CN206508590U - A kind of high speed centrifugation atomization combines the alcohol sink device of continuous alcohol precipitation - Google Patents

A kind of high speed centrifugation atomization combines the alcohol sink device of continuous alcohol precipitation Download PDF

Info

Publication number
CN206508590U
CN206508590U CN201621459285.6U CN201621459285U CN206508590U CN 206508590 U CN206508590 U CN 206508590U CN 201621459285 U CN201621459285 U CN 201621459285U CN 206508590 U CN206508590 U CN 206508590U
Authority
CN
China
Prior art keywords
delivery pump
alcohol
spray chamber
liquid level
liquid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN201621459285.6U
Other languages
Chinese (zh)
Inventor
宋新波
余河水
李正
别松涛
李忠林
刘长青
魏立群
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Weifang Shandong Jing Ying Medical Devices Co Ltd
Tianjin University of Traditional Chinese Medicine
Original Assignee
Weifang Shandong Jing Ying Medical Devices Co Ltd
Tianjin University of Traditional Chinese Medicine
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Weifang Shandong Jing Ying Medical Devices Co Ltd, Tianjin University of Traditional Chinese Medicine filed Critical Weifang Shandong Jing Ying Medical Devices Co Ltd
Priority to CN201621459285.6U priority Critical patent/CN206508590U/en
Application granted granted Critical
Publication of CN206508590U publication Critical patent/CN206508590U/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Landscapes

  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Extraction Or Liquid Replacement (AREA)

Abstract

A kind of high speed centrifugation atomization combines the alcohol sink device of continuous alcohol precipitation, it is characterized in that the alcohol sink device includes the water extracted immersing paste delivery pump, ethanol delivery pump, centrifugal turntable, spray chamber, atomized liquid delivery pump, stirred tank, liquid level limiter and sensor, the centrifugal turntable can carry out centrifugal atomizing respectively to two-way liquid material simultaneously, the outlet of the water extracted immersing paste delivery pump and ethanol delivery pump is connected with the different feeds mouthful of centrifugal turntable respectively, described spray chamber bottom conveys pump intake by pipeline and atomized liquid and is connected, atomized liquid conveying pump discharge is connected by pipeline with the charging aperture of stirred tank, the liquid level limiter is arranged on spray chamber side wall, the sensor is connected with liquid level limiter.

