CN206045439U - A kind of aseptic spray drying device - Google Patents
A kind of aseptic spray drying device Download PDFInfo
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- CN206045439U CN206045439U CN201620480231.1U CN201620480231U CN206045439U CN 206045439 U CN206045439 U CN 206045439U CN 201620480231 U CN201620480231 U CN 201620480231U CN 206045439 U CN206045439 U CN 206045439U
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- 238000001694 spray drying Methods 0.000 title claims abstract description 12
- 239000007788 liquid Substances 0.000 claims abstract description 42
- 238000001035 drying Methods 0.000 claims abstract description 15
- 238000009792 diffusion process Methods 0.000 claims abstract description 14
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 9
- 230000001954 sterilising effect Effects 0.000 claims abstract description 8
- 238000005192 partition Methods 0.000 claims description 15
- 239000000428 dust Substances 0.000 abstract description 8
- 238000004519 manufacturing process Methods 0.000 abstract description 4
- 238000004659 sterilization and disinfection Methods 0.000 abstract 1
- 239000003595 mist Substances 0.000 description 10
- 239000000463 material Substances 0.000 description 7
- 239000000243 solution Substances 0.000 description 6
- 239000012535 impurity Substances 0.000 description 3
- 241000894006 Bacteria Species 0.000 description 2
- 238000000889 atomisation Methods 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 239000007921 spray Substances 0.000 description 2
- RDEIXVOBVLKYNT-VQBXQJRRSA-N (2r,3r,4r,5r)-2-[(1s,2s,3r,4s,6r)-4,6-diamino-3-[(2r,3r,6s)-3-amino-6-(1-aminoethyl)oxan-2-yl]oxy-2-hydroxycyclohexyl]oxy-5-methyl-4-(methylamino)oxane-3,5-diol;(2r,3r,4r,5r)-2-[(1s,2s,3r,4s,6r)-4,6-diamino-3-[(2r,3r,6s)-3-amino-6-(aminomethyl)oxan-2-yl]o Chemical compound OS(O)(=O)=O.O1C[C@@](O)(C)[C@H](NC)[C@@H](O)[C@H]1O[C@@H]1[C@@H](O)[C@H](O[C@@H]2[C@@H](CC[C@@H](CN)O2)N)[C@@H](N)C[C@H]1N.O1C[C@@](O)(C)[C@H](NC)[C@@H](O)[C@H]1O[C@@H]1[C@@H](O)[C@H](O[C@@H]2[C@@H](CC[C@H](O2)C(C)N)N)[C@@H](N)C[C@H]1N.O1[C@H](C(C)NC)CC[C@@H](N)[C@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](NC)[C@@](C)(O)CO2)O)[C@H](N)C[C@@H]1N RDEIXVOBVLKYNT-VQBXQJRRSA-N 0.000 description 1
- WEEMDRWIKYCTQM-UHFFFAOYSA-N 2,6-dimethoxybenzenecarbothioamide Chemical compound COC1=CC=CC(OC)=C1C(N)=S WEEMDRWIKYCTQM-UHFFFAOYSA-N 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 229940088710 antibiotic agent Drugs 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- OOYGSFOGFJDDHP-KMCOLRRFSA-N kanamycin A sulfate Chemical compound OS(O)(=O)=O.O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CN)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](N)[C@H](O)[C@@H](CO)O2)O)[C@H](N)C[C@@H]1N OOYGSFOGFJDDHP-KMCOLRRFSA-N 0.000 description 1
- 229960002064 kanamycin sulfate Drugs 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 239000011343 solid material Substances 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 229960002385 streptomycin sulfate Drugs 0.000 description 1
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- Drying Of Solid Materials (AREA)
Abstract
Description
技术领域technical field
本实用新型涉及一种干燥装置,特别是一种无菌喷雾干燥装置。The utility model relates to a drying device, in particular to a sterile spray drying device.
背景技术Background technique
无菌喷雾干燥机是医药工业中粉针剂生产的主要设备,不少抗生素药品如:硫酸链霉素、硫酸庆大霉素、卡那霉素硫酸盐等,在其生产过程中都要使用无菌喷雾干燥来制备成品。在无菌喷雾干燥系统中,所有进入系统的物料和空气都必须除菌。产品的收集也必须在无菌室内进行,所以对需喷雾料液要经过过滤除菌后方能送至喷雾器,对喷雾用的压缩空气也必须净化后方能使用。干燥用空气经初效、中效过滤器,高效过滤器过滤后得净化空气,再经过加热器升温后送入喷雾干燥室。干燥后的成品和空气被旋风分离器分离。成品在无菌室净化工作台收集包装。尾气经袋滤器除尘后排空。现有的无菌喷雾干燥机结构复杂,雾化效果不均匀。Aseptic spray dryer is the main equipment for the production of powder injections in the pharmaceutical industry. Many antibiotics, such as streptomycin sulfate, gentamicin sulfate, kanamycin sulfate, etc., must use sterile Bacteria spray drying to prepare finished products. In an aseptic spray drying system, all materials and air entering the system must be sterilized. The collection of products must also be carried out in a sterile room, so the liquid to be sprayed must be filtered and sterilized before it can be sent to the sprayer, and the compressed air used for spraying must also be purified before it can be used. The air used for drying is filtered through primary, medium and high efficiency filters to obtain purified air, and then sent to the spray drying chamber after being heated by a heater. The dried finished product and air are separated by cyclone separator. The finished product is collected and packaged on the clean bench of the sterile room. The exhaust gas is emptied after dust removal by the bag filter. The structure of the existing aseptic spray dryer is complicated, and the atomization effect is not uniform.
