CN206339660U - A kind of bimodulus positron imaging machine based on event count - Google Patents
A kind of bimodulus positron imaging machine based on event count Download PDFInfo
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Abstract
A kind of bimodulus positron imaging machine based on event count, it includes：Unstable isotope injection module, gamma detector module, visible-light detector module, many example time windows sentence modeling block, visualization model.The system can recognize that the Cherenkov's photon and electron-positron pair that move transmitting due to charged particle bury in oblivion the gammaphoton pair of generation simultaneously during positron emission, effectively lifting system signal to noise ratio, imaging spatial and temporal resolution and sensitivity, reduce material cost.
Description
Technical field
Equipped and Biomedical Photonics field the present invention relates to high-energy physics and particle physics application, nuclear medicine, especially
It is related to a kind of bimodulus positron imaging machine based on event count.
Background technology
Radioactive events in nuclear physics are generally along with two kinds or two or more irradiation types.Particularly decay thing
When part can launch unstable charged particle, radioactive events can have a variety of radiation to send simultaneously.It is unstable with rich proton
Exemplified by isotope, when the positive electron launched has certain momentum, light photon, this physics will be irradiated on track
Phenomenon is Cerenkov radiation.Cerenkov radiation is as a kind of extremely convenient labeling method, in biomedicine imaging
There is extremely wide application value.And when the electronics generation material and antimatter in positive electron and environment is buried in oblivion, will radiate a pair
Gammaphoton with 511keV energy, that is to say, that a kind of isotope marks of rich proton element will provide two kinds of imaging sides
Formula：Optical imagery and gamma imaging.In addition to rich proton element, other parts unstable isotope also have cascade decay and
Different-energy, different electric charges, the situation of multiple particles of different penetration depths are radiated simultaneously, belong to the scope of discussion.It is existing
Imaging system special detection is not carried out to the probe of this " as two duties ", but independently use gamma camera（Or
Person PET）There are the organism of proton nuclear species or human body to be each imaged mark with optical camera, middle signal detection
It is entirely independent with data acquisition, finally carries out rear end standard in image aspect and close（Registration）.
This rear end standard closes extremely serious for two kinds of information losses irradiated.In gamma data, have greatly
Data are scattering and chance event, if optical data can be introduced in the form of event in physical layer, will be to scattering and Random event
Part, which is provided, extremely accurately sentences choosing.And visible ray in human body to transport noise extremely serious, if optical data can cut human relations
The collimation information of gammaphoton is introduced when section's husband's event is screened, the information for greatly lifting single Cherenkov's event is accurate
Degree.Therefore, being operated in the information fusion of the event level of physical layer, many irradiation systems will be produced with revolutionary influence.
The content of the invention
In view of this, it is an object of the invention to provide a kind of bimodulus positron imaging machine based on event count, this is
System can be simultaneously recognized during positron emission because charged particle moves the Cherenkov's photon and positron-electron of transmitting
Gammaphoton pair to burying in oblivion generation, effectively lifting system signal to noise ratio, imaging spatial and temporal resolution and sensitivity, reduction material into
This.
To achieve the above object, the present invention provides a kind of bimodulus positron imaging machine based on event count, including following
Module：Unstable isotope injection module 100, gamma detector module 200, visible-light detector module 300, many example times
Window sentences modeling block 400, visualization model 500, wherein,
Unstable isotope injection module 100, for entering rower to the material that physiology and biochemical process are participated in organism
Note, the label of many irradiation events, including radioactivity can be launched by shielding the bias light beyond organism, and carrying organism
Isotope drug delivery module 110, medicament injection module 120, organism transmission module 130, the closed module 140 of light；
Gamma detector module 200, realizes the detection to gammaphoton in the way of ring-type visual angle, obtains single gammaphoton
The time of event and energy properties, using scintillation detector principle, including scintillation crystal module 210, photoelectric conversion module 220,
Front-end electronics module 230, gamma events attributes encapsulation circuit module 240；
Visible-light detector module 300, for being realized in the way of high detection efficient to light photon and soft ultraviolet light
The detection of son, detector uses large-area planar structure, is available for extensive opto chip technique to be manufactured on a large scale, including
The sub- photoelectric conversion module 310 of Cherenkov light, Cherenkov's detection front-end electronics module 320, Cherenkov's event attribute envelope
Fill circuit module 330；
Many example time windows sentence modeling block 400, for judging whether Cherenkov's event and gammaphoton event belong to one
Secondary positive electricity subevent, the standard of judgement is in shorter time window（Such as 30 ns）Inside have at the same exist gammaphoton event and
Cherenkov's event, including many examples timing windowing circuit module 410, logical AND gate circuit module 420, total event timing windowing
Module 430, meets Event Package module 440, power module 450, digital circuit clock module 460；
Visualization model 500, it is anti-breaking by processor module 510 for carrying out subsequent treatment or discarding to irradiance data
Direct current electric source module 520, display apparatus module 530, network transport interface module 540 is constituted.
