CN206239777U - Thing is inserted in uterus and the imbedding system of thing is inserted in uterus - Google Patents
Thing is inserted in uterus and the imbedding system of thing is inserted in uterus Download PDFInfo
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- CN206239777U CN206239777U CN201620631149.4U CN201620631149U CN206239777U CN 206239777 U CN206239777 U CN 206239777U CN 201620631149 U CN201620631149 U CN 201620631149U CN 206239777 U CN206239777 U CN 206239777U
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Abstract
The utility model is related to that thing is inserted in uterus and the imbedding system of thing is inserted in uterus.Thing is inserted in the uterus at least includes body and the first connecting portion being connected with the body；The body includes the first human body degradation material；The first connecting portion includes the second human body degradation material.The imbedding system of thing is inserted in the uterus, including thing and embedded device are inserted in uterus, and there is the embedded device receiving uterus to insert the tubular-shaped structures of thing and push the action bars that thing is inserted in the uterus.The preparation method include it is following for preparing first connecting portion the step of：(1) the preposition treatment of small intestine and previous cleaning；(2) inactivation of virus；(3) cell is taken off；(4) DNA removings treatment；(5) it is molded.
Description
Technical field
The utility model belongs to medical instruments field on uterus Insertion.Specifically related to one kind can avoid generation
The uterus of Asherman's syndrom inserts thing, imbedding system and inserts the preparation method of thing
Background technology
Asherman's syndrom (intrauterine adhesions, IUA) also known as Asherman syndromes, are endometrium substrates
The part or all of adhesion of uterine cavity is inaccessible layer repairs obstacle after damaging caused by, causes menoxenia, periodic abdominalgia, infertile and anti-
A series of complication such as resurgent product.Under normal circumstances, uterine cavity as shown in Figure 1 represents uterine cavity, 20 tables in triangle wherein 10 is inverted
Show uterine wall, and uterine cavity front and rear wall is close to.Uterine wall ecto-entad is three layers of serous coat, muscle layer and inner membrance, is being implemented in uterine cavity
Post operation, may produce wound or the surface of a wound on inner membrance.Due to uterine cavity, front and rear wall is close under normal conditions, so in recovery process
Adhesion may be produced at wound or the surface of a wound.The schematic diagram that Fig. 2 sticks together for endometrium, 30 is the region for sticking together.
The common disease factor of IUA is that uteroventral operation causes endometrial impairment and endometrial bacterial infections, and its incidence of disease is gradually increasing, and hair
The sick age is in rejuvenation trend, it has also become the second largest cause of disease of women secondary infertility, the female fertility functional lesion caused by it
Clinically problem demanding prompt solution is turned into.
Treatment clinically for IUA at present is intended to recover uterine cavity shape, prevents adherence recurrence, promotes to damage endometrium
Reparative regeneration, recovers normal reproduction function.3 important steps for treating IUA are put in Asherman's syndrom exclusion, art under hysteroscope
Put intrauterine device, postoperative application estrogen and progestogen cycle therapy.This therapeutic modality has that treatment cycle is long, cure rate is low,
Adhesion rate is high again, the low problem of pregnancy rate.Although clinician constantly adjusts existing therapeutic scheme, still suffer from recovering at present
Uterine cavity normal morphology postfactor Endometrium injury repair ability, patient's fecundity are still difficult to the problems such as recovering normal, postoperative
1-2 pregnancy rate is only 33-56.6%, live birth rate 25-61.7%, the infertile and recurrent abortion for thus causing, premature labor, preposition
The obstetric complications such as placenta, placenta accreta or implantation seriously threaten the healthy reproduction of women.
Prevention Asherman's syndrom focuses primarily upon the design of isolation barrier, such as the carrier barrier system of Asherman's syndrom both at home and abroad at present
System, drug releasing stent etc. are only capable of helping to maintain the scheme of uterine cavity space structure.For example：Chinese patent literature discloses one kind
Uterine cavity prevents adhesion barrier system (publication number：CN104436422A), a kind of suitable type water pocket spline structure of uterine cavity is inserted by through uterine neck
The generation of postoperative adhesion again is prevented, but fails to carry the gross three-dimensional structure for promoting inner membrance repairing growth, during water pocket indwelling uterine cavity
Between it is limited, it is impossible to Preserving time；Another preventing and treating Asherman's syndrom medicine covered stnet (notification number：CN202044643U), relate to
And netted uterine cavity support, outside is coated with medicine carrying membrane, but it is unstable to there is supporting construction, medicine film non-degradable and takes out tired
Difficult problem；A kind of degradable composite active amnia material and its preparation method and application, and a kind of composite active amnia
Uterine cavity recovery support (the patent No.：CN103349798A it is crosslinking) to prepare a kind of uterine cavity recovery support, but amnion using people's amnion
Structure, inflammatory reaction is heavier after being fitted with endometrium, and sacculus takes out the deformation of process amnion support and laminating degree and cannot protect
Card, influences endometrium reparation.From the above, on the one hand currently existing scheme still suffers from that indwelling time is short, Repeated Operation
The problem of adhesion generation cannot be prevented effectively to place and take out to insert thing and insert thing.
Utility model content
A purpose of the present utility model is to provide a kind of uterus and inserts thing, and thing is inserted in the uterus can help uterus extensive
Multiple health status.
Another purpose of the present utility model is to provide a kind of uterus and inserts thing, and thing is inserted in the uterus contributes to intrauterine
The surface of a wound avoids sticking together in recovery process.
Another purpose of the present utility model is to provide a kind of imbedding system, and uterus is inserted into thing is safely and effectively placed into
Intrauterine.
Further object of the present utility model is to provide the preparation method that thing is inserted in a kind of uterus.
Above-mentioned purpose is realized by subordinate's technical scheme：
Thing is inserted in a kind of uterus, it is characterised in that thing is inserted in the uterus at least to be included body and be connected with the body
The first connecting portion for connecing；The body includes the first human body degradation material；The first connecting portion can drop including the second human body
Solution material.
Thing is inserted in uterus according to foregoing any one scheme, it is characterised in that the first connecting portion is covering
The coating at least part of surface of the body；Preferably described first connecting portion is the one kind in situations below：Described first
Connecting portion is completely covered the body；The first connecting portion covers the core of the body；The first connecting portion is covered
Cover the edge of the body；The first connecting portion covers at least part of edge of the body central and the body；Or
The first connecting portion at least covers the part edge of the body.
Thing is inserted in uterus according to foregoing any one scheme, it is characterised in that the first connecting portion is covering
The coating at least part of surface of the body, thing is inserted in the uterus includes upper end, bottom, left part and right part；
Preferably described first connecting portion is the one kind in situations below：The first connecting portion covering is located at one described of end
At least a portion of body；The first connecting portion covering is located at two at least a portion of the body of opposed end；Or
At least a portion of the first connecting portion covering positioned at the body of at least one end.