发明内容Contents of the invention
本实用新型需要解决的技术问题是通过增设的扩散机构使雾滴更加快速地充满整个上塔体,使雾滴与高温气体接触的更加充分完全,起到了提高干燥效率的作用;提供一种无菌喷雾干燥装置。The technical problem to be solved by the utility model is to make the mist droplet fill the entire upper tower body more quickly through the additional diffusion mechanism, so that the mist droplet can fully contact with the high-temperature gas, and play a role in improving the drying efficiency; provide a non-toxic Bacteria spray drying device.
为解决上述的技术问题,本实用新型的结构包括In order to solve the above-mentioned technical problems, the structure of the utility model includes
干燥塔,所述的干燥塔是由内腔截面为梯形的上塔体和下塔锥上下连接所组成,Drying tower, the drying tower is composed of an upper tower body with a trapezoidal inner cavity section and a lower tower cone connected up and down,
雾化器,所述的上塔体内的顶部设置有导流室,所述的雾化器安装在导流室内,所述的雾化器通过进液管与储液罐相连,所述的进液管上安装有供料泵,The atomizer, the top of the upper tower body is provided with a diversion chamber, the atomizer is installed in the diversion chamber, the atomizer is connected with the liquid storage tank through the liquid inlet pipe, and the inlet A feed pump is installed on the liquid pipe,
除菌过滤器,所述的除菌过滤器安装在进液管上,The sterilizing filter, the sterilizing filter is installed on the liquid inlet pipe,
扩散机构,所述的扩散机构安装在导流室的出口处,a diffusion mechanism, the diffusion mechanism is installed at the outlet of the diversion chamber,
进气管道,所述的进气管道的一端伸入至上塔体内,所述的进气管道的另一端与空气过滤器相连,所述的进气管道上还依次安装有第一送风机、加热器和耐温高效过滤器,Air intake pipe, one end of the air intake pipe extends into the upper tower body, the other end of the air intake pipe is connected with the air filter, and the first air blower and heater are installed in sequence on the air intake pipe and heat-resistant high-efficiency filters,
旋风分离器,所述的旋风分离器连接在下塔锥的底部,Cyclone separator, the cyclone separator is connected at the bottom of the lower tower cone,
无菌洁净室,所述的无菌洁净室与旋风分离器底部的出料口相连通,Aseptic clean room, the aseptic clean room communicates with the outlet at the bottom of the cyclone separator,
水膜除尘器,所述的水膜除尘器通过出气管连接在旋风分离器的出气口处,所述的出气管上安装有第二送风机。A water film dust collector, the water film dust collector is connected to the air outlet of the cyclone separator through an air outlet pipe, and a second air blower is installed on the air outlet pipe.
进一步:所述的储液罐内设置有分隔板,所述的储液罐的内部空间被分隔板分为左右两个部分,所述的分隔板的上端与储液罐的顶部之间存有间隙,所述的分隔板的下端与储液罐的底部相接触,所述的进液管的一端伸入至分隔板右侧的储液罐的底部,所述的位于储液罐内进液管的一端安装有滤网。Further: the liquid storage tank is provided with a partition plate, the internal space of the liquid storage tank is divided into left and right parts by the partition plate, the upper end of the partition plate and the top of the liquid storage tank There is a gap between them, the lower end of the partition plate is in contact with the bottom of the liquid storage tank, one end of the liquid inlet pipe extends into the bottom of the liquid storage tank on the right side of the partition plate, and the One end of the liquid inlet pipe in the liquid tank is equipped with a strainer.
又进一步:所述的扩散机构包括电机和旋转叶片,所述的电机安装在导流室内,所述的旋转叶片套装在电机的出轴端上,所述的旋转叶片位于导流室的出口处。Still further: the diffusion mechanism includes a motor and a rotating vane, the motor is installed in the guide chamber, the rotating vane is set on the shaft end of the motor, and the rotating vane is located at the outlet of the guide chamber .