Radio isotope drug delivery module 110, is under the jurisdiction of unstable isotope injection module 100, for steady to organism
Surely radiopharmaceutical is automatically sent into, it is to avoid the radiation injury that radiopharmaceutical may be caused to human body and organism, medicine
Thing enters drug injection module 120 via radio isotope drug delivery module 110；
Medicament injection module 120, is under the jurisdiction of unstable isotope injection module 100, for controlling injection biological in real time
Radiopharmaceutical dosage in body or human body, is made up of pusher and dosage measuring and calculating device；
Organism transmission module 130, is under the jurisdiction of unstable isotope injection module 100, for controlling organism in imaging
Feeding and submitting inside and outside chamber, are made up of pusher and supporting plate, and supporting plate holds organism, and pusher is responsible in imaging
It is preceding that supporting plate and organism feeding are imaged chamber, supporting plate and organism are sent out imaging chamber after the completion of imaging；
The closed module 140 of light, is under the jurisdiction of unstable isotope injection module 100, for carrying out lucifuge envelope to imaging chamber
Dress, it is ensured that imaging chamber does not have extra outside visible ray to inject in imaging.
Scintillation crystal module 210, is under the jurisdiction of gamma detector module 200, for absorbing gammaphoton, and a gamma
The energy of photon is converted into cluster visible ray or soft ultraviolet light photons, brilliant by scintillation crystal bare crystalline, flicker light reflecting material, flicker
Body package casing, light extraction glass are constituted；
Photoelectric conversion module 220, is under the jurisdiction of gamma detector module 200, for visible ray and the energy of soft ultraviolet light photons
Amount absorbs to be converted with electric signal, is amplified photoelectron stream cluster in a short time particular by avalanche process, then export to front end
Electronics module 230；
Front-end electronics module 230, is under the jurisdiction of gamma detector module 200, for the electricity exported to photoelectric conversion module
Signal carries out preposition enhanced processing, and carries out analog-to-digital conversion, and digitized scintillation pulse attribute is exported to gamma according to event
Event attribute encapsulated circuit module 240；
Gamma events attributes encapsulation circuit module 240, is under the jurisdiction of gamma detector module 200, to the attribute of gamma events
It is packaged, the content of encapsulation includes event time, gammaphoton energy, the rise time in scintillation pulse forward position and flicker arteries and veins
The deviation of punching and.
The sub- photoelectric conversion module 310 of Cherenkov light, is under the jurisdiction of visible-light detector module 300, for absorbing Qie Lunke
Husband's photon, and be translated into electric signal, particular by photoelectric effect and avalanche process, by photoelectron stream cluster in a short time
Amplification, then export to Cherenkov's detection front-end electronics module 320；
Cherenkov's detection front-end electronics module 320, is under the jurisdiction of visible-light detector module 310, for Qie Lunke
Husband's induction electric pulse carries out preposition amplification, and carries out analog-to-digital conversion, by digitized Cherenkov induction electric pulse attribute according to
Event is exported to Cherenkov's event attribute encapsulated circuit module 330；
Cherenkov's event attribute encapsulated circuit module 330, is under the jurisdiction of visible-light detector module 300, to Cherenkov
The attribute of event is packaged, and the content of encapsulation includes event time, gammaphoton energy, Cherenkov's induction electric pulse forward position
Rise time and Cherenkov induction electric pulse deviation and.
