CN206014925U - A kind of NK cell collections suit - Google Patents
A kind of NK cell collections suit Download PDFInfo
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- CN206014925U CN206014925U CN201620826060.3U CN201620826060U CN206014925U CN 206014925 U CN206014925 U CN 206014925U CN 201620826060 U CN201620826060 U CN 201620826060U CN 206014925 U CN206014925 U CN 206014925U
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- groove
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- primary importance
- collection
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Abstract
This utility model provides a kind of NK cell collections suit, the collection includes inner packaging box with suit, primary importance groove is offered on the inner packaging box, second position groove, 3rd location groove and the 4th location groove, at the bottom position that primary importance groove is located on the wall of the inner packaging box side offer draw-in groove, the primary importance groove, second position groove, 3rd location groove, ice chest is placed with respectively in 4th location groove and draw-in groove, collection suit operation instruction, capture card, bar code and blood taking bag, the collection is easy to use with suit, blood taking bag individually need not be put in refrigerator, its temperature can be kept；And environmental simulation in the blood taking bag of interior splendid attire NK cells human internal environment, is more suitable for the culture and preservation of NK cells, and can significantly improve the activity of NK cells.
Description
Technical field
This utility model belongs to collection suit field, more particularly to a kind of NK cell collections suit.
Background technology
NK cells (Natural killer cell, natural killer cell) are the important immunocytes of body, not only with anti-
Tumor, viral infection resisting are relevant with immunomodulating, and participate in allergy and autoimmune disease in some cases
Occur.
At present, for the research of NK cells is increasingly becoming a focus of cell engineering research, but prior art is based on
Disclosure understands, the storage and transport problem for being exactly NK cells to greatest problem present in its research process, its
Include all multi-steps such as collection, transport, separation, culture in storing process, need to deposit longer time in practical operation, once
After NK cell collections, departing from original internal milieu, its activity is just affected by factors, such as time, temperature, is oozed
Press thoroughly etc..Therefore for collection after NK cells preservation be its store or research process in essential step.Current NK
After cell collection, how using directly dress blood taking bag or the method for basal medium is added preserving.And collection bag is being preserved
When, need to be put in refrigerator and stored, cause storage inconvenient.Additionally, directly the holding time of dress blood taking bag is generally less than
12 hours, the transport, handing-over and detection to NK cells brought no small time pressure, also limit which and preserves business development
Scope；In addition, preserving NK cells by adding basal medium, because basal medium can not reach, clinical grade is other to be wanted
Ask, be that their preservation brings risk, had a strong impact on the activity of NK cells.Prior art discloses some collection sets
Dress, such as umbilical cord acquisition suit box disclosed in CN102334996, but it is not disclosed NK cell collections suit.
Utility model content
In order to solve above-mentioned technical problem, this utility model provides a kind of NK cell collections suit, the collection suit
Easy to use, blood taking bag individually need not be put in refrigerator, so that it may keep its temperature；And the blood taking bag of interior splendid attire NK cells can
Significantly improve the activity of NK cells.
This utility model concrete technical scheme is as follows：
On the one hand this utility model provides a kind of NK cell collections suit, and the collection includes inner packaging box with suit, interior
Primary importance groove, second position groove, the 3rd location groove and the 4th location groove is offered on packing box, is located on the wall of inner packaging box side
Draw-in groove, primary importance groove, second position groove, the 3rd location groove, the 4th location groove is offered at the bottom position of primary importance groove
Operation instruction, capture card, bar code and blood taking bag are set with ice chest, collection is placed with draw-in groove respectively.
The collection that this utility model is provided is easy to use with suit, is placed with the temperature that ice chest can ensure that blood taking bag needs in which
Degree.
Further improvement, the case lid that collection suit is also included extranal packing box and is hinged with extranal packing box, extranal packing box
Inside it is provided with refrigerating chamber and places the storage tank of inner packaging box, freezing interior is provided with ice chest；It is provided with refrigerating chamber to open at the top of refrigerating chamber
Mouthful, the two lateral walls of refrigerating chamber opening are provided with groove, be connected with the groove can horizontal extension electronics freezing chamber cap.
