation process is the most frequently used impurity-removing method of current industrialized production.The general principle of alcohol precipitation such as Chinese patent literature
It is not only to be dissolved in alcohol using the part active ingredient of Chinese medicine but also be dissolved in the property of water, using finite concentration described in CN103070919A
Alcohol precipitation be partially insoluble in so-called invalid component such as polysaccharide, albumen etc. of ethanol, reach refined finished product, raising finished dosage form matter
The purpose of amount.
The most alcohol precipitation equipment used at present, such as Chinese patent literature CN205340243U, CN205340241U,
Described in CN205323297U, by the cylinder with chuck, ellipse head, the cylinder of conical bottom and rotate out of liquid pipe and constitute.Alcohol
Heavy rear impurity is deposited in the cylinder bottom of conical bottom, and clear liquid is sucked out by rotating out of liquid pipe, and precipitation is exported by tank bottom and discharged.
At present, the alcohol precipitation process generally used in production is that Chinese medicine aqueous extract medicinal extract is added into alcohol precipitation equipment first
In, ethanol is added while stirring, releasing alcohol liquid after a period of time is then stood and is centrifuged or be filtered to remove precipitation, cleaning container is again
Carry out next group alcohol precipitation.
Under study for action it was found that traditional alcohol precipitation equipment and alcohol precipitation process are while completing to remove crudely and store essence, to Chinese medicine
The extract yield of each effective constituents has harmful effect, and it is main reason is that aqueous phase and alcohol phase are in mixing in alcohol precipitation
Because the invalid component insoluble in ethanol is larger in two-phase dissolubility difference, makes alcohol insoluble component in aqueous phase rapid precipitation and and glue
Clump together, adsorb and wrapped up part active ingredient；And traditional alcohol precipitation equipment and alcohol precipitation mode of operation can not make whole alcohol precipitation
Process is carried out continuously, and influences production efficiency, and alcohol precipitation can be improved by adding the unstability between Chinese medicine batch, therefore providing one kind
Technique is to the extract yield of effective component of chinese medicine, and it is in the prior art urgently to be capable of the alcohol precipitation device and method of continuous operation
The problem of solution.
The content of the invention
To solve aforementioned technical problem, the technical solution adopted in the utility model：
The alcohol sink device that a kind of high speed centrifugation atomization combines continuous alcohol precipitation is provided, it is characterized in that the alcohol sink device includes water
Extracted extract delivery pump, ethanol delivery pump, centrifugal turntable, spray chamber, atomized liquid delivery pump, stirred tank, liquid level limiter and sensing
Device, the centrifugal turntable can carry out centrifugal atomizing, the water extracted immersing paste delivery pump and second respectively to two-way liquid material simultaneously
The outlet of alcohol delivery pump is connected with the different feeds mouthful of centrifugal turntable respectively, and described spray chamber bottom passes through pipeline and atomization
Liquid conveying pump intake is connected, and atomized liquid conveying pump discharge is connected by pipeline with the charging aperture of stirred tank, the liquid level limit
Position device is arranged on spray chamber side wall, and the sensor is connected with liquid level limiter.
The utility model additionally provides the alcohol precipitating method that a kind of high speed centrifugation atomization combines continuous alcohol precipitation, it is characterized in that described
Method comprises the following steps：
1) feed：By proportion for 1.10~1.20 Chinese medicine aqueous extract medicinal extract and ethanol according to 1:1~1:5 volume flow
Amount ratio, is each delivered to centrifugal turntable respectively by pump pressure in 1.25~2.5Mpa delivery pump；
2) centrifugal atomizing：Chinese medicine aqueous extract medicinal extract and ethanol are under centrifugal turntable high speed turning effort respectively in spray chamber
Middle atomization, and contacted in atomization process, two-phase flow to spray chamber bottom after alcohol precipitation occurs for critical point and forms atomized liquid jointly,
The rotating speed of the centrifugal turntable is 5000-15000r/min；
3) continuous alcohol precipitation：When in spray chamber liquid level rise to setting liquid level it is high spacing when, open the valve of spray chamber bottom
Door and coupled atomized liquid delivery pump, stirred tank is delivered to by the atomized liquid of spray chamber bottom；When liquid level in spray chamber
When dropping to the liquid level lower bound position of setting, the valve and coupled atomized liquid delivery pump of spray chamber bottom are closed；
4) post-process：Stirred tank after 30~90min of stirring, is stood under the conditions of rotating speed is 60~80r/min, to be filtered.
