CN206177873U - A portable inductor and detecting system that is used for non - intervention nature detection - Google Patents

Abstract

The utility model provides a portable inductor that is used for non - intervention nature detection, a serial communication port, including base plate, preparation gate electrode unit, source hourglass channel unit and the lid of preparation on the base plate on the base plate, the lid is detained on the base plate for form the cavity of saying as the miniflow between lid and the base plate, and, some of gate electrode unit is in during the miniflow was said, another part extended to outside the miniflow is said, the source leak channel unit some be in during the miniflow was said, another part extended to outside the miniflow is said. The utility model discloses can realize the glucose monitoring of non - intervention formula, avoid the intervention formula to monitor the uncomfortable and infection risk of bringing for the patient, and simultaneously, the utility model discloses a product size and structure are fit for daily portable and use to, when realizing the miniaturization, the utility model discloses can also guarantee the required precision of daily glucose monitoring.

Description

A kind of portable induction apparatuss and detecting system for non-invasi detection

Technical field

This utility model is related to medical monitoring equipment technical field, and specifically, this utility model is related to a kind of for non- The portable induction apparatuss and detecting system of Interventional detection.

Background technology

Present Global has more than 4.15 hundred million people and suffers from diabetes, and to the year two thousand forty, number is expected to rise to 6.42 hundred million.Wherein with The patient of the U.S. and China at most, occupies respectively 2,000 9 million and 9,000 6 million.Annual increment is more than 30%.In order to correctly diagnose With research diabetes, Jing is needed often to carry out blood sugar test to patient.Due to sharply increasing for number of patients, portable measurement side Case will be conducive to medical personnel and patient to carry out blood sugar monitoring.In traditional portable blood sugar measurement scheme, first with matching somebody with somebody The blood taking needle of set punctures finger, extrudes drop of blood, and then drop of blood is transferred on special test paper, then by the special test paper with drop of blood The Blood Donation Area of portable electronic blood glucose meter is attached to, finally reading is provided by the electronic blood-glucose meter.Obvious this detection method Finger can be injured, the problems such as infection and damages is may result in.

Document：Liao,C.,Mak,C.,Zhang,M.,Chan,HL,&amp；Yan,F.(2015).Flexible organic electrochemical transistors for highly selective enzyme biosensors And used for saliva testing.Advanced Materials, 27 (4), a kind of utilization is proposed in 676-681. Saliva carries out the scheme of glucose monitoring, replaces blood sugar monitoring to avoid damage to monitoring of saliva, but the induction apparatuss of the program It can only utilize beaker (Beaker) as the container for carrying electrolyte (Electrolyte) and saliva sample to structures shape, That is although the program is a kind of non-intervention type glucose monitoring scheme, but remains in laboratory stage, not with just The property taken, is not suitable for daily application.

Therefore, currently in the urgent need to a kind of it is adapted to portable non-invasi glucose used in everyday (or uric acid, lactic acid etc. Analog) monitoring solution.

Utility model content

Task of the present utility model is to overcome the deficiencies in the prior art, there is provided a kind of to be adapted to portable non-Jie used in everyday Enter formula glucose analog such as (or) uric acid, lactic acid monitoring solution.

According to an aspect of the invention, there is provided a kind of portable induction apparatuss for non-invasi detection, including base Plate, the gate electrode unit being produced on substrate, the source-drain path unit being produced on substrate and lid；The lid is buckled in institute State on substrate so that formed between lid and substrate at the cavity as fluid channel, also, a part for the gate electrode unit In the fluid channel, another part is extended to outside the fluid channel, and a part for the source-drain path unit is in described micro- In runner, another part is extended to outside the fluid channel.

Wherein, the gate electrode unit includes the electrode slice being produced on substrate, and the electrode slice includes being located at the miniflow Gate electrode portion in road is processed simultaneously with the extension outside fluid channel, the surface in the gate electrode portion is extended to using nano platinum particle Thereon deposition has sensing material, and the sensing material is to have an effect with particular organisms fluid and the induction apparatuss are produced The material of the life induced signal related to the content of one or more predetermined substance in the particular organisms fluid.

Wherein, the sensing material is the organic crystal containing glucoseoxidase, and the particular organisms fluid is saliva.

Wherein, the particular organisms fluid is uric acid or lactic acid.

