Background technology
In wound healing process, fibroblastic propagation, Angiogenesiss, the synthesis of collagen and promoting epidermization are all
It is wherein important factor.Either unexpected occur or surgical operation caused by wound, injured in the near future, undifferentiated
Mesenchymal cell be transformed into animal migration fibroblast, it moves into and crosses impaired wound.It is currently known into fiber finer
Born of the same parents have aerobism, and fibroblast can produce collagen to promote wound healing after being upset.Confirmed by zooscopy,
The increase of collagen synthesis speed can occur under hyperoxic conditions.On the other hand, Angiogenesiss can be subject to hypoxic tissue gradient
Stimulation, new capillary vessel can upwardly extend towards the relatively low side of oxygen concentration.Epidermis generates plain rate also to be had with oxygen partial pressure
Close, for anoxia condition, under hyperoxic conditions, epitheliosis can have higher speed.
Because wound healing needs the participation of various cell, and the various growth factors of manufacture and collagen are required for fitting
When oxygen supply just can maintain the carrying out of whole wound healing process.When organizing oxygen partial pressure to be less than particular value, part
Cytosis needed for wound healing just cannot be carried out.According to existing research data, the phagocytosis of white blood cell must be in group
Knit competence exertion effect when oxygen partial pressure is more than 30mm Hg;Collagen needed for organization healing must be in wound oxygen partial pressure
Could synthesize more than during 30mm Hg;The sclerotin nucleus formation of fibroblast also must be more than 30mm Hg in local oxygen partial pressure
Shi Caineng is carried out.Additionally, when local oxygen partial pressure is less than 40mm Hg and does not have other auxiliary treatment, diabetic
Wound will be unable to restore.
Oxygen environment, in addition to can minimizing anaerobic bacteria flora by Developing restraint, can also reduce other pathogen
Concentration.There are three kinds of sources to healing wound tissue supply oxygen:In blood with hemoglobin chemistry combine oxygen, be dissolved in
Oxygen in blood plasma and the oxygen from outside is diffused into blood plasma or organizes.In the wound on surface, all of oxygen sources
All critically important.However, in the wound of high surface area, such as in ulcer wound, the tissue only at ulcer edge or its bottom
Can obtain being sufficiently fed of blood, and the granulation tissue in growing is not in the case of having oxygen to come in from outside diffusion, must
Must be by coming from the diffusion in blood vessel and blood plasma come oxygen supply, but this is a kind of relatively inefficient process.
For maintaining the hyperoxic conditions of wound tissue, in prior art, the existing product oxygen in order to provide oxygen to wound tissue applies
Material.Known product oxygen dressing generally uses foamed material as oxygen supporting substrate, so that oxygen is led in the way of external source of oxygen
Be transported to wound perimeter after crossing foamed material, or directly in the way of dissolved oxygen by oxygen storage in foamed material.However,
External source of oxygen need to configure air shooter, the not only more inconvenience and easily cause wound sense because of dealing with improperly when using
Dye.Additionally, although foamed material air permeability is good, because gas hold easily stored during because environment temperature change etc. factor and escape
Dissipate, therefore using foamed material as oxygen supporting substrate and maintain certain oxygen concentration to be not easy to, and connecing with wound body fluid
Touch and during discharging oxygen, general foamed material its partial pressure wayward and oxygen rate of release, therefore cannot obtain
Stable wound healing effect.
Therefore, need exist for the product oxygen dressing that a kind of oxygen partial pressure making wound circumference is more than 40mm Hg, it can avoid
Produce the reaction during storage of oxygen reactant to consume, and can avoid producing oxygen reactant or reacted product because with Wound contact and
Stimulate wound.
Utility model content
In view of this, the purpose of this utility model provides a kind of novel product oxygen wound dressing, and it can maintain wound circumference
Oxygen partial pressure to be effectively facilitated wound healing.Hold in space further, since producing oxygen reactant and being stored in difference, therefore can keep away
Exempt from product oxygen reactant to consume because of reaction during storage.
