CN206482682U - A kind of experiment treadmill of the upright synkinesia of adjustable animal - Google Patents
A kind of experiment treadmill of the upright synkinesia of adjustable animal Download PDFInfo
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- CN206482682U CN206482682U CN201620846776.XU CN201620846776U CN206482682U CN 206482682 U CN206482682 U CN 206482682U CN 201620846776 U CN201620846776 U CN 201620846776U CN 206482682 U CN206482682 U CN 206482682U
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Abstract
The utility model is related to a kind of experiment treadmill of the upright synkinesia of adjustable animal, mainly by main body slide strips formula runway, limit motion dividing plate group, carry food flat board, shadow shield, upright upper limb support plate, path angle adjusting means, control panel, runway elevation lowering or hoisting gear, runway frame, uprightly traction restraining, fixing device are constituted.Control panel is arranged on the one end of runway frame, it which is provided with power switch, speed and gradient display screen, work display lamp, speed set button, gradient select button, big minor adjustment button, runway direction of motion select button and beginning and stop button, can be according to specific experiment needs, clearly regulation is corresponding tests kinematic parameter.The utility model experiment treadmill at most can make 15 animals under equal conditions motion simultaneously, high degree of homogenous experiment condition simultaneously, make experimental result more credible, and very convenient and practical.
Description
Technical field
The utility model belongs to life science field, more particularly to a kind of reality of the upright synkinesia of adjustable animal
Test treadmill.
Background technology
Knee osteoarthritis (knee osteoarthritis, KOA) etc. are the passes occurred frequently of cause of disease complexity in person in middle and old age colony
Section disease, using knee cartilage strain and retrogression pathological changes as principal character, can cause synovial tissue of joint, cartilage and cartilage
The series pathological change such as lower bone structure destruction, brings to patient and prolongs continuous constantly pain, have a strong impact on quality of life and work, fortune
Kinetic force.Pathogenesis definite KOA is so far not yet completely clearly, but research finds that the related hazards of its disease include year
Age, acute or chronic Biomechanical, metabolic disorder of articular cartilage or bone tumour and cartilage microenvironment etc., the urgency in joint
Property or chronic biomethanics change be probably cause articular cartilage pathology change primary factor.The master of KOA injury repairs regulation
Factor is wanted to be acted on including intracellular molecules（Associated kinase cascade effect, autophagy, genetic transcription and miRNA etc.）With it is extracellular
Stimulation（Cell factor, hormone, Biomechanical force effect etc.）.Unbalance or mRNA, the albumen of these regulation factors
Overexpression or low expression and gene silencing etc. can cause the generation of articular cartilage Osteoarthritis, with advancing of disease, KOA
The continuous extensive inflammation to whole joint can be prolonged from synovitis and chondritis to react, cause the considerable damage of cartilaginous tissue, fiber group
The disorder of the severe hyperplasia knitted, new vessels and microenvironment metabolism, causes self chronic fibrosis reparation of cartilaginous tissue, causes
Local continuous of patient articular has an intense pain, joint deformity and motor function are limited etc..
The animal model for simulating KOA diseases is a lot of, mainly using rat, mouse and rabbit as research object, is broadly divided into three
Major class, i.e.,：1. spontaneous type KOA animal models, including natural spontaneous type and transgene mouse model etc.；2. induction type KOA animals
Model, i.e. experimental animal are under the factor of human intervention（Such as medicine, cold stimulation, biomethanics）Induction produces experimental animal
KOA；3. operation method KOA animal models, including meniscectomy, the cross-section art of front and rear ligamentaum cruciatum and Hulth models etc..Mesh
It is preceding because spontaneous type KOA animal model costs are higher, the induction type KOA animal model modeling times again it is oversize, so the KOA of rat
Hulth models and its improved model being used experiment modeling, although it can cause corresponding pathological change, but this many and KOA more
Pathogenesis and the clinically Osteoarthritis caused by strain property knee articular cartilage defect, which exist, not to be inconsistent significantly, especially hand
The scope and degree for the articular cartilage damage that art and physics sexual stimulus etc. are caused are difficult to control, and not only significantly affect molding standard
Uniformity, more severe jamming prevent and treat the scientific evaluation of intervening measure validity, and the knot such as meniscus, front and rear ligamentaum cruciatum is not destroyed
Structure, people's uprighting movement, the shortage of the experimental provision of motion strain can be but simulated very well, related disorders hair has even more been had a strong impact on
The accuracy of the metrics evaluation such as raw, development and exercise tolerance, rehabilitation training.