Many example timing windowing circuit modules 410, are under the jurisdiction of many example time windows and sentence modeling block 400, for each gal
Horse event and Cherenkov's event are timed windowing, i.e., 1 output is put in timing since event arrival time；
Logical AND gate circuit module 420, is under the jurisdiction of many example time windows and sentences modeling block 400, receives many example timings and opens a window
What circuit module 410 was exported puts after 1 signal, by carrying out sentencing choosing with logic to multiple examples with gate circuit, when in the presence of two gals
During more than horse photon and passage Cherenkov's event, 1 output is put, otherwise, keeps resetting output；
Total event timing windowing module 430, is under the jurisdiction of many example time windows and sentences modeling block 400, receive logical AND gate circuit
Signal is selected in sentencing with door for module 420, and since receive put 1 signal 1 output put with regular time window；
Meet Event Package module 440, be under the jurisdiction of many example time windows and sentence modeling block 400, from receiving total event timing
1 signal of putting of windowing module starts, and each event attribute received from many examples timing windowing circuit module is packaged into two
The bit stream of system；
Power module 450, is under the jurisdiction of many example time windows and sentences modeling block 400, for being stablized to each circuit module
Power supply, the external 220V electric mains of power supply；
Digital circuit clock module 460, is under the jurisdiction of many example time windows and sentences modeling block 400, for giving each digital circuit
Module tranmitting data register signal, clock signal is sine voltage signal, is provided by active crystal oscillator.
Processor module 510, is under the jurisdiction of visualization model 500, and correlation analysis, histogram are carried out to packaged example
Counting, statistical calculations, and the result for analyzing calculating is transferred to display apparatus module 530；
Anti-power failure DC power supplier 520, is under the jurisdiction of visualization model 500, for ensureing display apparatus module and processor
The steady operation of module, after system cut-off, still can keep the working power of more than 8 hours, so as to repairing before being shut down
Multiple and archive action；
Display apparatus module 530, is under the jurisdiction of visualization model 500, receives gamma attribute and the Cherenkov of positive electricity subevent
The various spectroscopy attributes that electron event is aligned after attribute are shown；
Network transport interface module 540, is under the jurisdiction of visualization model 500, the gamma attribute for transmitting positive electricity subevent
With Cherenkov's attribute and its spectroscopy chart.
Preferably, in the above-mentioned bimodulus positron imaging machine based on event count, described event arrival time is
Explorer response the gamma events either time of Cherenkov's event or explorer response gamma events or Cherenkov's thing
The time of part, the constant was applied to whole system at any time plus a constant constant.
Preferably, in the above-mentioned bimodulus positron imaging machine based on event count, the gal of described positive electricity subevent
Equus refers to that a pair of gammaphotons that positive electron is produced after burying in oblivion with electronics hit the response characteristic of gamma detector.
Preferably, in the above-mentioned bimodulus positron imaging machine based on event count, described positive electricity subevent is cut
Lun Kefu attributes refer to that Cherenkov's photon that positive electron is produced before burying in oblivion with electronics hits the response of visible-light detector
Feature.
Preferably, in the above-mentioned bimodulus positron imaging machine based on event count, described positive electricity subevent refers to
Rich proton nuclear species go out positive electron by decay emission.Positive electron motion when produce Cerenkov effect, with neighbouring electronics
After burying in oblivion, a pair of gammaphotons are produced, the attribute of gammaphoton is captured by gamma detector, the attribute of Cherenkov's photon
Captured by visible-light detector.
Preferably, in the above-mentioned bimodulus positron imaging machine based on event count, described many example time windows are sentenced
Choosing refers to the light photon detector and gamma photon detection device of system while when capturing two kinds of signals, system thinks this
Light photon and gammaphoton in the case of kind is smaller for the probability of background photon or dark excitation photon, and sentences and elect positive electricity as
The gammaphoton pair and Cherenkov's photon of subevent.
From above-mentioned technical proposal as can be seen that by using the bimodulus positron imaging based on event count of the present invention
Machine, can obtain the distributed intelligence of positron source under relatively low activity.Because the system need not drop to detector in advance
Temperature processing, can work at room temperature, and with more preferable spatial and temporal resolution and signal to noise ratio, thus with more preferably universality and
Practicality.
Compared with prior art, the beneficial effects of the invention are as follows：
（1）More preferable spatial and temporal resolution；
（2）Better image signal to noise ratio；
（3）Can be in working and room temperature；
（4）Cost is relatively low；
（5）Take full advantage of the much information of positron source.
Brief description of the drawings
In order to illustrate more clearly about the embodiment of the present invention or technical scheme of the prior art, below will be to embodiment or existing
The accompanying drawing to be used needed for having technology description is briefly described, it should be apparent that, it is for the present invention in describing below
Accompanying drawing is only some embodiments of the present invention, for those of ordinary skill in the art, is not paying creative work
Under the premise of, other accompanying drawings can also be obtained according to these accompanying drawings.
Fig. 1 is the system block diagram of the bimodulus positron imaging machine of the invention based on event count；
Fig. 2 is the path schematic diagram of two kinds of light of the invention.