The present invention is easy to the preservation of inner packaging box by arranging extranal packing box, and refrigerating chamber of setting can further to dissolving in which
Ice chest is freezed.
Further improvement, is additionally provided with temperature sensor, is provided with and temperature sensing on extranal packing box in primary importance groove
The temperature display that device is connected.This utility model passes through to arrange temperature sensor in the primary importance groove, and which can real-time monitoring the
Temperature in one location groove, is easy to provide a stationary temperature for blood taking bag.
Further improvement, extranal packing box are externally provided with the controller being connected with temperature sensor and the report being connected with controller
Alert device.Controller is used for receiving the temperature value in primary importance groove, when its temperature value is too high, will send warning to alarm
Instruction.
Further improvement, the medial wall of blood taking bag is laminated with anticoagulant layer.
Further improvement, is provided with the rotating suction disc mechanism being connected with controller, the rotating suction disc machine in extranal packing box
Structure includes that the first servomotor and rotary body, the rotary body include housing, two hollow rotations being arranged at housing drift angle
Axle and the sucker being inlaid on hollow rotary shaft side face, in the housing and the fixed gear that is connected with the first servomotor of main shaft
And two mesomerism gears ratcheting with fixed gear, two hollow rotary shafts are separately fixed at the central shaft of two mesomerism gears
On；The position of sucker is corresponding with the position of refrigerating chamber and primary importance groove respectively；The collection suit also includes electromagnetic valve,
External vacuum pump provides suction by vacuum tube for sucker, and the electromagnetic valve is arranged on vacuum tube.
Further improvement, the controller include that casing and the temperature collect module in casing, temperature compare mould
Block and control module.
By in extranal packing box, during the purpose of the rotating suction disc mechanism of setting, use to be set with when collection needs this utility model
When long-time is transported, the ice chest on its primary importance groove may dissolve, it is impossible to ensure the temperature required for blood taking bag, but due to
Cannot manually learn, and change inconvenience, so this utility model is after introducing rotating suction disc mechanism, when primary importance groove
When interior temperature is too high, controller receives temperature and compares, and controls electronics freezing chamber cap opening, drives rotating suction disc
Mechanism, plays a part of to change ice chest automatically, it is ensured that the temperature constant of blood taking bag in whole transportation.
The beneficial effects of the utility model are：The NK cell collections that this utility model is provided are easy to use with suit, are easy to
Environment in the storage and transport, and blood taking bag of NK cells fully simulates internal milieu, is more suitable for the existence of NK cells, energy
The survival rate of NK cell is enough significantly improved.
Description of the drawings
Fig. 1 is the structural representation of embodiment 1NK cell collection suit；
Fig. 2 is the structural representation of embodiment 2NK cell collection suit；
Fig. 3 is the structural representation of embodiment 3NK cell collection suit；
Fig. 4 is the structural representation of embodiment 4NK cell collection suit；
Structure enlarged diagrams of the Fig. 5 for 4 rotary body of embodiment；
Amplification views of the Fig. 6 for 4 rotary body of embodiment；
Fig. 7 is 5 controller internal structure fundamental diagram of embodiment.
Specific embodiment
Embodiment 1
A kind of NK cell collections suit, as shown in figure 1, the collection includes inner packaging box 1 with suit, on inner packaging box 1
Primary importance groove 11, second position groove 12, the 3rd location groove 13 and the 4th location groove 14 is offered, 1 side wall of inner packaging box is upper
Draw-in groove 15, primary importance groove 11, second position groove 12, the 3rd location groove is offered at the bottom position of primary importance groove 11
13rd, the 4th location groove 14 and the interior ice chest 3, collection that is placed with respectively of draw-in groove 15 are set with operation instruction, capture card, bar code and adopt
Blood bag 4.The position of the location groove opened up on the inner packaging box does not limit, and can start from left side, or set from right action
Put.
