CN206414800U - A kind of split type countercurrent chromatography separation column - Google Patents
A kind of split type countercurrent chromatography separation column Download PDFInfo
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- CN206414800U CN206414800U CN201720005887.2U CN201720005887U CN206414800U CN 206414800 U CN206414800 U CN 206414800U CN 201720005887 U CN201720005887 U CN 201720005887U CN 206414800 U CN206414800 U CN 206414800U
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- splitter
- hole
- cylindrical
- split type
- separation column
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Abstract
The utility model discloses a kind of split type countercurrent chromatography separation column, including the splitter I and II two by the integrally formed semicolumn structure of 3D printing technique, two splitters are sealed provided with a netted gasket seal in the middle of the splitter of two semi-cylindrical structures, the side wall of the splitter of two semi-cylindrical structures is linked into an integrated entity by attachment means, and the center line of the mounting hole of attachment means is vertical with the axis of two splitters；Certain pressure is applied to netted gasket seal by the fastening of attachment means.The closing structure of traditional splitter pipeline is changed into two open cells by the utility model, the cleaning of a pipeline is changed into powder cleaning in the cleaning of many open pipelines, pipeline easy.
Description
Technical field
The utility model is related to separation field of analytic instrument, more particularly to a kind of adverse current chromatogram of split type 3D printing point
From post.
Background technology
High speed adverse current chromatogram is that one kind is based on liquid luquid partition chromatography, is constantly mixed using immiscible two-phase solvent, will
Sample is distributed repeatedly, is eluted successively according to distribution coefficient.Because without any solid carrier or supporter, so can reach in short-term
Interior realize efficiently separates and prepared, and can reach thousands of theoretical cam curves.Compared with other class separation chromatographies, its
The shortcomings of not only overcoming sample adsorption, loss that stationary phase belt carrier comes, pollute, while being also equipped with that cost is low, solvent can be returned
The advantages of receipts.
Countercurrent chromatography separation column is the core of adverse current chromatogram, and conventional reverse-flow chromatography column is by polyfluortetraethylene pipe and pipeline
Supporter is constituted, and polyfluortetraethylene pipe multilayer is wound on pipe-support body, and this kind of structure countercurrent chromatography separation column be limited by
The limitation of commercialization polyfluortetraethylene pipe, on pipeline structure be difficult innovated, for current chromatographic column functional development by
Limit.
3D printing technique is also known as increases material manufacturing technology, the preparation method for being different from traditional molding processing, real by machine
Now successively processing, superposition forming, the technology broken away from the constraint of space geometry and design technology, can change any creative design
For entity products, huge space for the creativity has been expanded.The appearance of the technology compensate for conventional counter-current chromatography column and be limited by business
The deficiency of product polyfluortetraethylene pipe, can be innovated on splitter cast.Two-phase solvent is separated in view of adverse current chromatogram
Usually using organic solvent in system, the metal dust of organic solvent-resistant corrosion turns into the preferred material of 3D printing.But metal powder
The limitation of successively powdering technique is limited by during powder material 3D printing, metal powder material proportion is excessive, printing finish after
The cleaning of powder is into problem in tediously long pipeline.Therefore, split type countercurrent chromatography separation column structure need to be innovated, protected
Metal dust can be cleared up completely in card pipeline.
Utility model content
The utility model for technological difficulties present in 3D printing countercurrent chromatography separation column using metal dust as material,
A kind of split type countercurrent chromatography separation column is developed, the closing structure of traditional splitter pipeline is changed into two by the utility model
Individual open cell, the cleaning of a pipeline is changed into powder cleaning in the cleaning of many open pipelines, pipeline easy.
The technical solution adopted in the utility model is as follows：
A kind of split type countercurrent chromatography separation column, including two by the integrally formed semicolumn structure of 3D printing technique
Two splitters are entered by splitter I and II in the middle of the splitter of two semi-cylindrical structures provided with a netted gasket seal
Row sealing, the side wall of the splitter of two semi-cylindrical structures is linked into an integrated entity by attachment means, the mounting hole of attachment means
Center line it is vertical with the axis of two splitters；Netted gasket seal is applied necessarily by the fastening of attachment means
Pressure, it is ensured that the sealing of whole device.
Further, the splitter appearance structure of two described semicolumn structures is just the same；Two semicolumn structures
Splitter and netted sealing gasket combine after formed a cylindrical-shaped structure splitter.