Embodiment
The invention discloses a kind of bimodulus positron imaging machine based on event count, the system can be in positron emission
During identification simultaneously bury in oblivion the gamma light of generation due to the Cherenkov's photon and electron-positron pair that charged particle moves transmitting
Son is right, and effectively lifting system signal to noise ratio, imaging spatial and temporal resolution and sensitivity, reduce material cost.
Below in conjunction with the accompanying drawing in the embodiment of the present invention, the technical scheme in the embodiment of the present invention is retouched in detail
State, it is clear that described embodiment is only a part of embodiment of the invention, rather than whole embodiments.Based on the present invention
In embodiment, the every other implementation that those of ordinary skill in the art are obtained on the premise of creative work is not made
Example, belongs to the scope of protection of the invention.
As shown in figure 1, the bimodulus positron imaging machine disclosed by the invention based on event count, by gamma detector and
The gamma attribute and Cherenkov's attribute of light photon detector capture positive electricity subevent, realize the biology for aligning electronic marker
The imaging of body or human body, is specifically included：
Unstable isotope injection module 100, gamma detector module 200, visible-light detector module 300, many examples
Time window sentences modeling block 400, visualization model 500, wherein,
Unstable isotope injection module 100, for entering rower to the material that physiology and biochemical process are participated in organism
Note, the label of many irradiation events, including radioactivity can be launched by shielding the bias light beyond organism, and carrying organism
Isotope drug delivery module 110, medicament injection module 120, organism transmission module 130, the closed module 140 of light；
Gamma detector module 200, realizes the detection to gammaphoton in the way of ring-type visual angle, obtains single gammaphoton
The time of event and energy properties, using scintillation detector principle, including scintillation crystal module 210, photoelectric conversion module 220,
Front-end electronics module 230, gamma events attributes encapsulation circuit module 240；
Visible-light detector module 300, for being realized in the way of high detection efficient to light photon and soft ultraviolet light
The detection of son, detector uses large-area planar structure, is available for extensive opto chip technique to be manufactured on a large scale, including
The sub- photoelectric conversion module 310 of Cherenkov light, Cherenkov's detection front-end electronics module 320, Cherenkov's event attribute envelope
Fill circuit module 330；
Many example time windows sentence modeling block 400, for judging whether Cherenkov's event and gammaphoton event belong to one
Secondary positive electricity subevent, the standard of judgement is in shorter time window（Such as 30 ns）Inside have at the same exist gammaphoton event and
Cherenkov's event, including many examples timing windowing circuit module 410, logical AND gate circuit module 420, total event timing windowing
Module 430, meets Event Package module 440, power module 450, digital circuit clock module 460；
Visualization model 500, it is anti-breaking by processor module 510 for carrying out subsequent treatment or discarding to irradiance data
Direct current electric source module 520, display apparatus module 530, network transport interface module 540 is constituted.
Radio isotope drug delivery module 110, is under the jurisdiction of unstable isotope injection module 100, for steady to organism
Surely radiopharmaceutical is automatically sent into, it is to avoid the radiation injury that radiopharmaceutical may be caused to human body and organism, medicine
Thing enters drug injection module 120 via radio isotope drug delivery module 110；
Medicament injection module 120, is under the jurisdiction of unstable isotope injection module 100, for controlling injection biological in real time
Radiopharmaceutical dosage in body or human body, is made up of pusher and dosage measuring and calculating device；
Organism transmission module 130, is under the jurisdiction of unstable isotope injection module 100, for controlling organism in imaging
Feeding and submitting inside and outside chamber, are made up of pusher and supporting plate, and supporting plate holds organism, and pusher is responsible in imaging
It is preceding that supporting plate and organism feeding are imaged chamber, supporting plate and organism are sent out imaging chamber after the completion of imaging；
The closed module 140 of light, is under the jurisdiction of unstable isotope injection module 100, for carrying out lucifuge envelope to imaging chamber
Dress, it is ensured that imaging chamber does not have extra outside visible ray to inject in imaging.