The collection that this utility model is provided is easy to use with suit, is placed with the temperature that ice chest can ensure that blood taking bag needs in which
Degree.
Embodiment 2
A kind of NK cell collections suit, the collection use suit as different from Example 1, as shown in Fig. 2 collection set
The case lid 21 that dress is also included extranal packing box 2 and is hinged with extranal packing box 2, is provided with refrigerating chamber 22 and places interior bag in extranal packing box 2
The storage tank 23 of mounted box 1, is provided with ice chest 3 in refrigerating chamber 22；The two lateral walls of refrigerating chamber opening are provided with groove 5, described recessed
Be connected with groove 5 can horizontal extension electronics freezing chamber cap 24.
The medial wall of blood taking bag is laminated with anticoagulant layer, and the anticoagulant layer is through spray printing by conventional anticoagulant such as sodium citrate
Make etc. technology.Arranging anticoagulant layer can prevent the activity of blood coagulation and then raising NK cells in blood taking bag.
This utility model is easy to the preservation of inner packaging box by arranging extranal packing box, and the refrigerating chamber arranged in which can enter
One step is freezed to the ice chest for dissolving.
Embodiment 3
A kind of NK cell collections suit, the collection uses suit as different from Example 2, as shown in figure 3, primary importance
Temperature sensor is additionally provided with groove 11, the temperature display 6 being connected with temperature sensor is installed on extranal packing box 2.The present invention
By arranging temperature sensor in primary importance groove, the temperature which can be in real-time monitoring primary importance groove is easy to as blood taking bag
One stationary temperature is provided.
As shown in figure 3, extranal packing box 2 is provided with the controller 7 being connected with temperature sensor and the report being connected with controller 7
Alert device 8.Controller is used for receiving the temperature value in primary importance groove, when its temperature value is too high, will send report to alarm
Alert instruction.
Embodiment 4
A kind of NK cell collections suit, the collection uses suit as different from Example 3, as shown in figure 4,21 court of case lid
A fluting is provided with the inside of extranal packing box 2, is provided with the rotating suction disc mechanism being connected with controller 7, rotating suction disc in extranal packing box 2
Mechanism includes the first servomotor 91 and rotary body 92, and as seen in figs. 5-6, the rotary body 92 includes housing 921, is arranged on shell
Two hollow rotary shafts 922 and the sucker 923 being inlaid on 922 side face of hollow rotary shaft at 921 drift angle of body, located at housing
In 921 and the fixed gear 924 that is connected with the first servomotor 91 of main shaft and two mesomerism gears ratcheting with fixed gear 924
925, two hollow rotary shafts 922 are separately fixed on the central shaft of two mesomerism gears 925；The position of sucker 923 respectively with
Refrigerating chamber 22 is corresponding with the position of primary importance groove 11；The collection suit also includes that electromagnetic valve, external vacuum pump lead to
Crossing vacuum tube and suction being provided for sucker 923, the electromagnetic valve is arranged on vacuum tube.
Controller 7 includes casing and the temperature collect module in casing 71, temperature comparing module 72 and control module；
Temperature collect module 71 is used for receiving the temperature in the primary importance groove 11 of temperature sensor collection, and is sent to temperature comparison mould
Block 72；Temperature comparing module 72 is used for the temperature of reception to be compared with default temperature threshold, when the temperature for receiving is higher than
During preset temperature, the freezing chamber cap unlatching of control electronics is sent to control module and drive the instruction of rotating suction disc mechanism；Control mould
Block is used for controlling the opening and closing of electronics freezing chamber cap and the driving of rotating suction disc mechanism, realizes the purpose for changing automatically ice chest with this.
Embodiment 5
A kind of NK cell collections suit, the collection uses suit as different from Example 3, as shown in fig. 7, the control
Module includes rotating suction disc mechanism controls module 73, electronics freezing chamber cap open and close controlling module 74 and solenoid valve control module 75.
