CN206300919U - A kind of liquid biopsy genetic test circuit - Google Patents
A kind of liquid biopsy genetic test circuit Download PDFInfo
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- CN206300919U CN206300919U CN201621256014.0U CN201621256014U CN206300919U CN 206300919 U CN206300919 U CN 206300919U CN 201621256014 U CN201621256014 U CN 201621256014U CN 206300919 U CN206300919 U CN 206300919U
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Abstract
The utility model provides a kind of liquid biopsy genetic test circuit, including：Control module, voltage drive module and the liquid biopsy module being sequentially connected, control module are also connected with liquid biopsy module；Control module, for transmitting the first drive signal to voltage drive module, and for receiving the first detection signal of liquid biopsy module feedback and according to first detection signal judging whether the corresponding gene of body fluid sample to be detected produces mutation；Voltage drive module, for the first drive signal to be converted into the second drive signal, and the second drive signal is transmitted to liquid biopsy module；Liquid biopsy module, for making body fluid sample to be detected and reaction reagent that redox reaction to occur according to the second drive signal, and transmit to control module the first detection signal for reacting generation, it passes through the chemical reaction that electric field action is realized between the body fluid sample to be detected of patient and reaction reagent, reaction speed is very fast, the Efficiency and accuracy of detection is higher, and practicality is preferable.
Description
Technical field
The utility model is related to technical field of gene detection, in particular to a kind of liquid biopsy genetic test circuit.
Background technology
The environmental factors such as air pollution cause lung cancer number of patients in recent years to sharply increase, lung cancer have become the incidence of disease and
The malignant tumour that the death rate ranks the first.From 2011, the comprehensive cancer of U.S. clinical cancer association (ASCO) and country
Network (NCCN) suggestion late period non-squamous non-small cell lung cancer (NSCLC) patient carries out EGFR mutation tests.Wherein, EGFR is positive
Non-small cell lung cancer case it is more common in Asian countries, therefore non-small cell lung cancer patient to Asia carries out genotype survey
It is fixed to be more of practical significance.But in clinical practice, especially in some low developed areas, the gene mutation test of EGFR is subject to
Resource, the limitation on doctor and expense far can not also meet clinical demand.
In present clinical practice, doctor has to obtain tumour by the method for CT guided punctures or surgical operation
Tissue samples, then the species of EGFR genetic mutation measured by cumbersome process instruct the treatment of targeted drug.First,
This process often increases the pain of patient, produces extra operation risk, and tumour has heterogeneity, for having occurred and that
For the cancer patient of transfer, the cancerous tissue at certain position is only taken by puncturing or performing the operation, patient's entirety can not be reflected
Situation.Secondly, some patients situation of itself determines that he is not suitable for tissue biopsy, and some tumours are being punctured or performed the operation
Disturbance after, have accelerate shift risk.Finally, there are the problems such as expense high latency is long in tissue biopsy, its is stagnant
Treatment of the property to patient afterwards is also unfavorable.
Therefore, if can be by the type of peripheral blood direct detection lung cancer gene mutation, i.e., so-called liquid biopsy skill
Art, is always the emphasis of major diagnostic reagent company research and development.But, carry out sentencing for lung cancer gene mutation for liquid biopsy at present
It is disconnected to there is no perfect scheme.
Utility model content
In view of this, the purpose of this utility model is to provide a kind of liquid biopsy genetic test circuit, is made by electric field
With the chemical reaction realized between the body fluid sample of patient and reaction reagent, reaction speed is very fast, the Efficiency and accuracy of detection
It is higher, and practicality is preferable.
In a first aspect, the utility model embodiment provides a kind of liquid biopsy genetic test circuit, the circuit includes
Control module, voltage drive module and the liquid biopsy module being sequentially connected, the control module also with the liquid biopsy mould
Block is connected；
The control module, it is for transmitting the first drive signal to the voltage drive module and described for receiving
The first detection signal of liquid biopsy module feedback, and judge that body fluid sample to be detected is corresponding according to the first detection signal
Whether gene produces mutation；
The voltage drive module, for first drive signal to be converted into the second drive signal, and by described
Two driving signal is transmitted to the liquid biopsy module；
The liquid biopsy module, for trying the body fluid sample to be detected and reaction according to second drive signal
There is redox reaction in agent, and the first detection signal for reacting generation is transmitted to the control module.