Wherein, the source-drain path unit includes two electrode slices respectively as source electrode and drain electrode, used as source electricity The electrode slice of pole includes the source electrode portion being located inside fluid channel and the source electrode extension extended to outside fluid channel, used as leakage The electrode slice of electrode includes the drain electrode portion being located inside fluid channel and the drain electrode extension extended to outside fluid channel；In source PEDOT is deposited in electrode portion and drain electrode portion:PEDOT on PSS materials, and source electrode portion and drain electrode portion:PSS materials Join together, so as to form passage between source electrode portion and drain electrode portion；Gate electrode extension outside fluid channel, source Electrode extension, drain electrode extension are suitable to be connected with the terminal of the groove type seam of data acquisition unit.

Wherein, the entrance and exit for injecting and discharging biofluid is left on the lid.

Wherein, the substrate is glass substrate or polymeric substrates；The polymeric substrates include：Poly- naphthalenedicarboxylic acid second Diol ester, polyethylene terephthalate, polymethyl methacrylate or polydimethylsiloxane substrate.

According to a further aspect in the invention, a kind of portable detection system for non-invasi detection, bag are additionally provided Include：

It is previously described for the portable induction apparatuss of non-invasi detection；And

For providing power supply and drive signal for the induction apparatuss, at the same receive come from induction apparatuss can characterize saliva The data acquisition unit of the induced signal of middle glucose content.

Wherein, the data acquisition unit includes shell and the data acquisition unit positioned inside the shell；The shell has one The individual groove type interface for receiving induction apparatuss.

Wherein, the data acquisition unit includes microcontroller and the analog-digital converter, interior being connected with the microcontroller Embedded low-power consumption bluetooth module, power supply, signal source of clock and digital to analog converter.

Compared with prior art, this utility model has following technique effect：

1st, this utility model is capable of achieving the glucose monitoring of non-intervention type, it is to avoid insertion type is monitored and brought not to patient Suitable and infection risk.

2nd, product size of the present utility model and structure be adapted to it is daily it is portable use, also, realizing the same of miniaturization When, this utility model can also ensure that the precision needed for daily glucose monitoring.

Description of the drawings

Hereinafter, with reference to accompanying drawing describing embodiment of the present utility model in detail, wherein：

Fig. 1 shows the schematic top plan view of the induction apparatuss in this utility model one embodiment；

Fig. 2 shows the side elevational cross-section schematic diagram of the induction apparatuss in this utility model one embodiment；

Fig. 3 shows the non-invasi saliva detecting system for glucose monitoring of this utility model one embodiment The block diagram of electricity structure；

Fig. 4 shows the entity structure schematic diagram of the non-invasi saliva detecting system of Fig. 3.

Specific embodiment

According to one embodiment of the present utility model, there is provided a kind of non-invasi saliva for glucose monitoring is detected System, the detecting system includes induction apparatuss, data acquisition unit and mobile intelligent terminal.Induction apparatuss include can occurring with saliva (structure and operation principle of the organic electrochemistry transistor sensing unit will be for the organic electrochemistry transistor sensing unit of effect Described in hereafter), and for the adapter structure of embedding data harvester.Data acquisition unit includes shell and positioned inside the shell Data acquisition unit, the data acquisition unit is used to provide power supply and drive signal for the induction apparatuss, while receive coming from The induced signal that glucose content in saliva can be characterized of induction apparatuss.There is the shell of data acquisition unit one to be used to receive sense The groove type interface of device is answered, so, induction apparatuss can be by its adapter structure mechanically interface of embedding data harvester. Data acquisition unit is connected with mobile intelligent terminal by bluetooth approach, and the signal intensity for being monitored is included in intelligent movable On the frequency curtain of terminal.

Fig. 1 shows the schematic top plan view of the induction apparatuss in this utility model one embodiment, and Fig. 2 illustrates the sensing of Fig. 1 The side elevational cross-section schematic diagram of device.Wherein, the position of section shown in Fig. 2 shown in phantom in Fig. 1.In addition, it is necessary to illustrate, Fig. 2 Main purpose be illustrating each ingredient and their position relationship of induction apparatuss, the diagram in the form of profile Only schematically, it is not strict conformance in concrete size figure 2 above and Fig. 1.

