CN205729803U - A kind of genistein/EC PVA slow release composite particles preparation system - Google Patents
A kind of genistein/EC PVA slow release composite particles preparation system Download PDFInfo
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- CN205729803U CN205729803U CN201620413083.1U CN201620413083U CN205729803U CN 205729803 U CN205729803 U CN 205729803U CN 201620413083 U CN201620413083 U CN 201620413083U CN 205729803 U CN205729803 U CN 205729803U
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- preparation system
- pva
- storage tank
- genistein
- slow release
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Abstract
The utility model discloses a kind of genistein/EC PVA slow release composite particles preparation system, belong to field of pharmaceutical preparations, described genistein/EC PVA slow release composite particles preparation system includes dispersion phase preparation system, continuous phase preparation system, emulsifying systems, solvent recovering system, separation drying system, described dispersion phase preparation system connects emulsifying systems, described continuous phase preparation system connects emulsifying systems, described emulsifying systems connects solvent recovering system, and described solvent recovering system connects separation drying system.Genistein/EC PVA slow release the composite particles of nanometer or micron level can be prepared by the technical solution of the utility model, preparation system technological process is simple, production efficiency is high for this, prepared microgranule has good drug carrying ability and slow release effect, and grain diameter is little, even particle size distribution, has good market popularization value.
Description
[technical field]
This utility model belongs to pharmaceutical preparation preparing technical field, is specifically related to a kind of genistein/EC-PVA slow release multiple
Close microgranule preparation system.
[background technology]
Genistein (Genistein, GE) has another name called genistein, genistein, and chemical name is 5,7,4'-tri-hydroxyls
Base isoflavone (C15H10O5).There is the multiple pharmacodynamic features such as antioxidation, atherosclerosis, blood fat reducing, antitumor.Both at home and abroad
The approved multiple master isoflavone product containing genistein is used for crowd as food.American National tumor research center is in 1996
Genistein is listed in chemoprevention of cancer clinical drug development plan by year, as treatment breast carcinoma and the novel medicine of carcinoma of prostate
Thing.U.S. FDA in 1998 is ratified two kinds of masters food containing genistein (150mg/ grain) capsule simultaneously and is carried out production and sales, and 2004
The country one class new Chinese medicine dyestuff of year road, Chinese Medicine Leader institute of materia medica of The Fourth Military Medical University professor Wang Siwang development
Lignin crude drug and capsule thereof, through State Food and Drug Administration, approval enters clinical trial.
Have Genistein Capsule, XUEZHIKANG JIAONANG, genistein vaginal tablet, particularly good of hemorrhoid, Gubaoxinshen Tablets etc. at present
The main preparation containing genistein composition.So these preparation bioavailabilities are relatively low, and the most do not possess slow release effect, made by medicine
Slow releasing preparation, can improve medicine bioavailability in vivo, and can extend drug effect, greatly reduces the medicining times of patient, right
Critically ill patient treatment plays a crucial role.Ethyl cellulose (EC) and polyvinyl alcohol (PVA) have the ability of good packaging medicine,
And can be as drug stent, it is achieved medicament slow release discharges, and therefore, genistein, EC and PVA is prepared as have slow release effect
Composite particles has important research meaning, the document report the most not yet prepared about genistein/EC-PVA composite particles,
And traditional genistein composite particles preparation method is mainly solvent evaporation method, saturated water solution method etc., there is life
Produce the problems such as low, difficult solvent recovery, the product quality difference of efficiency.
[utility model content]
This utility model provides a kind of genistein/EC-PVA slow release composite particles preparation system, to solve conventional dyes
There is the problems such as low, difficult solvent recovery, the product quality difference of production efficiency, this utility model work in lignin composite particles preparation method
Process flow is simple, production efficiency is high, and prepared microgranule has good drug carrying ability and slow release effect and grain diameter is little, grain
Degree is evenly distributed, and considers solvent recovery, and environmentally safe has good market popularization value.