With reference in a first aspect, the utility model embodiment provide first aspect the first possible implementation method, its
In, it is connected with the signal in turn also including signal amplification module and analog-to-digital conversion module, after the liquid biopsy module and puts
Big module and the analog-to-digital conversion module, the analog-to-digital conversion module are electrically connected with the control module；
The signal amplification module, for the first detection signal of liquid biopsy module reaction generation to be amplified
Treatment, is amplified the second detection signal after treatment；
The analog-to-digital conversion module, for second detection signal to be carried out into analog-to-digital conversion process, obtains conversion process
The 3rd detection signal afterwards, and the 3rd detection signal is transmitted to the control module.
With reference to the first possible implementation method of first aspect, the utility model embodiment provides the of first aspect
Two kinds of possible implementation methods, wherein, also including amplifying control module；The amplification control module is connected to the control module
And the signal amplification module between；
The amplification control module, control, institute are switched over for the enhanced processing pattern to the signal amplification module
Stating enhanced processing pattern includes：High gain mode and low gain mode.
With reference to second possible implementation method of first aspect, the utility model embodiment provides the of first aspect
Three kinds of possible implementation methods, wherein, also including calibration module；The calibration module is connected to the control module and the electricity
Between pressure drive module；
The calibration module, for producing benchmark drive signal, and according to the benchmark drive signal to the control mould
First drive signal of block transmission carries out calibration process.
With reference to the third possible implementation method of first aspect, the utility model embodiment provides the of first aspect
Four kinds of possible implementation methods, wherein, also including universal input/output GPIO modules；
The amplification control module is electrically connected by the GPIO modules with the control module；The calibration module passes through
The GPIO modules are electrically connected with the control module.
With reference in a first aspect, the utility model embodiment provide first aspect the 5th kind of possible implementation method, its
In, also including bar code scan module；The bar code scan module is electrically connected with the control module；
The bar code scan module, for being scanned to the corresponding bar code of the liquid biopsy module, is scanned
As a result, and by the scanning result send to the control module.
With reference in a first aspect, the utility model embodiment provide first aspect the 6th kind of possible implementation method, its
In, also including Temperature and Humidity module；The Temperature and Humidity module is electrically connected with the control module；
The Temperature and Humidity module, detection process are carried out for the humiture to the liquid biopsy module, obtain temperature
Humidity variable quantity, and the humiture variable quantity is sent to the control module.
With reference in a first aspect, the utility model embodiment provide first aspect the 7th kind of possible implementation method, its
In, also including general-purpose serial bus USB module；The USB module is electrically connected with the control module；
The USB module, for the control module and ancillary equipment to be entered into row data communication.
With reference in a first aspect, the utility model embodiment provide first aspect the 8th kind of possible implementation method, its
In, also including power module；The power module is connected with the control module；
The power module, for being powered for the control module.
With reference to the first possible implementation method of first aspect, the utility model embodiment provides the of first aspect
Nine kinds of possible implementation methods, wherein, first drive signal is digital voltage signal；Second drive signal is simulation
Voltage signal；The first detection signal and second detection signal are analog current signal；3rd detection signal
It is digital current signal.
The liquid biopsy genetic test circuit that the utility model embodiment is provided, using control module, voltage drive module
Cause whole circuit automatic and integration with liquid biopsy module, with the prior art pass through CT guided punctures or surgery hand
The tissue samples that the method for art obtains tumour carry out tissue biopsy and there are the problems such as the costly, stand-by period is long and practicality
It is poor to compare, its use control module can to voltage drive module transmit the first drive signal, in order to the voltage drive mould
First drive signal is converted to the second drive signal by block, and is transmitted to liquid biopsy module, aforesaid liquid biopsy module then root
Make body fluid sample to be detected and reaction reagent that redox reaction to occur according to the second drive signal, and the first inspection of generation will be reacted
Survey signal transmission to control module so that the control module can judge body fluid sample correspondence to be detected according to first detection signal
Gene whether produce mutation, it passes through the chemistry that electric field action is realized between the body fluid sample to be detected of patient and reaction reagent
Reaction, reaction speed is very fast, and the Efficiency and accuracy of detection is higher, and can effectively judge body fluid sample correspondence to be detected
Gene whether produce mutation, practicality is preferable.