Utility model content
In order to change the deficiencies in the prior art, the purpose of this utility model is to provide a kind of high efficient and reliable, easy to use
The experiment treadmill of the upright synkinesia of adjustable animal.
A kind of experiment treadmill of the upright synkinesia of adjustable animal, mainly by main body slide strips formula runway, limit motion every
Plate group, load food flat board, shadow shield, upright upper limb support plate, path angle adjusting means, control panel, runway elevation lifting dress
Put, runway frame, uprightly traction restraining, fixing device composition.Whole experiment treadmill is solid rectangle structure, in main body slide strips formula
Runway is provided with restriction motion dividing plate group；Limit motion dividing plate group to be made up of 1-4 shape, the identical dividing plate of size,
Even genesis analysis is on main body slide strips formula runway, for will treat that experimental animal is limited to different runway scopes.Slided in main body
Belt runway is surrounded by runway frame, and runway frame is in rectangular configuration.Uniformly set in the whole top for limiting motion dividing plate group
There is a 1-3 effect case, each effect case spatially triangular structure is constituted by carrying food flat board and shadow shield, formed semi-enclosed
Responsiveness black hole.Limit the test sheet that whole experiment treadmill is separated into respective numbers by motion dividing plate group, runway frame and effect case
Member.One end of upright upper limb support plate is vertically fixed on the end for carrying food flat board, the other end and the upper end for limiting motion dividing plate group
It is in contact, gives experimental animal enough support forces of upper limbs when upright, reaches that the upright required mechanics of animal is supported.Effect case hangs down
Directly it is fixed on the longitudinally opposite two ends of runway frame.In carry food flat board on accommodating food, using the photophobism and sitotaxis of animal come
The autokinetic movement of animal is aided in, the effect required for experiment is reached.Path angle adjusting means is located at main body slide strips formula runway
One end, the motion gradient different available for regulation main body slide strips formula runway allows experimental animal to be carried out according to the different gradients corresponding
Level road motion, slope climbing movement, to reach corresponding test effect.Control panel is arranged on the one end of runway frame, sets thereon
Have power switch, speed and gradient display screen, work display lamp, speed set button, gradient select button, big minor adjustment by
Button, runway direction of motion select button and beginning and stop button, can be according to specific experiment needs, the clearly corresponding experiment of regulation
Kinematic parameter.Runway elevation lowering or hoisting gear is located at the bottom of whole experiment treadmill, the demand regulation that can be studied according to specific experiment
The height that whole experiment treadmill is put.Upright traction restraining and fixing device are used in combination, and are not influenceing experimental animal normal
In the case of breathing, motion, draught animal uprighting movement is simultaneously fixed in corresponding test unit.Fixing device is by 2 fixations
Folder composition, 2 geometrical clamps are separately fixed at the opposite end of corresponding test unit dividing plate.The utility model experiment treadmill at most may be used
Make 15 animals under equal conditions motion simultaneously, high degree of homogenous experiment condition simultaneously, make experimental result more credible, and
It is very convenient and practical.
Further, the path angle adjusting means slope control scope is -10 °~+15 °, while passing through control panel
Controllable animal movement speed, 0~82m/min of control range.
Further, main body slide strips formula runway overall length is 500~600mm, limits the height of motion dividing plate group median septum as 100
~150mm, length is 450~550mm；It is 70~80mm to carry the ultimate range between food flat board and shadow shield；Upright upper limbs branch
Fagging 450~500mm of length, is highly 50~140mm, and altitude range adapts to the different upright posture exercise tests of animal.