The utility model provides a kind of product oxygen wound dressing, and it comprises housing and wound-contacting layer.There is in housing resistance
Every portion, to be divided into aforementioned housing, reactant holds space and wound-contacting layer is held space.Reactant space of holding comprises
Hold space, the second reactant of first reactant is held space, non-return valve, flow regulator and gas delivery conduit.Before
State the first reactant and hold space in order to the first reactant of holding, it is held the aforementioned blocking part of spatial neighbor positioned at aforementioned reactants
Place.Aforementioned second reactant holds space in order to the second reactant of holding, and it holds space away from aforementioned positioned at aforementioned reactants
At blocking part.Aforementioned non-return valve holds space located at aforementioned first reactant and aforementioned second reactant is held between space.
Aforementioned flow adjusting means is held spatially located at aforementioned second reactant.These gases delivery conduit can gas connection aforementioned
One reactant holds space and aforementioned wound-contacting layer is held space.Aforementioned wound-contacting layer its be located at aforementioned wound-contacting layer
Hold in space with Wound contact.When aforementioned flow regulator start, aforementioned non-return valve is opened therewith, before controlling
State the second reactant and enter aforementioned first reactant via aforementioned non-return valve and hold the speed in space.
According to an embodiment of the present utility model, wherein These gases delivery conduit further includes pressure-regulating valve.
According to an embodiment of the present utility model, wherein These gases delivery conduit further includes ventilative water blocking layer.
According to an embodiment of the present utility model, wherein These gases delivery conduit further includes filter layer.
According to an embodiment of the present utility model, wherein aforementioned blocking part comprises baffler or the gas barrier film that blocks water.
According to an embodiment of the present utility model, wherein aforementioned flow adjusting means comprises depression bar.
According to an embodiment of the present utility model, wherein aforementioned non-return valve comprises duckbilled non-return valve.
According to an embodiment of the present utility model, wherein aforementioned wound-contacting layer has manifold structure.
According to an embodiment of the present utility model, the material of wherein aforementioned wound-contacting layer comprises:Polyurethane,
Polyolefin, vinyl acetate, poly- silica, the poly- silica of fluorine, fluoroelastomer, styrene, butadiene or thermoplastic elastomer (TPE).
According to an embodiment of the present utility model, wherein aforementioned housing is held at space more adjacent to aforementioned wound-contacting layer
Comprise relief valve.
According to an embodiment of the present utility model, wherein aforementioned housing further includes cushion, and it is located at aforementioned housing
Around opening.
Compared with prior art, because product oxygen wound dressing of the present utility model is stored in producing oxygen reactant not before use
Same region, thus can long term storage without because environmental condition and loss.Product oxygen wound dressing of the present utility model is by gas
Pressure-regulating valve on delivery conduit and the relief valve on housing can more easily control the oxygen content of wound circumference to adjust
Oxygen partial pressure needed for whole wound healing.There is easy storage, can effectively maintain wound according to product oxygen wound dressing of the present utility model
Oxygen partial pressure around mouthful, and the advantages of wound infection risk can be reduced, can really promote the healing of wound.
Above-mentioned utility model content aims to provide the simplification summary of this disclosure, so that reader has to this disclosure
Standby basic understanding.The complete overview of this utility model content not this disclosure, and it is not intended to pointing out this practicality
The key/critical element of new embodiment or define scope of the present utility model.After refering to following description, this practicality is new
Type those of ordinary skill in the art ought can will readily appreciate that essence spirit of the present utility model and the utility model
The technological means being adopted and embodiment.