Scintillation crystal module 210, is under the jurisdiction of gamma detector module 200, for absorbing gammaphoton, and a gamma
The energy of photon is converted into cluster visible ray or soft ultraviolet light photons, brilliant by scintillation crystal bare crystalline, flicker light reflecting material, flicker
Body package casing, light extraction glass are constituted；
Photoelectric conversion module 220, is under the jurisdiction of gamma detector module 200, for visible ray and the energy of soft ultraviolet light photons
Amount absorbs to be converted with electric signal, is amplified photoelectron stream cluster in a short time particular by avalanche process, then export to front end
Electronics module 230；
Front-end electronics module 230, is under the jurisdiction of gamma detector module 200, for the electricity exported to photoelectric conversion module
Signal carries out preposition enhanced processing, and carries out analog-to-digital conversion, and digitized scintillation pulse attribute is exported to gamma according to event
Event attribute encapsulated circuit module 240；
Gamma events attributes encapsulation circuit module 240, is under the jurisdiction of gamma detector module 200, to the attribute of gamma events
It is packaged, the content of encapsulation includes event time, gammaphoton energy, the rise time in scintillation pulse forward position and flicker arteries and veins
The deviation of punching and.
The sub- photoelectric conversion module 310 of Cherenkov light, is under the jurisdiction of visible-light detector module 300, for absorbing Qie Lunke
Husband's photon, and be translated into electric signal, particular by photoelectric effect and avalanche process, by photoelectron stream cluster in a short time
Amplification, then export to Cherenkov's detection front-end electronics module 320；
Cherenkov's detection front-end electronics module 320, is under the jurisdiction of visible-light detector module 310, for Qie Lunke
Husband's induction electric pulse carries out preposition amplification, and carries out analog-to-digital conversion, by digitized Cherenkov induction electric pulse attribute according to
Event is exported to Cherenkov's event attribute encapsulated circuit module 330；
Cherenkov's event attribute encapsulated circuit module 330, is under the jurisdiction of visible-light detector module 300, to Cherenkov
The attribute of event is packaged, and the content of encapsulation includes event time, gammaphoton energy, Cherenkov's induction electric pulse forward position
Rise time and Cherenkov induction electric pulse deviation and.
Many example timing windowing circuit modules 410, are under the jurisdiction of many example time windows and sentence modeling block 400, for each gal
Horse event and Cherenkov's event are timed windowing, i.e., 1 output is put in timing since event arrival time；
Logical AND gate circuit module 420, is under the jurisdiction of many example time windows and sentences modeling block 400, receives many example timings and opens a window
What circuit module 410 was exported puts after 1 signal, by carrying out sentencing choosing with logic to multiple examples with gate circuit, when in the presence of two gals
During more than horse photon and passage Cherenkov's event, 1 output is put, otherwise, keeps resetting output；
Total event timing windowing module 430, is under the jurisdiction of many example time windows and sentences modeling block 400, receive logical AND gate circuit
Signal is selected in sentencing with door for module 420, and since receive put 1 signal 1 output put with regular time window；
Meet Event Package module 440, be under the jurisdiction of many example time windows and sentence modeling block 400, from receiving total event timing
1 signal of putting of windowing module starts, and each event attribute received from many examples timing windowing circuit module is packaged into two
The bit stream of system；
Power module 450, is under the jurisdiction of many example time windows and sentences modeling block 400, for being stablized to each circuit module
Power supply, the external 220V electric mains of power supply；
Digital circuit clock module 460, is under the jurisdiction of many example time windows and sentences modeling block 400, for giving each digital circuit
Module tranmitting data register signal, clock signal is sine voltage signal, is provided by active crystal oscillator.
Processor module 510, is under the jurisdiction of visualization model 500, and correlation analysis, histogram are carried out to packaged example
Counting, statistical calculations, and the result for analyzing calculating is transferred to display apparatus module 530；
Anti-power failure DC power supplier 520, is under the jurisdiction of visualization model 500, for ensureing display apparatus module and processor
The steady operation of module, after system cut-off, still can keep the working power of more than 8 hours, so as to repairing before being shut down
Multiple and archive action；
Display apparatus module 530, is under the jurisdiction of visualization model 500, receives gamma attribute and the Cherenkov of positive electricity subevent
The various spectroscopy attributes that electron event is aligned after attribute are shown；
Network transport interface module 540, is under the jurisdiction of visualization model 500, the gamma attribute for transmitting positive electricity subevent
With Cherenkov's attribute and its spectroscopy chart.
In the bimodulus positron imaging machine based on event count above, described event arrival time is explorer response
Either the time of Cherenkov's event or the time of explorer response gamma events or Cherenkov's event add gamma events
A upper constant constant, the constant is applied to whole system at any time.
In the bimodulus positron imaging machine based on event count above, the gamma attribute of described positive electricity subevent is
Refer to, a pair of gammaphotons that positive electron is produced after burying in oblivion with electronics hit the response characteristic of gamma detector.
