CN205910121U - Flexible grating sensor and monitoring biological fluids optics refraction coefficient's device - Google Patents
Flexible grating sensor and monitoring biological fluids optics refraction coefficient's device Download PDFInfo
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- CN205910121U CN205910121U CN201620835912.5U CN201620835912U CN205910121U CN 205910121 U CN205910121 U CN 205910121U CN 201620835912 U CN201620835912 U CN 201620835912U CN 205910121 U CN205910121 U CN 205910121U
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Abstract
The utility model provides a flexible grating sensor, including a grating sensor and a hemispheroid fluid cavity, integrated being in of grating sensor the hemispheroid fluid cavity in, adopt hemispheroid fluid chamber's purpose to ensure that all diffracted beams distance of process in liquid is the same to the decay that feasible distance is equalled, and can ensure that the diffracted beam not because the refraction takes place to deflect at liquid polymer interface, still provides a device of monitoring biological fluids optics refraction coefficient simultaneously as above flexible grating sensor, the semiconductor optical maser, forward optical diffraction screen and photoelectric detector place the position in proper order for semiconductor optical maser, flexible grating sensor, photoelectric detector and forward optical diffraction screen.
Description
Technical field
This utility model belongs to medicine technology field, more particularly, to a kind of two-dimensional diffraction gratings sensor and spreading out containing its two dimension
The device penetrating grating sensor is used for monitoring the refractive indices of biofluid.
Background technology
Monitoring body fluid data plays the role of important in many fields of medical science, such as diagnoses the illness.Given birth to by detecting
The physical property of logistics body we can obtain abundant information, these physical propertys include coefficient of refraction, density, transparency,
Electrical conductivity and viscosity.The coefficient of refraction (ri) of wherein biofluid has very special status, because we are from coefficient of refraction
In can obtain many information, such as blood sugar level and unmarked interaction of molecules.In nearest decades, because optics passes
Sensor precision is high, dynamic range is wide, the feature of electric conductivity, repeatability, Noninvasive, create many optical pickocffs in order to
Measurement liquid and the data variation of biofluid.Many is had to be exactly special measurement coefficient of refraction, coefficient of refraction sensing system is general
Including laser interferance method, capillary imaging method, photonic crystal method, surface plasmon resonance, optical fiber method and diffraction light
Grid method.
Such as dialysis procedure is it would be desirable to be monitored to blood, thus obtaining different blood data, including tremulous pulse
Pressure and the concentration of vein pressure, dialysis solution and waste liquid, this needs multi-faceted monitoring, thus needs huge equipment and holds high
Expensive expense.Because life entity monitoring needs high sensitivity and degree of accuracy, optical pickocff is often used in real-time measurement liquid
Characteristic, such as laser interferometer can be used to measure refractive index and may also be used for measuring glucose concentration；Step refraction system
Number optical fiber can serve as the coefficient of refraction sensor of liquid；Backscatter interferometric instrument can be used to detect solution and unmarked molecule
Interaction；Hemodialysis whole blood situation can be monitored with transmission and the spectrometry that diffuses.
In many monitoring methods of above-mentioned introduction, major part is all only capable of measuring refractive index, and needs accurate equipment,
Including camera lens, beam splitter, spectrogrph etc., though exist some can measure simultaneously several including coefficient of refraction, absorption, temperature etc.
The example of parameter, they are required for the setting of complexity, and different parameters needs using different sensing solutions.
Can monitor simultaneously biofluid multiple data this have highly important meaning under current big data environment
Justice.Such as, when a people loses renal function, medically hemodialysis can be carried out to it.Dialysis is used primarily in goes for it
Moisture except waste and surplus in blood.In dialysis, multiple properties of blood, dense including pressure, dialysis solution and waste liquid
Degree is required for constantly monitoring.Pulse blood oxygen instrument monitoring opacity is thus monitor oxygen levels in hemoglobin or blood.