Specific embodiment
Hereinafter with reference to correlative type, illustrate according to the embodiment producing oxygen wound dressing of the present utility model, for making to be easy to manage
Solution, the similar elements in following embodiments to be illustrated with identical symbology.In following narration, it will introduce above-mentioned
Produce the exemplary configuration of oxygen wound dressing.In order to be readily understood by the event of described embodiment, many ins and outs are provided below.When
So, not all embodiment all needs these ins and outs.Meanwhile, some are widely known by the people structure or element, only can be with
The mode illustrated is drawn, in the drawings suitably to simplify schema content.The schema being used, its purport is only to be illustrated and assists
Specification is used, and the actual proportions after may not implementing for the utility model are configured with accurate, therefore the ratio of schema that should be just not appended
Example and configuration relation are understood, interest field on actual enforcement for the limitation the utility model.
Advantage of the present utility model, feature and the technical method reaching will enter with reference to exemplary embodiments and institute's accompanying drawings
Row is more fully described and is easier to understand, and the utility model or can realize in different forms, therefore not it is understood that only limiting
In embodiments set forth herein, on the contrary, for art tool usually intellectual, the embodiment being provided will
Make this exposure more thorough and comprehensive and intactly pass on category of the present utility model, and the utility model will only be attached
Claim is defined.
And unless otherwise defined, all terms (comprising science and technology and scientific terminology) being used in hereinafter and proper noun, in
Substantially equivalent in meaning with what the skilled worker in this field belonging to the utility model was typically understood, and for example in typically being used
Dictionary those terms defined should be understood that there is the meaning consistent with the content of association area, and unless significantly fixed
Justice, in hereinafter, is not understood with excessive idealization or the excessively formal meaning.
Refer to Fig. 1, Fig. 1 is the side structure schematic diagram of the product oxygen wound dressing of an embodiment of the present utility model.
As shown in figure 1, product oxygen wound dressing of the present utility model comprises housing 100 and wound-contacting layer 200.Housing 100 is in order to tie up
Hold the sealed environment at wound tissue position, to maintain the oxygen partial pressure around wound 900, it is preferred that housing 100 is rigid body.Shell
It is provided with blocking part 110 so that reactant holds space 120 and wound-contacting layer is held by being divided into inside housing 100 in body 100
Space 130.It is selectively included adhesion coating, it can be to have pressure sensitive acrylic acid series to glue around the opening of housing 100
Agent, in order to make product oxygen wound dressing be fixedly attached to the skin around wound tissue position.
Blocking part 110 is in order to by being divided into inside housing 100, reactant holds space 120 and wound-contacting layer is held sky
Between 130.Consider blocking part 110 to need to have the support force to reactant, prevent reactant diffusion or infiltrate into wound-contacting layer
The property in space 130 of holding and having intercepts gas and avoids the oxygen of output to diffuse to reactant holds the property in space 120,
Blocking part 110 can be baffler, block water gas barrier film or a combination thereof.
Wound-contacting layer 200 is held in space 130 positioned at wound-contacting layer.According to an embodiment of the present utility model,
Wound-contacting layer 200 has manifold structure.Manifold typically refer to be provided to assist in tissue site apply, transmission fluid or from
Tissue site removes material or the structure of fluid.Wound-contacting layer 200 includes being provided to tissue site and removing from tissue site
Remove multiple flow channels of fluid, multiple flow channels can be connected to each other.Wound-contacting layer 200 can be placed
It is the biocompatible material contacting and oxygen is distributed in tissue site with tissue site.The example of wound-contacting layer 200 can
For example including but not limited to have the material of the structural element of multiple flow channels, such as reticulated foams, open pores bubble
Foam, porous organization's aggregation, liquid, gel and include or be solidified into the foam including flow channel.In an embodiment
In, wound-contacting layer 200 is the manifold structure that foaming body component is formed, its be including plurality of interconnected abscess or hole using as
The porous foamed body of multiple flow channels.Porous foamed body can be polyurethane perforate or reticulated foam it is also possible to
It is perforate flexomer foaming body, such as polyolefin, ethylene vinyl acetate, poly- silica, the poly- silica of fluorine, fluoroelastomer, benzene
Ethene, butadiene or thermoplastic elastomer (TPE).
