CN206082236U - Device of mixed liquid of low temperature - Google Patents

Abstract

The application discloses device of mixed liquid of low temperature includes: keep the microthermal platform of mixing process, with the first syringe of T type union coupling and second syringe, and transmission, the platform can hold T type pipe first syringe with the second syringe. Transmission includes first pivot, second pivot, first handle, second handle and push rod, works as when the push rod was promoted, the motive force of production was transmitted extremely first pivot second pivot and then transmission are extremely first handle or second handle, thus make first handle or second handle extrude respectively first syringe or the mixture of liquid is realized to the piston of second syringe.

Description

A kind of device of low-temperature mixed liquid

Technical field

This utility model is related to a kind of device of low-temperature mixed liquid, the particularly device of automatic low-temp mixing liquid.

Background technology

China has many patients to suffer from corneal blindness.The main cause of corneal blindness is that such as funguses or herpes simplex virus etc. are drawn The severe infections that rise, the wound that causes of motion or be that the heritability keratopathy of such as keratoconuses etc. causes.Although eye Corneal transplantation is all to treat the standard approach of corneal blindness in many countries of the world, but seriously lacks cornea donations and make corneal blindness The operation of patient becomes extremely difficult.Therefore it is badly in need of the preparation method and device of artificial cornea at present.

Utility model content

This application provides a kind of device of low-temperature mixed liquid includes：Keep the platform and T-shaped pipe of mixed process low temperature First syringe and the second syringe of connection, and actuating device, the platform can accommodate the T-shaped pipe, first injection Device and second syringe, the actuating device includes first rotating shaft, the second rotating shaft, the first handle, the second handle and push rod, works as institute When stating push rod and being promoted, the motive force of generation is transferred to the first rotating shaft, second rotating shaft and then is transferred to described first Handle or the second handle, so that first handle or the second handle extrude respectively first syringe or second syringe Piston, realizes the mixing of liquid.

In one embodiment, the liquid in syringe is collagen protein, by the one of T-shaped pipe, not connected syringe The liquid of the end injection T-shaped pipe is the N-hydroxy-succinamide or cross-linking agent 1- ethyl -3- (3- dimethylaminos third of buffering Base) phosphinylidyne diimmonium salt hydrochlorate.In another embodiment, liquid is the recombined human type-iii collagen protein of purification.

Description of the drawings

Fig. 1 shows a kind of device of low-temperature mixed liquid.

Fig. 2 shows that the device in Fig. 1 embodiments further includes crank block.

Fig. 3 A-3D show that the rotation of crank block can promote push rod to move along direction A and direction B.

Specific embodiment

Such as used with claim herein, " including " refers to comprising elements below but is not excluded for other elements." liquid Body " refers to any material that can be flowed in syringe and T-shaped pipe, including but not limited to solution, suspension and colloidal fluid.

The preparation process of collagen protein cornea is related to the N-hydroxy-succinamide of people's recombined collagen and buffering (NHS) mixing, then again with cross-linking agent 1- ethyl -3- (3- dimethylaminopropyls) phosphinylidyne diimmonium salt hydrochlorate (EDC) Mix to carry out cross-linking reaction.The device of the application is applied to Per Pagerholm et al. (Science Translational Medicine, 2010, (2), 46,46-61) involved by collagen protein cornea film forming before people's restructuring Collagen protein and NHS, EDC mixing at low temperature, is also applied for the mixing at low temperature of other liquid.

In one embodiment, as shown in figure 1, the mixing arrangement includes platform 21, the first syringe 22a, the second injection Device 22b, T-shaped pipe 23 and actuating device 24.There is platform 21 a T fonts groove 25 to be used to accommodate two syringes 22a, 22b With T-shaped pipe 23, the syringe overall diameter of syringe less than T fonts groove 25 width 25a and syringe handle with diameter greater than the width 25a.Distinguish the vertical two ends of connecting T-shaped pipe 23 in the syringe end of two syringes.Actuating device 24 include first rotating shaft 26, the Two rotating shafts 27, the first handle 28, the second handle 29 and push rod 30.The order of connection is that push rod 30 connects first rotating shaft 26, first rotating shaft 26 Connect the second rotating shaft 27, the second rotating shaft 27 connects respectively the first handle 28 and the second handle 29.First handle 28 and the second handle 29 are in be more than Equal to 90 degree.When push rod 30 is promoted along direction A, motive force is transferred to the second rotating shaft 27 and so that second turn from first rotating shaft 26 Axle 27 is rotated along C directions, and then causes the second handle 29 to extrude the piston of the second syringe 22b.Similarly, when push rod 30 is along B side When motion, the first handle 28 extrudes the piston of the first syringe 22a.So move repeatedly so that the solution mixing in the device.

In one embodiment, one end 32 that T-shaped Guan Wei is connected by two syringes includes a stopper 33, and liquid can lead to Cross the end 32 to inject in the T-shaped pipe, the liquid in liquid and syringe in T-shaped pipe starts mixing.

In a preferred embodiment, push rod 30 can be provided with crank block 31, as shown in Fig. 2 crank block 31 connects That one end of push rod 30 away from first rotating shaft 26.As shown in figs.3 a and 3b, the rotation of crank block 31 can promote push rod 30 to A side To movement, Fig. 3 C are that crank block 31 can shift push rod 30 onto farthest along A directions, when crank block 31 is further continued for rotating When push rod 30 is started along the movement of B directions such as Fig. 3 D.Therefore, the rotation of crank block 31 can cause the piston of two syringes It is extruded respectively so as to realize the mixing of liquid.