Further, it is equipped with inside the splitter and netted sealing gasket of two described semicolumn structures for transmitting
After sample cylindrical hole, and three component combinations, the multi-turn cylindrical hole of head and the tail connection is formed between all cylindrical holes, cylindrical hole
One end is sample inlet, and the other end is sample export.
The connected mode one of the splitter of two semicolumn structures：
Further, described attachment means be screw, the splitter of two described semicolumn structures side wall with
And the upper and lower part of netted gasket seal is provided with corresponding screw installing hole, the position of superposed screw installing hole
Put the cylindricality hole site higher than peak；It is less than the cylindricality hole site of minimum point positioned at the position of the screw installing hole of bottom.
The splitter of one of semicolumn structure and the screw installing hole of netted gasket seal are through hole；Another attached column
The screw installing hole of the splitter of shape structure is blind hole, and described blind hole with described through-bore axis point-blank, spiral shell
Silk is arranged in blind hole and through hole.
The connected mode two of the splitter of two semicolumn structures：
Further, described attachment means are screw, on the side wall of the splitter of two described semicolumn structures
Portion and bottom are provided with corresponding screw installing hole, and the position of superposed screw installing hole is higher than the cylindricality of peak
Hole site；It is less than the cylindricality hole site of minimum point positioned at the position of the screw installing hole of bottom.
The screw installing hole of the splitter of one of semicolumn structure is through hole；The splitter of another semicolumn structure
Screw installing hole be blind hole, and described blind hole with described through-bore axis point-blank, screw be arranged on blind hole and
In through hole.
Further, in above-mentioned two connected mode, described screw installing hole is including multiple, along semicolumn structure
Splitter side wall circumferencial direction distribution, and superposed multiple screw installing holes center line in same horizontal plane；Position
In bottom multiple screw installing holes center line in same horizontal plane.
Further, the material of described netted gasket seal be polytetrafluoroethylene (PTFE) material, polytetrafluoro propylene etc. can it is pressure-resistant,
Ensure the corrosion-resistant material of sealing.
The beneficial effects of the utility model are as follows：
1. the closing structure of traditional splitter pipeline is changed into two open cells, the cleaning of a pipeline is changed into many
It is easy that root opens powder cleaning in the cleaning of pipeline, pipeline；
2. corrosion-resistant mesh pad has organic solvent-resistant corrosion, the good advantage of material compression seal；
3. the design of tensioned screw ensures uniform force after the extruding of tetrafluoroethene mesh pad, it is ensured that splitter no leakage.
4. tensioned screw is arranged on inside whole splitter, do not increase the overall volume of splitter, can be further
Realize that it is minimized.
5. screw installing hole is arranged on inside whole splitter by the utility model, while splitter connection is realized,
And do not increase the overall volume of splitter, it can be very good to be coordinated with existing equipment, and then saved cost.
Brief description of the drawings
, below will be to embodiment in order to illustrate more clearly of the utility model embodiment or technical scheme of the prior art
Or the accompanying drawing used required in description of the prior art is briefly described, it should be apparent that, drawings in the following description are these
Some embodiments of utility model, for those of ordinary skill in the art, on the premise of not paying creative work, also
Other accompanying drawings can be obtained according to these accompanying drawings.
Fig. 1 is a kind of top view of split type countercurrent chromatography separation column；
Fig. 2 is that a kind of split type countercurrent chromatography separation column cuts open schematic diagram；
Fig. 3 is that a kind of split type countercurrent chromatography separation column cuts open schematic diagram；
Fig. 4 is a kind of mesh pad schematic diagram of split type countercurrent chromatography separation column；
Fig. 5 is a kind of three-dimensional overall structure diagram of split type countercurrent chromatography separation column；
In figure：1- splitter splits；The netted gasket seals of 2-；3- splitter splits；4- tensioned screws.
Embodiment
The utility model is described in detail below in conjunction with the accompanying drawings：
The utility model is for asking that the metal powder material of existing split type countercurrent chromatography separation column is difficult to clear up
A kind of topic, it is proposed that split type countercurrent chromatography separation column, as shown in Fig. 1,2,3,5, the split type adverse current chromatogram of 3D printing
Splitter, including two the splitter by the integrally formed semicolumn structure of 3D printing technique, i.e. splitter split 1 and splitter
Split 3, described splitter split 1 and the side wall of splitter split 3 is integral by screw connection, and described screw is worn successively
Cross splitter 1, netted gasket seal 2 and splitter 3, the axis of the center line of the mounting hole of screw and two splitters hangs down
Directly；Certain pressure is applied to netted gasket seal by the fastening of screw, screw is not passed through splitter 3.