Reactant within housing 100 space 120 of holding comprises the first reactant and holds space 121 and the second reactant
Hold space 122.First reactant holds space 121 in order to the first reactant 700 of holding, and the first reactant is held space 121
Space 120 hold positioned at reactant at blocking part 110.Second reactant holds space 122 in order to the second reactant of holding
800, the second reactant hold space 122 positioned at reactant hold space 120 away from blocking part 110 at.First reactant is held
Space 121 and the second reactant are held and are provided with non-return valve (schema does not illustrate) between space 122, in order to prevent the first reactant
The oxygen of 121 outputs in space of holding diffuses to the second reactant and holds space 122.In an embodiment of the present utility model
In, non-return valve can be duckbilled non-return valve, it is preferred that non-return valve can be rubber duck-bill non-return valve.
Second reactant space 122 of holding is provided with flow regulator 150, in order to control the second reactant 800 via
Non-return valve enters the first reactant and holds the speed in space 121.When flow regulator 150 start, non-return valve is opened therewith,
Make the second reactant 800 can enter the first reactant via non-return valve to hold space 121, and then hold sky with the first reactant
Between the first reactant 700 reaction output oxygen in 121.In an embodiment of the present utility model, flow regulator 150
For depression bar, by start depression bar, pressure is applied to depression bar, the second reactant 800 can be made via the duckbill valve opened because of pressure
And enter the first reactant and hold space 121.The oxygen of the second reactant 800 and the first reactant 700 reaction institute output can mat
Space 121 is held by gas connection first reactant and the hold gas delivery conduit 140 in space 130 of wound-contacting layer conveys
To wound-contacting layer 200, then uniformly transfer to wound 900 via wound-contacting layer 200.When reaction terminates or wound 900
The oxygen partial pressure of surrounding can be via start flow regulator 150 again, to accelerate the first reactant 700 and second when not enough
The reaction of reactant 800 and output oxygen, to maintain suitable oxygen partial pressure around wound 900.
For controlling the oxygen partial pressure around wound 900, gas delivery conduit 140 can also comprise pressure-regulating valve 141, with
Control the transporting velocity of oxygen, in order to adjust the modest pressure around wound 900, the oxygen partial pressure around wound 900 is not enough
When can Opening pressure regulating valve 141 make the oxygen of institute's output in the first reactant accommodation space 121 diffuse to wound-contacting layer hold
130 between being empty, conversely, the oxygen partial pressure around wound 900 enough when can closing presure regulating valve 141, it is to avoid output
Oxygen persistently diffuses to around wound 900.In an embodiment of the present utility model, for guaranteeing via gas delivery conduit
140 oxygen being transmitted do not comprise unreacted reactant or wound harmful substance, gas delivery conduit 140 optionally in
The ventilative water blocking layer of inner side setting or filter layer.
First reactant 700 can be to produce oxygen predecessor, and the second reactant 800 can be to produce VPO catalysts, and first is anti-
Oxygen can be produced after answering thing 700 and the second reactant 800 reaction.In an embodiment of the present utility model, the first reaction
Thing 700 produces oxygen predecessor for solid-state, and suitable solid-state is produced oxygen predecessor and can be but not limited to calper calcium peroxide, lithium peroxide, mistake
Sodium oxide molybdena, carbamide peroxide, potassium superoxide, sodium carbonate peroxyhydrate, and the second reactant 800 is liquid catalyst, suitable
Liquid catalyst can be water or aqueous metallic ions, such as the manganese ion aqueous solution or the iron ion aqueous solution, but does not limit
In this, as shown in Figure 1.In another embodiment of the present utility model, the first reactant 700 produces oxygen predecessor for liquid, fits
The liquid closed is produced oxygen predecessor and can be but not limited to hydrogen peroxide, and the second reactant 800 is solid catalyst, and suitable consolidates
State catalyst may, for example, be manganese dioxide, but not limited to this, as shown in Figure 2.
