CN206014917U - A kind of full suspended biological reactor - Google Patents
A kind of full suspended biological reactor Download PDFInfo
- Publication number
- CN206014917U CN206014917U CN201620984071.4U CN201620984071U CN206014917U CN 206014917 U CN206014917 U CN 206014917U CN 201620984071 U CN201620984071 U CN 201620984071U CN 206014917 U CN206014917 U CN 206014917U
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- China
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- tank body
- biological reactor
- suspended biological
- reactor according
- heat
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Abstract
This utility model provides a kind of full suspended biological reactor, including a reacting tank body and the agitating device being arranged in reacting tank body, the reacting tank body is externally provided with heat-preservation cylinder, heat-preservation cotton is filled between the heat-preservation cylinder and reacting tank body, the agitating device includes the shaft driven by magnetic driving equipment, the shaft is provided with multigroup securing supports, every group of securing supports include along the circumferential direction uniform fixed support bar, the fixed support bar front end is provided with stirring vane, angled adjustable with the retort transverse plane institute which is located with the stirring vane on group securing supports.This utility model simple structure, when the bioreactor of reason difference angle arcuation transition greatly can reduce stirring, shearing force produces damage to cell to which, in addition, this utility model is additionally provided with cleaning disk and ensure that inside reactor carries out the cleaning without dead angle, and it is configured with the needs for changing liquid pipe, volume of culture flow under continuous condition of culture being met of self-cleaning.
Description
Technical field
This utility model is related to a kind of full suspended biological reactor.
Background technology
Existing bioreactor in bioprocesses are carried out easily to culture in cell easily cause damages, traditional
Top mechanical agitation or bottom mechanical agitation due to there is mechanical seal and easily reveal and easily causing incubation microbiological contamination, other existing knot
Liquid pipe of changing in structure is easily blocked, and what cleaning disk cannot be completed makes omnibearing cleaning to whole bioreactor, in addition
Cannot be directed to carries out sterile sampling in the biological respinse for carrying out.
Content of the invention
This utility model is improved to the problems referred to above, i.e., the technical problems to be solved in the utility model is existing outstanding
Pelagic organism reactor easily causes to damage and clean inconvenience to cell.
Specific embodiment of the present utility model is：A kind of full suspended biological reactor, including a reacting tank body and setting
Agitating device in reacting tank body, the reacting tank body are externally provided with heat-preservation cylinder, fill between the heat-preservation cylinder and reacting tank body
There are heat-preservation cotton, the agitating device to include that the shaft driven by magnetic driving equipment, the shaft are provided with multigroup fixation
Support member, every group of securing supports include along the circumferential direction uniform fixed support bar, and the fixed support bar front end is provided with to be stirred
Blade is mixed, angled adjustable with the retort transverse plane institute which is located with the stirring vane on group securing supports.
Further, the stirring vane is curved and edge is excessive in circular arc.
Further, the cleaning pipe being provided with the top of the tank body in the middle part of insertion tank body, the cleaning pipe lower end has can be real
The cleaning disk of existing radial water spray, tank body sidepiece have and change liquid pipe to what inner side extended, change liquid pipe end and are provided with rotating wash bowl.
Further, tank body population, air inlet, air vent, charging aperture, sampler, institute are additionally provided with the top of the tank body
State air intake-exhaust mouth and be provided with sterilization filter device.
Further, the tank body upper end has visor, with regarding lamp in the visor.
Further, the driving means are the magnetic stirring apparatuss for being arranged at tank bottoms middle part, the magnetic stirring apparatuss and change
Frequency motor connection, the magnetic stirring apparatuss side are additionally provided with pneumatic bleed valve.
Further, in the tank body, bottom is additionally provided with breather, and the breather includes the breather for bending, institute
The outlet side of breather is stated towards shaft bottom.
Further, it is additionally provided with temperature sensor, a pair of PH sensors, pressure transducer, a pair of DO to pass in the tank body
Sensor and liquidometer.
Compared with prior art, this utility model has the advantages that：This utility model have meet cell suspension
Magnetic agitation is put in the bottom of fostering requirement, while the problems such as avoiding the sealing of traditional mechanical Mixing Machine from easily revealing, tank body has certainly
The requirement that changes liquid pipe, can meet that continuous condition of culture assigns daily 5 times of volume of culture flows of cleaning, does not block, solely
Some bubble-free aeration devices.Various condition of culture bubbles injury to cell is thoroughly solved, while reaching 10ml/L/Hr oxygen
Transfer rate, meets High Density Cultivation requirement, the sterilizing sampler of innovation.Observation, detection can be sampled in any case, this
Each data value, temperature stabilization, reliability are tested using two stable reference points in structure.
Description of the drawings
Fig. 1 is this utility model structural representation；
Fig. 2 is this utility model breather structural representation；
Fig. 3 is this utility model sampler structural representation.
Specific embodiment
The utility model is described in more detail with reference to the accompanying drawings and detailed description.
As shown in figure 1, a kind of full suspended biological reactor, including a reacting tank body 10 and is arranged in reacting tank body 10
Agitating device, the reacting tank body are externally provided with heat-preservation cylinder 20, are filled with heat-preservation cotton between the heat-preservation cylinder 20 and reacting tank body
210, the agitating device includes that the shaft 30 driven by driving means, the shaft 30 are provided with multigroup fixed support
Part, every group of securing supports include that along the circumferential direction uniform fixed support bar 310,310 front end of fixed support bar are provided with
Stirring vane 311, angled different from the retort transverse plane institute which is located with the stirring vane on group securing supports.