再进一步:所述的下塔锥的外侧壁上安装有气锤震击器。A further step: an air hammer jar is installed on the outer wall of the lower tower cone.
采用上述结构后,本实用新型通过增设的扩散机构使雾滴更加快速地充满整个上塔体,使雾滴与高温气体接触的更加充分完全,起到了提高干燥效率的作用;并且本设计还具有结构简单、易于制造和实用高效的优点。After adopting the above structure, the utility model makes the mist droplets fill the whole upper tower body more quickly through the additional diffusion mechanism, so that the mist droplets can fully contact with the high-temperature gas, which plays a role in improving the drying efficiency; and this design also has It has the advantages of simple structure, easy manufacture, practicality and high efficiency.
附图说明Description of drawings
下面结合附图和具体实施方式对本实用新型作进一步详细的说明。Below in conjunction with accompanying drawing and specific embodiment, the utility model is described in further detail.
图1为本实用新型的结构示意图。Fig. 1 is the structural representation of the utility model.
图2为储液罐的结构示意图。Figure 2 is a schematic structural view of the liquid storage tank.
具体实施方式detailed description
如图1所示的一种无菌喷雾干燥装置,包括干燥塔1、雾化器5、除菌过滤器10、扩散机构、进气管道12、旋风分离器19、无菌洁净室20和水膜除尘器21,所述的干燥塔1是由内腔截面为梯形的上塔体2和下塔锥3上下连接所组成,所述的上塔体2内的顶部设置有导流室4,所述的雾化器5安装在导流室6内,所述的雾化器5通过进液管8与储液罐9相连,所述的进液管8上安装有供料泵11,所述的除菌过滤器10安装在进液管8上,所述的扩散机构安装在导流室4的出口处,所述的进气管道12的一端伸入至上塔体2内,所述的进气管道12的另一端与空气过滤器13相连,所述的进气管道12上还依次安装有第一送风机14、加热器17和耐温高效过滤器15,所述的旋风分离器19连接在下塔锥3的底部,所述的无菌洁净室20与旋风分离器19底部的出料口相连通,所述的水膜除尘器21通过出气管连接在旋风分离器19的出气口处,所述的出气管上安装有第二送风机22。工作时,启动供料泵11向雾化器1内输送物料,利用雾化器1使物料雾化后进入上塔体2内,与此同时启动第一送风机14和加热器17利用进气管道12向上塔体2内输送高温气体,雾滴与高温气体相接触后会迅速干燥,然后启动旋风分离器19进行固气分离,使固体物料自动从出料口进入无菌洁净室20进行储藏,尾气则输送进水膜除尘器21进行处理。本设计在对物料进行干燥的同时,启动扩散机构使雾滴更加快速地充满整个上塔体,使雾滴与高温气体接触的更加充分完全,起到了提高干燥效率的作用。A kind of aseptic spray drying device as shown in Figure 1, comprises drying tower 1, atomizer 5, sterilizing filter 10, diffusion mechanism, air inlet pipeline 12, cyclone separator 19, aseptic clean room 20 and water Membrane dust collector 21, the drying tower 1 is composed of an upper tower body 2 with a trapezoidal inner cavity section and a lower tower cone 3 connected up and down, the top of the upper tower body 2 is provided with a diversion chamber 4, The atomizer 5 is installed in the diversion chamber 6, the atomizer 5 is connected to the liquid storage tank 9 through the liquid inlet pipe 8, and the feed pump 11 is installed on the liquid inlet pipe 8, so that The above-mentioned sterilizing filter 10 is installed on the liquid inlet pipe 8, the described diffusion mechanism is installed at the outlet of the diversion chamber 4, and one end of the described air inlet pipe 12 extends into the upper tower body 2, and the described The other end of the air inlet pipe 12 is connected with the air filter 13, and the first air blower 14, the heater 17 and the temperature-resistant high-efficiency filter 15 are also installed successively on the described air inlet pipe 12, and the described cyclone separator 19 is connected At the bottom of the lower tower cone 3, the aseptic clean room 20 communicates with the outlet at the bottom of the cyclone separator 19, and the water film dust remover 21 is connected to the gas outlet of the cyclone separator 19 by an air outlet pipe. A second air blower 22 is installed on the air outlet pipe. When working, start the feed pump 11 to transport the material to the atomizer 1, use the atomizer 1 to atomize the material and enter the upper tower body 2, and at the same time start the first blower 14 and the heater 17 to use the intake pipe 12. Conveying high-temperature gas into the upper tower body 2, the mist droplets will dry quickly after contacting with the high-temperature gas, and then start the cyclone separator 19 to separate the solid and gas, so that the solid material automatically enters the aseptic clean room 20 from the discharge port for storage. The tail gas is transported into the water film dust collector 21 for processing. In this design, while drying the material, the diffusion mechanism is activated to make the mist droplets fill the entire upper tower body more quickly, so that the mist droplets can fully contact with the high-temperature gas, which plays a role in improving the drying efficiency.
