CN206431103U - A kind of chromatogram shunts on-line detecting system - Google Patents
A kind of chromatogram shunts on-line detecting system Download PDFInfo
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- CN206431103U CN206431103U CN201720087265.9U CN201720087265U CN206431103U CN 206431103 U CN206431103 U CN 206431103U CN 201720087265 U CN201720087265 U CN 201720087265U CN 206431103 U CN206431103 U CN 206431103U
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Abstract
The utility model provides a kind of chromatogram shunting on-line detecting system, including：Chromatogram pole unit, three-way connector, primary flow path collector shunts road collector, differential refraction detector, constant flow pump；The first port of the outlet connection three-way connector of the chromatogram pole unit, the second port of the three-way connector is connected to the primary flow path collector, and the 3rd port of the three-way connector passes sequentially through the constant flow pump and the differential refraction detector is connected to shunting road collector.This scheme reduces detection error, the reliability for collecting product is improved.
Description
Technical field
The utility model is related to chromatographic field, specifically, is related to a kind of chromatogram shunting on-line detecting system.
Background technology
During carrying out material purification work using liquid-phase chromatography method, on-line checking is to determine the important of fraction collection
Means.Monitored in real time by detector Describing Chromatographic Elution Profile, determine that chromatographic column flows out component, so as to ensure to isolate and purify
Result.
, can be by selecting high flux on-line checking pond, chromatogram when the flow that liquid-phase chromatographic column eluate flows out is smaller
Effluent all carries out on-line analysis, detection by flow cell；When the flow that liquid-phase chromatographic column eluate flows out exceedes detector
When the Peak Flow Rate scope of detection cell pond, it can be detected by way of shunting.Through type detection is a kind of common
Detection mode is shunted, as shown in Figure 1；Wherein input liquid stream is Q, and the liquid flowing resistance of two shuntings is respectively L1 and L2, exports liquid
Stream is respectively Q1 and Q2.Q1, Q2 are to determine split ratio, i.e. Q1/Q2=L2/L1 by liquid flowing resistance size.
This conventional shunting mode shown in Fig. 1 is primarily adapted for use in the liquid chromatography purification separation of laboratory scale, due to
The limitation of its split ratio, in the industrially prepared occasion that flow rate of liquid is larger, conventional shunt mode often fluctuates larger, it is impossible to obtain
The curved flow of chromatography that must stablize, so as to cause the error or even failure of target product collection process.
Utility model content
In order to overcome above-mentioned technical problem, the utility model provides a kind of chromatogram and shunts on-line detecting system, reduces
Detection error, improves the reliability for collecting product.
To achieve these goals, the utility model provides a kind of chromatogram and shunts on-line detecting system, including：
Chromatogram pole unit, three-way connector, primary flow path collector shunts road collector, differential refraction detector, constant current
Pump；
The first port of the outlet connection three-way connector of the chromatogram pole unit, the second of the three-way connector
Port is connected to the primary flow path collector, and the 3rd port of the three-way connector passes sequentially through the constant flow pump and described shown
Poor refraction detector is connected to shunting road collector.
In a kind of optional embodiment, the system also includes：
It can be seen that/UV-detector and flowmeter；
The second port of the three-way connector passes sequentially through the visible/UV-detector and the flowmeter is connected to
The primary flow path collector.
In a kind of optional embodiment, the differential refraction detector and described visible/UV-detector are electric respectively
Connect chromatography data system.
In a kind of optional embodiment, the flow velocity of the primary flow path is 100ml/min to 50L/min, the shunting
The flow velocity on road is 1ml/min to 150ml/min.
In a kind of optional embodiment, the constant flow pump is accurate constant flow pump.
A kind of chromatogram shunting on-line detecting system that the utility model embodiment is provided, including chromatogram pole unit, three lead to
Device is connect, primary flow path collector shunts road collector, differential refraction detector and constant flow pump.The outlet connection three of chromatogram pole unit
The first port of connectors, the second port of three-way connector is connected to primary flow path collector, the 3rd end of three-way connector
Mouth passes sequentially through constant flow pump and differential refraction detector is connected to shunting road collector.The flow velocity on program shunting road is more stable,
Detection error is small, and split channel flow velocity is adjusted by constant flow pump, it is ensured that primary flow path and the high level of synchronization on shunting road,
The target product being collected into has higher accuracy and reliability.