Description

A kind of high speed centrifugation atomization combines the alcohol sink device of continuous alcohol precipitation
Technical field
The utility model belongs to Chinese medicine separating and purifying technology and apparatus field, and more particularly to a kind of high speed centrifugation atomization is combined The alcohol precipitation of continuous alcohol precipitation.
Background technology
Aqueous extraction-alcohol precipitation technology is widely used in Chinese medicine preparation, and because ethanol price is relatively cheap, non-toxic, operation letter Just, alcohol precipitation process is the most frequently used impurity-removing method of current industrialized production.The general principle of alcohol precipitation such as Chinese patent literature It is not only to be dissolved in alcohol using the part active ingredient of Chinese medicine but also be dissolved in the property of water, using finite concentration described in CN103070919A Alcohol precipitation be partially insoluble in so-called invalid component such as polysaccharide, albumen etc. of ethanol, reach refined finished product, raising finished dosage form matter The purpose of amount.
The most alcohol precipitation equipment used at present, such as Chinese patent literature CN205340243U, CN205340241U, Described in CN205323297U, by the cylinder with chuck, ellipse head, the cylinder of conical bottom and rotate out of liquid pipe and constitute.Alcohol Heavy rear impurity is deposited in the cylinder bottom of conical bottom, and clear liquid is sucked out by rotating out of liquid pipe, and precipitation is exported by tank bottom and discharged.
At present, the alcohol precipitation process generally used in production is that Chinese medicine aqueous extract medicinal extract is added into alcohol precipitation equipment first In, ethanol is added while stirring, releasing alcohol liquid after a period of time is then stood and is centrifuged or be filtered to remove precipitation, cleaning container is again Carry out next group alcohol precipitation.
Under study for action it was found that traditional alcohol precipitation equipment and alcohol precipitation process are while completing to remove crudely and store essence, to Chinese medicine The extract yield of each effective constituents has harmful effect, and it is main reason is that aqueous phase and alcohol phase are in mixing in alcohol precipitation Because the invalid component insoluble in ethanol is larger in two-phase dissolubility difference, makes alcohol insoluble component in aqueous phase rapid precipitation and and glue Clump together, adsorb and wrapped up part active ingredient;And traditional alcohol precipitation equipment and alcohol precipitation mode of operation can not make whole alcohol precipitation Process is carried out continuously, and influences production efficiency, and alcohol precipitation can be improved by adding the unstability between Chinese medicine batch, therefore providing one kind Technique is to the extract yield of effective component of chinese medicine, and it is in the prior art urgently to be capable of the alcohol precipitation device and method of continuous operation The problem of solution.
The content of the invention
To solve aforementioned technical problem, the technical solution adopted in the utility model:
The alcohol sink device that a kind of high speed centrifugation atomization combines continuous alcohol precipitation is provided, it is characterized in that the alcohol sink device includes water Extracted extract delivery pump, ethanol delivery pump, centrifugal turntable, spray chamber, atomized liquid delivery pump, stirred tank, liquid level limiter and sensing Device, the centrifugal turntable can carry out centrifugal atomizing, the water extracted immersing paste delivery pump and second respectively to two-way liquid material simultaneously The outlet of alcohol delivery pump is connected with the different feeds mouthful of centrifugal turntable respectively, and described spray chamber bottom passes through pipeline and atomization Liquid conveying pump intake is connected, and atomized liquid conveying pump discharge is connected by pipeline with the charging aperture of stirred tank, the liquid level limit Position device is arranged on spray chamber side wall, and the sensor is connected with liquid level limiter.
The utility model additionally provides the alcohol precipitating method that a kind of high speed centrifugation atomization combines continuous alcohol precipitation, it is characterized in that described Method comprises the following steps:
1) feed:By proportion for 1.10~1.20 Chinese medicine aqueous extract medicinal extract and ethanol according to 1:1~1:5 volume flow Amount ratio, is each delivered to centrifugal turntable respectively by pump pressure in 1.25~2.5Mpa delivery pump;
2) centrifugal atomizing:Chinese medicine aqueous extract medicinal extract and ethanol are under centrifugal turntable high speed turning effort respectively in spray chamber Middle atomization, and contacted in atomization process, two-phase flow to spray chamber bottom after alcohol precipitation occurs for critical point and forms atomized liquid jointly, The rotating speed of the centrifugal turntable is 5000-15000r/min;
3) continuous alcohol precipitation:When in spray chamber liquid level rise to setting liquid level it is high spacing when, open the valve of spray chamber bottom Door and coupled atomized liquid delivery pump, stirred tank is delivered to by the atomized liquid of spray chamber bottom;When liquid level in spray chamber When dropping to the liquid level lower bound position of setting, the valve and coupled atomized liquid delivery pump of spray chamber bottom are closed;
4) post-process:Stirred tank after 30~90min of stirring, is stood under the conditions of rotating speed is 60~80r/min, to be filtered.
Described alcohol precipitating method, it is characterized in that using described alcohol sink device, the liquid level of setting is sensed with liquid level limiter High spacing and lower bound position, and the liquid level signal control spray chamber bottom valve of the liquid level limiter received by sensor and atomization Liquid delivery pump;Chinese medicine aqueous extract medicinal extract and ethanol are conveyed with the water extracted immersing paste delivery pump and ethanol delivery pump respectively.
The concentration of volume percent of the ethanol is 95%, it is preferred to use medicinal alcohol.