The upright synkinesia experiment treadmill of the utility model controllability animal, is designed using many runways, former classical
On the basis of motion treadmill model, with reference to this primary hazards of the acute or chronic Biomechanical in joint, and to clinical phase
Closing property sports injury disease incidence process carries out efficient simulation observation, creates a kind of upright synkinesia of controllability animal
Treadmill is tested, the long-term strain motion process of altitude simulation not only maintains the institutional framework of animal knee joint peripheral well
Integrality, also maintains the Metabolism regulation effect of articular cartilage and surrounding tissue microenvironment, and is in animal on this basis
Upright loading conditions are forced, the road-work load of some strength is given, joint stress is increased with reference to upslope motion mode,
The process that Human clinical's knee cartilage strains for a long time is simulated well, and knee osteoarthritis etc. is set up with this experimental provision auxiliary
Damage and degenerative disease model, are provided very for the pathogenesis and prophylactico-therapeutic measures of further study movement system related disorders
Good research tool, while the detection available for functional statuses such as animal movement endurance, rehabilitation trainings.
Brief description of the drawings
Fig. 1 is the structural representation that treadmill is tested in the upright synkinesia of the utility model animal；
Fig. 2 be the utility model animal upright synkinesia experiment treadmill upright traction restraining animal is fixed and its
Fixture structure schematic diagram；
Fig. 3 is the structural representation of the control panel of the upright synkinesia experiment treadmill of the utility model animal.
In figure：1- main body slide strips formulas runway, 2- limit motion dividing plate group, 3- and carry food flat board, 4- shadow shields, the upright upper limbs of 5-
Supporting plate, 6- path angles adjusting means, 7- control panels, 8- runway elevations lowering or hoisting gear, 9- runways frame, 10- are uprightly drawn
Restraining, 11- fixing devices, 12- power switches, 13- speed and gradient display screen, 14- work display lamp, the selection of 15- speed
Button, 16- gradients select button, the big minor adjustment buttons of 17-, 18- runway directions of motion select button, 19 start to press with stopping
Button.
Embodiment
The utility model is described in further detail below in conjunction with the accompanying drawings.
Zoopery, in particularly being studied with rat, mouse and rabbit etc. for the sports medical science and bone and joint diseases of model, mould
The problem of anthropomorphic type games or sports injury disease has one seriously, is exactly quadruped locomotion and the both legs motion of people of animal
There is very big otherness in pattern, the reliability of disease pathogenesis when can influence the model to set up, and be used for mouse, rabbit for testing etc.
Animal, there is the ability moved using double lower limb.Therefore, according to the life of the motion of people strain pattern, and experimental animal joint
Thing mechanical function, spy devises a kind of upright synkinesia of controllability animal for being easy to simulation mankind uprighting movement damage and tested
Treadmill.
As shown in FIG. 1 to 3, a kind of experiment treadmill of the upright synkinesia of adjustable animal, mainly by main body slide strips formula
Runway 1, restriction motion dividing plate group 2, load food flat board 3, shadow shield 4, upright upper limb support plate 5, path angle adjusting means 6, control
Panel 7 processed, runway elevation lowering or hoisting gear 8, runway frame 9, upright traction restraining 10, fixing device 11 are constituted.Whole experiment is run
Platform is solid rectangle structure, provided with restriction motion dividing plate group 2 on main body slide strips formula runway 1；Motion dividing plate group 2 is limited by 1-4
The identical dividing plate composition of individual shape, size, uniform genesis analysis is on main body slide strips formula runway 1, for experiment is dynamic
Thing is limited to different runway scopes.Runway frame 9 is surrounded by main body slide strips formula runway 1, runway frame 9 is in rectangular configuration.