Thing is inserted in uterus according to foregoing any one scheme, it is characterised in that the first connecting portion is covering
The coating at least part of surface of the body, thing is inserted in the uterus includes upper left side end, upper right hand end portion and bottom；
Preferably described first connecting portion is the one kind in situations below：The first connecting portion covering is located at one described of end
At least a portion of body；The first connecting portion covering is located at two at least a portion of the body of end；Or it is described
At least a portion of first connecting portion covering positioned at the body of each end.
Thing is inserted in uterus according to foregoing any one scheme, it is characterised in that the first connecting portion is and institute
State laminated structure or block structure that body is connected；Preferably described first connecting portion be situations below at least one or
Combinations thereof：At least partially embedded formula of first connecting portion is connected to the body；The first connecting portion with described
Body phase is connected, and the first connecting portion is located at the edge that thing is inserted in the uterus；Or the first connecting portion with it is described
Body is connected, and the first connecting portion is located at least part of edge that thing is inserted in the uterus.
Thing is inserted in uterus according to foregoing any one scheme, it is characterised in that the first connecting portion is and institute
Laminated structure or block structure that body is connected are stated, thing is inserted in the uterus includes upper end, bottom, left part and right-hand member
Portion；Preferably described first connecting portion is at least one in situations below：The first connecting portion is inserted positioned at the uterus
One end of thing；The first connecting portion is inserted at two opposed ends of thing positioned at the uterus；Or described first
Connecting portion inserts at least one end of thing in the uterus.
Thing is inserted in uterus according to foregoing any one scheme, it is characterised in that the first connecting portion is and institute
State laminated structure or block structure that body is connected, the uterus insert thing including upper left side end, upper right hand end portion and under
End；Preferably described first connecting portion is at least one in situations below：The first connecting portion is connected with the body
Connect, and at least one end of thing is inserted positioned at the uterus；The first connecting portion is connected with the body, and is located at
Two ends of thing are inserted in the uterus；Or the first connecting portion is connected with the body, and positioned at the uterus
Insert three ends of thing.
Thing is inserted in uterus according to foregoing any one scheme, it is characterised in that thing is inserted in the uterus also to be included
Second connecting portion, the second connecting portion includes third party's body degradation material, and the second connecting portion is the covering body
And/or the coating at least part of surface of the first connecting portion；Preferably described second connecting portion is in situations below
Kind：The second connecting portion is completely covered the body and/or the first connecting portion；The second connecting portion is at least in part
Cover the body and/or the first connecting portion；The second connecting portion at least cover the body not by described first
The part that connecting portion is covered；The second connecting portion only covers the portion not covered by the first connecting portion on the body
Point；The body of at least one end of thing is inserted in the second connecting portion covering positioned at the uterus and/or covering is located at
At least a portion of the first connecting portion of at least one end of thing is inserted in the uterus；The second connecting portion covers institute
State at least part of edge of body；Or described that the second connecting portion covering is inserted on the edge of thing positioned at the uterus
At least a portion for the first connecting portion that body and/or covering are inserted on the edge of thing positioned at the uterus.
Thing is inserted in uterus according to foregoing any one scheme, it is characterised in that thing is inserted in the uterus also to be included
Second connecting portion, the second connecting portion includes third party's body degradation material, and the second connecting portion is and described body phase
The laminated structure or block structure of connection；Preferably described second connecting portion is the one kind in situations below：Second connection
At least partially embedded formula in portion is connected to the body；The second connecting portion is connected with the body, and described second connects
Socket part is located at the edge that thing is inserted in the uterus；The second connecting portion is connected with the body, and second connection
Portion is located at least part of edge that thing is inserted in the uterus；The second connecting portion is connected with the body, and positioned at described
An end of thing is inserted in uterus；Or the second connecting portion is connected with the body, and inserted positioned at the uterus
At least one end of thing.
Thing is inserted in uterus according to foregoing any one scheme, it is characterised in that the body, first connecting portion
And/or the second connecting portion has the function of promoting endometrium to repair.
Thing is inserted in uterus according to foregoing any one scheme, it is characterised in that the body, first connection
Portion and the second connecting portion each include：Polylactic acid PLA polymeric material, polyglycolic acid PGA polymeric materials, polycaprolactone (PCL),
Fatty poly-ester carbonate, PTMC, one or more in collagen protein sponge；Preferably described body, institute
State first connecting portion and the second connecting portion also each includes heparin-binding epidermal growth factors (HB-EGF).
Thing is inserted in uterus according to foregoing any one scheme, it is characterised in that the first connecting portion includes people
Or the intestinal submucosa tissue of mammal；Preferably described first connecting portion also includes estrogen, vascular endothelial growth factor
One or more in sub (VEGF) or basic fibroblast growth factor (bFGF)；Or preferably described first connecting portion
Also include anti-inflammatory drug；And/or the second connecting portion includes the intestinal submucosa tissue of people or mammal；Preferably institute
Stating second connecting portion also includes estrogen, VEGF (VEGF) or basic fibroblast growth factor (bFGF)
In one or more；Or preferably described second connecting portion also includes anti-inflammatory drug.
Thing is inserted in uterus according to foregoing any one scheme, it is characterised in that thing is inserted in the uterus can be real
It is adapted to the shape of uterine cavity in matter.
Thing is inserted in uterus according to foregoing any one scheme, it is characterised in that thing is inserted in the uterus has ladder
Shape, triangle, heart, circle or annular shape.
Thing is inserted in uterus according to foregoing any one scheme, it is characterised in that the body be sheet, Y-shaped,
T-shaped, V-shaped or O fonts；Enable that the shape that thing is substantially adapted to uterine cavity is inserted in the uterus.
Thing is inserted in uterus according to foregoing any one scheme, it is characterised in that thing is inserted in the uterus to be included dashing forward
Go out portion, the protuberance is prevented from uterine neck internal orifice adhesion；Preferably described protuberance is included in the bottom.17.
The imbedding system of thing is inserted in a kind of uterus, it is characterised in that including the son described in any one in preceding claims
Thing and embedded device are inserted in palace, and there is the embedded device receiving uterus to insert the tubular-shaped structures of thing and push the uterus
Insert the action bars of thing.