With reference to Fig. 1 and Fig. 2, the induction apparatuss of the present embodiment include glass substrate 1, making gate electrode unit on substrate 1 2nd, making source-drain path unit 3 on substrate 1, and lid 4 (it should be noted that, although lid 4 is divided in fig. 2 Three parts, but in fact, these three parts are connected, simply leave two at the position of entrance 41 and outlet 42 Circular hole).The lid 4 is buckled on the glass substrate 1 so that cavity 5, the cavity 5 are formed between lid 4 and glass substrate 1 It is formed fluid channel.Gate electrode (Gate electrode, its Chinese can also be translated into gate electrode) unit 2 and source-drain path Unit 3 is in the fluid channel.Entrance 41 and outlet 42 are left on lid 4, for injecting and discharging biofluid (for example Saliva, electrolyte etc.).

Wherein, gate electrode unit 2 includes the gold electrode piece being produced on glass substrate 1, the gold electrode piece (i.e. gate electrode G) Including the gate electrode portion 21 in the fluid channel and extend to the extension 22 outside fluid channel.The surface in gate electrode portion 21 makes Processed with nano platinum particle 23, redeposited one layer contains glucoseoxidase in the gate electrode portion 21 after nano platinum particle process 24 organic crystal 25, the organic crystal 25 can be shitosan (Chitosan).In other embodiments, the gold electrode piece Can also be substituted with platinum electrode piece or silver electrode film.The glass substrate can also be substituted with polymeric substrates, for example：Poly- naphthalene Naphthalate (Polyethylene naphthalate, be abbreviated as PEN), polyethylene terephthalate (Polyethylene Terephthalate, be abbreviated as PET), polymethyl methacrylate (Poly (methyl Methacrylate), it is abbreviated as PMMA) or polydimethylsiloxane (Polydimethylsiloxane is abbreviated as PDMS) Etc. the substrate that material makes.

Source-drain path unit 3 is included respectively as source electrode S (source electrode i.e. Source electrode) and drain electrode D Two gold electrode pieces of (drain electrode is Drain electrode), and the organic channel 33 of connection source electrode S and drain electrode D. Organic channel 33 is made using poly- ethylenedioxythiophene-polystyrolsulfon acid, and the English name of the organic material is：Poly(3, 4-ethlyenedioxythiophene)-poly (styrenesulfonate), can be abbreviated as PEDOT:PSS.For ease of retouching State, hereinafter poly- ethylenedioxythiophene-polystyrolsulfon acid is referred to as into PEDOT:PSS materials.It is to be appreciated that can be used for this The material of bright organic channel is not unique, and in other embodiments, organic channel can also be electric using connecting source Other organic materials of pole S and drain electrode D make.

In the present embodiment, source electrode S includes the source electrode portion 31 being located inside fluid channel and extends to outside fluid channel Source electrode extension 32, drain electrode D includes the drain electrode portion 34 being located inside fluid channel and the electric leakage extended to outside fluid channel Pole extension 35.PEDOT is deposited in source electrode portion 31 and drain electrode portion 34:PSS materials, and source electrode portion 31 and electric leakage PEDOT in pole portion 34:PSS materials join together, so that PEDOT is formed between source electrode portion and drain electrode portion leading to Road.And be located at the gate electrode extension 22 outside fluid channel, source electrode extension 32, drain electrode extension 35 can easily with The terminal connection of the groove type seam of data acquisition unit, so as to be embodied as induction apparatuss power supply and drive signal, Yi Jijie are provided Receipts come from the function of the induced signal of induction apparatuss.Above-mentioned gate electrode, source electrode and drain electrode constitute organic electrochemistry crystal Three electrodes of pipe.

When using the induction apparatuss, first from entrance to fluid channel in inject PBS electrolyte (full name of PBS be Phosphate-buffered Saline, can be translated into phosphate buffered saline (PBS)), then again from entrance 41 to fluid channel in inject The saliva extracted from patient.Gate electrode can produce redox reaction with the blood glucose in saliva, so as to produce brake current (Gate Current), it is based on the inherent character (Intrinsic property) of organic electrochemistry transistor, the signal of the brake current Can be amplified by organic electrochemistry transistor, so, the brake current signal after measuring and amplifying, you can obtain the glucose in saliva Content.