Described alcohol precipitating method, it is characterized in that using described alcohol sink device, the liquid level of setting is sensed with liquid level limiter
High spacing and lower bound position, and the liquid level signal control spray chamber bottom valve of the liquid level limiter received by sensor and atomization
Liquid delivery pump；Chinese medicine aqueous extract medicinal extract and ethanol are conveyed with the water extracted immersing paste delivery pump and ethanol delivery pump respectively.
The concentration of volume percent of the ethanol is 95%, it is preferred to use medicinal alcohol.
The beneficial effects of the utility model：Compared with traditional alcohol precipitation equipment and alcohol precipitation mode of operation, the utility model
The alcohol precipitation device and method that a kind of high speed centrifugation atomization provided combines continuous alcohol precipitation has advantages below,
1) easy to operate, production efficiency is high, steady quality between batch；With the device in the utility model embodiment
And exemplified by method, when the stirred tank using same specification, production efficiency handles 6000Kg Chinese medicines by the 72h of traditional alcohol precipitating method
Aqueous extract medicinal extract, which is improved to 24h, can handle 6000Kg Chinese medicine aqueous extract medicinal extract
2) alcohol precipitating method of the present utility model, using high speed centrifugation is atomized and makes it in atomization respectively by aqueous phase and alcohol phase
The alcohol precipitation mode of contact, makes precipitation reaction occur in two critical points being in contact, eliminates traditional alcohol precipitation mode and two phase countercurrent flow
Locally the too high alcohol insoluble component precipitation caused is too fast for concentration of alcohol during contact, causes it to adsorb and wrap up the difficulty of active ingredient
Topic, reduces the loss of active ingredient, improves product recovery rate, equally with the device in the utility model embodiment and
Exemplified by method, the rate of recovery of the water-soluble root of red-rooted salvia phenolic acid in Salvia miltiorrhiza Bge water extract solution medicinal extract can be made to be improved extremely by original 85%
96%.
3) alcohol sink device of the present utility model, the characteristics of simultaneously being respectively atomized simultaneously with multiple feed using centrifugal turntable,
Allow aqueous phase and alcohol phase using same centrifugal turntable while completing atomization, that is, simplify device structure, be conducive to two-phase again
The abundant contact of droplet.
Brief description of the drawings
Fig. 1 is the overall structure for the alcohol sink device that a kind of high speed centrifugation atomization that the utility model is provided combines continuous alcohol precipitation
Schematic diagram；
In figure：
1. the water extracted immersing paste delivery pump, 2. pharmaceutical ethanol delivery pumps, 3. centrifugal turntables, 4. spray chambers, 5. atomized liquids are conveyed
Pump, 6. stirred tanks, 7. sensors, 8. liquid level limiters.
Embodiment
Explanation and embodiment are described further to the utility model below in conjunction with the accompanying drawings.
Reference picture 1, the utility model provides the alcohol sink device that a kind of high speed centrifugation atomization combines continuous alcohol precipitation, including water extraction
Medicinal extract delivery pump 1, ethanol delivery pump 2, centrifugal turntable 3, spray chamber 4, atomized liquid delivery pump 5, stirred tank 6, liquid level limiter 8 and
Sensor 7, the centrifugal turntable can carry out centrifugal atomizing, the water extracted immersing paste delivery pump respectively to two-way liquid material simultaneously
Outlet with ethanol delivery pump mouthful is connected with the different feeds of centrifugal turntable respectively, described spray chamber bottom by pipeline with
Atomized liquid conveying pump intake is connected, and atomized liquid conveying pump discharge is connected by pipeline with the charging aperture of stirred tank, the liquid
Position limiter is arranged on spray chamber side wall, and the sensor is connected with liquid level limiter.
