CN206414539U - A kind of composite stereo timbering material containing hierarchical porous structure - Google Patents
A kind of composite stereo timbering material containing hierarchical porous structure Download PDFInfo
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- CN206414539U CN206414539U CN201621108110.0U CN201621108110U CN206414539U CN 206414539 U CN206414539 U CN 206414539U CN 201621108110 U CN201621108110 U CN 201621108110U CN 206414539 U CN206414539 U CN 206414539U
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Abstract
The utility model belongs to medical composite material field, discloses a kind of composite stereo timbering material containing hierarchical porous structure.The composite stereo timbering material is composited by the fiber assembly with skin-core structure by network blackboard or stratiform interpenetrating structure, the fibre diameter of the fiber assembly is 20~2000nm, the composite stereo support has three-level pore structure, pore size is between 0.5~5 μm wherein between the fiber of fiber assembly, fiber surface micropore size is between 10~1000nm, and core fiber layer hole size is between 5~800nm.Composite stereo timbering material obtained by the utility model can be suitably applied organizational project in pattern and the natural extracellular matrix of fine simulation in size.
Description
Technical field
The utility model belongs to medical composite material field, and in particular to a kind of composite stereo support containing hierarchical porous structure
Material.
Background technology
Animal tissue is made up of the extracellular matrix for having planted cell, and natural extracellular matrix be one kind by a variety of
What albumen and polysaccharide were constituted, three-dimensional fiber porous network structure of the size at tens nanometers to several microns.Pass through electrostatic spinning
Obtained nanofiber pattern with it is closely similar with natural extracellular matrix in size, therefore hold promise as very much support
Materials application is in cell culture and organizational project, and the increasingly maturation of electrostatic spinning technique allows it to production complicated three
Nano-bracket is tieed up, so as to be conducive to different types of cell to be grown above and form artificial organ.
Electrostatic spinning is that a kind of simple, flexible fibre diameter for preparing is tens to hundreds of nanometers of spinning process, its base
Present principles are：The polymer solution or melt of capillary outlet are deformed into taylor cone, when quiet in the presence of high-voltage electrostatic field
When electric repulsive force exceedes the surface tension of drop, the top end of taylor cone will form thread, and be obtained in the motion of electric field
Further stretching, while as solvent volatilizees (or melt cooling), obtaining nanofiber.Electrostatic spinning has following obvious
Advantage：1st, high porosity；2nd, high-specific surface area；3rd, the diameter and structure and extracellular matrix of electrospun fibers have fine
Similitude.Though coaxial electrostatic spinning method prepares composite construction nano-fiber material and simply just started to walk in recent years, it develops speed
Degree is quite fast.Coaxial electrostatic spinning uses different cortex component and sandwich layer component, and right on the device of conventional electrostatic spinning
Spinneret is improved, and spins the composite nano fiber with special construction and function.The multi-level nanofiber of structure apply compared with
To be extensive.Coaxial electrostatic spinning method is mainly to prepare hollow Nano fiber in use (nano-micrometer pipe), core-shell structure nanofiber etc.,
Its powerful advantages is fully integrate the premium properties of fiber center core layer and shell, and prepared nanofiber is in biology
The fields such as medical material, filtering, catalysis, the energy, photoelectricity play great function.
Utility model content
Based on above prior art, the purpose of this utility model is to provide a kind of composite stereo branch containing hierarchical porous structure
Frame.
The utility model purpose is achieved through the following technical solutions：
A kind of composite stereo timbering material containing hierarchical porous structure, network is passed through by the fiber assembly with skin-core structure
Interpenetrating structure or stratiform interpenetrating structure are composited, and the fibre diameter of the fiber assembly is 20~2000nm, described compound
Three-dimensional bracket has three-level pore structure, and wherein pore size is between 0.5~5 μm between the fiber of fiber assembly, fiber table
Face micropore size is between 10~1000nm, and core fiber layer hole size is between 5~800nm.
The fiber assembly with skin-core structure refers to the fiber assembly prepared by coaxial electrostatic spinning.
The composite stereo timbering material containing hierarchical porous structure is by coaxial electrostatic spinning technique by cortex component and core
Layer component machine-shaping, and the fiber assembly formation net with skin-core structure is made as collection device using dynamic solidification bath
The composite construction of network interpenetrating structure or stratiform interpenetrating structure, finally by freeze-drying, phase separation-freeze-drying,
The post-processing approach such as Thermal inactive, Solid-Liquid Separation, obtain the composite stereo timbering material with three-level pore structure.