For solve above technical problem, this utility model by the following technical solutions:
A kind of genistein/EC-PVA slow release composite particles preparation system, including dispersion phase preparation system (1), continuous phase
Preparation system (2), emulsifying systems (3), solvent recovering system (4), separation drying system (5), described dispersion phase preparation system (1)
Connecting emulsifying systems (3), described continuous phase preparation system (2) connects emulsifying systems (3), and described emulsifying systems (3) connects solvent
Recovery system (4), described solvent recovering system (4) connects separation drying system (5)；Described dispersion phase preparation system (1) includes
C2H2Cl2Storage tank (11), dispersal device (12) and GE/EC storage tank (13), described C2H2Cl2Storage tank (11) and GE/EC storage tank (13)
Connect with dispersal device (12) respectively；Described continuous phase preparation system (2) include distilled water storage tank (21), PVA storage tank (22) and
Dissolver (23), described distilled water storage tank (21) and PVA storage tank (22) are connected with dissolver (23) respectively；Described emulsion type
System (3) is emulsifier unit (31)；Described solvent recovering system (4) includes vaporising device (41), vacuum pump (42), condensing unit
And solvent recovery tank (44) (43), described vaporising device (41) is connected with emulsifier unit (31) and condensing unit (43), described very
Empty pump (42) is connected with condensing unit (43) upper end outlet, and described solvent recovery tank (44) is connected with condensing unit (43) outlet；
Described separation drying system (5) includes segregation apparatus (51), devil liquor recovery tank (52), drying device (53) and product storage tank
(54), described devil liquor recovery tank (52) is connected with the outlet of segregation apparatus (51) lower end, described drying device (53) and segregation apparatus
(51) outlet connects, and described product storage tank (54) is connected with the outlet of drying device (53) lower end.
The most described dispersal device (12) is constant-temperature ultrasonic dispersion machine.
The most described GE/EC storage tank (13) is double-layer storage tank, and every layer is equipped with individually outlet.
The most described dissolver (23) is constant temperature blender with magnetic force.
The most described emulsifier unit (31) is ultrasonic homogenizer.
The most described vaporising device (41) is single effect evaporator.
The most described segregation apparatus (51) is GZX-1 high speed separator.
The most described drying device (53) is frozen vacuum dryer.
This utility model has the advantages that
(1) dispersal device in dispersion phase preparation system uses constant-temperature ultrasonic dispersion machine, GE and EC can be made in perseverance
Temperature, under ul-trasonic irradiation rapid dispersion to C2H2Cl2In, form dispersion phase, be substantially shorter jitter time, improve dispersion efficiency；
(2) in dispersion phase preparation system, GE/EC tank designs is double-layer storage tank, and every layer is equipped with individually outlet, can
Realize two kinds of raw materials of GE and EC to store respectively, add, save and produce space；
(3) constant temperature blender with magnetic force that the dissolver in continuous phase preparation system uses, can realize PVA rapid solution,
Form continuous phase；
(4) emulsifier unit in emulsifying systems uses high pressure homogenizer, can realize continuous phase and dispersion phase is the most newborn
Change, form nanometer or the composite particles of micron level；
(5) vaporising device in solvent recovering system combines vacuum pump, may be implemented in quick solvent flashing under vacuum and low temperature,
Effectively reduce the dissolvent residual of composite particles, be additionally provided with condensing unit, organic solvent high efficiente callback can be realized, effectively
Reduce product dissolvent residual, improve product quality；
(6) separate the GZX-1 high speed separator that the segregation apparatus in drying system uses, composite particles and solution can be realized
High efficiency separation；
(7) drying device separated in drying system uses frozen vacuum dryer, can realize composite particles very
It is dried under empty low temperature, it is ensured that product quality.
[accompanying drawing explanation]
Fig. 1 is system schematic of the present utility model.
In figure, Each part title is as follows:
1, dispersion phase preparation system；2, continuous phase preparation system；3, emulsifying systems；4, solvent recovering system；5, separation is dry
Drying system；11、C2H2Cl2Storage tank；12, dispersal device；13, GE/EC storage tank；21, distilled water storage tank；22, PVA storage tank；23, molten
Solve device；31, emulsifier unit；41, vaporising device；42, vacuum pump；43, condensing unit；44 solvent recovery tanks；51, dress is separated
Put；52, devil liquor recovery tank；53, drying device；54, product storage tank.
[detailed description of the invention]
It is specifically described below in conjunction with specific embodiment.
The working method of preparation system described in the utility model and principle: ultrasound wave is disperseed by this preparation system, magnetic force
The multiple technologies such as stirring, high pressure homogenize, high speed centrifugation and lyophilisation are combined dexterously, the most first open C2H2Cl2
Outlet switchs, and is passed through the C of certain volume to dispersal device (12)2H2Cl2, GE and EC is added the most successively
Enter dispersal device (12), under ul-trasonic irradiation, carry out constant temperature dispersion, prepared composition dephasing；Meanwhile, open distilled water storage tank to go out
Mouth switch, is passed through the distilled water of certain volume, then adds a certain amount of PVA, at magnetic to dispersal device (12) to dissolver (23)
Rapid solution under power stirring action, forms continuous phase；Continuous phase and dispersion phase are transferred to the emulsifier unit in emulsifying systems (3)
(31), in, under the quick stirring action of high pressure homogenizer, emulsifying is quickly realized；Emulsifying product is transferred to solvent recovering system
(4) vaporising device (41) in is evaporated, and the solvent being vaporized, under the drive of vacuum pump (42), enters condensing unit (43)
It is condensed into liquid, leaves solvent recovery tank (44) in；After recycling design, surplus products enter the separation dress separated in drying system
Putting (51) and carry out high speed centrifugation, upper strata waste liquid leaves devil liquor recovery tank (52) in, and precipitation enters drying device (53) after filtering
In carry out lyophilisation, product is stored in product storage tank (54) the most at last, i.e. complete genistein/EC-PVA slow release be combined
The preparation of microgranule.