The beneficial effects of the utility model:Compared with traditional alcohol precipitation equipment and alcohol precipitation mode of operation, the utility model The alcohol precipitation device and method that a kind of high speed centrifugation atomization provided combines continuous alcohol precipitation has advantages below,
1) easy to operate, production efficiency is high, steady quality between batch;With the device in the utility model embodiment And exemplified by method, when the stirred tank using same specification, production efficiency handles 6000Kg Chinese medicines by the 72h of traditional alcohol precipitating method Aqueous extract medicinal extract, which is improved to 24h, can handle 6000Kg Chinese medicine aqueous extract medicinal extract
2) alcohol precipitating method of the present utility model, using high speed centrifugation is atomized and makes it in atomization respectively by aqueous phase and alcohol phase The alcohol precipitation mode of contact, makes precipitation reaction occur in two critical points being in contact, eliminates traditional alcohol precipitation mode and two phase countercurrent flow Locally the too high alcohol insoluble component precipitation caused is too fast for concentration of alcohol during contact, causes it to adsorb and wrap up the difficulty of active ingredient Topic, reduces the loss of active ingredient, improves product recovery rate, equally with the device in the utility model embodiment and Exemplified by method, the rate of recovery of the water-soluble root of red-rooted salvia phenolic acid in Salvia miltiorrhiza Bge water extract solution medicinal extract can be made to be improved extremely by original 85% 96%.
3) alcohol sink device of the present utility model, the characteristics of simultaneously being respectively atomized simultaneously with multiple feed using centrifugal turntable, Allow aqueous phase and alcohol phase using same centrifugal turntable while completing atomization, that is, simplify device structure, be conducive to two-phase again The abundant contact of droplet.
Brief description of the drawings
Fig. 1 is the overall structure for the alcohol sink device that a kind of high speed centrifugation atomization that the utility model is provided combines continuous alcohol precipitation Schematic diagram;
In figure:
1. the water extracted immersing paste delivery pump, 2. pharmaceutical ethanol delivery pumps, 3. centrifugal turntables, 4. spray chambers, 5. atomized liquids are conveyed Pump, 6. stirred tanks, 7. sensors, 8. liquid level limiters.
Embodiment
Explanation and embodiment are described further to the utility model below in conjunction with the accompanying drawings.
Reference picture 1, the utility model provides the alcohol sink device that a kind of high speed centrifugation atomization combines continuous alcohol precipitation, including water extraction Medicinal extract delivery pump 1, ethanol delivery pump 2, centrifugal turntable 3, spray chamber 4, atomized liquid delivery pump 5, stirred tank 6, liquid level limiter 8 and Sensor 7, the centrifugal turntable can carry out centrifugal atomizing, the water extracted immersing paste delivery pump respectively to two-way liquid material simultaneously Outlet with ethanol delivery pump mouthful is connected with the different feeds of centrifugal turntable respectively, described spray chamber bottom by pipeline with Atomized liquid conveying pump intake is connected, and atomized liquid conveying pump discharge is connected by pipeline with the charging aperture of stirred tank, the liquid Position limiter is arranged on spray chamber side wall, and the sensor is connected with liquid level limiter.
A kind of high speed centrifugation atomization that the utility model is provided combines the alcohol precipitating method of continuous alcohol precipitation, using the utility model The alcohol sink device of offer, its specific steps include
1) feed:By proportion for D Chinese medicine aqueous extract medicinal extract and ethanol respectively through the water extracted immersing paste delivery pump and ethanol Centrifugal turntable is delivered to after delivery pump, the conveying pump pressure of the water extracted immersing paste delivery pump and ethanol delivery pump is P Mpa, Chinese medicine The volume ratio of aqueous extract medicinal extract and ethanol is 1:V;
2) centrifugal atomizing:Chinese medicine aqueous extract medicinal extract (abbreviation aqueous phase) and ethanol (abbreviation alcohol phase) revolve at a high speed in centrifugal turntable Transfer to and be atomized respectively in spray chamber with lower, and contacted in atomization process, two-phase is flow to jointly after alcohol precipitation occurs for critical point Atomized liquid is formed on spray chamber bottom, and the rotating speed of centrifugal turntable is R1r/min;
3) continuous alcohol precipitation:When in spray chamber liquid level rise to setting liquid level it is high spacing when, open the valve of spray chamber bottom Door and coupled atomized liquid delivery pump, stirred tank is delivered to by the atomized liquid of spray chamber bottom;When liquid level in spray chamber When dropping to the liquid level lower bound position of setting, the valve and coupled atomized liquid delivery pump of spray chamber bottom are closed;
4) post-process:Stirred tank is R in rotating speed2Under the conditions of r/min, after stirring Tmin, stand, it is to be filtered.
Device embodiment
Spray chamber specification:
Straight barrel60 ° of cone angle.Inner bag material is 304 stainless steels, thick 2.5mm.
Centrifugal turntable specification:
Model RW500, maximum throughput 500kg/h, rotating speed 5000-15000r/min, power 12kw, material is 304 Stainless steel.
Stirred tank specification:
Belt stirrer, power of agitator 12kw, inner bag material is 304 stainless steels, volume 15m3
Embodiment of the method 1~3:
With the alcohol sink device in device embodiment, and with 500L red sage root aqueous extract medicinal extract and volume percent content 95% Medicinal alcohol handled according to the alcohol precipitating method, specific process parameter and the water-soluble root of red-rooted salvia phenolic acid rate of recovery such as following table:
Although embodiment of the present utility model is disclosed as above, it is not restricted in specification and embodiment Listed to use, it can be applied to various suitable fields of the present utility model completely, for those skilled in the art Speech, is easily achieved other modification, therefore under the universal limited without departing substantially from claim and equivalency range, this Utility model is not limited to specific details and shown here as the legend with description.