Brief description of the drawings
Fig. 1 is the separate system schematic diagram of prior art；
Fig. 2 shunts the schematic diagram of on-line detecting system for a kind of chromatogram that the utility model embodiment is provided；
Fig. 3 shunts the schematic diagram of first detecting system for another chromatogram that utility model embodiment is provided；
Fig. 4 is chromatogram of the target product in UV-detector；
Fig. 5 is chromatogram of the target product in differential refraction detector.
Embodiment
Below with reference to the accompanying drawings embodiment of the present utility model is illustrated.In an accompanying drawing of the present utility model or a kind of implementation
Element and feature described in mode can be with the elements and feature that are shown in one or more other accompanying drawings or embodiment
It is combined.It should be noted that it is general to eliminate, this area unrelated with the utility model for purposes of clarity, in accompanying drawing and explanation
The expression and description of part or processing known to logical technical staff.
The utility model is described further below in conjunction with the accompanying drawings.
The utility model embodiment provides a kind of chromatogram and shunts on-line detecting system, as shown in Fig. 2 the system includes：
Chromatogram pole unit 1, three-way connector 2, primary flow path collector 5, constant flow pump 6, differential refraction detector 7 shunts road collector 8.
The first port of the outlet connection three-way connector 2 of chromatogram pole unit 1, the second port connection of three-way connector 2
To primary flow path collector 5, the 3rd port of three-way connector 2 passes sequentially through constant flow pump 6 and differential refraction detector 7 is connected to point
Stream collector 8.
Eluent and target product are included from the mixing liquid of the outlet outflow of chromatogram pole unit 1, the mixing liquid enters
The first port of three-way connector 2, most of mixing liquid enters primary flow path via second port, remaining a small amount of mixing liquid via
3rd port enters shunting road.
Primary flow path collector 5 collects most cut, and shunting road collector 8 collects remaining cut or useless for collecting
Liquid.
Visible/UV-detector 3 and flowmeter 4 are additionally provided with a kind of specific embodiment, in primary flow path, is such as schemed
Shown in 3, the second port of three-way connector 2 passes sequentially through visible/UV-detector 3 and flowmeter 4 is connected to primary flow path collection
Device 5.
In technical grade prepares chromatogram purification separation process, mixing liquid flows out from chromatographic column, by three-way connector
2nd, visible/UV-detector 3 and flowmeter 4 enter in primary flow path collector 5.It can be seen that/UV-detector 3 is to mesh in mixing liquid
Mark product number detected.Flowmeter 4 carries out real-time traffic monitoring, to constant flow pump if flow and setting value have deviation
6 are adjusted so that flow recovers to setting value.
In shunting road, mixing liquid is by accurate constant flow pump 6, and differential refraction detector 7 enters shunting road collector 8
In.By the flow velocity for adjusting constant flow pump 6 so that the flow velocity on shunting road is within the allowed band of differential refraction detector 7.
The flow velocity of primary flow path is more than the flow velocity on shunting road, and the flow rates of primary flow path are typically 100ml/min to 50L/
Min, it is 1ml/min to 150ml/min that the flow rates on shunting road, which are typically,.
Concentration of the target product in eluent changes with the time, causes ultraviolet absorption value and index of refraction also to become
Change.It can be seen that/UV-detector 3 and differential refraction detector 7 detect the ultraviolet absorption value and index of refraction of target product respectively, and will
Detected value is converted into electric signal, output to the chromatography data system with each electrically connecting.Chromatography data system records the stream of chromatogram
Go out curve.
For example, demarcated in chromatogram shunting on-line detecting system with standard substance (methanol solution of such as naphthalene),
Obtain respectively and the retention time of target product is obtained in chromatogram as shown in Figure 4 and Figure 5, transverse axis represents the time, axis represents to inhale
Receipts degree.Wherein, Fig. 4 is chromatogram of the target product in UV-detector, retention time Ts=4.519min.Fig. 5 is target
Chromatogram of the product in differential refraction detector 7, retention time ts=4.723min.
According to Ts and ts numerical value, the flow velocity of constant flow pump 6 is adjusted so that Ts=ts.Now, two detectors are same
Step, can carry out the sign that target product in primary flow path flows out chromatographic column by shunting the differential refraction detector in road.