To enable above-mentioned purpose of the present utility model, feature and advantage to become apparent, preferred embodiment cited below particularly, and
Coordinate appended accompanying drawing, be described in detail below.
Brief description of the drawings
In order to illustrate more clearly of the technical scheme of the utility model embodiment, below will be to be used needed for embodiment
Accompanying drawing be briefly described, it will be appreciated that the following drawings illustrate only some embodiments of the present utility model, therefore should not be by
Regard the restriction to scope as, for those of ordinary skill in the art, on the premise of not paying creative work, may be used also
Other related accompanying drawings are obtained with according to these accompanying drawings.
Fig. 1 shows a kind of structural representation of liquid biopsy genetic test circuit that the utility model embodiment is provided
Figure；
Fig. 2 shows that a kind of concrete structure of liquid biopsy genetic test circuit that the utility model embodiment is provided shows
It is intended to；
Fig. 3 shows a kind of liquid biopsy genetic test circuit alignment control that the utility model embodiment is provided
Circuit diagram.
Main element symbol description：
11st, control module；22nd, voltage drive module；33rd, liquid biopsy module；44th, signal amplification module；55th, modulus turns
Mold changing block；66th, control module is amplified；77th, calibration module；88th, USB module；99th, power module.
Specific embodiment
It is new below in conjunction with this practicality to make the purpose, technical scheme and advantage of the utility model embodiment clearer
Accompanying drawing in type embodiment, is clearly and completely described, it is clear that described to the technical scheme in the utility model embodiment
Embodiment be only a part of embodiment of the utility model, rather than whole embodiments.Generally described in accompanying drawing herein
Can arrange and design with a variety of configurations with the component of the utility model embodiment for showing.Therefore, below to
The detailed description of the embodiment of the present utility model provided in accompanying drawing is not intended to limit claimed model of the present utility model
Enclose, but be merely representative of selected embodiment of the present utility model.Based on embodiment of the present utility model, those skilled in the art exist
The every other embodiment obtained on the premise of not making creative work, belongs to the scope of the utility model protection.
The tissue samples of tumour are obtained in view of the method in correlation technique by CT guided punctures or surgical operation, then
There is costly, stand-by period long, tissue acquisition difficulty and can increase in the species for measuring EGFR genetic mutation by cumbersome process
Plus the problems such as the pain of patient, based on this, the utility model provides a kind of liquid biopsy genetic test circuit, the detection
The chemical reaction that circuit can be realized between the body fluid sample of patient and reaction reagent by electric field action, reaction speed is very fast,
The Efficiency and accuracy of detection is higher, and practicality is preferable.
Referring to Fig. 1, the utility model embodiment provides a kind of liquid biopsy genetic test circuit.The detection circuit is specific
Including：Control module 11, voltage drive module 22 and the liquid biopsy module 33 being sequentially connected, control module 11 are also lived with liquid
Inspection module 33 is connected；
Control module 11, for transmitting the first drive signal to voltage drive module 22, and for receiving liquid biopsy
The first detection signal of the feedback of module 33, and judge whether the corresponding gene of body fluid sample to be detected produces according to first detection signal
Raw mutation；
Voltage drive module 22, for the first drive signal to be converted into the second drive signal, and by the second drive signal
Transmit to liquid biopsy module 33；
Liquid biopsy module 33, for aoxidizing body fluid sample to be detected and reaction reagent according to the second drive signal
Reduction reaction, and the first detection signal for reacting generation is transmitted to control module 11.