In other embodiment of the present utility model, induction apparatuss can change different sensing material (Sensing Material) replacing the organic crystal containing glucoseoxidase, as long as the sensing material replaced can be with particular organisms stream Body is (for example:Uric acid, lactic acid) have an effect and induction apparatuss is produced and one or more specific thing in the particular organisms fluid The related induced signal of the content of matter.Induction apparatuss are communicated with data acquisition unit, and provide induced signal, and then make number The data of respective analyte are obtained according to harvester.Data acquisition unit is based on transmission time-histories with the communication of mobile intelligent terminal (transmission schedule) is realized, it may be through manual operation (Manual Interaction) or in response to movement The request (Request) of intelligent terminal starts.In addition, induction apparatuss both can be used as the non-invasi saliva for glucose monitoring One ingredient of the embodiment of detecting system, it is also possible to be separately formed independent embodiment of the present utility model.

Fig. 3 shows the electricity structure of the non-invasi saliva detecting system for glucose monitoring of one embodiment Block diagram, Fig. 4 shows the entity structure schematic diagram of the non-invasi saliva detecting system of Fig. 3, with reference to Fig. 3 and Fig. 4, should Detecting system includes sensor unit, data acquisition unit and mobile intelligent terminal.Wherein, data acquisition unit includes modulus Transducer, microcontroller, embedded low-power consumption bluetooth module, power supply, signal source of clock and digital to analog converter.

Simulation digital converter can configure by sensor unit obtain analyte voltage signal, and voltage signal by Analogue signal (Analog Signal) is converted into digital signal (Digital Signal).For example:Simulation digital converter can be with Obtain the change in voltage produced by being had an effect by microchannel induction apparatuss and saliva.Again for example:Analog-digital converter can be obtained Take the change in voltage produced by being had an effect by induction apparatuss on reagent paper and saliva.Analog-digital converter can be with microcontroller (Microcontroller) connect, the analogue signal of induction apparatuss is changed into digital signal, and by digital signals through communication connection (Communication Link) is sent to microcontroller and performs an analysis.

Microcontroller provides dram-source voltage and lock voltage for organic electrochemistry transistor induction apparatuss.Through with numeral The connection of analog converter, microcontroller can set different size of voltage through computer program.Microcontroller can be analyzed The digital signal transmitted by simulation digital converter, and relevant signal is passed to smart mobile phone through embedded low-power consumption bluetooth.

Clock (Clock) can provide accurate clock frequency rule (Clock frequency) for microprocessor, and clock includes shaking Swing device (Oscillator) or other devices are adapted to generation clock signal and indicate actual time.

Power supply (Power Supply) provide power supply including any appropriate device for data acquisition unit.It is central to potentially include Cable power (Wired power source), aneroid battery (Dry cell batteries) such as NI-G Nickel-cadmium (NiCd), nickel zinc Nickel-zinc (NiZn), Ni-MH battery Nickel metal hydride (NiMH), lithium battery Lithium-ion(Li-ion)；Solaode (Solar cell), fuel cell (Fuel cell)

Embedded low-power consumption bluetooth (Embedded Bluetooth Low Energy) can enter news of advancing with external device, External device can be smart mobile phone, PC or panel computer.In some situations, communication interface can be set as wired (Wired) and wirelessly (Wireless) communicates to connect (Communication link).Wire communication can be Ethernet (Ethernet), serial (Serial) and infrared ray (Infrared).Radio communication may use one or more less radio-frequencies (Radio Frequency), near-field communication (Near-field Communication), radio frequency identification (Radio Frequency Identification), WiFi or related one or more wireless communication protocols (Wireless Communication Protocol) and provide safety, radio communication and avoid data collision (Data Collision) and Interference (Data Interference).

Analog-digital converter, microcontroller, digital analog converter, clock, power supply, embedding low power consumption bluetooth module can So that one or more electronics group portions (Electronic unit) as separating component (Separate unit), can also be combined into, Circuit board (Electronic circuit) or chip (Chip).

Smart mobile phone application (Smartphone App) is then a kind of smartphone software (Smartphone Software), it carries out signal reception by embedded low-power consumption bluetooth module, and corresponding signal is become diagrammatic representation in screen On.And relevant data storage in interior magazine, or upload on the hard disk of high in the clouds through WiFi.Using can be based on ARIXTRA System (Android System) or iOS.High in the clouds hard disk may be then Google Drive or iCloud.

In certain embodiments, one or more induction apparatuss, data acquisition unit and smart mobile phone can configure multiple wired And wireless communication link.Radio communication may use one or more less radio-frequencies (Radio Frequency), near-field communication (Near-field Communication), radio frequency identification (Radio Frequency Identification), WiFi Or other wireless communication protocols (Wireless Communication Protocol), these communications can be protected Barrier communication security, for example, avoid data collision (Data Collision) and data interference (Data Interference).