Claims (1)

1. a kind of high speed centrifugation atomization combines the alcohol sink device of continuous alcohol precipitation, it is characterized in that the alcohol sink device includes the water extracted immersing paste Delivery pump, ethanol delivery pump, centrifugal turntable, spray chamber, atomized liquid delivery pump, stirred tank, liquid level limiter and sensor, it is described Centrifugal turntable can carry out centrifugal atomizing, the water extracted immersing paste delivery pump and ethanol delivery pump respectively to two-way liquid material simultaneously Outlet mouthful be connected with the different feeds of centrifugal turntable respectively, described spray chamber bottom passes through pipeline and atomized liquid delivery pump Entrance is connected, and atomized liquid conveying pump discharge is connected by pipeline with the charging aperture of stirred tank, and the liquid level limiter is installed In spray chamber side wall, the sensor is connected with liquid level limiter.
CN201621459285.6U 2016-12-29 2016-12-29 A kind of high speed centrifugation atomization combines the alcohol sink device of continuous alcohol precipitation Active CN206508590U (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201621459285.6U CN206508590U (en) 2016-12-29 2016-12-29 A kind of high speed centrifugation atomization combines the alcohol sink device of continuous alcohol precipitation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201621459285.6U CN206508590U (en) 2016-12-29 2016-12-29 A kind of high speed centrifugation atomization combines the alcohol sink device of continuous alcohol precipitation

Publications (1)

Publication Number Publication Date
CN206508590U true CN206508590U (en) 2017-09-22

Family

ID=59862678

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201621459285.6U Active CN206508590U (en) 2016-12-29 2016-12-29 A kind of high speed centrifugation atomization combines the alcohol sink device of continuous alcohol precipitation

Country Status (1)

Country Link
CN (1) CN206508590U (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106512466A (en) * 2016-12-29 2017-03-22 天津中医药大学 Alcohol precipitation apparatus and method combining high-speed centrifugal atomization with continuous alcohol precipitation

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106512466A (en) * 2016-12-29 2017-03-22 天津中医药大学 Alcohol precipitation apparatus and method combining high-speed centrifugal atomization with continuous alcohol precipitation

Similar Documents

Publication Publication Date Title
CN103070919B (en) Alcohol precipitation device with combination of high pressure atomization and countercurrent and method
CN206508590U (en) A kind of high speed centrifugation atomization combines the alcohol sink device of continuous alcohol precipitation
CN106512466A (en) Alcohol precipitation apparatus and method combining high-speed centrifugal atomization with continuous alcohol precipitation
CN106512477B (en) A kind of alcohol precipitation device and method of pressure type mechanical atomization combination continuous alcohol precipitation
CN206508594U (en) A kind of alcohol sink device of pressure type mechanical atomization combination continuous alcohol precipitation
CN206676023U (en) A kind of traditional Chinese medicine extraction separator
CN206334389U (en) Astragalus polyose multistage continuous extracting device
CN109169965B (en) Preparation method of ginseng seed oil microcapsule powder
CN103622831A (en) Fixed-quantity infusion device for nasogastric tube feeding
CN211190000U (en) Vacuum powder suction device
CN207545889U (en) One kind isolates and purifies system
CN203420845U (en) Mixing pump
CN208552504U (en) A kind of traditional Chinese herbal decoction solidification preparation facilities
CN106237706A (en) High-efficient automatic purifying plant
CN206577144U (en) The decoloration device of extract oral liquid formulation
CN203736896U (en) Screw extraction device of traditional Chinese medicines
CN111848435A (en) Extraction equipment and extraction process for extracting theanine from tea leaves
CN204017679U (en) Supersonic quick firer on a kind of jet uniform filtration device
CN206229241U (en) Easy sampling type water reducer storage tank
CN104001424A (en) Supersonic jet gun used in jet flow homogeneous filter
CN212440221U (en) Filter cover for preparing mannan peptide oral liquid
CN205252593U (en) Traditional chinese medicine of dispersion feed liquor draws jar
CN202342946U (en) Ultrasonic counter-flow percolation extractor
CN216584823U (en) System for be used for dendrobii officmalis caulis polysaccharide to draw
CN205965097U (en) Breviscapinun concentrated system of filtrating

Legal Events

Date Code Title Description
GR01 Patent grant
GR01 Patent grant