In the present embodiment, securing supports have two groups, 3 per group fixed support bars 310.In the present embodiment, the stirring
Blade is curved and edge is excessive in circular arc, and to reduce the damage to cell, mixing speed can be arranged to the function of time, full
The requirement of the mixing speed of foot difference incubation time section, driving means described in the present embodiment are to be arranged at tank bottoms magnetic agitation
Device 40, the magnetic stirring apparatuss 40 are connected with frequency conversion motor, and the magnetic stirring apparatuss side is additionally provided with pneumatic bleed valve 110.
The cleaning pipe 50 being provided with the top of the tank body 10 in the middle part of insertion tank body, 50 lower end of the cleaning pipe is with can realize spoke
The cleaning disk 510 of shape water spray is penetrated, and tank body sidepiece has and liquid pipe 60 is changed to what inner side extended, changes liquid pipe end and be provided with rotating wash bowl 610.
Tank body population 120, air inlet, air vent, charging aperture, sampler 140, the row is additionally provided with the top of the tank body
QI KOU is provided with defecator, and the tank body upper end has in form, the form with angularly disposed regarding lamp.
As shown in Fig. 2 bottom is additionally provided with breather in tank body, the breather includes the breather 130 for bending, institute
The outlet side of breather is stated towards shaft bottom, Air Bubble Size causes cell injury to have direct relation with which, according to different thin
Born of the same parents' tolerance shearing force is of different sizes, produces the different reduction damages of the bubble to cell of Air Bubble Size by controlling breather, with
When meet cell cultivation process to ventilate requirement.
As shown in figure 3, sampler 140 designs two mouths of pipe, one is steam inlet 141, and another is condensed for steam
Water and material outlet 142, sampling front opening steam valve carry out steam sterilization, open valve knob sampling, after sampling after sterilizing
After closing valve knob, it is again turned on steam valve and is sterilized, it is ensured that the valve after sampling is in aseptic condition.
Temperature sensor, PH sensors, pressure transducer, DO sensors and liquidometer is additionally provided with the tank body, wherein
Temperature sensor layout has multiple realizing in multiple points realizing the accurate of temperature.
The foregoing is only preferred embodiment of the present utility model, all according to this utility model claim done equal
Deng change and modification, should all belong to covering scope of the present utility model.
Claims (8)
1. a kind of full suspended biological reactor, it is characterised in that including a reacting tank body and the stirring being arranged in reacting tank body
Device, the reacting tank body are externally provided with heat-preservation cylinder, are filled with heat-preservation cotton, the stirring dress between the heat-preservation cylinder and reacting tank body
The shaft including being driven is put by magnetic driving equipment, and the shaft is provided with multigroup securing supports, per group of fixed support
Part includes that along the circumferential direction uniform fixed support bar, the fixed support bar front end are provided with stirring vane, supports with group is fixed
The retort transverse plane institute that stirring vane on part is located with which is angled adjustable.
2. a kind of full suspended biological reactor according to claim 1, it is characterised in that the stirring vane curved and
Edge is excessive in circular arc.
3. a kind of full suspended biological reactor according to claim 1, it is characterised in that be provided with insertion at the top of the tank body
Cleaning pipe in the middle part of tank body, the cleaning pipe lower end inwardly have with the cleaning disk that can realize radial water spray, tank body sidepiece
What side extended changes liquid pipe, changes liquid pipe end and is provided with rotating wash bowl.
4. a kind of full suspended biological reactor according to claim 1, it is characterised in that be additionally provided with tank at the top of the tank body
Body population, air inlet, air vent, charging aperture, sampler, the air intake-exhaust mouth are provided with sterilization filter device.
5. a kind of full suspended biological reactor according to claim 4, it is characterised in that the tank body upper end has and regards
With regarding lamp in mirror, the visor.
6. a kind of full suspended biological reactor according to claim 4, it is characterised in that bottom is additionally provided with the tank body
Breather, the breather include the breather for bending, and the outlet side of the breather is towards shaft bottom.
7. a kind of full suspended biological reactor according to claim 1, it is characterised in that the driving means are for being arranged at
The magnetic stirring apparatuss at tank bottoms middle part, the magnetic stirring apparatuss are connected with frequency conversion motor, and the magnetic stirring apparatuss side is additionally provided with gas
Dynamic bleed valve.
8. a kind of full suspended biological reactor according to claim 1, it is characterised in that be additionally provided with temperature in the tank body
Sensor, a pair of PH sensors, pressure transducer, a pair of DO sensors and liquidometers.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201620984071.4U CN206014917U (en) | 2016-08-30 | 2016-08-30 | A kind of full suspended biological reactor |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201620984071.4U CN206014917U (en) | 2016-08-30 | 2016-08-30 | A kind of full suspended biological reactor |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN206014917U true CN206014917U (en) | 2017-03-15 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201620984071.4U Active CN206014917U (en) | 2016-08-30 | 2016-08-30 | A kind of full suspended biological reactor |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN206014917U (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110799262A (en) * | 2017-06-30 | 2020-02-14 | 沙特基础工业全球技术有限公司 | Oligomerization reactor with improved feed system |
-
2016
- 2016-08-30 CN CN201620984071.4U patent/CN206014917U/en active Active
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110799262A (en) * | 2017-06-30 | 2020-02-14 | 沙特基础工业全球技术有限公司 | Oligomerization reactor with improved feed system |
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| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant |