CN206315188U - Medicine-filling device under Tenon capsules - Google Patents

Abstract

The utility model is related to medicine-filling device under a kind of Tenon capsules, and it includes conduit and connector, wherein the conduit includes proximal portion, bending section and distal portion；The connector includes connecting portion and interface, and the connecting portion is connected with the proximal portion of the conduit, and the interface is used to connect injection device；And angle α is formed between wherein described proximal portion and the distal portion, one or more medicine-pouring ports are provided with the distal portion, and the distal end of the distal portion is not provided with opening.The complication possibility of injection under Tenon capsules can be greatly reduced using medicine-filling device under Tenon capsules of the present utility model, the security of patient is added；It is easy to use, greatly reduce the difficulty of injection under Tenon capsules；And the prosthomere and deutomerite of eyes can be easily delivered drugs into treat prosthomere or deutomerite disease.

Description

Medicine-filling device under Tenon capsules

Technical field

The utility model is related to a kind of eye medicine-filling device, in particular it relates to which injection is filled one kind under Tenon capsules after ball Put.

Background technology

Tenon capsule hemostasis is a kind of conventional operating technology of ophthalmology, is frequently utilized for injection hormone to treat deutomerite at the moment Inflammation treatment.Medicine can be improved using Medicated Permeation eyeball rear portion sclera by drug injection under Tenon capsules by the operation Thing is in concentration near the eyes so that medicine can quick acting, and compared with by vitreous chamber direct injection, the operation and Send out disease and side effect all very littles.

Although Tenon capsule hemostasis has the advantages that complication is small, easily operated, still there is certain in practical operation Generation complication risk.The method of Tenon capsule hemostasis is typically using 25G syringe needles in temporo lower section fornix portion with certain angle Degree (being usually 40 °) inserting needle, needle point is pierced under chou membrane vesicle, along eyeball radian inserting needle, through conjunctiva towards sclera to fornix portion With Tenon capsules, syringe needle is placed at posterior scleral, acknowledgement bit postpones injection.The operation requires inserting needle one-time-reach-place, enters needle speed and fits Spend and slow, and need to select suitable syringe needle；Secondly, inserting needle can not it is too deep can not be excessively shallow, it is too deep to damage group after ball Knit, blood vessel and nerve etc., excessively shallow, medicine does not reach therapeutic purposes into bulbar conjunctiva.Accordingly, it would be desirable to which operator, which has, compares ripe Experienced operative skill.

Because conventional Tenon capsule hemostasis is operated using conventional needle, therefore, subconjunctival hemorrhage is common complication. If in addition, as described above, operator's operative skill is unskilled, inserting needle position is improper or patient compliance is not good enough so that inserting needle mistake It is shallow, cause medicine to enter under bulbar conjunctiva, produce chemosis.In clinical practice, also one common complication is blindness, That is, the unexpected no light perception of patient after injection, may cause topical remedy's accumulation to cause socket of the eye pressure drastically because infusion of medicine speed is too fast Caused by rise compressing optic nerve, or caused by medicine causes arter centralis retinae spasm.More serious rare complications following is to wear Logical eyeball, the complication is also relevant with the technical ability and sharp needle of operator.

To overcome some shortcomings of above-mentioned Tenon capsule hemostasis, CN 202777431U disclose Tenon capsules after a bulb Lower injection needle, the injection needle is using arc body and the passivity head of closure.After CN202777431U ball under Tenon capsules Injection needle solves the control problem to depth of needle and position using the needle body of arc, is avoided using passivity head to consolidating Film, blood vessel and nerve are stabbed, and avoid using the lateral openings of needle tip direct impact of the medicine to optic nerve.But It is that, according to the description of the utility model and accompanying drawing, the design of the utility model is actually not only difficult to carry out, and is difficult to reality The existing technique effect that it is declared, because it does not consider the actual techniques problem encountered in true operation.First, arc Although needle body reduces the stop of surrounding tissue and resistance in inserting needle path to a certain extent, due to lacking the stop of tissue Sense, also just reduces feel, operator can not (feel be for operator by feel accurate assurance depth of needle and position It is often critically important, be particularly even more important in ophthalmologic surgical procedures).Further, since on the design of arc, pin body just The mark or mark (for example, projection or scale) of guiding operation are lacked so that operator can neither can not by feel Observe by the naked eye to obtain the substantially assessment or judgement to depth of needle and position.For the above reasons, in actual operation During, the utility model, which can not be played, declared holds depth of needle and the technique effect at position.

Secondly, in CN 202777431U, pin hole (medicine-pouring port) is arranged on the both sides of syringe needle end, from accompanying drawing substantially Estimation, pinhole diameter is roughly equivalent to the cross section of syringe needle.Although the utility model declares that injection can be avoided by this design Direct impact of the medicine to optic nerve.However, being difficult to reach in this effect practice.Due to Tenon capsules space than narrow and Connective tissue is also there are between institutional framework before not being stripped, if so the injection amount in the unit interval is small, even if Very big impulsive force directly will not be also produced to optic nerve from needle tip injection.In the case of two STHs, if unit Injection amount in time is larger, in narrow space, from both sides flow out medicine stream converge in front of syringe needle head after still It is possible to directly impact optic nerve.Moreover, medicine causes socket of the eye pressure rise in local Rapid Accumulation in the Tenon capsules just peeled away And then the influence caused by involving optic nerve is much bigger more than the influence directly impacted.Therefore, to be solved in practical operation Technical problem be in the unit interval medicine in the adverse consequences produced by local short time rapid accumulation.And in the utility model This technical problem is not mentioned not only, does not more provide corresponding effective solution.