The closing structure of traditional splitter pipeline is changed into two open cells by the utility model, by the clear of pipeline
It is easy that reason is changed into powder cleaning in the cleaning of many open pipelines, pipeline；
Further, the splitter appearance structure of splitter split 1 and splitter split 3 is just the same；Two semicolumns
The splitter of structure and netted sealing gasket form the splitter of a cylindrical-shaped structure after combining.
Further, it is equipped with inside the splitter split 1,3 of two described semicolumn structures and netted sealing gasket 2
For transmitting after sample cylindrical hole, and three component combinations, the multi-turn cylindrical hole of head and the tail connection is formed between all cylindrical holes,
One end of cylindrical hole is sample inlet, i.e. splitter import, the other end is sample export, that is, separates column outlet.
Two ways is connected with splitter split 1 and splitter split 3：
Mode one：
On the side wall of splitter split 1,3 of two described semicolumn structures and the top of netted gasket seal 2 and
Bottom is provided with corresponding screw installing hole, and the position of superposed screw installing hole is higher than the cylindricality hole position of peak
Put；It is less than the cylindricality hole site of minimum point positioned at the position of the screw installing hole of bottom.
As shown in Fig. 2 splitter split 1 and the screw installing hole of netted gasket seal 2 of one of semicolumn structure
For through hole；The screw installing hole of the splitter split 3 of another semicolumn structure is blind hole, and described blind hole with it is described logical
Point-blank, screw is arranged in blind hole and through hole axially bored line.
The screw thread coordinated with screw is provided with described blind hole, through hole.
Screw installing hole includes multiple, and screw installing hole installs a screw, and multiple screws are along semicolumn structure
The circumferencial direction of splitter side wall be sequentially distributed, and superposed multiple screw installing holes center line in same level
Face；Positioned at bottom multiple screw installing holes center line in same horizontal plane.
Mode two：
Only two semicolumn structures splitter split 1,3 side wall upper part and bottom be provided with corresponding screw
Mounting hole, the position of superposed screw installing hole is higher than the cylindricality hole site of peak；Screw installing hole positioned at bottom
Position be less than minimum point cylindricality hole site.
The screw installing hole of the splitter split 1 of one of semicolumn structure is through hole；Another semicolumn structure
The screw installing hole of splitter split 3 is blind hole, and described blind hole with described through-bore axis point-blank, screw peace
In blind hole and through hole.The screw thread coordinated with screw is provided with described blind hole, through hole.
Screw installing hole includes multiple, and screw installing hole installs a screw, and multiple screws are along semicolumn structure
The circumferencial direction of splitter side wall be sequentially distributed, and superposed multiple screw installing holes center line in same level
Face；Positioned at bottom multiple screw installing holes center line in same horizontal plane.
Above two mode can be so that difference is the difference of pad, and screw installing hole is arranged on whole by the utility model
Inside individual splitter, while splitter connection is realized, and do not increase the overall volume of splitter, can be very good with it is existing
Equipment coordinated, and then saved cost.
The design of tensioned screw simultaneously ensures uniform force after the extruding of tetrafluoroethene mesh pad, it is ensured that splitter does not leak
Liquid.
Gasket construction in embodiment 2 is as shown in figure 4, the material of netted gasket seal is polytetrafluoroethylene (PTFE) material, polytetrafluoro
Propylene etc. can corrosion-resistant material that is pressure-resistant, ensureing sealing；The upper and lower part of netted gasket seal 2 is not provided with being used for screw
The through hole passed through.
Screw in the utility model is also designed to bolt, is replaced by bolt, the inside spiral shell of specific mounting hole
Line is adjusted according to the difference of bolt.
The use of 3D printing technique in the utility model so that the shape of cylindrical hole is no longer limited, can be designed to any
It is abnormally-structured, greatly improve adverse current chromatogram separative efficiency.
It is not new to this practicality although above-mentioned embodiment of the present utility model is described with reference to accompanying drawing
The limitation of type protection domain, one of ordinary skill in the art should be understood that on the basis of the technical solution of the utility model, ability
Field technique personnel need not pay the various modifications that creative work can make or deform still in protection model of the present utility model
Within enclosing.