The utility model embodiment provide liquid biopsy genetic test circuit, with the prior art pass through CT guided punctures
Or the method for surgical operation obtains the tissue samples of tumour and carries out tissue biopsy and there is the costly, stand-by period long etc. many asking
Topic and practicality is poor compares, it uses the control module 11 can to transmit the first drive signal to voltage drive module 22, so as to
First drive signal is converted into the second drive signal in the voltage drive module 22, and is transmitted to liquid biopsy module 33, on
State liquid biopsy module 33 then makes body fluid sample to be detected and reaction reagent that redox reaction to occur according to the second drive signal,
And transmit to control module 11 first detection signal for reacting generation so that the control module 11 can be according to the first detection letter
Number judge whether the corresponding gene of body fluid sample to be detected produces mutation, it passes through the body fluid to be detected that electric field action realizes patient
Chemical reaction between sample and reaction reagent, reaction speed is very fast, and the Efficiency and accuracy of detection is higher, and can be effective
Judge whether the corresponding gene of body fluid sample to be detected produces mutation, practicality is preferable.
Specifically, the control module 11 in the liquid biopsy genetic test circuit that is provided of the utility model embodiment can
The first drive signal is transmitted to voltage drive module 22, to enable that above-mentioned voltage drive module 22 carries out the first drive signal
To the conversion of the second drive signal, and by conversion after the second drive signal transmit to liquid biopsy module 33, with cause it is above-mentioned
It is anti-that liquid biopsy module 33 can make body fluid sample to be detected and reaction reagent that redox to occur according to second drive signal
Should, and the first detection signal for reacting generation is fed back into control module 11, the first inspection then according to the feedback of control module 11
Survey signal and directly judge whether the corresponding gene of body fluid sample to be detected produces mutation.
Wherein, in the utility model embodiment control module 11 is preferably using FPGA (Field-Programmable
Gate Array, field programmable gate array) QIJIAN, and each functional module can be realized by burning Firmware programs
Be in communication with each other and control.
In addition, the liquid biopsy genetic test circuit that the utility model embodiment is provided be available for use reaction reagent have
Various, reaction result between differential responses reagent and body fluid sample to be detected is by the catastrophe of corresponding different genes section.
Further, in order to preferably the first detection signal of the reaction generation of liquid biopsy module 33 is analyzed and is located
Reason, referring to Fig. 2, the utility model embodiment is connected with signal amplification module 44 and modulus in turn after liquid biopsy module 33
Modular converter 55, and the analog-to-digital conversion module 55 electrically connects with control module 11.Specifically, liquid biopsy module 33 is detected
The more faint first detection signal for arriving, a waveform for the device of triode is exported is obtained by individual core similar, amplitude
But second detection signal more much bigger than ultra-weak electronic signal before, then, analog-to-digital conversion module 55 and signal amplification module 44
Electrical connection, the second detection signal that can be obtained enhanced processing is converted to the 3rd detection signal, and the 3rd detection letter is passed
Control module 11 is transported to, directly the 3rd detection signal of numeral can be read out and be shown in order to the control module 11.
Wherein, be preferably for the first drive signal by the liquid biopsy genetic test circuit that the utility model embodiment is provided
Digital voltage signal, the second drive signal is preferably analog voltage signal, and liquid biopsy module 33 detects the first inspection for obtaining
Survey signal is analog current signal, and the second detection signal after the first detection signal is amplified also is analog current signal, and this
The 3rd detection signal after two detection signal analog-to-digital conversion process is digital current signal.
In addition, the 3rd detection signal that the detection electric circuit inspection that the utility model embodiment is provided is obtained can be by pre-
If threshold value carries out the judgement whether corresponding gene of body fluid sample to be detected produces mutation.Additionally, by the positive control for setting
And negative control, above-mentioned 3rd detection signal be more than predetermined threshold value when, above-mentioned body fluid sample to be detected is positive, less than or wait
When predetermined threshold value, the body fluid sample to be detected is negative.