The preparation method of thing is inserted for preparing the uterus according to foregoing any one scheme, it is characterised in that bag
Include it is following for preparing first connecting portion the step of：
(1) the preposition treatment of small intestine and previous cleaning
Small intestine's cleaning of fresh slaughtered animals is chosen, submucous layer of small intestine is isolated；
(2) inactivation of virus
Using Peracetic acid-ethanol solution method inactivation of viruses, the constant-temperature ultrasonic cleaning that the step can vibrate in rinse bath
Carried out in device；
(3) cell is taken off
Carried out in the constant-temperature ultrasonic washer that rinse bath can vibrate, first inserted in rinse bath biomaterial, so
Sodium hydroxide solution is injected in rinse bath afterwards, washer is opened and is cleaned, closed washer and sodium hydroxide solution inclines
Go out, injection phosphate buffer is cleaned, and is then again turned on washer and is cleaned, the phosphate-buffered after detection cleaning
The pH value of liquid, after pH reaches predetermined value, with the water for injection cleaning material for flowing, end when detection electrical conductivity is not higher than predetermined value
Only；
(4) DNA removings treatment
Carried out in the constant-temperature ultrasonic washer that rinse bath can vibrate, sodium chloride solution is injected in rinse bath, opened
Washer is cleaned, then the water for injection cleaning material to flow, and detection electrical conductivity terminates when being not higher than predetermined value；
(5) it is molded
Fixed including fixture, be coated with body, freeze-drying and laser micropore 4 steps of punching, biomaterial is compressed into tablet form,
It is fixed on fixture, then uses water for injection cleaning, the material that will have attached to fixture is coated in this in vitro, is put in freezing
In drying machine, freeze-drying is carried out according to the lyophilized flow being pre-designed, after the completion of freezing, beaten using laser micropore puncher
Hole.
Preparation method according to foregoing any one scheme, it is characterised in that the animal origin in the step (1)
It is tire ox, new born bovine, tire pig or neonatal pig.
Preparation method according to foregoing any one scheme, the body including collagen sponge, its feature exists
In the preparation process of the collagen protein sponge is as follows：
Collagen protein powder, chitosan powder, sodium alginate are mixed and is dissolved in aqua sterilisa distilled water, be mixed into collagen pre-
Standby liquid；After by preparation liquid sterilization treatment, in gnotobasis, pour in a mold, described uterine cavity branch is obtained after cool drying
Support arrangement.
Preparation method according to foregoing any one scheme, it is characterised in that：The mixing of collagen preparation liquid is molten
The mass fraction of each component is in liquid：Collagen protein powder 0.1-48 mass parts, chitosan powder 0.1-48 mass parts, sodium alginate powder
0.05-2 mass parts.
Brief description of the drawings
Fig. 1 is the uterus schematic diagram under normal condition；
Fig. 2 is the schematic diagram sticked together in the uterine cavity of uterus；
Fig. 3 a-3b are respectively the front view and sectional view that thing is inserted according to the uterus of one implementation method of the utility model；
Fig. 4 a-4b are respectively the front view and section view that thing is inserted according to the uterus of the utility model another implementation method
Figure；
Fig. 4 c-4d are respectively the front view and section view that thing is inserted according to the uterus of the utility model another implementation method
Figure；
Fig. 4 e-4f are respectively the front view and section view that thing is inserted according to the uterus of the utility model another implementation method
Figure；
Fig. 4 g-4h are respectively the front view and section view that thing is inserted according to the uterus of the utility model another implementation method
Figure；
Fig. 4 i-4j are respectively the front views that thing is inserted according to the uterus of the utility model other embodiment；
Fig. 5 a-5b are respectively the front view and section view that thing is inserted according to the uterus of the utility model another implementation method
Figure；
Fig. 5 c-5d are respectively the sectional views of the alternative that thing is inserted in uterus shown in Fig. 5 b；
Fig. 5 e-5f are respectively the front view and section view that thing is inserted according to the uterus of the utility model another implementation method
Figure；
Fig. 5 g-5h are respectively the front view and partial cutaway that thing is inserted according to the uterus of the utility model another implementation method
View；
Fig. 5 i-5l are respectively the front views that thing is inserted according to the uterus of the utility model other embodiment；
Fig. 6 a-6b are respectively the front view and section view that thing is inserted according to the uterus of the utility model another implementation method
Figure；
Fig. 6 c-6d are respectively the section views of the front view that thing is inserted according to the uterus of the utility model another implementation method
Figure；
Fig. 6 e-6g are respectively the front views that thing is inserted according to the uterus of the utility model other embodiment；
Fig. 6 h-6i are respectively the section views of the front view that thing is inserted according to the uterus of the utility model another implementation method
Figure；
Fig. 6 j-6l are respectively the front views that thing is inserted according to the uterus of the utility model other embodiment；
Fig. 7 a-7b are respectively the front view and section view that thing is inserted according to the uterus of the utility model another implementation method
Figure；
Fig. 8 is the front view that thing is inserted according to the uterus of the utility model another implementation method；
Fig. 9 is the profile of the imbedding system that thing is inserted according to the uterus of one implementation method of the utility model.
Above-mentioned accompanying drawing is used and carries out complementary explanation to the technical solution of the utility model, to help to be expressly understood this
Utility model.But, not the utility model is defined using the purpose of above-mentioned accompanying drawing.Additionally, content is not in accompanying drawing
It is drawn to scale, thus be also not construed as to limitation of the present utility model.The entirety of the content shown in accompanying drawing or its
Middle part can be combined and be changed based on art technology.
Specific embodiment
Based on the profile of uterus uterine cavity, thing is inserted in uterus has the shape for being adapted to uterus uterine cavity, is suitable for uterus
Insert thing and insert uterine cavity.Thing is inserted in uterus can also have have a generally triangular shape, trapezoidal, heart-shaped, circular or annular foreign steamer
It is wide.It can also be the shape on the whole with wide end and narrow end that thing is inserted in uterus, and uterine cavity is placed into adapt to uterine cavity.Due to system
Inserting the material of thing has certain flexibility, therefore inserts thing and can be adapted to the shape of uterine cavity by suitable profile,
The shape of uterine cavity can also be equally adapted to based on the dough deformation for inserting thing material.Further, uterus is inserted under thing
End can also include protuberance for preventing uterine neck from sticking together.
Uterine cavity front and rear wall is isolated using thing is inserted, is helped avoid inner membrance and is sticked together.The utility model uses people
The degradable material of body so that only once inserted operation and put into thing and be put into uterine cavity, without taking out again.Recover in inner membrance
Thing degraded is inserted afterwards so that the taking-up operation without carrying out inserting thing again, so on the one hand alleviate the pain of patient, more greatly
Benefit be fundamentally avoid to implement to take out the secondary insult for inserting the endometrium that the operation of thing is brought, it is to avoid two
Secondary wound also eliminates the possibility for sticking together again naturally.
The utility model uses include two or more parts to insert thing, in whole inner membrane of uterine cavity Restoration stage, puts
Enter thing and buffer action is on the one hand played in uterine cavity, on the other hand the part for recovering function with auxiliary therein can help interior
Film recovers.According to the actual conditions of patient, the region with pharmaceutical activity on thing can be inserted by design and select intrauterine
By medicine region, to carry out the targetedly treatment of wound or the surface of a wound, it is possible to reduce absorption of the Non-invasive surface to medicine.