More than the bimodulus positron imaging machine based on event count in, Cherenkov's attribute of described positive electricity subevent
Refer to, Cherenkov's photon that positive electron is produced before burying in oblivion with electronics hits the response characteristic of visible-light detector.
In the bimodulus positron imaging machine based on event count above, described many example time windows sentence choosing and refer to system
Light photon detector and gamma photon detection device simultaneously when capturing two kinds of signals, system thinks in this case
Light photon and gammaphoton are smaller for the probability of background photon or dark excitation photon, and sentence the gal for electing positive electricity subevent as
Horse photon pair and Cherenkov's photon.
Fig. 1 is the system block diagram of the bimodulus positron imaging machine of the invention based on event count；Fig. 2 is two kinds of light of the invention
Path schematic diagram.With reference to Fig. 1 and Fig. 2, by several specific embodiments, to bimodulus positive electricity of the present invention based on event count
Sub- developing device system is described further.Bimodulus positron imaging machine system proposed by the present invention based on event count, it is related to
And arrive set division, function deriving mode and its priority orders, coded system, threshold parameter need according to fetched data
The characteristics of be adjusted to reach enough statistic properties.The parameter of involved Application Example processing data is listed herein.
Example 1：Bimodulus positron imaging machine based on event count
The parameter of the processing data of the present embodiment 1 is listed herein：
The radioactive source activity used in module 100 is 100 uCi, and the closed module size of light is the cm of diameter 10,5 cm of ring thickness
Cup-shaped geometry；
The size of the scintillation crystal bar used in module 200 is the mm of 2 mm x, 2 mm x 13, and test surface is 2 mm x
2 mm, scintillation crystal uses sodium iodide crystal；
The photon detection unit size used in module 300 is the mm of 2 mm x 2, and detector uses silicon photoelectric multiplier；
The time window used in module 400 is 5 ns；
Processor uses FPGA in module 500（Field programmable gate array）Processor, display uses liquid crystal
Show device, network transport interface uses industrial ethernet protocol.
Example 2：Bimodulus positron imaging machine based on event count
The parameter of the processing data of the present embodiment 2 is listed herein：
The radioactive source activity used in module 100 is 200 uCi, and the closed module size of light is the cm of diameter 20, ring thickness 15
Cm tubbiness geometry；
The size of the scintillation crystal bar used in module 200 is the mm of 3 mm x, 3 mm x 13, and test surface is 3 mm x
3 mm, scintillation crystal uses lanthanum bromide crystal；
The photon detection unit size used in module 300 is the mm of 3 mm x 3, and detector uses silicon photoelectric multiplier；
The time window used in module 400 is 15 ns；
Processor uses processor of single chip computer in module 500, and display uses liquid crystal display, and network transport interface is used
Ethernet protocol.
Example 3：Bimodulus positron imaging machine based on event count
The parameter of the processing data of the present embodiment 3 is listed herein：
The radioactive source activity used in module 100 is 1.00 mCi, and the closed module size of light is the cm of diameter 50, ring thickness 50
Cm tubbiness geometry；
The size of the scintillation crystal bar used in module 200 is the mm of 5 mm x, 5 mm x 13, and test surface is 5 mm x
5 mm, scintillation crystal uses lanthanum bromide crystal；
The photon detection unit size used in module 300 is the mm of 4 mm x 3, and detector uses silicon photoelectric multiplier；
The time window used in module 400 is 25 ns；
Processor uses digital signal processor in module 500, and display uses electronics tube display, network transport interface
Using PCIe protocol.
The present invention relates to high-energy physics and particle physics application, nuclear medicine equipment and biomedical diagnosis and treatment field, especially relate to
And a kind of bimodulus positron imaging machine system based on event count.
By contrast as can be seen that using the bimodulus positron imaging machine based on event count of the present invention, the system energy
Recognize that the Cherenkov's photon and electron-positron pair that move transmitting due to charged particle fall into oblivion simultaneously during positron emission
Go out the gammaphoton pair of generation, and effectively lifting system signal to noise ratio, imaging spatial and temporal resolution and sensitivity, reduce material cost.
Compared with prior art, the beneficial effects of the invention are as follows：
（1）More preferable spatial and temporal resolution；
（2）Better image signal to noise ratio；
（3）Can be in working and room temperature；
（4）Cost is relatively low；
（5）Take full advantage of the much information of positron source.