In a particular embodiment, dynamic driving means can promote crank block 31 rotation or push-and-pull push rod from And cause the mixing velocity of liquid to reach expection, such as 60 times/60 seconds -120 times/60 seconds (two syringes are extruded speed It is each 60-120 time per 60 seconds).In another embodiment, Power Drive Unit is motor.In another embodiment, push rod 30 Push stroke reach 20mm.In another embodiment, the mixing arrangement has sudden-stop function order to the power for promoting push rod Jerk.

In one embodiment, two syringes are connected in 90 degree with T-shaped pipe, realize T-shaped mixing.

In one embodiment, the mixing arrangement is provided with enumerator, can set and show push rod push times.

In another embodiment, the mixing arrangement has driver scalable and shows motor speed.

In a preferred embodiment, platform 21 have keep syringe in liquid and T-shaped pipe in liquid cryogen and Liquid during mixing also keeps the effect of low temperature.In a preferred embodiment, platform 21 makes whole mixed process In being maintained at 0-3 DEG C of temperature.

In a particular embodiment, recombinant human collagen protein is housed, NHS passes through not note with two in a syringe The T-shaped pipe is injected in one end of the T-shaped pipe of emitter connection, when recombinant human collagen protein and NHS are after the device mixing, EDC The T-shaped pipe is injected also by the one end for the T-shaped pipe not being connected with two syringes complete mixed process again.It is specific at another In embodiment, recombinant human collagen protein is the recombined human type-iii collagen protein of purification.

The volume and length of two syringes may be the same or different.In one embodiment, two syringes can be respectively The syringe of 3mL and 10mL capacity.In another embodiment, the syringe of two syringes can be adjusted to the capacity of 50-150mL.

Unless otherwise defined, all technologies as used herein and scientific terminology have as this utility model art The identical implication that is generally understood of those of ordinary skill.Although similar to or be equal to any method described herein and material During material can be used for enforcement of the present utility model or test, but method for optimizing and material are described at present.Referred herein to All open file heres incorporated herein by reference in, drawn so as to describe and disclose relative reference content Customizing messages.

Exemplified with enforcement of the present utility model in nonlimiting examples.Scope of the present utility model is only by appended power Profit requires to limit that it is definitely not to be limited by perhaps scope in embodiment.For example, syringe can be any with identical work( The container of energy.Crank block can be other power transmissions with identical function etc..

Claims (16)

1. a kind of device of low-temperature mixed liquid, including：

Keep the platform of mixed process low temperature；

The first syringe being connected with T-shaped pipe and the second syringe, the platform can accommodate the T-shaped pipe, first injection Device and second syringe；And

Actuating device, the actuating device includes first rotating shaft, the second rotating shaft, the first handle, the second handle and push rod,

Wherein when the push rod is promoted, the motive force of generation is transferred to the first rotating shaft, second rotating shaft and then passes First handle or second handle are handed to, so that first handle or second handle extrude respectively first injection The piston of device or second syringe, realizes the mixing of liquid.

2. device as claimed in claim 1, further includes crank block, and the crank block is connected to the remote of the push rod From one end of the first rotating shaft, the rotation of the crank block makes first handle or second handle extrude described respectively The piston of one syringe or second syringe is completing the mixing of liquid.

3. device as claimed in claim 1, wherein the platform has a T font groove, the T fonts groove accommodates institute State the first syringe, second syringe and the T-shaped pipe.

4. device as claimed in claim 3, wherein the syringe overall diameter of first syringe and second syringe is little In the width of the T fonts groove, first syringe and second syringe syringe handle with diameter greater than the width Degree.

5. device as claimed in claim 1, wherein the syringe end difference of first syringe and second syringe Connect the vertical two ends of the T-shaped pipe.

6. device as claimed in claim 1, wherein push rod connection first rotating shaft, first rotating shaft connects the second rotating shaft, the Two rotating shafts connect respectively the first handle and the second handle, and the first handle and the second handle are in more than or equal to 90 degree.

7. device as claimed in claim 1, further includes Power Drive Unit, and the Power Drive Unit can promote institute The push-and-pull speed for stating push rod is 60 times/60 seconds -120 times/60 seconds.

8. device as claimed in claim 7, wherein the Power Drive Unit is motor.

9. device as claimed in claim 1, wherein the push stroke of the push rod reaches 20mm.

10. device as claimed in claim 1, wherein described device have the order of sudden-stop function device to the power urgency for promoting push rod Stop.

11. devices as claimed in claim 1, wherein described device has enumerator, can set and show what the push rod was pushed Number of times.

12. devices as claimed in claim 1, wherein described device have driver scalable and show motor speed.

13. devices as claimed in claim 1, wherein the platform can keep first syringe and second syringe In liquid and the T-shaped pipe in liquid cryogen and the liquid in mixed process also keep low temperature, the low temperature is 0-3 ℃。

14. devices as claimed in claim 1, wherein the T-shaped Guan Wei is by first syringe and second syringe One end of connection includes a stopper, and liquid can inject the T-shaped pipe by the end.

15. devices as claimed in claim 14, wherein being equipped with recombined human in first syringe or second syringe Class collagen protein, the N-hydroxy-succinamide and cross-linking agent 1- ethyl -3- (3- dimethylaminopropyls) phosphinylidyne two of buffering is sub- Amine hydrochlorate can be injected separately into the T-shaped pipe by the end.

16. devices as claimed in claim 15, wherein recombinant human collagen protein are the recombined human type-iii collagen eggs of purification In vain.