United States Patent (USP) US 6,413,245B1 disclose a kind of method and apparatus for being used to deliver pharmaceutical preparation to human eye.Should The method of United States Patent (USP) includes its device being inserted into the lower section of Tenon capsules and the top of sclera at macula lutea rear, then injects Pharmaceutical preparation is so as to the formation drug-reservoir (drug depot) on the outer surface of sclera.The distal portion of the Patent equipment be in and eye The tubular structure of " reaping hook " shape that ball curvature is consistent.However, Tenon capsules are actually non-open capsule under native state, Therefore the leading head of device is closer to macula lutea, and the danger for puncturing sclera and damage optic nerve is bigger, so if not good Good tissue is peeled off and operating handle, and the possibility for occurring complication is still very big.Further, since lack reference point, when making When inserting intraocular with the device, operator can not see end head, also with regard to the position of uncontrollable entry point.3rd, the dress Put by customizing the radian and length in reaping hook portion in advance to ensure that depth of needle reaches the position more rearward of Tenon capsules (that is, after Tenon injection capsules).And in order to different inserting needle positions and meet different radians eyeball be accomplished by manufacture have different radians and The device of " reaping hook " distal portion of length, also just reduces the ease for use of device and improves and use complexity.Further, since should Device is designed to inject a small amount of medicine to form drug-reservoir, thus itself and be not concerned with being locally implanted larger injection amount and The problem of rate of administration, and the end head of its distal portion and without release effect.

Therefore, need to develop and design a kind of safe, easy to operate in the art, depth of needle can either be controlled Medicine-filling device under the Tenon capsules of the intracapsular Local Injection amounts of Tenon can be controlled again.

Utility model content

To solve above mentioned problem of the prior art, the purpose of this utility model, which is to provide one kind, can be easy to Tenon capsules Lower injection operation and it can effectively control medicine-filling device under the Tenon capsules of Local Injection amount.

Medicine-filling device (is hereinafter sometimes referred to simply as " injection dress of the present utility model under Tenon capsules of the present utility model Put ") include conduit and connector, wherein the conduit includes proximal portion, bending section and distal portion；The connector includes connection Portion and interface, the connecting portion are connected with the proximal portion of the conduit, and the interface is clinically commonly used for detachably connected Various injection devices such as syringe, syringe pump；And angle α is formed between wherein described proximal portion and the distal portion, The distal portion is provided with one or more medicine-pouring ports, and the distal end of the distal portion is not provided with opening.

According to the utility model, the size of angle α can be selected, more at 110-160 ° in the range of preferably 120-150 ° Preferably 120 °.The selection of angle α is considered as the operation ease of operator, and angle is excessive or too small is all likely to result in operator Inconvenience, the angle close with the radian of eyeball or radian are selected as far as possible.

In a preferred embodiment, one or more projections can be provided with the arc top of the bending section.This The purpose and effect of sample design are, when the distal portion of medicine-filling device of the present utility model is advanced along eyeball within the eye, bending Projection in portion can by the outside jack-up of the bulbar conjunctiva of corresponding site on travel path, although therefore can't see the end of conduit, It is such design cause operator still can observe by the naked eye the projection on bulbar conjunctiva judge bending section position and then Estimate the location of distal end of distal portion.That is, projection plays a part of position instruction, so as to help operator's control note The depth of medicine device and position.If however, just not reaching such effect only with cambered design.

In the utility model, the shape of projection is unrestricted, if can play position instruction effect and will not The structures surrounding on eye inner tissue or travel path is damaged to, for example, can be made for spherical, hemispherical etc..It is prominent The number risen is also unrestricted, can set one or more, as long as realizing the effect of above-mentioned indicating positions.In addition, prominent Rise material and manufacture method it is also unrestricted, as long as bio-compatible (for example, medical steel, medical macromolecular materials or life Thing material etc.) and can be according to techniques known in the art or method (for example, the mode such as bonding, welding, engagement, engagement) peace On the arc top of the bending section of dress or conduit fixed to medicine-filling device of the present utility model.In addition, projection can be made for With certain color, for example, the cyan or blueness of cool tone, purple, green or the black of neutralc tint, or these colors are any Combination.Because bulbar conjunctiva is very thin, the color of setting can aid in the position for more intuitively observing projection.It is preferred that not making With warm tones such as red, in order to avoid obscure with blood color.

In the utility model, the proximal portion of the conduit of medicine-filling device and the shape of cross section of bending section and size preferably may be used To be identical.The cross section of proximal portion and bending section (and/or their inner chamber) can be circular or ellipse, or be easy to note The other arbitrary shapes of medicine such as square, rectangle, rhombus, triangle or parallelogram, circular or ellipse.Closely Sidepiece and the shape of cross section and size of bending section preferably can be identicals.The cross section of distal portion (and/or its inner chamber) Shape is also unrestricted, can be circle, ellipse, square, rectangle, rhombus, triangle and parallelogram etc., preferably Circular or ellipse.In an especially preferred embodiment, the cross section of distal portion can also be flat ellipse or band one Determine the flat ellipse of radian.

In an embodiment of medicine-filling device of the present utility model, distal portion and proximal portion (and/or bending section) Shape of cross section and size can be identicals.

In an embodiment of medicine-filling device of the present utility model, the horizontal stroke of distal portion in the whole length of distal portion Sectional dimension can be constant or different, for example, expanding towards distal end or tapered.

In another embodiment of medicine-filling device of the present utility model, the thickness of distal portion in the sagittal plane of distal portion Degree is gradually reduced towards distal end, and the width of distal portion is more than the width of proximal portion on the coronal-plane of distal portion.This reality Applying the distal portion in scheme can be designed to that (that is, the width of distal portion is kept not so-called " duckbilled " shape on coronal-plane Become), or " flat horn mouth " shape (that is, width of the width of the distal end of distal portion more than near-end on coronal-plane).This distal side Portion design purpose and effect be：Reduce because distal portion gradually becomes flat so that entering the resistance advanced after Tenon capsules, simultaneously During moving on, wider distal portion separates more more than the distal portion shape do not widened in access path Space, does not need so extra strip operation just can obtain bigger localized liquid receiving space after target site is reached, Quickly product produces excessive pressure to medicine in local small space when also avoiding follow-up injection simultaneously, has thus buffered pressure Sharply increase.And the syringe needle used in the prior art is constant due to diameter, it is impossible to expand local space, therefore in Local Injection It when measuring larger, may temporarily cause part " lump " to cause local pressure temporarily to raise, and then raise socket of the eye pressure and intraocular pressure.Separately Outside, as it was previously stated, in the position close to macula lutea rear, puncturing sclera and damaging the dangerous very big of optic nerve, be somebody's turn to do when needing to treat During the lesion at place, using above-mentioned danger zone injection need not be proceeded to during medicine-filling device of the present utility model at all, because originally The medicine-filling device of utility model can separate larger local space at prosthomere, can be on the premise of optic nerve is not involved Larger amount of medicine is injected, medicine can be entered above-mentioned danger zone by osmosis, thus significantly reduce Tenon The danger of injection and potential complication is avoided under capsule.

In medicine-filling device of the present utility model, medicine-pouring port is arranged on distal portion.According to purpose purposes, injection medicine The factor such as species, injection amount and rate of administration, the medicine-pouring port of one or more than 2 can be set.In constant injection pressure Under power, medicine-pouring port is more, more scattered to the pressure of local organization during injection, is not to concentrate on one or two point, it is to avoid Hypertonia at local a single point.

In one embodiment, distal portion is provided with multiple medicine-pouring ports, and medicine-pouring port can be in the longitudinal direction side of distal portion It is evenly distributed upwards.

In another embodiment, distal portion is provided with multiple medicine-pouring ports, and medicine-pouring port can be in the longitudinal direction of distal portion Alternately it is distributed on direction.

In a preferred embodiment, can be provided with two medicine-pouring ports on the same cross section of distal portion.Preferably, Two medicine-pouring ports can relatively be distributed on the girth of same cross section.

In the embodiment that above-mentioned wherein distal portion is designed to so-called " duckbilled " shape or " flat horn mouth " shape, note The distribution of medicine mouthful can also be configured according to any combination of various modes recited above.I.e., it is possible to be arranged on distal portion One or both sides (on coronal-plane), can also be arranged on before distal portion and/or below, or take two sides with it is preceding Face and any combination mode below set medicine-pouring port.

In medicine-filling device of the present utility model, the shape of medicine-pouring port is unrestricted, can selected from circular, ellipse, just Square, rectangle, rhombus, triangle or parallelogram, circular or ellipse.

In medicine-filling device of the present utility model, conduit also includes inner chamber, and proximally portion is extended through for the inner chamber Bending section and distal portion, to the distal end of distal portion at terminate.That is, opening is not provided with the distal end of distal portion.Distal side The distal end in portion preferably can be configured to blunt nosed form, such as hemispherical or semiellipsoid shape (for example, in coronal-plane or Can be circular arc, semicircle or half elliptic shape in sagittal plane), blunt separation can be played, it is to avoid sharp point Terminal spine injured tissue, nerve and blood vessel etc..

In medicine-filling device of the present utility model, connecting portion and the conduit of connector can be it is integrally formed, can also Take connected mode as known in the art detachably connected.The interface of connector can be used for connection all kinds and size Injection device, for example, syringe, syringe pump etc..In order to be connected with some with externally threaded injection device, interface can be with Internal thread is provided with to engage with these injection devices.

Due to conventional injection device and without speed control unit (the expensive and complex structure of syringe pump, It is unfavorable for large-scale application in clinic), therefore in order to control rate of administration, medicine-filling device of the present utility model can also include one Individual or multiple cushion pads, the cushion pad is configured to be positioned in the connecting portion of connector and/or interface, and its effect is to delay Rate of administration.The thickness of each cushion pad could be arranged to 1-2mm.

In one embodiment, cushion pad is made of porous materials, preferably natural sponge or synthetic sponge or other are more Hole macromolecular material.

In the utility model, proximal portion, bending section, connecting portion and the distal portion of medicine-filling device can be by medical plastics (Teflon, polyethylene, polypropylene, other conventional medical plastics etc.) or medical metal material (for example, medical steel, such as Other medical metals beyond 304L medical stainless steels, medical steel, metal alloy etc.) or their any combination be made.Nearside Portion, bending section, distal portion and connecting portion can also be made of different materials, for example, proximal portion, bending section and distal portion by Metal material (such as, medical stainless steel) is made, and connecting portion is made up of medical plastic.Preferably, distal portion and proximal portion by Medical stainless steel is made.Projection on bending section can be made of medical plastic, to reduce the damage to tissue.It is specific at one In embodiment, the distal end of distal portion can be made of plastics, and remainder can be then made of metal.For using Medical plastic for, plastics preferably have enough pliability and/or flexible so as to when injection of the present utility model be filled Put and be inserted into the possibility for reducing and penetrating sclera or Tenon capsules of being tried one's best when eyes swell.

In a preferred embodiment, connecting portion can be made up of plastics such as medical plastic.

In a preferred embodiment, scale is marked with proximal portion, consequently facilitating operator's estimation distal portion enters The depth of Tenon capsules.Can be using bending section as 0 calibration points, the proximally facing mark scale in proximal portion.In general, can be with Using 0.5cm as a master calibration point, 3 master calibrations are at least marked, subscale mark point can also be marked between two master calibration points, For example, 2-5 sub- calibration points of mark.

In the utility model, medicine-filling device of the present utility model can be used to deliver various forms of medicines, medicine Form or formulation are unrestricted, include, but not limited to solution, supensoid agent, emulsion, ointment, gel-forming solution, gel Agent, can bioerodible polymer or non-bioerodible polymers, biodegradable polymers or non-biodegradable polymer, Etc..In addition, medicine can also be formed into following formulation：I.e. can also be as medicine after it is injected under Tenon capsules Thing bank exists to discharge medicine in the form of controlled release (for example, sustained release).