Claims (9)
1. a kind of split type countercurrent chromatography separation column, it is characterised in that including two by 3D printing technique integrally formed half
The splitter I and II of column structure, provided with a netted gasket seal to two in the middle of the splitter of two semi-cylindrical structures
Individual splitter is sealed, and the side wall of the splitter of two semi-cylindrical structures is linked into an integrated entity by attachment means, connection dress
The center line for the mounting hole put is vertical with the axis of two splitters；By the fastening of attachment means to netted gasket seal
Apply certain pressure.
2. split type countercurrent chromatography separation column as claimed in claim 1, it is characterised in that two described semi-cylindrical knots
The splitter appearance structure of structure is just the same；The splitter and netted sealing gasket of two round semicolumn structures combine rear shape
Into the splitter of a cylindrical-shaped structure.
3. split type countercurrent chromatography separation column as claimed in claim 1, it is characterised in that in two described semi-cylindricals
It is equipped with inside the splitter of structure and netted sealing gasket for transmitting after sample cylindrical hole, and three component combinations, it is all
The multi-turn cylindrical hole of head and the tail connection is formed between cylindrical hole, one end of cylindrical hole is sample inlet, and the other end is sample export.
4. split type countercurrent chromatography separation column as claimed in claim 1, it is characterised in that described attachment means are spiral shell
Silk, is provided with the side wall of the splitter of two described semi-cylindrical structures and the upper and lower part of netted gasket seal
Corresponding screw installing hole, the position of superposed screw installing hole is higher than the cylindricality hole site of peak；Positioned at bottom
Screw installing hole position be less than minimum point cylindricality hole site.
5. split type countercurrent chromatography separation column as claimed in claim 4, it is characterised in that one of semi-cylindrical structure
Splitter and netted gasket seal screw installing hole be through hole；The screw of the splitter of another semi-cylindrical structure is installed
Hole is blind hole, and described blind hole with described through-bore axis point-blank, screw is arranged in blind hole and through hole.
6. split type countercurrent chromatography separation column as claimed in claim 1, it is characterised in that described attachment means are spiral shell
Silk, is provided with corresponding screw in the side wall upper part of the splitter of two described semi-cylindrical structures and bottom and installs
Hole, the position of superposed screw installing hole is higher than the cylindricality hole site of peak；Positioned at the position of the screw installing hole of bottom
Set low in the cylindricality hole site of minimum point.
7. split type countercurrent chromatography separation column as claimed in claim 6, it is characterised in that one of circle semicolumn structure
Splitter screw installing hole be through hole；The screw installing hole of the splitter of another semi-cylindrical structure is blind hole, and institute
With described through-bore axis point-blank, screw is arranged in blind hole and through hole the blind hole stated.
8. the split type countercurrent chromatography separation column as described in claim 4 or 6, it is characterised in that described screw installing hole
Including multiple, it is distributed along the circumferencial direction of the splitter side wall of semicolumn structure, and superposed multiple screw installing holes
Center line in same horizontal plane；Positioned at bottom multiple screw installing holes center line in same horizontal plane.
9. split type countercurrent chromatography separation column as claimed in claim 1, it is characterised in that described netted gasket seal
Material is corrosion-resistant material.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201720005887.2U CN206414800U (en) | 2017-01-04 | 2017-01-04 | A kind of split type countercurrent chromatography separation column |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201720005887.2U CN206414800U (en) | 2017-01-04 | 2017-01-04 | A kind of split type countercurrent chromatography separation column |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN206414800U true CN206414800U (en) | 2017-08-18 |
Family
ID=59573364
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201720005887.2U Active CN206414800U (en) | 2017-01-04 | 2017-01-04 | A kind of split type countercurrent chromatography separation column |
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| CN (1) | CN206414800U (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106731001A (en) * | 2017-01-04 | 2017-05-31 | 山东省分析测试中心 | A kind of split type countercurrent chromatography separation column |
| CN107756857A (en) * | 2017-11-25 | 2018-03-06 | 颍上烨徽生物科技有限公司 | A kind of combined straw press forming disk |
-
2017
- 2017-01-04 CN CN201720005887.2U patent/CN206414800U/en active Active
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106731001A (en) * | 2017-01-04 | 2017-05-31 | 山东省分析测试中心 | A kind of split type countercurrent chromatography separation column |
| CN107756857A (en) * | 2017-11-25 | 2018-03-06 | 颍上烨徽生物科技有限公司 | A kind of combined straw press forming disk |
| CN107756857B (en) * | 2017-11-25 | 2024-04-30 | 秀山县佳沃农业发展有限公司 | Combined forming disc of straw pressing machine |
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