In the whole top for limiting motion dividing plate group 2 uniformly provided with 1-3 effect case, each effect case spatially triangular structure,
Constituted by carrying food flat board 3 and shadow shield 4, form semi-enclosed responsiveness black hole.Limit motion dividing plate group 2, runway frame 9 and effect
Whole experiment treadmill is separated into the test unit of respective numbers by case.One end of upright upper limb support plate 5 is vertically fixed on load food
The end of flat board 3, the other end is in contact with limiting the upper end of motion dividing plate group 2, enough branch to experimental animal upper limbs when upright
Support force, to reach that the upright required mechanics of animal is supported.Effect case is vertically fixed on the longitudinally opposite two ends of runway frame 9.Carrying
Accommodating food on flat board 3 is eaten, the autokinetic movement of animal is aided in using the photophobism and sitotaxis of animal, reaches that experiment is required
Effect.Path angle adjusting means 6 is located at one end of main body slide strips formula runway 1, available for regulation main body slide strips formula runway 1
The different motion gradients, allows experimental animal to carry out corresponding level road motion, slope climbing movement according to the different gradients, corresponding to reach
Test effect.Control panel 7 is arranged on the one end of runway frame 9, which is provided with power switch 12, speed and gradient display screen
13rd, work display lamp 14, speed set button 15, gradient select button 16, big minor adjustment button 17, the selection of the runway direction of motion
Button 18 and beginning and stop button 19, can be according to specific experiment needs, and clearly regulation is corresponding tests kinematic parameter.Runway is high
The bottom that lowering or hoisting gear 8 is located at whole experiment treadmill is spent, the whole experiment treadmill pendulum of demand regulation that can be studied according to specific experiment
The height put.Upright traction restraining 10 and fixing device 11 be used in combination, and is not influenceing experimental animal eupnea, motion
In the case of, draught animal uprighting movement is simultaneously fixed in corresponding test unit.Fixing device 11 is made up of 2 geometrical clamps, 2
Geometrical clamp is separately fixed at the opposite end of corresponding test unit dividing plate.The utility model experiment treadmill can at most make 15 simultaneously
Animal under equal conditions moves simultaneously, and high degree of homogenous experiment condition makes experimental result more credible, and very convenient reality
With.
The utility model can set experiment treadmill to put height according to experiment needs by runway elevation lowering or hoisting gear 8；Run
Road angle regulator 6 set the different motion gradient, the slope control scope of path angle adjusting means 6 be -10 °~+
15 °, while can control animal movement speed, 0~82m/min of control range by control panel 7.
To cause the utility model to reach more preferable experiment effect, the overall length of main body slide strips formula runway 1 is 500~600mm, limit
Surely the height of the median septum of motion dividing plate group 2 is 100~150mm, and length is 450~550mm；Carry between food flat board 3 and shadow shield 4
Ultimate range be 70~80mm；Upright 450~the 500mm of length of upper limb support plate 5, is highly 50~140mm, altitude range is fitted
Answer the different upright posture exercise tests of animal.
Whole experiment treadmill operationally, is moved to required experiment place, is balanced fixation, root by the utility model
Demand regulation runway elevation lowering or hoisting gear 8, path angle adjusting means 6 are factually tested, to determine the height, angle and speed of treadmill
Degree.After animal uprightly fixes, 2 geometrical clamps are separately fixed to the opposite end of dividing plate, at the same experimental animal with it is upright on
The EDGE CONTACT of limb supporting plate 5.Start the corresponding button on control panel 7, you can reach synchronized motion simultaneously, need to only control motion
Time, use is very simple and convenient.Upright traction restraining 10, fixing device 11 coordinate with limiting motion dividing plate group 2, can
According to the individual difference adjusting tightness and movement position of animal, to ensure the uprighting movement quality of animal.
The experiment treadmill advantage that the utility model can adjust the upright synkinesia of animal is as follows：
(1) realizes the uprighting movement mode of experimental animal；
(2) is provided with black hole and carries food platform, make use of the natural habit of animal to promote animal autokinetic movement；
(3) individuations restraining and geometrical clamp, can change size and elastic according to the different building shape of animal；
(4) can convert the height, the gradient and speed of treadmill as needed, and it is more reasonable to design；
(5) can at most be such that 15 animals move simultaneously, at the same speed, and one time test sample amount is big, and experiment condition homogeneity is high.