The electronics freezing chamber cap open and close controlling module 74 is used for controlling the opening and closing that electronics freezes chamber cap；The rotating suction disc mechanism controls
Module is used for the driving for controlling the first servomotor；Solenoid valve control module is used for the opening and closing for controlling electromagnetic valve.
This utility model specific workflow is as follows：The temperature in primary importance groove that temperature collect module will be received, and
It is sent to temperature comparing module；The temperature of reception is compared by temperature comparing module with default temperature threshold, when received
When temperature is higher than preset temperature, chamber cap open and close controlling module is freezed to electronics and send the instruction that unlatching electronics freezes chamber cap, while
The instruction for driving rotating suction disc mechanism is sent to rotating suction disc mechanism controls module；Electronics freeze chamber cap open and close controlling module according to
The instruction for opening electronics freezing chamber cap of reception, opens electronics freezing chamber cap；Rotating suction disc mechanism controls module is according to reception
The instruction of rotating suction disc mechanism is driven, the motion of the first servomotor is driven, when a sucker moves to the position of primary importance groove
When, stop driving the first servomotor, while sending the instruction of opens solenoid valve to solenoid valve control module；Solenoid valve control mould
Instruction of the tuber according to the opens solenoid valve for receiving, opens solenoid valve control two suckers respectively to refrigerating chamber and first with this
The ice chest that puts in groove is adsorbed, then sends the instruction for driving rotating suction disc mechanism to rotating suction disc mechanism controls module, rotation
Sucking disc mechanism control module drives the first servomotor to move according to the instruction for driving rotating suction disc mechanism for receiving again, when
Be adsorbed with the indoor ice chest of freezing sucker move to primary importance groove position when, stop driving the first servomotor, at the same to
Solenoid valve control module sends the instruction for closing electromagnetic valve.
By in extranal packing box, during the purpose of the rotating suction disc mechanism of setting, use to be set with when collection needs this utility model
When long-time is transported, the ice chest on its primary importance groove may dissolve, it is impossible to ensure the temperature required for blood taking bag, but due to
Cannot manually learn, and change inconvenience, so this utility model is after introducing rotating suction disc mechanism, when primary importance groove
When interior temperature is too high, controller receives temperature and compares, and controls electronics freezing chamber cap opening, drives rotating suction disc
Mechanism, plays a part of to change ice chest automatically, it is ensured that the temperature constant of blood taking bag in whole transportation.
Module disclosed in this utility model can be conventional hardware configurations of the prior art, and such as temperature collect module can
Think receptor, temperature comparing module can be able to be dress for each control module of comparator, control module and its lower locator qualification
It is loaded with different processor of known software etc..
Above example only expresses several embodiments of the present utility model, and its description is more concrete and detailed, but simultaneously
Therefore the restriction to this utility model the scope of the claims can not be interpreted as.It should be pointed out that the ordinary skill for this area
For personnel, without departing from the concept of the premise utility, some deformations and improvement can also be made, these belong to this
The protection domain of utility model.Therefore, the protection domain of this utility model patent should be defined by claims.
Claims (7)
1. a kind of NK cell collections are set with, it is characterised in that the collection includes inner packaging box (1), the interior bag with suit
Primary importance groove (11), second position groove (12), the 3rd location groove (13) and the 4th location groove (14) is offered in mounted box (1),
At the bottom position that primary importance groove (11) is located on the wall of inner packaging box (1) side offer draw-in groove (15), described first
Put in groove (11), second position groove (12), the 3rd location groove (13), the 4th location groove (14) and draw-in groove (15) and be placed with ice respectively
Box (3), collection suit operation instruction, capture card, bar code and blood taking bag (4).
