CN206266588U - A kind of micro-fluid separation chip - Google Patents
A kind of micro-fluid separation chip Download PDFInfo
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- CN206266588U CN206266588U CN201621397674.0U CN201621397674U CN206266588U CN 206266588 U CN206266588 U CN 206266588U CN 201621397674 U CN201621397674 U CN 201621397674U CN 206266588 U CN206266588 U CN 206266588U
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- outer tube
- fluid separation
- basal body
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Abstract
The utility model discloses a kind of micro-fluid separation chip, including chip basal body, the front of chip basal body sets fluted, horizontal channel is fixed with the horizontal direction in groove, horizontal channel is respectively fixed at two ends with a termination, the bottom of horizontal channel is fixed with least one sieve connected with horizontal channel from passage, the back side of chip basal body is fixed with lower connection sheet at bottom, the back side of chip basal body is fixed with connection sheet at top, lower connection sheet is hinged with supporting plate, the drive device of adjustable in length is fixed with the top of supporting plate, the top of drive device is hinged with upper connection sheet.Its advantage is：Can support, it is easy to use.
Description
Technical field
The utility model is related to a kind of micro-fluid separation chip.
Background technology
The sperm of survival, the microfluidic separation of Chinese patent 200620170822.5 are isolated from frozen semen for convenience
Chip, including a level isometrical straight tube-like main channel, in the arranged beneath tubulose split tunnel of main channel, the split tunnel
Two ends there is cross-sectional area in identical, the middle part of the split tunnel connects with the middle part of main channel, the straight tube-like of formation
Communicating passage has identical inner section, and the length of the communicating passage is 500~10000 μm, vertical height in communicating passage
It is 5~1000 μm.The utility model utilizes lamina flow principle, can be by motile sperm cells are from conventional semen sample and use traditional sperm
Separation method is difficult or impossible to be separated in separate sample.But the structure of the utility model is excessively simple, no
Facilitate user to support to be fixed up, poor practicability.
Utility model content
Problem to be solved in the utility model is to provide one can be supported, micro-fluid separation chip easy to use.
In order to solve the above-mentioned technical problem, the technical solution adopted in the utility model is：A kind of micro-fluid separation chip, bag
Chip basal body is included, the front of the chip basal body sets fluted, is fixed with horizontal channel in the horizontal direction in the groove, institute
The termination that is respectively fixed at two ends with of horizontal channel is stated, the bottom of the horizontal channel is fixed with least one and leads to the level
The sieve of road connection is from passage, it is characterised in that the back side of the chip basal body is fixed with lower connection sheet, the core at bottom
The back side of sheet matrix is fixed with connection sheet at top, and the lower connection sheet is hinged with supporting plate, and the top of the supporting plate is consolidated
Surely have a drive device of adjustable in length, the drive device include inclined two pieces of support plates being fixed at the top of the supporting plate,
It is fixed on the first splay end plate above the support plate, the outer tube being fixed at the top of the first splay end plate, is fixed on outside described
The inner sleeve that second splay end plate of cannula tip, top are hinged with the upper connection sheet, the bottom of the inner sleeve is described in
Second splay end plate is simultaneously extended in the outer tube, is slided in the outer tube and is provided with a rotor plate, the top of the rotor plate
Portion is fixed with the leading screw extended in the inner sleeve, and the inwall of the inner sleeve is provided with and is connected through a screw thread with the leading screw
Internal thread, the bottom of the rotor plate is fixed with through the first splay end plate and extends to the rotating shaft outside the outer tube,
The termination of the rotating shaft is fixed with armature.
Preferably, above-mentioned micro-fluid separation chip, wherein length side of the inwall of the outer tube along the outer tube
To at least one piece limited block is fixed with, chute is provided with the limited block, the outer wall of the inner sleeve is fixed with least one
Sliding block, the sliding block is corresponded with the chute and the sliding block is connected with corresponding slide.
Preferably, above-mentioned micro-fluid separation chip, wherein the outer wall of the armature is provided with anti-slip tank.