如图2所示的储液罐9内设置有分隔板24,所述的储液罐12的内部空间被分隔板24分为左右两个部分,所述的分隔板24的上端与储液罐12的顶部之间存有间隙,所述的分隔板24的下端与储液罐12的底部相接触,所述的进液管8的一端伸入至分隔板24右侧的储液罐12的底部,所述的位于储液罐12内进液管8的一端安装有滤网23。物料溶液先输送进分隔板24左侧的储液罐12内,进行自然沉降,随着溶液不断流入,除杂后的溶液会通过分隔板24与储液罐12的间隙进入分隔板24右侧的储液罐12内;本实用新型通过采用上述设计对溶液进行除杂,减少了溶液中的固体杂质,保证了物料溶液的雾化效率。The liquid storage tank 9 shown in Figure 2 is provided with a dividing plate 24, and the internal space of the described liquid storing tank 12 is divided into left and right two parts by the dividing plate 24, and the upper end of the described dividing plate 24 is connected to There is a gap between the tops of the liquid storage tanks 12, the lower end of the partition plate 24 is in contact with the bottom of the liquid storage tank 12, and one end of the liquid inlet pipe 8 extends into the right side of the partition plate 24. At the bottom of the liquid storage tank 12 , a filter screen 23 is installed at the end of the liquid inlet pipe 8 in the liquid storage tank 12 . The material solution is first transported into the liquid storage tank 12 on the left side of the partition plate 24 for natural settlement. As the solution continues to flow in, the solution after removal of impurities will enter the partition plate through the gap between the partition plate 24 and the liquid storage tank 12 In the liquid storage tank 12 on the right side of 24; the utility model removes impurities from the solution by adopting the above-mentioned design, reduces the solid impurities in the solution, and ensures the atomization efficiency of the material solution.
如图1所示的扩散机构包括电机6和旋转叶片7,所述的电机6安装在导流室4内,所述的旋转叶片7套装在电机6的出轴端上,所述的旋转叶片7位于导流室4的出口处。当需要对雾滴进行扩散时,启动电机6使其带着旋转叶片7进行旋转,雾滴在旋转叶片7的作用下会迅速充满整个上塔体2,使雾滴与高温气体接触的更加充分,起到了提高干燥效率的作用。The diffusion mechanism shown in Figure 1 includes a motor 6 and a rotating blade 7, the motor 6 is installed in the guide chamber 4, the rotating blade 7 is sleeved on the shaft end of the motor 6, and the rotating blade 7 is located at the outlet of the diversion chamber 4 . When it is necessary to diffuse the mist, start the motor 6 to make it rotate with the rotating blade 7, and the mist will quickly fill the entire upper tower body 2 under the action of the rotating vane 7, so that the mist can fully contact with the high-temperature gas , played a role in improving the drying efficiency.
如图1所示的下塔锥3的外侧壁上安装有气锤震击器18,本设计通过气锤震击器18来敲击下塔锥3的侧壁,使残留在下塔锥3内侧壁上的干燥物料掉落,其具有结构简单、易于制造和实用高效的优点。Air hammer jar 18 is installed on the outer wall of lower tower cone 3 as shown in Fig. The dry material on the wall falls, which has the advantages of simple structure, easy manufacture, practicality and high efficiency.
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| CN201620480231.1U CN206045439U (en) | 2016-05-24 | 2016-05-24 | A kind of aseptic spray drying device |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110327642A (en) * | 2019-07-08 | 2019-10-15 | 浙江正裕化学工业有限公司 | A kind of spray dryer of solid dye production |
| CN110542280A (en) * | 2019-07-18 | 2019-12-06 | 中山市马里奥机械科技有限公司 | Powder drying system |
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2016
- 2016-05-24 CN CN201620480231.1U patent/CN206045439U/en not_active Expired - Fee Related
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110327642A (en) * | 2019-07-08 | 2019-10-15 | 浙江正裕化学工业有限公司 | A kind of spray dryer of solid dye production |
| CN110542280A (en) * | 2019-07-18 | 2019-12-06 | 中山市马里奥机械科技有限公司 | Powder drying system |
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Address after: 213116 Liang Zhuang bridge, Zhenglu Town, Wujin District, Changzhou, Jiangsu, China Patentee after: Jiangsu pilot Drying Technology Co., Ltd. Address before: 213000 Liang Zhuang bridge, Zhenglu Town, Wujin District, Changzhou, Jiangsu, China Patentee before: Changzhou Xiandao Drying Equipment Co., Ltd. |
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Granted publication date: 20170329 Termination date: 20210524 |