2. NK cell collections as claimed in claim 1 are set with, it is characterised in that the collection suit also includes outer package
Bag in being provided with refrigerating chamber (22) in case (2) and the case lid (21) being hinged with extranal packing box (2), extranal packing box (2) and placing
Ice chest (3) is provided with the storage tank (23) of mounted box (1), refrigerating chamber (22)；Freezing is provided with the top of refrigerating chamber (22)
Room opening, the two lateral walls of the refrigerating chamber opening are provided with groove (5), and groove (5) interior being connected with can horizontal extension
Electronics freezing chamber cap (24).
3. NK cell collections as claimed in claim 1 are set with, it is characterised in that is additionally provided with primary importance groove (11)
Temperature sensor, is provided with the temperature display (6) being connected with temperature sensor on extranal packing box (2).
4. NK cell collections as claimed in claim 3 are set with, it is characterised in that extranal packing box (2) are provided with and temperature
Controller (7) and the alarm (8) being connected with controller (7) that degree sensor is connected.
5. NK cell collections as claimed in claim 1 are set with, it is characterised in that the medial wall of the blood taking bag is laminated with anti-
Solidifying layer.
6. NK cell collections as claimed in claim 4 are set with, it is characterised in that is provided with and control in extranal packing box (2)
The rotating suction disc mechanism that device (7) processed are connected, the rotating suction disc mechanism include the first servomotor (91) and rotary body (92), institute
Rotary body (92) is stated including housing (921), two hollow rotary shafts (922) being arranged at housing (921) drift angle and is inlaid in
Sucker (923) on hollow rotary shaft (922) side face, in housing (921) and main shaft is connected with the first servomotor (91)
Fixed gear (924) and two mesomerism gears (925) ratcheting with fixed gear (924), two hollow rotary shafts (922) point
Be not fixed on the central shaft of two mesomerism gears (925), the position of sucker (923) respectively with refrigerating chamber (22) and primary importance
The position of groove (11) is corresponding；The collection suit also includes electromagnetic valve, and external vacuum pump is sucker by vacuum tube
(923) suction is provided, and the electromagnetic valve is arranged on vacuum tube.
7. NK cell collections as claimed in claim 6 are set with, it is characterised in that described controller (7) include casing and set
Temperature collect module, temperature comparing module and control module in the casing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201620826060.3U CN206014925U (en) | 2016-08-01 | 2016-08-01 | A kind of NK cell collections suit |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201620826060.3U CN206014925U (en) | 2016-08-01 | 2016-08-01 | A kind of NK cell collections suit |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN206014925U true CN206014925U (en) | 2017-03-15 |
Family
ID=58245250
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201620826060.3U Active CN206014925U (en) | 2016-08-01 | 2016-08-01 | A kind of NK cell collections suit |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN206014925U (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107674830A (en) * | 2016-08-01 | 2018-02-09 | 北京世纪劲得生物技术有限公司 | A kind of NK cell collections suit |
-
2016
- 2016-08-01 CN CN201620826060.3U patent/CN206014925U/en active Active
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107674830A (en) * | 2016-08-01 | 2018-02-09 | 北京世纪劲得生物技术有限公司 | A kind of NK cell collections suit |
| CN107674830B (en) * | 2016-08-01 | 2023-09-12 | 北京世纪劲得生物技术有限公司 | NK cell gathers and uses suit |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| TR01 | Transfer of patent right | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20191017 Address after: Room 1506A, 19 Chaowai Street, Chaoyang District, Beijing 100102 Patentee after: Beijing Zhongwei Medical Zheng Technology Co., Ltd. Address before: 101214 Pinggu District, Beijing, dense road, the road (three sections) No. 388, building 6 Patentee before: Beijing Century Jinde Biotechnology Co., Ltd. |
|
| TR01 | Transfer of patent right | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20200623 Address after: 101200 Pinggu District, Beijing, dense road, the road (three sections) No. 388, building 6 Patentee after: CENTURY BIOSTRENGTH BEIJING Pty Ltd. Address before: Room 1506A, 19 Chaowai Street, Chaoyang District, Beijing 100102 Patentee before: Beijing Zhongwei Medical Zheng Technology Co.,Ltd. |