Further, referring to Fig. 2, the utility model embodiment also connects between control module 11 and signal amplification module 44
Amplification control module 66 is connected to, the amplification control module 66 can be controlled to the enhanced processing pattern of signal amplification module 44
System, wherein, above-mentioned enhanced processing module includes high gain mode and low gain mode.In addition, the amplification control module 66 passes through
GPIO (the General Purpose Input that the liquid biopsy genetic test circuit that the utility model embodiment is provided includes
Output, universal input/output) module electrically connects with control module 11, i.e., and control module 11 is by the I/O port (GPIO) that expands
Realize the control to amplifying control module 66.
Further, the precise control of the first drive signal for being transmitted in order to ensure control module 11, referring to Fig. 2, this reality
Also include calibration module 77 with new embodiment, the calibration module 77 for producing benchmark drive signal, and drives according to benchmark
Signal carries out calibration process to the first drive signal that control module 11 is transmitted.Likewise, the calibration module 77 is by above-mentioned
GPIO modules are electrically connected with control module 11, i.e., control module 11 is realized to calibration module 77 by the I/O port (GPIO) for expanding
Control.
Specifically, the control module 11 in above-mentioned detection circuit makes calibration module 77 export difference by controlling analog switch
Reference voltage (benchmark drive signal), the reference voltage is connected to " the connection internal calibration voltage " end in Fig. 3.Whole calibration
Process is realized especially by following steps：
1) " the lower range calibration control " switch and " high range calibration control " switch in Fig. 3 are disconnected, " range control is closed
System " switch, it is Voff to gather lower range bias voltage with analog-to-digital conversion module 55low；" range control " switch is opened, modulus is used
The collection high range bias voltage of modular converter 55 is Voffhi。
2) " the lower range calibration control " switch in Fig. 3 is opened, " high range calibration control " switch is closed, " range is closed
Control " switch, control calibration module 77 exports -2.048V and 2.048V, then the actual current being input into is respectively -2.048V/
10M, Ω=- 204.8nA and 204.8nA, the numerical value respectively V1 and V2 gathered respectively with analog-to-digital conversion module 55.
3) " the high range calibration control " switch in Fig. 3 is opened, " lower range calibration control " switch is closed, " range is opened
Control " switch, control calibration module 77 exports -2.048V and 2.048V, then the actual current being input into is respectively -2.048V/
40.2k, Ω=- 50.95uA and 50.95uA, the numerical value gathered with analog-to-digital conversion module 55 are respectively V3 and V4.
4) electric current of actual measurement presses the parameter conversion of above-mentioned calibration.During lower range, I=(Vout-Vofflow)*204.8*
2/(V2-V1)nA；During high range, I=(Vout-Voffhi)*50.95*2/(V4-V3)uA.Wherein Vout is analog-to-digital conversion module
55 values for collecting.
Further, the detection circuit that the utility model embodiment is provided also includes bar code scan module, and the bar code is swept
Retouch module to be electrically connected with control module 11, for being scanned to the corresponding bar code of liquid biopsy module 33, and will scan
To scanning result send to control module 11, carry out real time inspection to be transmitted to ancillary equipment by the control module 11.
Further, the detection circuit that the utility model embodiment is provided also includes Temperature and Humidity module, and this is warm and humid
Degree detection module is electrically connected by with control module 11, and the temperature that Temperature and Humidity treatment is obtained will be carried out to liquid biopsy module 33
Humidity variable quantity is sent to control module 11, and subsequent analysis treatment is carried out with by the control module 11.
Further, referring to Fig. 2, in order to preferably realize the data communication between above-mentioned detection circuit and ancillary equipment,
The utility model embodiment also includes USB (Universal Serial Bus, USB) module, the USB module 88
It is connected with control module 11, is the bridge of the communication of control module 11 for realizing ancillary equipment (such as PC) and detection circuit, PC
Being connected to control module 11 by USB data line carries out the transmission and treatment of data, and control module 11 then controls the work(of USB module 88
The normal operation of energy.
Further, referring to Fig. 2, the utility model embodiment also includes power module 99, the power module 99 and control
Module 11 is electrically connected, for being powered for the control module 11.In addition, the power module 99 also includes power cut-out switch and LED
The input interface of display lamp and equipment D/C power, can be powered for the said equipment.