Composite stereo timbering material of the present utility model has the following advantages that and beneficial effect：
(1) composite stereo timbering material of the present utility model forms network interpenetrating by the fiber assembly with skin-core structure
The composite construction of structure, stratiform interpenetrating structure, and three-level pore structure is obtained by aftertreatment technology；
(2) fibre diameter of composite stereo timbering material of the present utility model is that aperture is big between 20~2000nm, fiber
It is small between 0.5~5 μm, fiber surface micropore size is between 10~1000nm, and core fiber layer hole size is in 5~800nm
Between, can be in pattern and the natural extracellular matrix of fine simulation in size；
(3) composite stereo timbering material of the present utility model does not have toxicity to cell, therefore is being contacted with each other with cell
Cell adherence, propagation, migration can be promoted among process and broken up.
Brief description of the drawings
Fig. 1 is the network interpenetrating of composite stereo timbering material of the gained of the utility model embodiment 1 and 3 containing hierarchical porous structure
Structural representation；
Fig. 2 is the stratiform IPN knot of composite stereo timbering material of the gained of the utility model embodiment 2 containing hierarchical porous structure
Structure schematic diagram；
Fig. 3 is the three-level hole knot of composite stereo timbering material of the gained of the utility model embodiment 1~3 containing hierarchical porous structure
Structure schematic diagram.
Embodiment
The utility model is described in further detail with reference to embodiment and accompanying drawing, but implementation of the present utility model
Mode not limited to this.
Embodiment 1
A kind of composite stereo timbering material containing hierarchical porous structure of the present embodiment, by by the fiber collection with skin-core structure
Zoarium be composited by network blackboard, wherein the fibre diameter of fiber assembly be 100-700nm between, between fiber
Aperture (one-level hole) size is between 1~2.5 μm, and fiber surface micropore (second hole) size is between 60~400nm, fibre core
Layer hole (three-level hole) size is between 45~350nm.The network blackboard of composite stereo timbering material obtained by the present embodiment
Schematic diagram is as shown in figure 1, its three-level pore structure schematic diagram is as shown in Figure 3.
The composite stereo timbering material containing hierarchical porous structure of the present embodiment is prepared via a method which：
PLA (PLA, Mw=2 × 105G/mol) using chloroform as solvent, magnetic agitation 4h under normal temperature is obtained
Mass fraction is 8% PLA solution；Sodium alginate (SA, Mw=2 × 105G/mol) using deionized water as solvent, often
The lower magnetic agitation 12h of temperature, obtains the sodium alginate soln that mass fraction is 2%；Two kinds of solution are mixed, using sorbester p17 conduct
Emulsifying agent, after 7000r/min is emulsified 10 minutes at a high speed, obtains uniform emulsion., will be small using the emulsion prepared as cortex component
Molecular medicine solution is as sandwich layer component, using coaxial electrostatic spinning machine-shaping, using CaCl2Solution as coagulating bath, and
It is aided with magnetic agitation as dynamic reception device, the distance between reception device and syringe needle about 5cm are spun under 12kV voltages
Type.Shaping after compound support frame material post-processed by being freeze-dried, obtain the PLA/ alginates containing hierarchical porous structure/
Small-molecule drug composite stereo timbering material.
In the composite stereo timbering material containing hierarchical porous structure that the present embodiment is obtained fibre diameter 100-700nm it
Between, aperture (one-level hole) size is between 1~2.5 μm between fiber, and fiber surface micropore (second hole) size is in 60~400nm
Between, core fiber layer hole (three-level hole) size, can be natural in pattern and fine simulation in size between 45~350nm
Extracellular matrix, and with good biocompatibility and there is no toxicity to cell, in the process contacted with each other with cell
It is central to promote cell adherence, propagation, migration and break up, it is adaptable to which that organizational project repairs wound.
Embodiment 2
A kind of composite stereo timbering material containing hierarchical porous structure of the present embodiment, by by the fiber collection with skin-core structure
Zoarium be composited by stratiform interpenetrating structure, wherein the fibre diameter of fiber assembly be 300-1000nm between, fiber it
Between aperture (one-level hole) size between 1.5~3 μm, fiber surface micropore (second hole) size is fine between 180~700nm
Sandwich layer hole (three-level hole) size is tieed up between 140~550nm.The stratiform IPN of composite stereo timbering material obtained by the present embodiment
Structural representation is as shown in Fig. 2 its three-level pore structure schematic diagram is as shown in Figure 3.
The composite stereo timbering material containing hierarchical porous structure of the present embodiment is prepared via a method which：
Polycaprolactone (PCL, Mw=6 × 104G/mol) using chloroform as solvent, magnetic agitation 6h under normal temperature is obtained
To the PCL solution that mass fraction is 12%；Gelatin (Mw=6 × 105G/mol) using deionized water as solvent, under normal temperature
Magnetic agitation 12h, obtains the gelatin solution that mass fraction is 5%；It is using the PCL solution prepared as cortex component, gelatin is molten
Liquid is as sandwich layer component, using coaxial electrostatic spinning machine-shaping, using genipin solution as coagulating bath, and is aided with magnetic force and stirs
Mix as dynamic reception device, the distance between reception device and syringe needle about 7cm, the spinning moulding under 14kV voltages.Shaping
Compound support frame material is post-processed by being freeze-dried afterwards, obtains the gelatin-compounded three-dimensional bracket materials of PCL/ containing hierarchical porous structure
Material.