Pharmaceutical dosage form for injection can be comprising the acceptable pharmaceutically active agents of one or more ophthalmology, and may be used also To include one or more inactive drug excipients.The example of the pharmaceutically active agents includes, anti-infective, including but not It is limited to, antibiotic, antivirotic and antifungal agent；Antiabnormal reaction agent and mast cell stabilizers；Steroidal and non-steroidal anti-inflammatory Agent (such as nepafenac)；Cyclooxygenase-2 inhibitors, for example, Cox-1 and Cox-2 inhibitor；The group of anti-infective and antiinflammatory Close；Decongestant；Betimol, includes but is not limited to, adrenergic agent, beta-adrenaline blocking agent, α-adrenaline Activator, parasympathomimetics, anticholinesterase, carbonic anhydrase inhibitor, and prostaglandin；The group of Betimol Close；Antioxidant；Nutritious supplementary pharmaceutical；Medicine for treating macular cystoid edema, for example, NSAIDs；For treating ARMD medicine, for example, angiogenesis inhibitors and cellosolve；Wound conditioning agent, for example, growth factor；Antimetabolite；Nerve Protective agent, for example, Eliprodil；(include but is not limited to, ARMD, CNV, retinopathy, retina with for treating deutomerite disease Inflammation, uveitis, macular edema and glaucoma) suppression angiogenesis steroids.

Beneficial effect

1. can not only carry out preceding Tenon injection capsules using medicine-filling device under Tenon capsules of the present utility model to operate, also may be used Operated with Tenon injection capsules after progress.

2. medicine-filling device has local organization release effect under Tenon capsules of the present utility model, it can expand and treat injection portion Position local space, so as to reduce the pressure that the local Rapid Accumulation of medicine is produced, it is adaptable to treat the disease of eyeball prosthomere and deutomerite Disease.

3. it can greatly reduce the concurrent of injection under Tenon capsules using medicine-filling device under Tenon capsules of the present utility model Disease possibility simultaneously reduces potential complication, adds the security of patient, and can deliver various pharmaceutical preparations, energy It is enough to be used in outpatient service.

4. medicine-filling device of the present utility model is easy to use, the difficulty of injection under Tenon capsules is greatly reduced, is especially suitable for The unskilled oculist of injection operative skill uses under conventional Tenon capsules.

5. using medicine-filling device of the present utility model can easily deliver drugs into the prosthomere and deutomerite of eyes so as to Treat keratitis, sclerotitis, prosthomere ischemic syndrome, ARMD, CNV, PVR, the retinitis, uveitis, macula lutea water Swollen, glaucoma and other prosthomeres or deutomerite disease.

Brief description of the drawings

The dissection schematic diagram of Fig. 1 behaviour eyeball Tenon capsules.

Fig. 2 shows the structural representation of an embodiment of medicine-filling device of the present utility model.

Fig. 3 shows the zoomed-in view of the bending section 7 of Fig. 2 medicine-filling device 1, illustrated therein is projection 9 and angle α.

Fig. 4 shows in the schematic diagram of an embodiment of the distal portion 6 of Fig. 2 medicine-filling device 1, figure and shown remote Multiple medicine-pouring ports 11 have been evenly distributed on the longitudinal direction of sidepiece 6.

Fig. 5 shows in the profile of another embodiment of the distal portion 6 of Fig. 2 medicine-filling device 1, figure and shown Two medicine-pouring ports 11 are relatively distributed with the same cross section of distal portion 6.

Fig. 6 shows in the profile of another embodiment of the distal portion 6 of Fig. 2 medicine-filling device 1, figure and shown Multiple medicine-pouring ports 11 are interspersed on distal portion 6.

Fig. 7, which to be shown, shown in the profile of another embodiment of the distal portion 6 of Fig. 2 medicine-filling device 1, figure separately A kind of medicine-pouring port is interspersed mode.

Fig. 8 shows the injection view of Fig. 2 medicine-filling device 1.

Fig. 9 shows the structural representation of another embodiment of medicine-filling device of the present utility model.

The coronal of different embodiments that Figure 10-15 schematically shows the distal portion 6 of Fig. 9 medicine-filling device 101 is cutd open Face figure.

Figure 16 schematically shows the profile along the line A-A interception in Figure 10.

Figure 17 shows the injection view of Fig. 9 medicine-filling device 101.

Figure 18 A-18D are the operating procedure schematic diagrames of medicine-filling device 101 under the Tenon capsules using Fig. 9, and wherein Figure 18 A are The state that medicine-filling device 101 enters before conjunctiva, Figure 18 B are state when medicine-filling device 101 enters conjunctiva, and Figure 18 C are injection Device 101 enters after conjunctiva, and projection 109 enters state during conjunctiva, and Figure 18 D are the state of Tenon capsules after injection.

Reference in accompanying drawing is as follows：

Medicine-filling device 1,101；Conduit 2,102；

Connector 3,103；The distal end 4,104 of distal portion；

Proximal portion 5,105；Bending section 7,107；

Distal portion 6,106；Projection 9,109；

Connecting portion 10,110；Interface 8,108；

Medicine-pouring port 11,111；Medical abortion 12,112；

Treat injection position 13,113；Cushion pad 20,120；

Distal portion outer wall 200；Distal portion inwall 201；

Distal portion inner chamber 202.

Embodiment

Preferred embodiment of the present utility model is described below in conjunction with the accompanying drawings, it will be understood by those skilled in the art that be following Embodiment or embodiment with reference to described in accompanying drawing, which are merely to illustrate, realizes preferred forms of the present utility model, rather than incite somebody to action this The scope of utility model is limited to these embodiments.

Definition

Distal side or distal end：In this manual, when description device of the present utility model refers to " distal side or distal end ", the art Language generally refers to be relatively distant from one end or side of user.

Nearside or near-end：In this manual, when description device of the present utility model refers to " nearside or near-end ", the art Language generally refers to one end or side of relatively close user.

Sagittal plane：By the plane (i.e. median sagittal plane) of human body (or other objects) vertical axis and the longitudinal axis and in parallel All planes be referred to as sagittal plane, i.e., human body or object are divided into left and right two halves.

Coronal-plane：All claimed by the plane and all planes in parallel of human body (or other objects) vertical axis and transverse axis Human body or object are divided into former and later two parts for coronal-plane, i.e. these planes.In the utility model, mention before object Face and below when, for the coronal-plane of human body or object.

Diameter：The definition of diameter is arrived by a planar graph or solid (such as circle, conic section, ball, cube) center The distance of point-to-point transmission on side.Herein, diameter refers to the maximum length for referring to object.Come for the object with irregular shape Say, diameter is the length of the most long cross section of the object.In addition, herein, if without otherwise indicated, diameter is referred both to External diameter.

Tenon capsules：Also known as fascia bulbi, is one layer of very thin fibr tissue, is covered from optic nerve entrance to angle Gong Yuan whole Individual eyeball.At nearly corneal limbus 1mm, fascia bulbi combines together securely with seeking mustard, therefore, positioned at the operative incision of corneal limbus Three-layer weave can be penetrated simultaneously.Portion is passed through fascia bulbi by extraocular muscle under the line.Every extraocular muscle from starting point to attachment point all There is fiber flesh sheath to thicken.

The dissection schematic diagram of Fig. 1 behaviour eyeball Tenon capsules.From figure 1 it appears that Tenon capsules are a thin layer fiber group Knit film, be covered in eyeball surface, from around optic nerve forward near corneal limbus, there is fibre bundle to be connected between sclera, itself and Gap between sclera is episcleral space.Tenon capsules are divided a word with a hyphen at the end of a line with optic nerve dura mater backward, are closely cured with sclera at corneal limbus forward .Manadesma rear portion is that ciliary blood vessel and nerve are passed through；Its ambitus is passed through by venae vorticosae；Front portion has 6 eye muscle tendons to pass through, manadesma Thus anti-folding surrounds tendon as flesh sheath backward, as being worn on finger finger-stall.Fiber membrane is sent and thin by flesh sheath Beam, expands to other parts and plays support and fixation.

Fig. 2 is the structural representation of an embodiment of medicine-filling device of the present utility model.Shown example in fig. 2 In, medicine-filling device 1 includes conduit 2 and connector 3 under Tenon capsules of the present utility model, and wherein conduit 2 includes proximal portion 5, bending Portion 7 and distal portion 6；Connector 3 includes connecting portion 10 and interface 8, and connecting portion 10 is connected with the proximal portion 5 of conduit 2；And wherein Angle α is formed between proximal portion 5 and distal portion 6, one or more medicine-pouring ports 11 are provided with distal portion 6.

In Fig. 2 medicine-filling device 1, proximally portion 5 extends through bending section 7 and distal portion 6 for the inner chamber of conduit 2, Terminated to the distal end 4 of distal portion 6.That is, opening is not provided with the distal end 4 of distal portion 6.The distal side end of distal portion 6 End 4 is semicircle blunt nosed, can play blunt separation, it is to avoid stab tissue, nerve and blood vessel etc. in tip.Distal side Portion 6 is provided with multiple medicine-pouring ports 11.

The connecting portion 10 of connector 3 can be with conduit 2 it is integrally formed, can also be detachably connected.Connector 3 Interface 8 can be used for the injection device for connecting all kinds and size, for example, syringe, syringe pump etc..

It can be seen in fig. 2 that being provided with a semicircle black projection 9 at the arc top of bending section 6.It is to be understood that to the greatest extent Pipe only show 1 projection 9 of setting in the example of figure 2, but according to description and interpretation above, and those skilled in the art can be with Multiple projections are easily designed, and various numbers, variously-shaped, shades of colour, the projection of various suitable materials can be designed, only Position instruction effect as described above can be realized.

Catheter proximal 5, bending section 7 and its shape of cross section of inner chamber of Fig. 2 medicine-filling device 1 for common circle or The cross section of ellipse, distal portion 6 and its inner chamber is also common circular or ellipse.In addition, Fig. 2 medicine-filling device 1 is remote The shape of cross section and size of sidepiece 6, bending section 7 and proximal portion 5 are identicals, i.e., their diameter is identical.Distal portion 6 Distal end 4 to be hemispheric blunt nosed.

Fig. 3 is the zoomed-in view of bending section 7 in Fig. 2.From figure 3, it can be seen that in medicine-filling device 1, proximal portion 5 with it is remote Angle α is formed between sidepiece 6, the size of angle α can be selected, more preferably at 110-160 ° in the range of preferably 120-150 ° 120°。

Fig. 2 medicine-filling device 1 can also add one or more cushion pads 20 (dotted line part in connector 3 in fig. 2 Point) to delay rate of administration, the cushion pad 20 is placed in the interface 8 of connector 3.Although display buffer pad in fig. 2 20 are placed in interface 8, it will be appreciated by a person skilled in the art that cushion pad 20 can also be placed in connecting portion 10, together Sample can also play a part of delaying rate of administration.The thickness of each cushion pad could be arranged to 1-2mm.

As described above, scale can be indicated in proximal portion 5.Specifically, can be with the projection 9 on bending section 7 for 0 scale Point, the near-end mark scale in proximally facing portion 5 in proximal portion 5.Scale can correspond to the distal end 4 of distal portion 6 The meter of length or standard.

On the size of medicine-filling device of the present utility model, those skilled in the art are referred to traditional 19G~25G pins The size of head or gear division syringe needle makes, and specific size can depend on physical property, state and/or the volume to be injected.With Exemplified by the example of Fig. 2 medicine-filling device 1, the length of the proximal portion 5 of conduit 2 can be 8mm~15mm, preferably 9mm~11mm, directly Footpath can be 16G~30G (for example, 1.16mm~0.16mm), preferably 19G~25G (for example, 0.7mm~0.26mm) scope, The length of distal portion 6 can be 5~10mm, preferably 5~7mm, diameter can for 16G~30G (for example, 1.16mm~ 0.16mm), preferably 19G~25G (for example, 0.7mm~0.26mm).Diameter, shape and the length of interface 8 and connecting portion 10 can be with Determined according to the specific size of the injection device to be connected (for example, syringe of 2mL, 5mL, 10mL equal-specification).But ability Field technique personnel are understood that preferred size range recited above is only exemplary, are not intended to the utility model Scope limited to this.

Fig. 4 shows the schematic diagram of an embodiment of the distal portion 6 of Fig. 2 medicine-filling device 1.In Fig. 4, medicine-pouring port 11 are evenly distributed on the longitudinal direction (can be in sagittal plane or coronal-plane) of distal portion 6.

Fig. 5 shows the profile of another embodiment of the distal portion 6 of Fig. 2 medicine-filling device 1.In Figure 5, remote Two medicine-pouring ports 11 are relatively distributed with the same cross section of sidepiece 6.

Fig. 6 shows the profile of another embodiment of the distal portion 6 of Fig. 2 medicine-filling device 1.In figure 6, remote Multiple medicine-pouring ports 11 are relatively interspersed on the both sides of sidepiece 6.

Fig. 7 shows the profile of another embodiment of the distal portion 6 of Fig. 2 medicine-filling device 1.In the figure 7, remote The both sides of sidepiece 6 are relatively distributed with two medicine-pouring ports 11, the outer wall between two sides staggeredly on same cross section Row's medicine-pouring port 11 is distributed with ground.

Fig. 8 shows state during Fig. 21 injection of medicine-filling device.Reach injection position 13, i.e., can be with after Tenon capsules By the injection device (not shown) of connection to treating that injection position 13 injects medicine.As can be seen from Fig. 8, medical abortion 12 is from injection Mouth 11, which is injected into, treats injection position 13.

In Fig. 2 medicine-filling device 1, the shape of medicine-pouring port 11 can be with preferably circular or ellipse.In addition, according to injection The number and location of mouth, the diameter of medicine-pouring port can be in the range of 1.16mm~0.16mm, preferably 0.7mm~0.26mm.But It will be apparent to one skilled in the art that the size preferred scope of medicine-pouring port recited above is only exemplary, it is not intended to By scope limited to this of the present utility model.

Fig. 9 is the structural representation of another embodiment of medicine-filling device of the present utility model.Fig. 9 medicine-filling device 101 is essentially identical with the structure of Fig. 2 medicine-filling device 1, and difference is the distal portion 6 in the shape and Fig. 2 of distal portion 106 It is different.Below in the description of Fig. 9 medicine-filling device 101, omitting the description with Fig. 2 identical part of medicine-filling device 1.

The design of distal portion 106 shown in Fig. 9 is so-called " duckbilled " shape.As can be seen from Fig. 9, in distal portion Distal portion 106 is gradually reduced towards distal end 104 in 106 sagittal plane.Figure 10 shows the hat of Fig. 9 medicine-filling device 101 Shape face schematic diagram.From figure 10, it is seen that the width of distal portion 106 is more than proximal portion 105 and curved on the coronal-plane of distal portion 106 The width (bending section 107 is identical with the diameter of proximal portion 105) of pars convoluta 107, and the distal portion in the whole length of distal portion 106 Width be constant.Although showing that the cross sectional dimensions of the distal portion 106 in the whole length of distal portion is constant in Figure 10 Example, but art technology is understood that the width of distal portion 106 can also gradually expand towards distal end 104, shape Into so-called " flat horn mouth " shape.The latter can also realize the purpose and effect of such distal portion design (see on).

For the example shown in Fig. 9, as an example, the size of distal portion 106 can be：On coronal-plane, distal side The length in portion 106 is 5~10mm, and preferably 5~7mm, width is 3~7mm, preferably 4~6mm；In sagittal plane, distal portion 106 Thickness be 1~2mm, preferably 1.25mm.

In the utility model, the specification that the size of the inner chamber of the various pieces of conduit can be used according to various pieces Correspondingly to set.For example when conduit proximal portion according to the specification of 16G syringe needles (for example, external diameter：1.64mm, internal diameter： When 1.16mm) manufacturing, then the internal diameter of proximal portion inner chamber then uses corresponding internal diameter size.

It will be apparent to one skilled in the art that preferred size range recited above is only exemplary, it is not intended to By scope limited to this of the present utility model.

Figure 10-15 shows the different medicine-pouring port distribution modes of the distal portion 106 of Fig. 9 medicine-filling device 101.

In Fig. 10, medicine-pouring port 111 is uniform on the longitudinal direction (can be in sagittal plane or coronal-plane) of distal portion 106 Ground is distributed, and two medicine-pouring ports 111 are relatively distributed with the same cross section of distal portion 106.

In fig. 11, multiple medicine-pouring ports 111 are relatively interspersed on the both sides of distal portion 106.

In fig. 12, two medicine-pouring ports 111 are relatively distributed with same cross section in the both sides of distal portion 106, Row's medicine-pouring port 111 is alternately distributed with outer wall between two sides.

In fig. 13, two medicine-pouring ports 111 are relatively distributed with same cross section in the both sides of distal portion 106, Two horizontally-parallel row's medicine-pouring ports 111 are alternately distributed with outer wall between two sides.

In fig. 14, two medicine-pouring ports 111 are relatively distributed with same cross section in the both sides of distal portion 106, Staggered two rows medicine-pouring port 111 is alternately distributed with outer wall between two sides.

In fig .15, multiple medicine-pouring ports 111 are relatively interspersed on the both sides of distal portion 106, and two sides Between outer wall on staggered two rows medicine-pouring port 111 is alternately distributed with.

Figure 16 schematically shows the profile of the distal portion 106 along the line A-A interception in Figure 10.Show in figure 16 The distal portion section shape of flat ellipse, the notch geometry in the left and right sides is two medicine-pouring ports 111, the solid line of outside is remote The outer wall 200 of sidepiece 106, internal dotted line is the inwall 201 of distal portion 106, wherein being inner chamber 202.

Figure 17 shows state during Fig. 9 101 injection of medicine-filling device.Reach injection position 113, i.e., after Tenon capsules, Can be by the injection device (not shown) of connection to treating that injection position 113 injects medicine.As can be seen from Fig. 17, medical abortion 112 are injected into from medicine-pouring port 111 and treat injection position 113.

Illustrate the operating procedure (note of Fig. 9 medicine-filling device 101 with reference to Figure 18：Although showing Fig. 9's in figure 18 The injection step of medicine-filling device 101, it will be appreciated by those skilled in the art that the shown step in Figure 18 is equally applicable to Fig. 2 medicine-filling device 1).

First, the operating procedure of Fig. 9 medicine-filling device 101 is illustrated with reference to Figure 18：

1. drop advises patient's eyes to watch attentively to nasal downside with after ocular arcotic, effect of conjunctiva sclera above exposure eyeball temporo, necessary When, operator can touch in patient upper eyelid upwards, reach that injection position exposes sufficient purpose, then lift position with Smooth forceps The conjunctiva of tent sample is cut off an osculum, cuts off positional distance cornea by the conjunctiva between corneoscleral junction and temporo top, eye scissors Edge about 7mm (Figure 18 A).

2. the medicine-filling device 101 that will be connected with syringe (for simplicity, not showing syringe in Figure 18) is opened from conjunctiva Mouthful place's entrance, Tenon blister cavities is entered using the radian of distal portion 106 along the eyeball radian wall of eyeball that reclines to the slow inserting needle of passivity after ball (Figure 18 B).

3. entering after Tenon blister cavities, distal portion 106 is gradually goed deep into, is judged to enter according to the projection 109 of bending section 107 Decoction, after pumpback is without blood, is slowly pushed into (Figure 18 C) by depth.

4. after the completion of injection, gently it is pressed into cotton swab at pin while slowly extracting syringe needle out, the decoction of injection limits to and protruded In eyeball surface formation bulge, note there is ne-leakage, continuation is oppressed at inserting needle for a period of time with cotton swab, advises patient's eyeball to be back to just Depending on normality and close mesh rest (Figure 18 D).

Here, brief description carries out the operating procedure of injection under Tenon capsules using Fig. 2 medicine-filling device 1：

1. drop advises patient's eyes to watch attentively to nasal downside with after ocular arcotic, effect of conjunctiva sclera above exposure eyeball temporo, necessary When, operator simultaneously can touch in patient upper eyelid upwards, reach that injection position exposes sufficient purpose.

2. above eyeball temporo apart from corneal limbus 7-10mm position along eyeball radian recline ball wall enter, ball is pierced into first Conjunctiva, the wall of eyeball that continues to recline slowly is segregated into Tenon blister cavities (note to passivity after ball：Although Fig. 2 medicine-filling device 1 is remote The distal end 4 of sidepiece 6 is blunt nosed, but because diameter is still thinner, therefore still can puncture the bulbar conjunctiva of weakness).

3. entering after Tenon blister cavities, distal portion 6 is gradually goed deep into, is judged to enter depth according to the projection 9 of bending section 7, returned Take out after no blood, be slowly pushed into decoction.

4. after the completion of injection, gently it is pressed into cotton swab at pin while slowly extracting syringe needle out, the decoction of injection limits to and protruded In eyeball surface formation bulge, note there is ne-leakage, continuation is oppressed at inserting needle for a period of time with cotton swab, advises patient's eyeball to be back to just Depending on normality and close mesh rest.

The utility model provides following non-limiting embodiments：

1. medicine-filling device under a kind of Tenon capsules, including conduit and connector, the conduit include proximal portion, bending section and Distal portion；The connector includes connecting portion and interface, and the connecting portion is connected with the proximal portion of the conduit；It is wherein described near The angle α of 110-160 ° of formation between sidepiece and the distal portion, is provided with one or more medicine-pouring ports on the distal portion, and The distal end of the distal portion is not provided with opening.

2. medicine-filling device under the Tenon capsules described in embodiment 1, wherein the angle α is 120-150 °, preferably 120 °.

3. medicine-filling device under the Tenon capsules described in embodiment 1, wherein being provided with one at the arc top of the bending section Or multiple projections.

4. medicine-filling device under the Tenon capsules any one of embodiment 1-3, wherein the proximal portion, the bending Portion or the cross section of the distal portion are selected from circle, ellipse, square, rectangle, rhombus, triangle and parallelogram Shape, circular or ellipse.

5. medicine-filling device under the Tenon capsules any one of embodiment 1-4, wherein the distal portion, the bending The shape of cross section and size of portion and the proximal portion are identicals.

6. medicine-filling device under the Tenon capsules any one of embodiment 1-4, wherein in the sagittal plane of the distal portion The thickness of the upper distal portion is gradually reduced towards the distal end, and the distal portion on the coronal-plane of the distal portion Width be more than the proximal portion width.

7. medicine-filling device under the Tenon capsules described in embodiment 6, wherein described remote in the whole length of the distal portion The width of sidepiece is constant.

8. medicine-filling device under the Tenon capsules any one of embodiment 1-7, wherein the distal side of the distal portion End structure is into hemispherical or the shape of semiellipsoid.

9. medicine-filling device under the Tenon capsules any one of embodiment 1-8, wherein the distal portion is provided with multiple Medicine-pouring port, and the medicine-pouring port is evenly distributed on the longitudinal direction of the distal portion.