The utility model embodiment provide liquid biopsy genetic test circuit, with the prior art pass through CT guided punctures
Or the method for surgical operation obtains the tissue samples of tumour and carries out tissue biopsy and there is the costly, stand-by period long etc. many asking
Topic and practicality is poor compares, it uses the control module 11 can to transmit the first drive signal to voltage drive module 22, so as to
First drive signal is converted into the second drive signal in the voltage drive module 22, and is transmitted to liquid biopsy module 33, on
State liquid biopsy module 33 then makes body fluid sample to be detected and reaction reagent that redox reaction to occur according to the second drive signal,
And transmit to control module 11 first detection signal for reacting generation so that the control module 11 can be according to the first detection letter
Number judge whether the corresponding gene of body fluid sample to be detected produces mutation, it passes through the body fluid to be detected that electric field action realizes patient
Chemical reaction between sample and reaction reagent, reaction speed is very fast, and the Efficiency and accuracy of detection is higher, and can be effective
Judge whether the corresponding gene of body fluid sample to be detected produces mutation, practicality is preferable.
In embodiment provided by the utility model, it should be understood that disclosed device, can be by another way
Realize.Device embodiment described above is only schematical, for example, the division of the unit, only a kind of logic
Function is divided, and can have other dividing mode when actually realizing, and for example, multiple units or component can combine or can be with
Another system is integrated into, or some features can be ignored, or do not perform.It is another, it is shown or discussed each other
Coupling or direct-coupling or communication connection can be the INDIRECT COUPLING or communication link of device or unit by some communication interfaces
Connect, can be electrical, mechanical or other forms.
The unit that is illustrated as separating component can be or may not be it is physically separate, it is aobvious as unit
The part for showing can be or may not be physical location, you can with positioned at a place, or can also be distributed to multiple
On NE.Some or all of unit therein can be according to the actual needs selected to realize the mesh of this embodiment scheme
's.
In addition, during each functional unit in the embodiment that the utility model is provided can be integrated in a processing unit,
Can also be that unit is individually physically present, it is also possible to which two or more units are integrated in a unit.
If the function is to realize in the form of SFU software functional unit and as independent production marketing or when using, can be with
Storage is in a computer read/write memory medium.Based on such understanding, the technical solution of the utility model substantially or
Person says that the part of the part or technical scheme contributed to prior art can be embodied in the form of software product,
The computer software product is stored in a storage medium, including some instructions are used to so that computer equipment (can be with
It is personal computer, server, or network equipment etc.) perform whole or the portion of the utility model each embodiment methods described
Step by step.And foregoing storage medium includes：USB flash disk, mobile hard disk, read-only storage (ROM, Read-Only Memory), with
Machine access memory (RAM, Random Access Memory), magnetic disc or CD etc. are various can be with Jie of store program codes
Matter.
It should be noted that：Similar label and letter represents similar terms in following accompanying drawing, therefore, once a certain Xiang Yi
It is defined in individual accompanying drawing, then it need not be further defined and explained in subsequent accompanying drawing, additionally, term " the
One ", " second ", " the 3rd " etc. are only used for distinguishing description, and it is not intended that indicating or implying relative importance.
Finally it should be noted that：Embodiment described above, specific embodiment only of the present utility model is used to illustrate this
The technical scheme of utility model, rather than its limitations, protection domain of the present utility model is not limited thereto, although with reference to foregoing
Embodiment has been described in detail to the utility model, it will be understood by those within the art that：It is any to be familiar with this skill
In the technical scope that the utility model is disclosed, it still can be to the skill described in previous embodiment for the technical staff in art field
Art scheme is modified or can readily occur in change, or carries out equivalent to which part technical characteristic；And these modifications,
Change is replaced, and does not make the spirit and model of essence disengaging the utility model embodiment technical scheme of appropriate technical solution
Enclose.Should all cover within protection domain of the present utility model.Therefore, protection domain of the present utility model described should be wanted with right
The protection domain asked is defined.