It is also an option that thing is inserted in three kinds of composition described above parts, using such setting can be to further refinement uterus
Inner membrance Restoration stage, and the material and/or active material of thing part are inserted for each Restoration stage；Additionally, may be used also
The region that can targetedly aid in the cause of disease recovering is carried with the wound for intrauterine different pathogeny or surface of a wound selection, with
Intrauterine difference wound or the surface of a wound is set targetedly to be treated.
Fig. 3 a are the front views that thing is inserted according to the uterus of one implementation method of the utility model；Fig. 3 b are that Fig. 3 a are related to
The line A-A sectional view of implementation method.Knowable to Fig. 3 a and Fig. 3 b, in this embodiment, thing is inserted in uterus includes the He of body 1
The first connecting portion 2 being connected with body, wherein first connecting portion 2 coat body 1 completely.Body 1 and first connecting portion 2 all can be by
Human body degradation material makes.The two can contribute to the function that endometrium is repaired.Body 1 can include polylactic acid PLA
Polymeric material, polyglycolic acid PGA polymeric materials, polycaprolactone (PCL), fatty poly-ester carbonate, PTMC, collagen
One or more in protein sponge.The first connecting portion 2 can include the intestinal submucosa tissue of people or mammal.
By the selection to body and first connecting portion material, first connecting portion can be made to be played in wound or surface of a wound initial stages of restoration and to be made
With, and degraded by human body in initial stages of restoration.And body then the phase plays a role after recovery, and degrade.Preferably, described
Body 1 also includes heparin-binding epidermal growth factors (HB-EGF).Mentioned component can help endometrium effectively to recover.Preferably
The first connecting portion 2 can also include estrogen, VEGF (VEGF) or basic fibroblast growth because
One or more in sub (bFGF), or preferably described first connecting portion 2 is also including anti-inflammatory drug, to contribute to intrauterine
Film avoids the occurrence of inflammation when recovering.Additionally, first connecting portion 2 can also to be only completely covered body 1 unilateral, such structure can be with
Reduce the consumption of first connecting portion material requested and/or reduce the amount that active material is used in first connecting portion, so as to reduce into
This.
As it was previously stated, the profile based on uterus uterine cavity, thing is inserted in uterus has the shape for being adapted to uterus uterine cavity, with suitable
Uterine cavity is inserted in uterus is inserted into thing.Thing is inserted in uterus can also have have a generally triangular shape, trapezoidal, circular or annular shape
Shape or outline.It can also be the shape on the whole with wide end and narrow end that thing is inserted in uterus, and palace is placed into adapt to uterine cavity
Chamber.
Additionally, body can be the sheet as described in Fig. 3 a and 3b, for ensure uterus insert thing have it is enough
Intensity, can carry out inserting operation, and adapt to uterus uterine cavity shape after inserting.Additionally, body 1 can also be T-shaped, Y words
Shape, V-shaped or O fonts, and enough intensity is provided to insert thing, can equally carry out inserting operation, and inserting
After make to insert thing and adapt to uterus uterine cavity shape.
Fig. 4 a-4i are respectively the schematic diagram or sectional view that thing is inserted according to the uterus of the utility model other embodiment.
When wound and the surface of a wound do not spread all over whole uterine cavity, first connecting portion can be directed to and easily wound and wound occur
The position in face is configured.For example, being carried out for the wound or the surface of a wound that palace of the Qing Dynasty operation, Asherman's syndrom eliminate the intrauterine surgicals such as operation
Set.Fig. 4 a are that, according to one front view of implementation method of the utility model, Fig. 4 b are the B-B of the implementation method involved by Fig. 4 a
Line sectional view.As illustrated, first connecting portion 2 wherein to be set to cover the core of the body；Contribute to correspondence position
The wound or the surface of a wound put are recovered.And first connecting portion is not provided with other positions, to reduce material needed for first connecting portion
The consumption of material and/or active material, so as to reduce absorption of the human body to unnecessary material.
Further, since uterus is front and rear be in the normal state close to, thus uterine cavity wall has folding position, in these folding positions
Relatively easily stick together., it is necessary to aid in wound or the surface of a wound to recover in corresponding position after these adhesions are eliminated.Involved by Fig. 4 c
And implementation method in, first connecting portion 2 is set to cover the marginal portion of the body 1；For the wound of correspondence position
Or the surface of a wound is recovered.Although the whole edge of body 1 is all covered by first connecting portion 2 in Fig. 4 c, it is actually used in can also
By the way of covering part edge, for example, cover three edges in direction.Fig. 4 d are the line C-Cs of the implementation method that Fig. 4 c are related to
Profile.
Uterus uterine cavity connects fallopian tubal respectively in left and right upper lateral part, and connects uterine neck, these positions in uterus uterine cavity bottom
Put and fall within the incidental region of adhesion, thus uterus is inserted thing and can targetedly be designed.Knot shown by Fig. 4 e
In structure, thing is inserted in uterus includes upper left end 8a, upper right end 8b and bottom 9；The covering of first connecting portion 2 is located at left upper end
Body 1 in portion 8a, upper right end 8b and bottom 9.Fig. 4 f show the D line partial sectional views of upper right end 8b, wherein the
Body 1 in the covering upper right of two connecting portion 2 end 8b.
In structure shown by Fig. 4 g, thing is inserted in uterus includes upper end 8 and bottom 9, and the covering of first connecting portion 2 is located at
Body 1 in upper end 8 and bottom 9.Fig. 4 f are the E-E line sectional views of the implementation method involved by Fig. 4 g.Fig. 4 i and 4j point
It is not the front view that thing is inserted according to the uterus of the utility model other embodiment, involved uterus is inserted in wherein Fig. 4 i
Thing includes left part and right part, body 1 of the covering of first connecting portion 2 in left part 5 and right part 4.The implementation method
F-F lines sectional view it is same or similar with Fig. 4 d.In implementation method involved by Fig. 4 j, first connecting portion 2 covering upper end, under
End and central part, its G-G lines sectional view are same or similar with Fig. 4 b.
Structure according to shown by above-mentioned figure, these related embodiments cause that the restitution for inserting thing has more and are directed to
Property, while the relative use for reducing unnecessary medicine or therapeutant, also reduces human body to unnecessary medicine or therapeutant
Absorb.Preferably for the situation in Fig. 4 g and 4i, first connecting portion 2 can be made only to cover according to wound or surface of a wound physical location
Body of the lid in an end, two ends or three ends for inserting thing, and not all end；Can also be to therein
Each end is combined, and thing is inserted to obtain the stronger uterus of specific aim.