10. medicine-filling device under the Tenon capsules any one of embodiment 1-8, wherein the distal portion is provided with more Individual medicine-pouring port, and the medicine-pouring port is alternately distributed on the longitudinal direction of the distal portion.

11. medicine-filling device under the Tenon capsules any one of embodiment 1-9, wherein in the same of the distal portion Cross section is provided with two medicine-pouring ports.

12. medicine-filling device under the Tenon capsules described in embodiment 11, wherein described two medicine-pouring ports are in the cross section Relatively it is distributed on girth.

13. medicine-filling device under the Tenon capsules any one of embodiment 1-12, wherein the shape choosing of the medicine-pouring port From circle, ellipse, square, rectangle, rhombus, triangle or parallelogram.

14. medicine-filling device under the Tenon capsules any one of embodiment 1-13, wherein the connecting portion is led with described Pipe is integrally formed.

15. medicine-filling device under the Tenon capsules any one of embodiment 1-14, wherein the interface is provided with interior spiral shell Line.

16. medicine-filling device under the Tenon capsules any one of embodiment 1-15, wherein injection under the Tenon capsules Device also includes one or more cushion pads, and the cushion pad is configured to be positioned in the connecting portion or the interface.

17. medicine-filling device under the Tenon capsules described in embodiment 16, wherein the cushion pad is made of porous materials, it is excellent Select natural sponge or synthetic sponge or other porous polymer materials.

18. medicine-filling device under the Tenon capsules described in embodiment 1, wherein the proximal portion, the bending section and described remote Sidepiece is made up of medical metal material, and the medical metal material is selected from its beyond medical steel such as medical stainless steel, medical steel Any of his medical metal and medical metal alloy.

19. medicine-filling device under the Tenon capsules any one of embodiment 1-18, wherein the connecting portion is by medical plastic Material is made, and the medical plastic is preferably chosen from Teflon, polyethylene, polypropylene and other conventional medical plastics.

20. medicine-filling device under the Tenon capsules any one of embodiment 1-10, wherein the distal side end of the distal portion End is made up of medical plastic or medical metal material, and the medical metal material is selected from medical steel such as medical stainless steel, medical steel Any of other medical metals and medical metal alloy in addition, the medical plastic are preferably chosen from Teflon, poly- second Alkene, polypropylene and other conventional medical plastics.

21. medicine-filling device under the Tenon capsules any one of embodiment 1-20, wherein the projection is by medical plastic It is made, the medical plastic is preferably chosen from Teflon, polyethylene, polypropylene and other conventional medical plastics.

22. medicine-filling device under the Tenon capsules any one of embodiment 1-19, wherein the proximal portion, described curved Pars convoluta, the connecting portion and the distal portion are made by medical metal material, and the medical metal material is selected from medical steel such as Any of other medical metals and medical metal alloy beyond medical stainless steel, medical steel.

23. medicine-filling device under the Tenon capsules described in embodiment 1, wherein the proximal portion of the conduit is marked with scale.

24. medicine-filling device under the Tenon capsules described in embodiment 3, wherein the color of the projection be selected from cyan, blueness, Any of purple, green, black or their any combination.

The utility model is illustrated by specific embodiment and embodiment above, but it is evident that not carried on the back On the premise of spirit and scope of the present utility model, those skilled in the art can make various to above-mentioned specific embodiment Change.Although for example, describing medicine-filling device of the present utility model injection, this practicality under Tenon capsules in the description New medicine-filling device can be used to deliver medicine on the outer surface of sclera.It is possible if desired to change the length of distal portion So as to deliver drugs into sclera Posterior pole (typically above macula lutea or above the other parts of retina), etc..

Claims (10)

1. medicine-filling device under a kind of Tenon capsules, including conduit and connector,

The conduit includes proximal portion, bending section and distal portion；

The connector includes connecting portion and interface, and the connecting portion is connected with the proximal portion of the conduit；

The angle α of 110-160 ° of formation between wherein described proximal portion and the distal portion, is provided with one on the distal portion Or multiple medicine-pouring ports, and the distal end of the distal portion is not provided with opening.

2. medicine-filling device under the Tenon capsules described in claim 1, it is characterised in that be provided with one at the arc top of the bending section Individual or multiple projections.

3. medicine-filling device under the Tenon capsules described in claim 1, it is characterised in that the proximal portion, the bending section or described The cross section of distal portion is the shape selected from circle, ellipse, square, rectangle, rhombus, triangle or parallelogram.

4. medicine-filling device under the Tenon capsules described in claim 1, it is characterised in that the distal portion, the bending section and described The shape of cross section and size of proximal portion are identicals.

5. medicine-filling device under the Tenon capsules described in claim 1, it is characterised in that described remote in the sagittal plane of the distal portion The thickness of sidepiece is gradually reduced towards the distal end, and the width of the distal portion is big on the coronal-plane of the distal portion In the width of the proximal portion.

6. medicine-filling device under the Tenon capsules described in claim 5, it is characterised in that described on the coronal-plane of the distal portion The width of the distal portion is constant in the whole length of distal portion.

7. medicine-filling device under the Tenon capsules described in claim 1, it is characterised in that the distal portion is provided with multiple medicine-pouring ports, And the medicine-pouring port is evenly distributed on the longitudinal direction of the distal portion.

8. medicine-filling device under the Tenon capsules described in claim 1, it is characterised in that the distal portion is provided with multiple medicine-pouring ports, And the medicine-pouring port is alternately distributed on the longitudinal direction of the distal portion.

9. medicine-filling device under the Tenon capsules described in claim 1, it is characterised in that the connecting portion and the conduit be one into Type.

10. medicine-filling device under the Tenon capsules any one of claim 1-9, it is characterised in that injection under the Tenon capsules Device also includes one or more cushion pads, and the cushion pad is configured to be placed in the connecting portion or the interface.