Claims (3)
1. a kind of experiment treadmill of the upright synkinesia of adjustable animal, it is characterised in that：The experiment treadmill is mainly slided by main body
Belt runway（1）, limit motion dividing plate group（2）, carry food flat board（3）, shadow shield（4）, upright upper limb support plate（5）, runway angle
Spend adjusting means（6）, control panel（7）, runway elevation lowering or hoisting gear（8）, runway frame（9）, uprightly draw restraining（10）, it is solid
Determine device（11）Composition；Whole experiment treadmill is solid rectangle structure, in the main body slide strips formula runway（1）Transported provided with limiting
Dynamic dividing plate group（2）；Limit motion dividing plate group（2）It is made up of 1-4 shape, the identical dividing plate of size, uniform longitudinal direction point
Cloth is in main body slide strips formula runway（1）On；In main body slide strips formula runway（1）Be surrounded by runway frame（9）, runway frame（9）In square
Shape structure；Motion dividing plate group is limited whole（2）Top uniformly provided with 1-3 effect case, each effect case spatially three
Angular structure, by carrying food flat board（3）And shadow shield（4）Composition, forms semi-enclosed responsiveness black hole；It is described to limit motion dividing plate
Group（2）, runway frame（9）Whole experiment treadmill is separated into the test unit of respective numbers with effect case；Upright upper limb support plate
（5）One end be vertically fixed on load food flat board（3）End, the other end with limit motion dividing plate group（2）Upper end be in contact；Effect
Case is answered to be vertically fixed on runway frame（9）Longitudinally opposite two ends；Path angle adjusting means（6）Positioned at main body slide strips formula runway
（1）One end, available for regulation main body slide strips formula runway（1）The different motion gradients；The control panel（7）It is arranged on runway
Frame（9）One end, which is provided with power switch（12）, speed and gradient display screen（13）, work display lamp（14）, speed choosing
Select button（15）, gradient select button（16）, big minor adjustment button（17）, runway direction of motion select button（18）With start with
Stop button（19）；Runway elevation lowering or hoisting gear（8）Positioned at the bottom of whole experiment treadmill；The upright traction restraining（10）
And fixing device（11）It is used in combination, draught animal uprighting movement is simultaneously fixed in corresponding test unit；Fixing device（11）
It is made up of 2 geometrical clamps, 2 geometrical clamps limit the opposite end for moving dividing plate between being separately fixed at test unit inner track.
2. the experiment treadmill of the upright synkinesia of adjustable animal according to claim 1, it is characterised in that：The runway
Device for adjusting height（8）The required height of adjustable experiment treadmill；Path angle adjusting means（6）Can be by main body slide strips formula runway
（1）Range of grade control at -10 °~+15 °；Control panel（7）Can be by the control of animal movement velocity interval in 0~82m/
min。
3. the experiment treadmill of the upright synkinesia of adjustable animal according to claim 1 or 2, it is characterised in that：It is described
Main body slide strips formula runway（1）Overall length is 500~600mm, limits motion dividing plate group（2）The height of median septum is 100~150mm,
Length is 450~550mm；Carry food flat board（3）With shadow shield（4）Between ultimate range be 70~80mm；Upright upper limb support
Plate（5）450~500mm of length, is highly 50~140mm, and altitude range adapts to the different upright posture exercise tests of animal.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201620846776.XU CN206482682U (en) | 2016-08-08 | 2016-08-08 | A kind of experiment treadmill of the upright synkinesia of adjustable animal |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201620846776.XU CN206482682U (en) | 2016-08-08 | 2016-08-08 | A kind of experiment treadmill of the upright synkinesia of adjustable animal |
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| CN206482682U true CN206482682U (en) | 2017-09-12 |
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| CN201620846776.XU Expired - Fee Related CN206482682U (en) | 2016-08-08 | 2016-08-08 | A kind of experiment treadmill of the upright synkinesia of adjustable animal |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108669917A (en) * | 2018-05-07 | 2018-10-19 | 广西科技大学鹿山学院 | Baby crawling training device |
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2016
- 2016-08-08 CN CN201620846776.XU patent/CN206482682U/en not_active Expired - Fee Related
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108669917A (en) * | 2018-05-07 | 2018-10-19 | 广西科技大学鹿山学院 | Baby crawling training device |
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| Date | Code | Title | Description |
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| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20170912 Termination date: 20180808 |