In certain embodiments, data acquisition unit is configured to collect the analyte data for carrying out self-inductor.For example:Number Can be configured to be adapted to microchannel induction apparatuss according to the socket of harvester, and analysis to be measured is measured according to the induced signal of induction apparatuss The data of thing.

In certain embodiments, communication media can be set as wired or wireless communication mode.Wire communication can be with Too network (Ethernet) or string line (Serial).Radio communication may using one or more infrared ray (Infrared), Less radio-frequency (Radio Frequency), near-field communication (Near-field Communication), radio frequency identification (Radio Frequency Identification), WiFi or other wireless communication protocols (Wireless Communication Protocol), these communications can ensure communication security, for example, avoid data collision (Data Collision) and data disturb (Data Interference).

Finally it should be noted that above example is only to describe the technical solution of the utility model rather than to this technology Method is limited, and this utility model can extend to other modifications, change, application and embodiment in application, and because This thinks all such modifications, change, application, embodiment all in the range of spirit or teaching of the present utility model.

Claims (12)

1. it is a kind of for non-invasi detection portable induction apparatuss, it is characterised in that including substrate, the lock being produced on substrate Electrode unit, the source-drain path unit being produced on substrate and lid；The sky as fluid channel is formed between lid and substrate Chamber, also, a part for the gate electrode unit is in the fluid channel, and a part for the source-drain path unit is in institute In stating fluid channel.

2. portable induction apparatuss according to claim 1, it is characterised in that the gate electrode unit includes being produced on substrate On electrode slice, the electrode slice includes the gate electrode portion being located in the fluid channel and the extension that extends to outside fluid channel.

3. portable induction apparatuss according to claim 2, it is characterised in that the surface in the gate electrode portion uses platinum nanometer Particle process is simultaneously deposited thereon and has a sensing material, and the sensing material is to have an effect with particular organisms fluid and cause institute State the material that induction apparatuss produce the induced signal related to the content of one or more predetermined substance in the particular organisms fluid.

4. portable induction apparatuss according to claim 3, it is characterised in that the sensing material is glycoxidative containing Fructus Vitis viniferae The organic crystal of enzyme, the particular organisms fluid is saliva.

5. portable induction apparatuss according to claim 3, it is characterised in that the particular organisms fluid is uric acid or breast Acid.

6. portable induction apparatuss according to claim 1, it is characterised in that the source-drain path unit include respectively as Two electrode slices of source electrode and drain electrode, as source electrode electrode slice include be located at fluid channel inside source electrode portion and Extend to the source electrode extension outside fluid channel, as drain electrode electrode slice include be located at fluid channel inside drain electrode portion with And extend to drain electrode extension outside fluid channel.

7. portable induction apparatuss according to claim 6, it is characterised in that deposit in source electrode portion and drain electrode portion PEDOT:PEDOT on PSS materials, and source electrode portion and drain electrode portion:PSS materials join together, so as in source electrode portion Passage is formed and drain electrode portion between；Gate electrode extension, source electrode extension outside fluid channel, drain electrode extension It is suitable to be connected with the terminal of the groove type seam of data acquisition unit.

8. portable induction apparatuss according to claim 1, it is characterised in that leave on the lid for injecting and discharging The entrance and exit of biofluid.

9. portable induction apparatuss according to claim 1, it is characterised in that the substrate is glass substrate or polymer Substrate；The polymeric substrates include：PEN, polyethylene terephthalate, polymethylacrylic acid Methyl ester or polydimethylsiloxane substrate.

10. it is a kind of for non-invasi detection portable detection system, it is characterised in that include：

The portable induction apparatuss for non-invasi detection any one of claim 1 to 9；And

For providing power supply and drive signal for the induction apparatuss, at the same receive come from induction apparatuss can characterize Portugal in saliva The data acquisition unit of the induced signal of grape sugared content.

11. portable detection systems according to claim 10, it is characterised in that the data acquisition unit include shell and Positioned at the data acquisition unit of inside the shell；The shell has a groove type interface for being used to receive induction apparatuss.

12. portable detection systems according to claim 11, it is characterised in that the data acquisition unit includes micro-control Device processed and the analog-digital converter being connected with the microcontroller, embedded low-power consumption bluetooth module, power supply, signal source of clock sum Weighted-voltage D/A converter.