In an embodiment of the present utility model, housing 100 neighbouring wound contact layer is held at space 130 selectively
Comprise relief valve 160, in order to exclude excessive oxygen to adjust the oxygen partial pressure around wound 900.
For increasing the comfortableness of user, in an embodiment of the present utility model, housing 100 is selectively included
Cushion 300, it is located at the edge of opening of housing 100, is being applied using product oxygen wound of the present utility model in order to increase user
Comfortableness during material, as shown in Figures 1 and 2.The material of cushion 300 can for example comprise the enclosing foam with suitable thickness
Material, rubber, latex or air cushion buffering structure.Cushion 300 is selectively included adhesion coating, and it can be had
Pressure sensitive acrylic acid series sticker, in order to make product oxygen wound dressing be attached to the skin around wound tissue, to increase product oxygen
The stationarity of wound dressing.
Accordingly, when using product oxygen wound dressing of the present utility model, start flow regulator 150 makes to be stored in first
Second reactant 800 of the second reactant accommodation space 122 enters the first reactant accommodation space 121 via non-return valve, makes the
Output oxygen after two reactants 800 and the first reactant 700 reaction, and it is adjusted by the pressure tune in gas delivery conduit 140
Section valve 141, so that oxygen is can spread in wound-contacting layer accommodation space 130, through wound-contacting layer 200 by oxygen uniformly transfer to
Around wound 900, to maintain the oxygen partial pressure around wound 900, can start flow regulator 150 again after reaction terminates
Make the second reactant 800 enter the first reactant accommodation space 121 and produce oxygen and react with profit via non-return valve persistently to carry out.Work as wound
Also pressure-regulating valve 141 or relief valve 160 is can be utilized to adjust the oxygen partial pressure around wound 900 when partial pressure around 900 is too high.
Using product oxygen wound dressing of the present utility model because can preferably maintain the oxygen partial pressure of wound circumference, therefore wound can be effectively facilitated
Healing.
The utility model has following advantage:
1. mutually more conventional product oxygen dressing with dissolved oxygen mode by oxygen storage in dressing, because of the present utility model product oxygen wound
Dressing is stored in zones of different by producing oxygen reactant before use, thus can long term storage without because environmental condition and loss.
2. produce oxygen reactant to be separately stored in the zones of different of enclosure interior and away from wound, therefore wound will not be stimulated.This
Outward, by the setting of the ventilative water blocking layer in gas delivery conduit or filter layer, wound can be avoided because contacting the incomplete of spilling
Reaction reactant and come to harm.
3. except can preferably maintain the oxygen partial pressure of wound circumference, product oxygen wound of the present utility model applies for the design of housing
Material can more easily control the oxygen of wound circumference by the pressure-regulating valve in gas delivery conduit and the relief valve on housing
Gas content is to adjust the oxygen partial pressure needed for wound healing.
4. housing and reactant can sterilized process post package, so that product oxygen wound dressing of the present utility model is internally formed no
Bacterium space, and because being not required to impressed pressure source, therefore wound infection will not be caused because pipeline is improper.
From the above, there is easy storage, can effectively maintain wound circumference according to product oxygen wound dressing of the present utility model
Oxygen partial pressure, and the advantages of wound infection risk can be reduced, can really promote the healing of wound.
Although the utility model is disclosed above with embodiment, so it is not limited to the utility model, above institute
The embodiment stated only illustrates technological thought of the present utility model and feature, and its purpose enables those skilled in the art
Understand content of the present utility model and implement according to this, when the scope of the claims of the present utility model being limited with this, that is, generally according to this
Impartial change or modification that spirit disclosed in utility model is made, must cover in the scope of the claims of the present utility model, this
The protection domain of utility model ought be defined depending on appended the defined person of claim.