Uterus shown in Fig. 4 a-4j is inserted in thing and its distressed structure, and first connecting portion 2 can cover the list of body
Side, or first connecting portion 2 can cover the corresponding position of bilateral of body, or correspond to wound according to thing upper and lower surface is inserted
With the physical location of the surface of a wound, carry out by the independent assortment of the coating position of unilateral first connecting portion 2 shown in Fig. 4 a-4j.
Further preferably, the body 1 can also include anti-inflammatory drug, estrogen or other cells for promoting inner membrance to repair
The factor, for example：VEGF (VEGF), basic fibroblast growth factor (bFGF) etc., to contribute to inner membrance
Recover.
According to other implementation methods of the application, first connecting portion 2 is the laminated structure or block being connected with the body
Shape structure.Fig. 5 a-5i show position of the first connecting portion 2 in thing is inserted in uterus.Wherein, in the implementation method shown in Fig. 5 a,
In thing center position insertion body 1 is inserted, the insertion can be that first connecting portion 2 is embedded in body 1 to first connecting portion 2
Single side face, and body 1 is not penetrated；Or first connecting portion 2 includes that two parts are embedded in the front and rear side of body 1 respectively
Face, and the two is mutually not in contact with each other；Or first connecting portion 2 is embedded in body 1 in the way of penetrating；Details can be by ginseng
See Fig. 5 b-5d and will be readily understood that.
Another implementation method involved by Fig. 5 e, wherein first connecting portion 2 are inserting the whole margin location in body 1 of thing
Put and be connected with body 1, accompanying drawing 5f is the sectional view of the implementation method.Accompanying drawing 5g, 5i, 5j and 5k are replacing for above-mentioned implementation method
For implementation method, wherein：Referring to Fig. 5 g, wherein first connecting portion 2 insert the upper left end of thing, upper right end and bottom with
Body 1 is connected.First connecting portion 2 can also only in three ends for inserting thing one or two end vicinity
It is connected with body.Fig. 5 h are part sectioned views of Fig. 5 g at J lines, as can see from Figure 5 body 1 and the phase of first connecting portion 2
Connection.Referring to Fig. 5 i, first connecting portion 2 is connected with body 1 at the neighbouring position in both the upper end and bottom of thing inserting.
First connecting portion 2 only can also be connected near the upper end or bottom for inserting thing with body.Referring to Fig. 5 j, wherein first
Connecting portion 2 is connected with body 1 inserting the left side of thing and right side edge.First connecting portion 2 only can also insert the institute of thing
State and be connected with body 1 at left side edge or right side edge.Referring to Fig. 5 k, first connecting portion 2 at the part edge for inserting thing with
Body is connected.Structure wherein shown in K-K, L-L and M-M line section of Fig. 5 i, 5j and 5k and Fig. 5 f is same or similar.
The utility model further relates to alternative mode, wherein in the alternative of Fig. 5 e-5k implementation methods, the company
It can be that first connecting portion 2 is connected with the edge of body 1 to connect, or the first connecting portion 2 is embedded in the single side face of body 1, and
Body 1 is not penetrated；Or first connecting portion 2 includes that two parts are embedded in the front and back sides of body 1, and the two phase respectively
It is not in contact with each other；Or first connecting portion 2 is embedded in body 1 in the way of penetrating.
Implementation method of the present utility model further includes second connecting portion.Referring to Fig. 6 a-6b, wherein Fig. 6 a are according to this
The front view of thing is inserted in the uterus of utility model another implementation method, and Fig. 6 b are the O-O lines that thing is inserted in uterus shown in Fig. 6 a
Sectional view.
According to Fig. 6 a, thing is inserted in the uterus of the implementation method has same or analogous profile with foregoing thing of inserting；According to figure
Thing is inserted with three part-structures, including body 1, first connecting portion 2 and second connecting portion 3 in 5b, the uterus in the implementation method.
Wherein body 1 and first connecting portion 2 be identical with the structure being related in implementation method and associated description corresponding to Fig. 3 a-3b or phase
Seemingly, the material that wherein body 1 and first connecting portion 2 are used also with the implementation method and associated description corresponding to Fig. 3 a-3b in
The material being related to is same or similar.Second connecting portion 3 is outermost coating.Second connecting portion 3 coats first connecting portion 2 completely.The
Two connecting portions 3 also have the function of promoting endometrium to repair.
The second connecting portion 3 includes third party's body degradation material.Preferably, second connecting portion 3 can include people or
The intestinal submucosa tissue of mammal.By the selection to body and second connecting portion material, second connecting portion can be made
Played a role in wound or surface of a wound initial stages of restoration, and degraded by human body in initial stages of restoration.And first connecting portion 2 can be in recovery
Phase plays a role, and degrades.Then the phase plays a role body 1 after recovery, and degrades.Preferably, described second connects
Socket part includes anti-inflammatory drug, to contribute to endometrium to recover.Preferably, the second connecting portion also includes heparin binding epidermal
Growth factor (HB-EGF).Mentioned component can help endometrium effectively to recover.Preferably described second connecting portion can be with
Including the one kind or many in estrogen, VEGF (VEGF) or basic fibroblast growth factor (bFGF)
Kind.
As can be seen that second connecting portion 3 can in a variety of ways be covered in the first company from the structure involved by Fig. 6 c-6g
Socket part 2.Although it is not shown in the figure, second connecting portion 3 can also at least cover second connecting portion 2 and/or body 1.It is preferred that
Ground, the area of second connecting portion 3 can be bigger or small than the area of first connecting portion 2.
From the structure involved by Fig. 6 h-6l as can be seen that second connecting portion 3 can in a variety of ways with first connecting portion
2 complementally coat body 1.Could also say that, second connecting portion only covers the surface of the body 1 not covered by first connecting portion 1.
Or, second connecting portion 3 at least coats the surface of the body 1 not coated by first connecting portion 2.Preferably, second connecting portion 3
The surface of body 1 can be located at with the complementation of first connecting portion 2 and with the partly overlapping mode of first connecting portion 2.
Preferably, second connecting portion 3 and/or first connecting portion 1 can also only coat the one side of body 1.To reduce material
Usage amount and the unnecessary drug absorption of reduction.
According to other embodiment of the present utility model, implementation method involved by Fig. 5 a-5i insert thing on the basis of,
Second connecting portion 3 is further included, the second connecting portion 3 is the laminated structure or block structure being connected with the body.
Fig. 7 a and 7b show a kind of specific embodiment, and wherein first connecting portion 2 and second connecting portion 3 is located at the left and right two for inserting thing
Side, and be connected with body 1.Although it is not shown in the figure, second connecting portion 3 can be replaced shown in accompanying drawing 5g, 5i and 5j
Some in multiple first connecting portions 2 in structure, or second connecting portion 3 can replace knot shown in accompanying drawing 5a, 5e, 5k and 5i
The part in a first connecting portion 2 in structure, is connected so as to be constituted with first connecting portion 2 with the combined type of body 1.