Can accomplish to monitor multiple data currently without a device simultaneously.Therefore, when an equipment needs to comprise multiple monitoring instruments
During the such as ph survey meter of arterial-venous pressure monitor, temperature monitor, dialysis solution, will become very heavy, expensive.
Utility model content
For the deficiencies in the prior art, the present invention provides a kind of deformable grating sensor, can be same by this sensor
When monitoring biofluid multiple data, than if monitoring its refractive indices and pressure.
For realizing goal of the invention, this utility model takes following technical scheme:
A kind of deformable grating sensor, including a grating sensor and a hemisphere fluid cavity, described grating
Using the purpose of hemisphere fluid chamber, sensor integration, in described hemisphere fluid intracavity, is to ensure that all of diffracted beam exists
The distance passed through in liquid is identical, so that distance obtains equal decay, and can ensure that diffracted beam not due to refraction
Deflect at liquid polymerses interface.
Preferably, described hemisphere fluid cavity is arranged on substrate, on the bottom surface side of described hemisphere fluid cavity
The passage of two intercommunications that edge is provided with, one is liquid inlet channel, and one is liquid outlet passage, described grating sensor
Centre position positioned at hemisphere fluid cavity bottom surface.
Preferably, the material of the grating of described grating sensor, hemisphere fluid cavity, two passages and substrate is
Elastomeric polymer, the grating of grating sensor is pyramid two-dimensional grating.
Preferably, the described pyramid length of side is 0.5-3 micron, highly for 0.5-1.0 micron, adjacent pyramid center
Distance is 1-3 micron.
Preferably, described elastomeric polymer is polydimethylsiloxane (pdms), it is in ultraviolet-visible light 300
It is transparent under 800nm.
Preferably, the thickness of the grate film of described grating sensor is 0.1 ± 0.01mm.
Preferably, the material of the grating of described grating sensor, hemisphere fluid cavity and substrate also contains firming agent, institute
The polydimethylsiloxane (pdms) stated and the weight of firming agent ratio for 15～25:1, adds firming agent can become soft, Gu
Agent is commercially available product.
Preferably, the material of described two passages also contains firming agent, described polydimethylsiloxane (pdms)
And firming agent, its weight is than for 3-8:1.
The theoretical basiss of the deformable grating sensor of the present invention are that grating diffration figure is general, and described deformable grating passes
Sensor, is made using elastomeric material, as microsensor be advantageous in that its susceptiveness height, the high resolution in space, can
High, with low cost and manufacture method is simple by property.
Another object of the present invention is to providing a kind of device of monitoring biofluid refractive indices, take following
Technical scheme:
A kind of device of monitoring biofluid refractive indices, including deformable grating sensor as above, half
Conductor optical maser, positive optical diffraction screen and photodetector, placement location is followed successively by semiconductor light Amplifier Based On Stimulated Emission Of Radiation, deformable grating
Sensor, photodetector and positive optical diffraction screen.
Preferably, described semiconductor light Amplifier Based On Stimulated Emission Of Radiation launches one 4mw power, the light beam of 633nm wavelength.
Preferably, the center of the described beam alignment photodetector of semiconductor light Amplifier Based On Stimulated Emission Of Radiation transmitting.
Preferably, described deformable grating sensor and positive optical diffraction screen are at a distance of 16cm.
Using the present invention monitor biofluid refractive indices device monitoring biofluid refractive indices be
According to one-dimensional grating sensor diffraction equation:
ndsin(θm)=m λ (1)
In equation 1, by laser wavelength lambda, grating coefficient d, and order of diffraction m, scatteringangleθ m can be measured by collection of illustrative plates
Obtain, so we just can be calculated the refractive indices n of biofluid to be monitored.
It is dense that the present invention is used for medicine in real-time monitoring transfusion by using the device of monitoring biofluid refractive indices
The homogeneity of degree.In fact namely pass through to monitor the refractive indices of biofluid, if this coefficient does not change, that
The concentration of this biofluid of explanation is homogeneous.
The present invention is to be passed based on the multi-functional deformable grating of diffracting spectrum with regard to monitoring the coefficient of refraction of biofluid
Sensor.This deformable grating sensor is commonly used to Photoelectric Detection, and the deformable grating sensor that the present invention is used is as micro- biography
Sensor is advantageous in that its susceptiveness height, high resolution, highly reliable, with low cost and make simple.The present invention be a with
Multi-functional, convenient, the inexpensive deformable grating sensor being adapted to clinical application based on optical diffraction collection of illustrative plates；Two dimension
Grating sensor employ elastomeric polymer carry out replicate pyramid array be made, its shape, size and diffraction are strong
Degree can provide some information for us, and including coefficient of refraction, this optical pickocff is easy to manufacture, and low cost, for
Biofluid, such as blood can accomplish high-precision real-time monitoring.
Brief description
Fig. 1 is the structural representation of the deformable grating sensor of the present invention；
Wherein, 1. pyramid grating sensor, 2. hemisphere fluid cavity, 3. liquid inlet channel, 4. liquid outlet lead to
Road, 5. substrate；
Fig. 2 is the structural representation of the device of monitoring biofluid refractive indices of the present invention；
Wherein, 1. semiconductor light Amplifier Based On Stimulated Emission Of Radiation, 2. deformable grating sensor, 3. photodetector, 4. positive optical diffraction screen；
Fig. 3 is embodiment 2 to be obtained to different medium (empty gas and water, 10%, 20%, 30%, 40% D/W)
Positive diffracting spectrum；
Fig. 4 is the angle of diffraction figure being calculated according to Fig. 3；
Fig. 5 is the average diffraction work(under the mean power order of diffraction 10,11 that embodiment 2 silicon photodetector is measured
Rate figure.
Specific embodiment
The invention will be further described with reference to the accompanying drawings and examples.
Embodiment 1
A kind of deformable grating sensor as shown in Figure 1, including a grating sensor 1 and a hemisphere fluid cavity
2, described grating sensor 1 is integrated in described hemisphere fluid cavity 2, is to ensure that institute using the purpose of hemisphere fluid chamber
The distance that some diffracted beams pass through in a liquid is identical, so that distance obtains equal decay, and can ensure that diffraction light
Bundle is not because refraction deflects at liquid polymerses interface；Described hemisphere fluid cavity arranges on the substrate 5, described
Hemisphere fluid cavity the passage of two intercommunications that is provided with of bottom edge, one is liquid inlet channel 3, and one is liquid discharge
Mouthful passage 4, described grating sensor 1 is located at the centre position of hemisphere fluid cavity bottom surface, the light of described grating sensor
Grid, the material of hemisphere fluid cavity, two passages and substrate are elastomeric polymer, and the grating of grating sensor is pyramid
Two-dimensional grating.
The described pyramid length of side is 0.5-3 micron, and highly for 0.5-1.0 micron, adjacent pyramid centre distance is 1-3
Micron.
Described elastomeric polymer is polydimethylsiloxane (pdms), and it is under ultraviolet-visible light 300 800nm
Bright.The thickness of the grate film of described grating sensor is 0.1 ± 0.01mm.
The material of the grating of described grating sensor, hemisphere fluid cavity and substrate also contains firming agent, and described poly- two
The weight of methylsiloxane (pdms) and firming agent ratio for 15～25:1, adds firming agent can become soft, firming agent is city
Sell product.
The material of two described passages also contains firming agent, described polydimethylsiloxane (pdms) and firming agent,
Its weight is than for 3-8:1.
Embodiment 2
A kind of device of monitoring biofluid refractive indices as shown in Figure 2, including the deformable grating of embodiment 1
Sensor 2, semiconductor light Amplifier Based On Stimulated Emission Of Radiation 1, photodetector 3 and positive optical diffraction screen 4, placement location is followed successively by semiconductor light lasing
Device 1, deformable grating sensor 2, photodetector 3 and positive optical diffraction screen 4, described semiconductor light Amplifier Based On Stimulated Emission Of Radiation launches one
Road 4mw power, the light beam of 633nm wavelength；The center of the described beam alignment photodetector of semiconductor light Amplifier Based On Stimulated Emission Of Radiation transmitting；
Described deformable grating sensor and positive optical diffraction screen are at a distance of 16cm.