Also, carry out split channel stream due to employing constant flow pump 6 (being specifically as follows accurate constant flow pump) in shunting road
The adjustment of speed, therefore this shunting mode is more actively.By in the acceptable system of debugging, detector 3 and stream in primary flow path
Gauge 4 can be removed from system, until chromatogram shunting on-line detecting system carries out operation confirmation (Operational
Qualification, OQ) when add system again.
A kind of chromatogram shunting on-line detecting system that the utility model embodiment is provided, including chromatogram pole unit, three lead to
Device is connect, primary flow path collector shunts road collector, differential refraction detector and constant flow pump.The outlet connection three of chromatogram pole unit
The first port of connectors, the second port of three-way connector is connected to primary flow path collector, the 3rd end of three-way connector
Mouth passes sequentially through constant flow pump and differential refraction detector is connected to shunting road collector.Program shunting road flow velocity is more stable, inspection
Survey error is small, and the flow velocity for shunting road is adjusted by constant flow pump, it is ensured that primary flow path and the high level of synchronization on shunting road, carries
The accuracy and reliability for collecting target product are risen.
Although the utility model and its advantage has been described in detail it should be appreciated that without departing from by appended right
It is required that various changes can be carried out in the case of the spirit and scope of the present utility model limited, substitute and convert.Moreover, this
The scope of application is not limited only to process described by specification, equipment, means, the specific embodiment of method and steps.This area
Interior those of ordinary skill will readily appreciate that from disclosure of the present utility model, according to the utility model can use execution with
The essentially identical function of corresponding embodiment described herein or acquisition result, the existing and future essentially identical with it will quilts
Process, equipment, means, method or the step of exploitation.Therefore, appended claim includes this in the range of being directed at them
Process, equipment, means, method or the step of sample.
Claims (5)
1. a kind of chromatogram shunts on-line detecting system, it is characterised in that including：
Chromatogram pole unit, three-way connector, primary flow path collector shunts road collector, differential refraction detector, constant flow pump；
The first port of the outlet connection three-way connector of the chromatogram pole unit, the second port of the three-way connector
It is connected to the primary flow path collector, the 3rd port of the three-way connector passes sequentially through the constant flow pump and described shows poor folding
Photodetector is connected to shunting road collector.
2. chromatogram according to claim 1 shunts on-line detecting system, it is characterised in that the system also includes：
It can be seen that/UV-detector and flowmeter；
The second port of the three-way connector passes sequentially through the visible/UV-detector and the flowmeter be connected to it is described
Primary flow path collector.
3. chromatogram according to claim 2 shunts on-line detecting system, it is characterised in that the differential refraction detector and
Visible/the UV-detector is electrically connected chromatography data system.
4. chromatogram according to claim 1 shunts on-line detecting system, it is characterised in that the flow velocity of the primary flow path is
100ml/min to 50L/min, the flow velocity on the shunting road is 1ml/min to 150ml/min.
5. chromatogram according to claim 1 shunts on-line detecting system, it is characterised in that the constant flow pump is accurate constant current
Pump.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201720087265.9U CN206431103U (en) | 2017-01-20 | 2017-01-20 | A kind of chromatogram shunts on-line detecting system |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201720087265.9U CN206431103U (en) | 2017-01-20 | 2017-01-20 | A kind of chromatogram shunts on-line detecting system |
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| Publication Number | Publication Date |
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| CN206431103U true CN206431103U (en) | 2017-08-22 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115078558A (en) * | 2021-03-16 | 2022-09-20 | 株式会社岛津制作所 | Preparative liquid chromatograph and analysis method |
-
2017
- 2017-01-20 CN CN201720087265.9U patent/CN206431103U/en active Active
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115078558A (en) * | 2021-03-16 | 2022-09-20 | 株式会社岛津制作所 | Preparative liquid chromatograph and analysis method |
| US12105066B2 (en) | 2021-03-16 | 2024-10-01 | Shimadzu Corporation | Preparative liquid chromatograph and analysis method |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of utility model: A Chromatographic Split Flow Online Detection System Effective date of registration: 20230612 Granted publication date: 20170822 Pledgee: Luanxian Lvhe Agricultural Technology Co.,Ltd. Pledgor: BEIJING CHUANGXIN TONGHENG SCIENCE AND TECHNOLOGY Co.,Ltd. Registration number: Y2023110000228 |
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| PE01 | Entry into force of the registration of the contract for pledge of patent right |