A kind of high speed centrifugation atomization that the utility model is provided combines the alcohol precipitating method of continuous alcohol precipitation, using the utility model
The alcohol sink device of offer, its specific steps include
1) feed：By proportion for D Chinese medicine aqueous extract medicinal extract and ethanol respectively through the water extracted immersing paste delivery pump and ethanol
Centrifugal turntable is delivered to after delivery pump, the conveying pump pressure of the water extracted immersing paste delivery pump and ethanol delivery pump is P Mpa, Chinese medicine
The volume ratio of aqueous extract medicinal extract and ethanol is 1：V；
2) centrifugal atomizing：Chinese medicine aqueous extract medicinal extract (abbreviation aqueous phase) and ethanol (abbreviation alcohol phase) revolve at a high speed in centrifugal turntable
Transfer to and be atomized respectively in spray chamber with lower, and contacted in atomization process, two-phase is flow to jointly after alcohol precipitation occurs for critical point
Atomized liquid is formed on spray chamber bottom, and the rotating speed of centrifugal turntable is R1r/min；
3) continuous alcohol precipitation：When in spray chamber liquid level rise to setting liquid level it is high spacing when, open the valve of spray chamber bottom
Door and coupled atomized liquid delivery pump, stirred tank is delivered to by the atomized liquid of spray chamber bottom；When liquid level in spray chamber
When dropping to the liquid level lower bound position of setting, the valve and coupled atomized liquid delivery pump of spray chamber bottom are closed；
4) post-process：Stirred tank is R in rotating speed2Under the conditions of r/min, after stirring Tmin, stand, it is to be filtered.
Device embodiment
Spray chamber specification：
Straight barrel60 ° of cone angle.Inner bag material is 304 stainless steels, thick 2.5mm.
Centrifugal turntable specification：
Model RW500, maximum throughput 500kg/h, rotating speed 5000-15000r/min, power 12kw, material is 304
Stainless steel.
Stirred tank specification：
Belt stirrer, power of agitator 12kw, inner bag material is 304 stainless steels, volume 15m3。
Embodiment of the method 1~3：
With the alcohol sink device in device embodiment, and with 500L red sage root aqueous extract medicinal extract and volume percent content 95%
Medicinal alcohol handled according to the alcohol precipitating method, specific process parameter and the water-soluble root of red-rooted salvia phenolic acid rate of recovery such as following table：
Although embodiment of the present utility model is disclosed as above, it is not restricted in specification and embodiment
Listed to use, it can be applied to various suitable fields of the present utility model completely, for those skilled in the art
Speech, is easily achieved other modification, therefore under the universal limited without departing substantially from claim and equivalency range, this
Utility model is not limited to specific details and shown here as the legend with description.
Claims (1)
1. a kind of high speed centrifugation atomization combines the alcohol sink device of continuous alcohol precipitation, it is characterized in that the alcohol sink device includes the water extracted immersing paste
Delivery pump, ethanol delivery pump, centrifugal turntable, spray chamber, atomized liquid delivery pump, stirred tank, liquid level limiter and sensor, it is described
Centrifugal turntable can carry out centrifugal atomizing, the water extracted immersing paste delivery pump and ethanol delivery pump respectively to two-way liquid material simultaneously
Outlet mouthful be connected with the different feeds of centrifugal turntable respectively, described spray chamber bottom passes through pipeline and atomized liquid delivery pump
Entrance is connected, and atomized liquid conveying pump discharge is connected by pipeline with the charging aperture of stirred tank, and the liquid level limiter is installed
In spray chamber side wall, the sensor is connected with liquid level limiter.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106512466A (en) * | 2016-12-29 | 2017-03-22 | 天津中医药大学 | Alcohol precipitation apparatus and method combining high-speed centrifugal atomization with continuous alcohol precipitation |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106512466A (en) * | 2016-12-29 | 2017-03-22 | 天津中医药大学 | Alcohol precipitation apparatus and method combining high-speed centrifugal atomization with continuous alcohol precipitation |
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