A kind of method of monitoring biofluid refractive indices, comprises the steps:
1. using the device monitoring biofluid refractive indices as above, toward in deformable grating sensor
Biofluid to be monitored is injected in hemisphere cavity；
2. laser beam is hit grating sensor, in a different direction by optical grating diffraction, diffraction is formed on screen
Collection of illustrative plates, according to one-dimensional grating sensor diffraction equation:
ndsin(θm)=m λ (1)
In equation 1, by laser wavelength lambda, grating coefficient d, and order of diffraction m, scatteringangleθ m can be measured by collection of illustrative plates
Obtain, so we just can be calculated the refractive indices n of biofluid to be monitored.
We first determine that the coefficient of refraction of grating is 1.4, and if the n value of liquid is more than 1.38, diffracting spectrum can become
Obtaining cannot be it is clear that such sensitivity also can decline.
In order to prove the measurement to biofluid coefficient of refraction, we have prepared the glucose solution of variable concentrations.Refraction
Coefficient can be found in handbook of chemistry and physics, is shown in Table 1.
| Concentration of glucose | n(ri) | The order of diffraction 00 power | The order of diffraction 11 power | The order of diffraction 10 power | The angle of diffraction of the order of diffraction 11 |
| Air | 1 | 0.9mw | 33.78μw | 168.3μw | 28.3° |
| 0% | 1.333 | 2.582mw | 2.95μw | 11.68μw | 21.2° |
| 10% | 1.348 | 2.81mw | 2.13μw | 7.8μw | 20.8° |
| 20% | 1.364 | 2.78mw | 1.36μw | 4.57μw | 20.2° |
| 30% | 1.381 | 2.67mw | 0.93μw | 2.71μw | 19.4° |
| 40% | 1.4 | 2.5mw | \ | \ | \ |
| 50% | 1.42 | 2.5mw | \ | \ | \ |
According to the method for above-mentioned monitoring biofluid refractive indices, respectively to empty gas and water, 10%, 20%,
30%th, 40% D/W is detected.
Measure coefficient of refraction by the angle of diffraction and two parameters of diffracted power.Fig. 3 is that embodiment 2 is (empty to different medium
Gas and water, 10%, 20%, 30%, 40% D/W) the positive diffracting spectrum that obtains；Fig. 4 is to be calculated according to Fig. 3
Angle of diffraction figure out；Fig. 5 is flat under the mean power order of diffraction 10,11 that embodiment 2 silicon photodetector is measured
All diffracted power figures.
It is identical for obtaining data from Fig. 4 and Fig. 5 with table 1, so the monitoring biofluid light refraction system of the present invention
The device of number can be used for monitoring biofluid refractive indices.
Claims (10)
1. deformable grating sensor is it is characterised in that including a grating sensor and a hemisphere fluid cavity, described
Grating sensor is integrated in described hemisphere fluid intracavity.
2. deformable grating sensor according to claim 1 is it is characterised in that described hemisphere fluid cavity is arranged on
On substrate, the passage of two intercommunications being provided with the bottom edge of described hemisphere fluid cavity, one is liquid inlet channel,
One is liquid outlet passage, and described grating sensor is located at the centre position of hemisphere fluid cavity bottom surface.
3. deformable grating sensor according to claim 1 and 2 is it is characterised in that the light of described grating sensor
Grid, the material of hemisphere fluid cavity, two passages and substrate are elastomeric polymer, and the grating of grating sensor is pyramid
Two-dimensional grating.
4. deformable grating sensor according to claim 3 is it is characterised in that the described pyramid length of side is that 0.5-3 is micro-
Rice, highly for 0.5-1.0 micron, adjacent pyramid centre distance is 1-3 micron.