Claims (10)
1. a kind of liquid biopsy genetic test circuit, it is characterised in that including the control module, the voltage drive module that are sequentially connected
With liquid biopsy module, the control module is also connected with the liquid biopsy module；
The control module, for transmitting the first drive signal to the voltage drive module, and for receiving the liquid
The first detection signal of biopsy module feedback, and the corresponding gene of body fluid sample to be detected is judged according to the first detection signal
Whether generation is mutated；
The voltage drive module, for first drive signal to be converted into the second drive signal, and described second is driven
Move signal transmission to the liquid biopsy module；
The liquid biopsy module, for sending out the body fluid sample to be detected and reaction reagent according to second drive signal
Raw redox reaction, and the first detection signal for reacting generation is transmitted to the control module.
2. circuit according to claim 1, it is characterised in that also including signal amplification module and analog-to-digital conversion module, institute
State and be connected with the signal amplification module and the analog-to-digital conversion module, the analog-to-digital conversion mould in turn after liquid biopsy module
Block is electrically connected with the control module；
The signal amplification module, for the first detection signal of liquid biopsy module reaction generation to be amplified into place
Reason, is amplified the second detection signal after treatment；
The analog-to-digital conversion module, for second detection signal to be carried out into analog-to-digital conversion process, after obtaining conversion process
3rd detection signal, and the 3rd detection signal is transmitted to the control module.
3. circuit according to claim 2, it is characterised in that also including amplifying control module；The amplification control module
It is connected between the control module and the signal amplification module；
The amplification control module, control is switched over for the enhanced processing pattern to the signal amplification module, described to put
Big tupe includes：High gain mode and low gain mode.
4. circuit according to claim 3, it is characterised in that also including calibration module；The calibration module is connected to institute
State between control module and the voltage drive module；
The calibration module, for producing benchmark drive signal, and passes according to the benchmark drive signal to the control module
Defeated first drive signal carries out calibration process.
5. circuit according to claim 4, it is characterised in that also including universal input/output GPIO modules；
The amplification control module is electrically connected by the GPIO modules with the control module；The calibration module is by described
GPIO modules are electrically connected with the control module.
6. circuit according to claim 1, it is characterised in that also including bar code scan module；The bar code scan module
Electrically connected with the control module；
The bar code scan module, for being scanned to the corresponding bar code of the liquid biopsy module, obtains scanning result,
And send to the control module scanning result.
7. circuit according to claim 1, it is characterised in that also including Temperature and Humidity module；The Temperature and Humidity
Module is electrically connected with the control module；
The Temperature and Humidity module, detection process are carried out for the humiture to the liquid biopsy module, obtain humiture
Variable quantity, and the humiture variable quantity is sent to the control module.
8. circuit according to claim 1, it is characterised in that also including general-purpose serial bus USB module；The USB moulds
Block is electrically connected with the control module；
The USB module, for the control module and ancillary equipment to be entered into row data communication.
9. circuit according to claim 1, it is characterised in that also including power module；The power module and the control
Molding block is connected；
The power module, for being powered for the control module.
10. circuit according to claim 2, it is characterised in that first drive signal is digital voltage signal；It is described
Second drive signal is analog voltage signal；The first detection signal and second detection signal are analog current letter
Number；3rd detection signal is digital current signal.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201621256014.0U CN206300919U (en) | 2016-11-18 | 2016-11-18 | A kind of liquid biopsy genetic test circuit |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201621256014.0U CN206300919U (en) | 2016-11-18 | 2016-11-18 | A kind of liquid biopsy genetic test circuit |
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| Publication Number | Publication Date |
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| CN206300919U true CN206300919U (en) | 2017-07-04 |
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|---|---|---|---|
| CN201621256014.0U Expired - Fee Related CN206300919U (en) | 2016-11-18 | 2016-11-18 | A kind of liquid biopsy genetic test circuit |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106525925A (en) * | 2016-11-18 | 2017-03-22 | 北京易活生物科技有限公司 | Detection circuit for liquid biopsy gene |
-
2016
- 2016-11-18 CN CN201621256014.0U patent/CN206300919U/en not_active Expired - Fee Related
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106525925A (en) * | 2016-11-18 | 2017-03-22 | 北京易活生物科技有限公司 | Detection circuit for liquid biopsy gene |
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