On the basis of the implementation method involved by any one aforementioned figures, thing is inserted in uterus therein can also be included
There are protuberance 4, structure shown in Figure 8.Because adhesion is same it can also happen that in uterine neck, thus can be by the protuberance
4 are placed in uterine neck, prevent the adhesion occurred in recovery process.The protuberance 4 can be included in any foregoing reality
The bottom of thing is inserted in the mode uterus of applying.Preferably shown protuberance is contained in the lower end that thing is inserted in uterus.Or preferably,
Shown protuberance can be formed by body according to actual conditions, formed by first connecting portion or formed by second connecting portion,
Or combined by body, first connecting portion and/or second connecting portion and formed.Preferably, can also be formed by body, and by first
Connecting portion and/or second connecting portion are covered；Or formed by first connecting portion and covered by second connecting portion；Or with other classes
As material and mode formed.
In the utility model, in each implementation method for body, first connecting portion and the respective selection of second connecting portion
Mode is general.Between body, first connecting portion and second connecting portion can using directly coating, biological glue sticking, sew up
Mode is connected.Can also using combination pour by the way of or pressure insertion mode be fitted together to.Or use 3D printing
Mode is connected or generated.
Can be set with using different materials according to the different activities composition needed for endometrium diverse location
First connecting portion 2 and second connecting portion 3, or using first connecting portion 2 and second connecting portion 3 with different activities composition.
The first connecting portion 2 and the of the identical drug ingedient with various concentrations can also be set according to the order of severity of wound or the surface of a wound
Two connecting portions 3.
Fig. 9 is the imbedding system that thing is inserted according to the uterus of an implementation method of the present utility model, the imbedding system
Including that can accommodate the tubular-shaped structures 6 of the inner matter 7 and push the action bars 5 that the main body of thing 7 is inserted in uterus, control stick is in pipe
Can freely advance in type structure or retreat, arbitrarily inserting thing inserts uterine cavity by foregoing.Wherein described tubular-shaped structures can be with
It is stereoplasm tube or the pipe with certain flexibility, diameter can be 0.5-4 centimetres, preferably 1-3 centimetres or preferably 2 centimetres.
According to an implementation method of the present utility model, the biology of the de- cell epimatrix that non-corium can be originated
Material is used in the prevention and treatment of Asherman's syndrom.The extracellular base with animal tissue as raw material based on organizational engineering principle
Matter (extracellular matrix, ECM) material is the main development direction of medical embedded material.ECM is by various big points
The sub- material such as composition such as collagen, non-collagen glycoprotein, aminoglycan, proteoglycans, elastin laminin, builds with structure by a certain percentage
Into it is complicated organic three-dimensional overall, for the existence and activity of various cells provide suitable place and microenvironment, can adjust
Save growth, shape, metabolism, migration, propagation and the differentiation of various cells, and then organization of regulation control and organ dysfunction.
It is the outer base of the optimal de- cell comprising promotion organization reparation and regeneration by the material selection of first connecting portion
The biomaterial in matter source, combines with the degradable body in utero conforming to uterine cavity shape, is formed a set of with uterus
Thing is inserted in the uterus of inner membrance repair function
By changing the animal origin of cell epimatrix material, the utility model is by pig or the submucous layer of small intestine of Niu Laiyuan
Tire pig, neonatal pig or tire ox, the submucous layer of small intestine in new born bovine source are changed to, make the utility model with existing similar products phase
Than, immunogenicity can be preferably reduced, inflammatory reaction promotes the recovery of endometrial morphology and function
As first connecting portion and/or the preparation method of the biomaterial of second connecting portion, including following operating procedure：
(1.1) the preposition treatment of small intestine and previous cleaning
The fresh small intestine's cleaning for butchering tire pig, neonatal pig or tire ox, new born bovine is chosen, mucous membrane of small intestine is isolated
Lower floor, is rinsed 3 times using sterile water for injection；
(1.2) inactivation of virus
Using Peracetic acid-ethanol solution method inactivation of viruses, the constant-temperature ultrasonic cleaning that the step can vibrate in rinse bath
Carried out in device, wherein the volumn concentration of Peracetic acid is 0.05~0.2%, and inactivation time is 1~2h, and temperature range is 4
~40 DEG C, then cleaned 2~5 times in phosphate buffer, each 15min, the pH of the phosphate buffer after detection cleaning
Value, after pH reaches 6.5-7.5, with the water for injection cleaning material for flowing, end when detection electrical conductivity reaches 1.5 μm/below s
Only；
(1.3) cell is taken off
The step is carried out in the constant-temperature ultrasonic washer that rinse bath can vibrate, and biomaterial is inserted into rinse bath first
In, sodium hydroxide solution is then injected in rinse bath, washer is opened, scavenging period is 5~30min, sodium hydroxide solution
Concentration is 5~100mmol/L, is then shut off washer, and sodium hydroxide solution is poured out, and injection phosphate buffer is carried out clearly
Wash, open washer, scavenging period is 5~20min, phosphate buffer repeated washing 2~5 times, the phosphoric acid after detection cleaning
The pH value of salt buffer, after pH reaches 6.5-7.5, with the water for injection cleaning material for flowing, detection electrical conductivity reaches 1.5 μ
Terminate during below m/s；
(1.4) DNA removings treatment
The step is carried out in the constant-temperature ultrasonic washer that rinse bath can vibrate, and sodium chloride solution is injected into rinse bath
In, washer is opened, scavenging period is 5~30min, and concentration of sodium chloride solution is 0.015mol/l or 2mol/L, and pH value does not surpass
7.8 are crossed, then the water for injection cleaning material to flow, detection electrical conductivity terminates when reaching 1.5 μm/below s；
(1.5) it is molded
4 steps that the step is fixed including fixture, coating stent, freeze-drying and laser micropore punch, by biomaterial 2~4
Layer is compressed into tablet form, and is fixed on fixture, then uses water for injection cleaning, and the material that will have attached to fixture is coated in this
In vitro, it is put in freeze drier, freeze-drying is carried out according to the lyophilized flow being pre-designed：Pre-freeze is protected to -25~-50 DEG C
Temperature 0.5~4 hour, heats up 15 DEG C, is incubated 4~12 hours, heats up 15 DEG C, is incubated 0.5~4 hour, is warming up to 25 DEG C, insulation 4
Hour, after the completion of freezing, being punched using laser micropore puncher, pore diameter range is 0.5~2mm, and hole is at intervals of 0.3~0.5cm.
Preferably, tire pig, neonatal pig or tire ox, new born bovine, more preferably tire pig in the step (1.1).