5. deformable grating sensor according to claim 3 is it is characterised in that described elastomeric polymer is poly- diformazan
Radical siloxane.
6. a kind of deformable grating sensor according to claim 3 is it is characterised in that the light of described grating sensor
The thickness of grid thin film is 0.1 ± 0.01mm.
7. a kind of device of monitoring biofluid refractive indices is it is characterised in that include as any one of claim 1 to 6 institute
The deformable grating sensor stated, semiconductor light Amplifier Based On Stimulated Emission Of Radiation, positive optical diffraction screen and photodetector, placement location is followed successively by half
Conductor optical maser, deformable grating sensor, photodetector and positive optical diffraction screen.
8. a kind of device of monitoring biofluid refractive indices according to claim 7 is it is characterised in that described
Semiconductor light Amplifier Based On Stimulated Emission Of Radiation launches one 4mw power, the light beam of 633nm wavelength.
9. a kind of device of monitoring biofluid refractive indices according to claim 7 is it is characterised in that described
The center of the beam alignment photodetector of semiconductor light Amplifier Based On Stimulated Emission Of Radiation transmitting.
10. a kind of device of monitoring biofluid refractive indices according to claim 7 is it is characterised in that described
Deformable grating sensor and positive optical diffraction screen are at a distance of 16cm.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106290251A (en) * | 2016-08-03 | 2017-01-04 | 杭州美卜升医学科技有限公司 | A kind of deformable grating sensor and containing the device of its sensor and application |
| CN110154290A (en) * | 2018-07-17 | 2019-08-23 | 山东科技大学 | It is a kind of for the flexible deformable photon crystal material of monitoring structural health conditions and application |
| CN111226107A (en) * | 2017-10-18 | 2020-06-02 | 马克斯-普朗克科学促进学会 | Method and apparatus for comparing optical properties of two liquids |
-
2016
- 2016-08-03 CN CN201620835912.5U patent/CN205910121U/en active Active
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106290251A (en) * | 2016-08-03 | 2017-01-04 | 杭州美卜升医学科技有限公司 | A kind of deformable grating sensor and containing the device of its sensor and application |
| CN111226107A (en) * | 2017-10-18 | 2020-06-02 | 马克斯-普朗克科学促进学会 | Method and apparatus for comparing optical properties of two liquids |
| CN111226107B (en) * | 2017-10-18 | 2023-03-28 | 马克斯-普朗克科学促进学会 | Method and apparatus for comparing optical properties of two liquids |
| CN110154290A (en) * | 2018-07-17 | 2019-08-23 | 山东科技大学 | It is a kind of for the flexible deformable photon crystal material of monitoring structural health conditions and application |
| CN110154290B (en) * | 2018-07-17 | 2021-03-16 | 山东科技大学 | Flexible deformable photonic crystal material for structural health monitoring and application |
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Effective date of registration: 20171117 Address after: No. 9, 39 gate, petrifaction village, Qingshan Town, Qingshan District, Wuhan, Hubei Patentee after: Liu Gang Address before: Hangzhou City, Zhejiang province Yuhang District 311100 West 1500 Street warehouse before No. 6 unit 4 Building 7 floor Patentee before: Hangzhou Medical Technology Co., Ltd. |
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| CP01 | Change in the name or title of a patent holder |
Address after: No. 9, 39 gate, petrifaction village, Qingshan Town, Qingshan District, Wuhan, Hubei Patentee after: Liu Gang Address before: No. 9, 39 gate, petrifaction village, Qingshan Town, Qingshan District, Wuhan, Hubei Patentee before: Liu Gang |
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Effective date of registration: 20211013 Address after: 200540 room 111, building 2, No. 2467, Tingfeng Road, Zhujing Town, Jinshan District, Shanghai Patentee after: LIANGZHUN (SHANGHAI) INDUSTRIAL Co.,Ltd. Address before: 430082 No. 9, gate 39, petrochemical village, Qingshan Town, Qingshan District, Wuhan City, Hubei Province Patentee before: Liu Gang |