Preferably, above-mentioned micro-fluid separation chip, wherein described sieve is respectively fixed with a separation and connects from the termination of passage
Head.
Preferably, above-mentioned micro-fluid separation chip, wherein the quantity of the limited block is two pieces, the quantity of the chute
It is two.
It is of the present utility model to have the technical effect that：Supporting plate, chip basal body, drive device may be constructed a triangle
Shape, therefore the utility model can be supported, it is easy to use；User can by adjust the length of drive device come
Chip basal body rotation is promoted, and then adjusts the angle of chip basal body and vertical direction, so as to adjust sieve from passage and vertical direction
Angle, and then motile sperm cells are adjusted by sieve from the complexity of passage, so as to realize separating different activities
Motile sperm cells so that the utility model is more practical；User rotates armature, and rotor plate can be driven to rotate, and then drives
Leading screw rotates, and because leading screw is connected with inner sleeve by internal thread, this allows for inner sleeve up and down motion, realizes drive device
Length adjustment, be easy to use.
Brief description of the drawings
Fig. 1 is structural representation of the present utility model；
Fig. 2 is the right view of Fig. 1；
Fig. 3 is the structural representation of drive device in Fig. 1；
Fig. 4 is the structural representation of limited block in Fig. 3.
Specific embodiment
Below in conjunction with accompanying drawing, specific embodiment of the present utility model is further described, so that the utility model
Technical scheme be more readily understood and grasp.
As shown in Figure 1,2,3, 4, a kind of micro-fluid separation chip, including chip basal body 1, the front of chip basal body 1 is set
Fluted 10, it is fixed with horizontal channel 11 in groove 10 in the horizontal direction, horizontal channel 11 is respectively fixed at two ends with a termination
12, the bottom of horizontal channel 11 is fixed with two sieves connected with horizontal channel 11 from passage 13.Wherein sieve from the end of passage 13
Head is respectively fixed with a separating joint 90.It is dead smart, residual without kinetic energy when having certain stable flow velocity in horizontal channel 11
The bones of the body, and active low sperm then flows to another end motion of horizontal channel 11 with top dielectric, and the height with kinetic energy therein
Mass activity sperm then shakes off top dielectric stream, is moved to lower floor's medium flow field, while these high-quality viable sperms are situated between in lower floor
Under the flow velocity effect of mass flow, to sieve from another end motion of passage 13, the screening of viable sperm is realized.
The back side of chip basal body 1 is fixed with lower connection sheet 21 at bottom, and the back side of chip basal body 1 is consolidated at top
Surely there is upper connection sheet 22, lower connection sheet 21 is hinged with supporting plate 23, and the top of supporting plate 23 is fixed with the drive device of adjustable in length
3.When chip basal body 1 and horizontal plane are placed, viable sperm is easiest to enter into sieve in passage 13；When chip basal body 1
During close to horizontal positioned, viable sperm is most difficult to enter into sieve in passage 13.
Drive device 3 includes inclined two pieces of support plates 31 for being fixed on the top of supporting plate 23, is fixed on the of the top of support plate 31
One splay end plate 32, the outer tube 33 for being fixed on the top of the first splay end plate 32, the second splay end plate 34 for being fixed on the top of outer tube 33,
The inner sleeve 35 that top is hinged with upper connection sheet 22, the bottom of inner sleeve 35 passes through the second splay end plate 34 and extends to outer tube 33
It is interior, to be slided in outer tube 33 and be provided with a rotor plate 36, the top of rotor plate 36 is fixed with the leading screw extended in inner sleeve 35
37, the inwall of inner sleeve 35 is provided with the internal thread 38 being connected through a screw thread with leading screw 37, and the bottom of rotor plate 36 is fixed with wears
Cross the plate of the first splay end 32 and extend to the rotating shaft 39 outside outer tube 33, the termination of rotating shaft 39 is fixed with armature 40.
Wherein the inwall of outer tube 33 is fixed with two pieces of limited blocks 41 along the length direction of outer tube 33, is set on spacing 41 pieces
Be equipped with chute 42, the outer wall of inner sleeve 35 is fixed with two sliding blocks 43, sliding block 43 corresponded with chute 42 and sliding block 43 with it is right
The chute 42 answered is slidably connected, and so design prevents inner sleeve 35 to be rotated together with leading screw 37.