Preferably, the step, in the step (1.2), (1.3), (1.4) rinse bath frequency of oscillation be 100~
300rpm, more preferably 200rpm.
Preferably, ultrasonic frequency is 20~80KHZ in the step (1.2), (1.3), (1.4), further preferably
It is 45KHZ.
The compound method of phosphate buffer described in the utility model for claim 7.9gNaCl, 0.2gKCl,
0.24gKH2PO4、1.8gK2HPO4, it is dissolved in 800ml distilled water, the pH value of solution is adjusted to 7.4 with HCl, then add distilled water
It is settled to 1L.
The use standard of water for injection specifies according in NF in the utility model.
The supersonic wave cleaning machine that rinse bath described in the utility model can vibrate is by the clear of conventional ultrasonic wave cleaning machine
Washing trough
It is combined with mechanical oscillator, enables rinse bath that machinery concussion to occur while ultrasonic wave is cleaned, is realized
Mechanical oscillation is cleaned to combine simultaneously with ultrasonic wave and played a role.
Preferably, according to another implementation method of the present utility model, wherein can be used for the selection of bulk material
Following manner.
The material that the body that thing is inserted in uterus is used is polylactic acid PLA polymeric material, and polyglycolic acid PGA polymeric materials gather
Caprolactone PCL, fatty poly-ester carbonate, PTMC, the one kind in collagen protein sponge.It is wherein specific to prepare
Can adopt with the following method.
(2.1) preparation of collagen protein sponge
Collagen protein powder, chitosan powder, sodium alginate are mixed and is dissolved in aqua sterilisa distilled water or comprising cell factor or medicine
In the solution of thing composition, collagen preparation liquid is mixed into；After by preparation liquid sterilization treatment, in gnotobasis, palace is cast in
In the mould of chamber form, described body is obtained after cool drying, wherein the mass percent of each component is in mixed solution：Glue
Former albumen powder 0.1-48 mass parts, chitosan powder 0.1-48 mass parts, sodium alginate powder 0.05-2 mass parts.
(2.2) packaging sterilizing
In gnotobasis, thing is inserted into uterus and is compressed at the upper end open of embedded device, to be put into cylinder structure,
Inserted in cylinder structure at control stick autonomous agent embedded device lower ending opening, packed under aseptic conditions, one layer of use
Spy defend strong paper, another layer use vinyon, sterilized using oxirane after the completion of packaging.
Preferably, collagen protein sponge prepares solution, more preferably factor-containing in the step (2.1)
Or the solution of drug solution, the mass fraction of each component is for more preferably：The mass parts of collagen protein powder 18, chitosan powder 12
Mass parts, the mass parts of sodium alginate powder 0.8.
The utility model is by the outer base of the optimal de- cell of generally acknowledged in the world at present promotion organization reparation and regeneration
The biomaterial in matter source, inserts thing and combines with the degradable uterus in utero conforming to uterine cavity shape, forms a cover
Endometrium reparation supports barrier system, the Asherman's syndrom and the postoperative uterine cavity of Asherman's syndrom caused after effective prevention uteroventral operation
Adhesion again.
It is of the present utility model develop it is a can voluntarily be degraded in uterine cavity, and good elasticity and just can be provided
Property, thing is inserted with the uterus for conforming to uterine cavity shape, this is inserted thing and includes cytokine profiles or pharmaceutical component, and slowly releases
Put, the recovery of endometrial morphology and function can be advantageously promoted.
Compared with prior art, the utility model prepares biomaterial, with following remarkable advantage and beneficial effect：This reality
With the new animal origin for changing cell epimatrix material, using tire pig submucous layer of small intestine as extracellular matrix material
Material source, is effectively reduced harmful antibody and complement component, preferably reduces immunogenicity, reduces xenograft and draws
The immunization inflammatory reaction for rising, more effectively promotes the recovery of endometrial morphology and function.
Claims (25)
1. thing is inserted in a kind of uterus, it is characterised in that
Thing is inserted in the uterus at least includes body and the first connecting portion being connected with the body；
The body includes the first human body degradation material；
The first connecting portion includes the second human body degradation material.
2. thing is inserted in uterus according to claim 1, it is characterised in that
The first connecting portion is the coating at least part of surface for covering the body.
3. thing is inserted in uterus according to claim 1, it is characterised in that
The first connecting portion is the one kind in situations below：
The first connecting portion is completely covered the body；
The first connecting portion covers the core of the body；
The first connecting portion covers the edge of the body；
The first connecting portion covers at least part of edge of the body central and the body；Or
The first connecting portion at least covers the part edge of the body.
4. thing is inserted in uterus according to claim 1, it is characterised in that
The first connecting portion is the laminated structure or block structure being connected with the body.
5. thing is inserted in uterus according to claim 1, it is characterised in that
The first connecting portion is at least one or combinations thereof in situations below：
At least partially embedded formula of first connecting portion is connected to the body；
The first connecting portion is connected with the body, and the first connecting portion is located at the side that thing is inserted in the uterus
Edge；Or
The first connecting portion is connected with the body, and the first connecting portion inserts thing at least positioned at the uterus
Part edge.
6. thing is inserted in uterus according to claim 1, it is characterised in that
The first connecting portion is the coating at least part of surface for covering the body, and thing is inserted in the uterus includes upper end
Portion, bottom, left part and right part；The first connecting portion is the one kind in situations below：
The first connecting portion covering is located at an at least a portion for the body of end；
The first connecting portion covering is located at two at least a portion of the body of opposed end；Or
At least a portion of the first connecting portion covering positioned at the body of at least one end.
7. thing is inserted in uterus according to claim 1, it is characterised in that
The first connecting portion is the laminated structure or block structure being connected with the body, and thing is inserted including upper in the uterus
End, bottom, left part and right part；The first connecting portion is at least one in situations below：
The first connecting portion is located at the end that thing is inserted in the uterus；
The first connecting portion is inserted at two opposed ends of thing positioned at the uterus；Or
The first connecting portion is located at least one end that thing is inserted in the uterus.
8. thing is inserted in uterus according to claim 1, it is characterised in that
The first connecting portion is the coating at least part of surface for covering the body, and thing is inserted in the uterus includes upper left side
End, upper right hand end portion and bottom；The first connecting portion is the one kind in situations below：
The first connecting portion covering is located at an at least a portion for the body of end；
The first connecting portion covering is located at two at least a portion of the body of end；Or
At least a portion of the first connecting portion covering positioned at the body of each end.
9. thing is inserted in uterus according to claim 1, it is characterised in that
The first connecting portion is the laminated structure or block structure being connected with the body, and thing is inserted in the uterus includes a left side
Upper side end, upper right hand end portion and bottom；The first connecting portion is at least one in situations below：
The first connecting portion is located at least one end that thing is inserted in the uterus；
The first connecting portion is located at two ends that thing is inserted in the uterus；Or
The first connecting portion is located at three ends that thing is inserted in the uterus.