It is obvious to a person skilled in the art that the invention is not restricted to the details of above-mentioned one exemplary embodiment, Er Qie
In the case of without departing substantially from spirit or essential attributes of the invention, the present invention can be realized in other specific forms.Therefore, no matter
From the point of view of which point, embodiment all should be regarded as exemplary, and be nonrestrictive, the scope of the present invention is by appended power
Profit is required rather than described above is limited, it is intended that all in the implication and scope of the equivalency of claim by falling
Change is included in the present invention.Any reference in claim should not be considered as to the claim involved by limitation.
Moreover, it will be appreciated that although the present specification is described in terms of embodiments, not each embodiment is only wrapped
Containing an independent technical scheme, this narrating mode of specification is only that for clarity, those skilled in the art should
Using specification as an entirety, the technical solutions in the various embodiments may also be suitably combined, forms those skilled in the art
It may be appreciated other embodiment.
Claims (10)
1. a kind of bimodulus positron imaging machine based on event count, is characterised by including with lower module：
Unstable isotope injection module, for the material that physiology and biochemical process are participated in organism to be marked, is shielded
Bias light beyond organism, and make organism with the label of many irradiation events can be launched；
Gamma detector module, realizes the detection to gammaphoton in the way of ring-type visual angle, obtains single gammaphoton event
Time and energy properties, gammaphoton is detected using scintillation detector principle；
Visible-light detector module, for realizing the spy to light photon and soft ultraviolet photon in the way of high detection efficient
Survey, detector uses large-area planar structure, is available for extensive opto chip technique to be manufactured on a large scale；
Many example time windows sentence modeling block, for judging whether Cherenkov's event and gammaphoton event belong to a positive electron
Event, whether the standard of judgement is while there is gammaphoton event and Cherenkov's event in time window；
Visualization model, for carrying out subsequent treatment or discarding to irradiance data, by processor module, anti-power failure dc source
Module, display apparatus module, network transport interface module composition.
2. a kind of bimodulus positron imaging machine based on event count according to claim 1, it is characterised in that unstable
Isotope injection module includes：
Radio isotope drug delivery module, for stably automatically sending into radiopharmaceutical to organism, it is to avoid radioactivity
The radiation injury that medicine may be caused to human body and organism, medicine enters drug injection via radio isotope drug delivery module
Module；
Medicament injection module, for controlling the radiopharmaceutical dosage in injection organism or human body in real time, is filled by pushing
Put and constituted with dosage measuring and calculating device；
Organism transmission module, for controlling feeding and submitting of the organism inside and outside imaging chamber, by pusher and supporting plate
Constitute, supporting plate holds organism, pusher is responsible for before imaging supporting plate and organism feeding imaging chamber, in imaging
After the completion of supporting plate and organism are sent out imaging chamber；
The closed module of light, for carrying out lucifuge encapsulation to imaging chamber, it is ensured that imaging chamber does not have extra outside in imaging
Visible ray is injected.
3. a kind of bimodulus positron imaging machine based on event count according to claim 1, it is characterised in that gamma is visited
Surveying device module includes：
Scintillation crystal module, cluster visible ray or soft is converted into for absorbing gammaphoton, and the energy of a gammaphoton
Ultraviolet light photons, are made up of scintillation crystal bare crystalline, flicker light reflecting material, scintillation crystal package casing, light extraction glass；
Photoelectric conversion module, energy absorption and electric signal for visible ray and soft ultraviolet light photons are converted, particular by snow
Collapse process to amplify photoelectron stream cluster in a short time, then export and give front-end electronics module；
Front-end electronics module, the electric signal for being exported to photoelectric conversion module carries out preposition enhanced processing, and carries out modulus
Conversion, digitized scintillation pulse attribute is exported according to event and gives gamma events attributes encapsulation circuit module；
Gamma events attributes encapsulation circuit module, is packaged to the attribute of gamma events, the content of encapsulation include event time,
Gammaphoton energy, the deviation of the rise time in scintillation pulse forward position and scintillation pulse and.
4. a kind of bimodulus positron imaging machine based on event count according to claim 1, it is characterised in that visible ray
Detector module includes：
The sub- photoelectric conversion module of Cherenkov light, for absorbing Cherenkov's photon, and is translated into electric signal, specifically leads to
Cross photoelectric effect and avalanche process, photoelectron stream cluster amplified in a short time, then export give Cherenkov detection front end electronics
Learn module；
Cherenkov detects front-end electronics module, for carrying out preposition amplification to Cherenkov's induction electric pulse, and carries out mould
Number conversion, digitized Cherenkov induction electric pulse attribute is exported according to event and gives Cherenkov's event attribute encapsulated circuit
Module；
Cherenkov's event attribute encapsulated circuit module, is packaged, the content of encapsulation includes to the attribute of Cherenkov's event
Event time, gammaphoton energy, the rise time in Cherenkov's induction electric pulse forward position and Cherenkov's induction electric pulse
Deviation and.