The outer wall of the armature 40 in the utility model is provided with anti-slip tank 8, and so design is increased between staff
Frictional force.
Certainly, these are only preferred embodiment of the present utility model, it is non-therefore limit to patent of the present utility model
Simple modification and the equivalent structure change for it of scope, all utilization the utility model specifications and schema content institute, all should similarly wrap
It is contained within scope of patent protection of the present utility model.
Claims (5)
1. a kind of micro-fluid separation chip, including chip basal body, the front of the chip basal body sets fluted, in the groove
It is fixed with horizontal channel in the horizontal direction, the horizontal channel is respectively fixed at two ends with a termination, the bottom of the horizontal channel
Portion is fixed with least one sieve connected with the horizontal channel from passage, it is characterised in that：The back side of the chip basal body is leaned on
Lower connection sheet is fixed with nearly bottom, the back side of the chip basal body is fixed with connection sheet, the lower connection at top
Piece is hinged with supporting plate, and the drive device of adjustable in length is fixed with the top of the supporting plate, and the drive device includes inclined
It is fixed at the top of the supporting plate two pieces of support plates, the first splay end plate being fixed on above the support plate, to be fixed on described first oblique
In outer tube at the top of end plate, the second splay end plate being fixed at the top of the outer tube, top and the upper connection sheet are hinged
Sleeve pipe, the bottom of the inner sleeve passes through the second splay end plate and extends in the outer tube, is slided in the outer tube
Be provided with a rotor plate, be fixed with the leading screw extended in the inner sleeve at the top of the rotor plate, the inner sleeve it is interior
Wall is provided with the internal thread being connected through a screw thread with the leading screw, and the bottom of the rotor plate is fixed with through first splay end
Plate simultaneously extends to the rotating shaft outside the outer tube, and the termination of the rotating shaft is fixed with armature.
2. micro-fluid separation chip according to claim 1, it is characterised in that：The inwall of the outer tube is along the overcoat
The length direction of pipe is fixed with least one piece limited block, and chute is provided with the limited block, and the outer wall of the inner sleeve is fixed
There is at least one sliding block, the sliding block is corresponded with the chute and the sliding block is connected with corresponding slide.
3. micro-fluid separation chip according to claim 1, it is characterised in that：The outer wall of the armature is provided with anti-
Chute.
4. micro-fluid separation chip according to claim 1, it is characterised in that：Described sieve is fixed respectively from the termination of passage
There is a separating joint.
5. micro-fluid separation chip according to claim 2, it is characterised in that：The quantity of the limited block is two pieces, institute
The quantity for stating chute is two.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201621397674.0U CN206266588U (en) | 2016-12-20 | 2016-12-20 | A kind of micro-fluid separation chip |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201621397674.0U CN206266588U (en) | 2016-12-20 | 2016-12-20 | A kind of micro-fluid separation chip |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN206266588U true CN206266588U (en) | 2017-06-20 |
Family
ID=59047100
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201621397674.0U Active CN206266588U (en) | 2016-12-20 | 2016-12-20 | A kind of micro-fluid separation chip |
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| CN (1) | CN206266588U (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115491301A (en) * | 2022-09-05 | 2022-12-20 | 武汉大学 | Microfluidic chip integrating sperm capacitation, sperm sorting, in-vitro fertilization and embryo culture, and preparation method and application thereof |
-
2016
- 2016-12-20 CN CN201621397674.0U patent/CN206266588U/en active Active
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115491301A (en) * | 2022-09-05 | 2022-12-20 | 武汉大学 | Microfluidic chip integrating sperm capacitation, sperm sorting, in-vitro fertilization and embryo culture, and preparation method and application thereof |
| CN115491301B (en) * | 2022-09-05 | 2023-09-15 | 武汉大学 | Microfluidic chip integrating sperm capacitation, sperm sorting, in-vitro fertilization and embryo culture and preparation method and application thereof |
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