In the composite stereo timbering material containing hierarchical porous structure that the present embodiment is obtained fibre diameter 300-1000nm it
Between, between fiber aperture (one-level hole) size between 1.5~3 μm, fiber surface micropore (second hole) size 180~
Between 700nm, core fiber layer hole (three-level hole) size between 140~550nm, can in pattern and size mould well
Intend natural extracellular matrix, and with good biocompatibility and there is no toxicity to cell, contacted with each other with cell
Process among can promote cell adherence, propagation, migration and break up, it is adaptable to organizational project repair wound.
Embodiment 3
A kind of composite stereo timbering material containing hierarchical porous structure of the present embodiment, by by the fiber collection with skin-core structure
Zoarium be composited by network blackboard, wherein the fibre diameter of fiber assembly be 500-1100nm between, fiber it
Between aperture (one-level hole) size between 1~2.5 μm, fiber surface micropore (second hole) size is fine between 300~600nm
Sandwich layer hole (three-level hole) size is tieed up between 200~500nm.The network interpenetrating of composite stereo timbering material obtained by the present embodiment
Structural representation is as shown in figure 1, its three-level pore structure schematic diagram is as shown in Figure 3.
The composite stereo timbering material containing hierarchical porous structure of the present embodiment is prepared via a method which：
Poly butyric ester (PHB, Mw=2 × 106G/mol) using dichloromethane as solvent, magnetic agitation under normal temperature
8h, obtains the PHB solution that mass fraction is 8%；Hyaluronic acid (Mw=2 × 105G/mol) using deionized water as molten
Magnetic agitation 10h under agent, normal temperature, obtains the hyaluronic acid solution that mass fraction is 10%；It regard the PHB solution prepared as cortex
Component, using hyaluronic acid solution as sandwich layer component, using coaxial electrostatic spinning machine-shaping, solidification is used as using ethanol solution
Bath, and it is aided with magnetic agitation as dynamic reception device, the distance between reception device and syringe needle about 4cm, under 12kV voltages
Spinning moulding.Compound support frame material after shaping is post-processed by Thermal inactive, the PHB/ containing hierarchical porous structure is obtained
Hyaluronic acid composite stereo timbering material.
In the composite stereo timbering material containing hierarchical porous structure that the present embodiment is obtained fibre diameter 500-1100nm it
Between, between fiber aperture (one-level hole) size between 1~2.5 μm, fiber surface micropore (second hole) size 300~
Between 600nm, core fiber layer hole (three-level hole) size between 200~500nm, can in pattern and size mould well
Intend natural extracellular matrix, and with good biocompatibility and there is no toxicity to cell, contacted with each other with cell
Process among can promote cell adherence, propagation, migration and break up, it is adaptable to organizational project repair wound.
Above-described embodiment is the utility model preferably embodiment, but embodiment of the present utility model is not by above-mentioned
The limitation of embodiment, it is other it is any without departing from Spirit Essence of the present utility model with made under principle change, modify, replace
Generation, combination, simplification, should be equivalent substitute mode, are included within protection domain of the present utility model.
Claims (2)
1. a kind of composite stereo timbering material containing hierarchical porous structure, it is characterised in that：The composite stereo timbering material is by having
The fiber assembly for having skin-core structure is composited by network blackboard or stratiform interpenetrating structure, the fiber assembly
Fibre diameter is 20~2000nm, and the composite stereo support has three-level pore structure, wherein between the fiber of fiber assembly
Pore size between 0.5~5 μm, fiber surface micropore size between 10~1000nm, core fiber layer hole size 5~
Between 800nm.
2. a kind of composite stereo timbering material containing hierarchical porous structure according to claim 1, it is characterised in that：The tool
The fiber assembly for having skin-core structure refers to the fiber assembly prepared by coaxial electrostatic spinning.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110124102A (en) * | 2019-05-05 | 2019-08-16 | 南京邦鼎生物科技有限公司 | Method of the preparation for the doughnut conduit and its bundle structure object of neural restoration |
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2016
- 2016-10-09 CN CN201621108110.0U patent/CN206414539U/en active Active
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110124102A (en) * | 2019-05-05 | 2019-08-16 | 南京邦鼎生物科技有限公司 | Method of the preparation for the doughnut conduit and its bundle structure object of neural restoration |
| CN110124102B (en) * | 2019-05-05 | 2021-06-01 | 南京邦鼎生物科技有限公司 | Method for preparing hollow fiber catheter for nerve repair and bundling structure thereof |
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