5. a kind of bimodulus positron imaging machine based on event count according to claim 1, it is characterised in that many examples
Time window, which sentences modeling block, to be included：
Many examples timing windowing circuit modules, for being timed windowing to each gamma events and Cherenkov's event, i.e., from
Event arrival time starts timing and puts 1 output；
Logical AND gate circuit module, receives putting after 1 signal for many examples timing windowing circuit modules output, by with gate circuit pair
Multiple examples carry out sentencing choosing with logic, when there is Cherenkov's event of more than two gammaphotons and a passage, put 1 defeated
Go out, otherwise, keep resetting output；
Total event timing windowing module, receives sentencing with door for logical AND gate circuit module and selects signal, and puts 1 signal from receiving and open
Beginning puts 1 output with regular time window；
Meet Event Package module, since receive total event timing windowing module put 1 signal, will from many examples timing open
Each event attribute that window circuit module is received is packaged into binary bit stream；
Power module, for the power supply stablized to each circuit module, the external electric main of power supply；
Digital circuit clock module, for giving each digital circuit blocks tranmitting data register signal, clock signal is sine voltage
Signal, is provided by active crystal oscillator.
6. a kind of bimodulus positron imaging machine based on event count according to claim 1, it is characterised in that visualization
Module includes：
Processor module, carries out correlation analysis, histogram counts, statistical calculations to packaged example, and by analysis meter
The result of calculation is transferred to display apparatus module；
Anti-power failure DC power supplier, the steady operation for ensureing display apparatus module and processor module, after system cut-off,
Still the working power of more than 8 hours can be kept, so as to the reparation before being shut down and archive action；
The various spectroscopys of electron event are aligned after display apparatus module, the gamma attribute and Cherenkov's attribute that receive positive electricity subevent
Attribute is shown；
Network transport interface module, gamma attribute and Cherenkov's attribute and its spectroscopy chart for transmitting positive electricity subevent.
7. a kind of bimodulus positron imaging machine based on event count according to claim 1, it is characterised in that event is arrived
It is that explorer response gamma events either the time of Cherenkov's event or explorer response gamma events or are cut up to the time
The time of Lun Kefu events, the constant was applied to whole system at any time plus a constant constant.
8. a kind of bimodulus positron imaging machine based on event count according to claim 1, it is characterised in that positive electron
The gamma attribute of event refers to that a pair of gammaphotons that positive electron is produced after burying in oblivion with electronics hit the sound of gamma detector
Feature is answered, Cherenkov's attribute of positive electricity subevent refers to that Cherenkov's photon that positive electron is produced before burying in oblivion with electronics is hit
The response characteristic of middle visible-light detector.
9. a kind of bimodulus positron imaging machine based on event count according to claim 1, it is characterised in that positive electron
Event refers to that rich proton nuclear species go out positive electron by decay emission, and positive electron produces Cerenkov effect in motion, with it is attached
After near electronics is buried in oblivion, a pair of gammaphotons are produced, the attribute of gammaphoton is captured by gamma detector, Cherenkov light
The attribute of son is captured by visible-light detector.
10. a kind of bimodulus positron imaging machine based on event count according to claim 1, it is characterised in that many examples
Time window sentences choosing and refers to the light photon detector and gamma photon detection device of system while when capturing two kinds of signals, being
System thinks that light photon and gammaphoton in this case is smaller for the probability of background photon or dark excitation photon, and sentences
Elect the gammaphoton pair and Cherenkov's photon of positive electricity subevent as.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106199673A (en) * | 2016-09-07 | 2016-12-07 | 武汉京邦科技有限公司 | A kind of bimodulus positron imaging machine based on event count |
| WO2021016747A1 (en) * | 2019-07-26 | 2021-02-04 | Shenzhen Xpectvision Technology Co., Ltd. | Radiation detector with scintillator |
-
2016
- 2016-09-07 CN CN201621041574.4U patent/CN206339660U/en not_active Withdrawn - After Issue
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106199673A (en) * | 2016-09-07 | 2016-12-07 | 武汉京邦科技有限公司 | A kind of bimodulus positron imaging machine based on event count |
| WO2021016747A1 (en) * | 2019-07-26 | 2021-02-04 | Shenzhen Xpectvision Technology Co., Ltd. | Radiation detector with scintillator |
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