10. thing is inserted in the uterus according to any one of preceding claims 1-9, it is characterised in that
Thing is inserted in the uterus also includes second connecting portion, and the second connecting portion includes third party's body degradation material, described
Second connecting portion is coating or at least part of surface of the first connecting portion at least part of surface for covering the body
Coating.
Thing is inserted in 11. uterus according to any one of preceding claims 1-9, it is characterised in that
Thing is inserted in the uterus also includes second connecting portion, and the second connecting portion includes third party's body degradation material, described
Second connecting portion is coating or at least part of surface of the first connecting portion at least part of surface for covering the body
Coating；The second connecting portion is the one kind in situations below：
The second connecting portion is completely covered the body or the first connecting portion；
The second connecting portion is completely covered the body and the first connecting portion；
The second connecting portion covers the body or the first connecting portion at least in part；
The second connecting portion at least covers the part not covered by the first connecting portion of the body；
The second connecting portion only covers the part not covered by the first connecting portion on the body；
The body of at least one end of thing is inserted in the second connecting portion covering positioned at the uterus, or covering is located at institute
State uterus insert thing at least one end the first connecting portion at least a portion；
The second connecting portion covers at least part of edge of the body；Or
At least a portion for the body that the second connecting portion covering is inserted on the edge of thing positioned at the uterus or covering
At least a portion of the first connecting portion on the edge that thing is inserted in the uterus.
Thing is inserted in 12. uterus according to any one of preceding claims 1-9, it is characterised in that
Thing is inserted in the uterus also includes second connecting portion, and the second connecting portion includes third party's body degradation material,
The second connecting portion is the laminated structure or block structure being connected with the body；The second connecting portion is following
One kind in situation：
At least partially embedded formula of second connecting portion is connected to the body；
The second connecting portion is connected with the body, and the second connecting portion is located at the side that thing is inserted in the uterus
Edge；
The second connecting portion is connected with the body, and the second connecting portion inserts thing at least positioned at the uterus
Part edge；
The second connecting portion is connected with the body, and an end of thing is inserted positioned at the uterus；Or
The second connecting portion is connected with the body, and at least one end of thing is inserted positioned at the uterus.
Thing is inserted in 13. uterus according to preceding claims 10, it is characterised in that
The body, the first connecting portion and the second connecting portion each include：Polylactic acid PLA polymeric material, PVOH
Sour PGA polymeric materials, polycaprolactone (PCL), fatty poly-ester carbonate, PTMC, in collagen protein sponge one
Plant or various.
Thing is inserted in 14. uterus according to preceding claims 13, it is characterised in that
The body, the first connecting portion and the second connecting portion also each include heparin-binding epidermal growth factors.
Thing is inserted in 15. uterus according to any one in preceding claims 1-9, it is characterised in that
The first connecting portion includes the intestinal submucosa tissue of people or mammal.
Thing is inserted in 16. uterus according to preceding claims 15, it is characterised in that
The first connecting portion is also including in estrogen, VEGF or basic fibroblast growth factor
Plant or various；Or first connecting portion is stated also including anti-inflammatory drug.
Thing is inserted in 17. uterus according to preceding claims 10, it is characterised in that
The second connecting portion includes the intestinal submucosa tissue of people or mammal.
Thing is inserted in 18. uterus according to preceding claims 17, it is characterised in that
The second connecting portion is also including in estrogen, VEGF or basic fibroblast growth factor
Plant or various；Or the second connecting portion also includes anti-inflammatory drug.
Thing is inserted in 19. uterus according to any one in preceding claims 1-9, it is characterised in that
Thing is inserted in the uterus can substantially be adapted to the shape of uterine cavity；Or
Thing is inserted in the uterus has trapezoidal, triangle, heart, circle or annular shape；Or
The body is sheet, Y-shaped, T-shaped, V-shaped or O fonts；Enable that the uterus is inserted thing and substantially fitted
Should be in the shape of uterine cavity.
Thing is inserted in 20. uterus according to preceding claims 10, it is characterised in that
Thing is inserted in the uterus can substantially be adapted to the shape of uterine cavity；Or
Thing is inserted in the uterus has trapezoidal, triangle, heart, circle or annular shape；Or
The body is sheet, Y-shaped, T-shaped, V-shaped or O fonts；Enable that the uterus is inserted thing and substantially fitted
Should be in the shape of uterine cavity.
Thing is inserted in 21. uterus according to any one in preceding claims 1-9, it is characterised in that
Thing is inserted in the uterus includes protuberance, and the protuberance is prevented from uterine neck internal orifice adhesion.
Thing is inserted in 22. uterus according to preceding claims 10, it is characterised in that
Thing is inserted in the uterus includes protuberance, and the protuberance is prevented from uterine neck internal orifice adhesion.
Thing is inserted in 23. uterus according in preceding claims 21, it is characterised in that
The protuberance is included in the bottom.
Thing is inserted in 24. uterus according in preceding claims 22, it is characterised in that
The protuberance is included in the bottom.
The imbedding system of thing is inserted in a kind of 25. uterus, it is characterised in that including any one institute in preceding claims
Thing and embedded device are inserted in the uterus stated, and there is the embedded device receiving uterus to insert the tubular-shaped structures of thing and push institute
State the action bars that thing is inserted in uterus.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201620631149.4U CN206239777U (en) | 2016-06-23 | 2016-06-23 | Thing is inserted in uterus and the imbedding system of thing is inserted in uterus |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201620631149.4U CN206239777U (en) | 2016-06-23 | 2016-06-23 | Thing is inserted in uterus and the imbedding system of thing is inserted in uterus |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN206239777U true CN206239777U (en) | 2017-06-13 |
Family
ID=58997749
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201620631149.4U Expired - Fee Related CN206239777U (en) | 2016-06-23 | 2016-06-23 | Thing is inserted in uterus and the imbedding system of thing is inserted in uterus |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN206239777U (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105903092A (en) * | 2016-06-23 | 2016-08-31 | 刘芸 | Uterus implant and implanting system for same |
| CN107951550A (en) * | 2017-12-14 | 2018-04-24 | 易浦润（上海）生物技术有限公司 | A kind of degradable inner membrane of uterine cavity implant system |
-
2016
- 2016-06-23 CN CN201620631149.4U patent/CN206239777U/en not_active Expired - Fee Related
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105903092A (en) * | 2016-06-23 | 2016-08-31 | 刘芸 | Uterus implant and implanting system for same |
| CN107951550A (en) * | 2017-12-14 | 2018-04-24 | 易浦润（上海）生物技术有限公司 | A kind of degradable inner membrane of uterine cavity implant system |
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| CF01 | Termination of patent right due to non-payment of annual fee |
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