As shown in Figure 1: include that dispersion phase preparation system (1), continuous phase preparation system (2), emulsifying systems (3), solvent return
Receipts system (4), separation drying system (5), described dispersion phase preparation system (1) connects emulsifying systems (3), prepared by described continuous phase
System (2) connects emulsifying systems (3), and described emulsifying systems (3) connects solvent recovering system (4), described solvent recovering system (4)
Connect and separate drying system (5)；Described dispersion phase preparation system (1) includes C2H2Cl2Storage tank (11), dispersal device (12) and GE
With EC storage tank (13), described C2H2Cl2Storage tank (11) and GE/EC storage tank (13) connect with dispersal device (12) respectively；Described continuously
Phase preparation system (2) includes distilled water storage tank (21), PVA storage tank (22) and dissolver (23), described distilled water storage tank (21)
It is connected with dissolver (23) respectively with PVA storage tank (22)；Described emulsifying systems (3) is emulsifier unit (31)；Described solvent returns
Receipts system (4) includes vaporising device (41), vacuum pump (42), condensing unit (43) and solvent recovery tank (44), described evaporation dress
Putting (41) to be connected with emulsifier unit (31) and condensing unit (43), described vacuum pump (42) is with condensing unit (43) upper end outlet even
Connecing, described solvent recovery tank (44) is connected with condensing unit (43) outlet；Described separation drying system (5) includes segregation apparatus
(51), devil liquor recovery tank (52), drying device (53) and product storage tank (54), described devil liquor recovery tank (52) and segregation apparatus
(51) lower end outlet connects, and described drying device (53) is connected with segregation apparatus (51) outlet, and described product storage tank (54) is with dry
The outlet of dry device (53) lower end connects.
Dispersal device (12) in described dispersion phase preparation system (1) uses constant-temperature ultrasonic dispersion machine, can make GE
With EC under constant temperature, ul-trasonic irradiation rapid dispersion to C2H2Cl2In, form dispersion phase, be substantially shorter jitter time, improve
Dispersion efficiency；
In described dispersion phase preparation system (1), GE/EC storage tank (13) is designed as double-layer storage tank, and every layer is equipped with individually to go out
Mouthful, two kinds of raw materials of GE and EC can be realized and store respectively, add, save and produce space；
The constant temperature blender with magnetic force that dissolver (23) in described continuous phase preparation system (2) uses, can realize PVA fast
Instant solution, forms continuous phase；
Emulsifier unit (31) in described emulsifying systems (3) uses high pressure homogenizer, can realize continuous phase and dispersion
Phase quick emulsification, forms nanometer or the composite particles of micron level；
Vaporising device (41) in described solvent recovering system (4) combines vacuum pump (42), may be implemented under vacuum and low temperature
Quickly solvent flashing, effectively reduces the dissolvent residual of composite particles, is additionally provided with condensing unit (43), can realize organic
Solvent high-efficiency reclaims, and effectively reduces product dissolvent residual, improves product quality, and also can reduce solvent discharge, to environment without dirt
Dye；
Segregation apparatus (51) in described separation drying system (5) uses GZX-1 high speed separator, can realize being combined
Microgranule and the high efficiency separation of solution；
Drying device (53) in described separation drying system (5) uses frozen vacuum dryer, can realize being combined
Microgranule is dried under vacuum and low temperature, it is ensured that product quality.
Above content is it cannot be assumed that this utility model is embodied as being confined to these explanations, for art
For those of ordinary skill, under without departing from this concept thereof, it is also possible to make some simple deduction or replace, all should be considered as
Belong to the scope of patent protection that this utility model is determined by the claims submitted to.
Claims (8)
1. genistein/EC-PVA slow release composite particles preparation system, it is characterised in that: include dispersion phase preparation system
(1), continuous phase preparation system (2), emulsifying systems (3), solvent recovering system (4), separate drying system (5), described dispersion phase
Preparation system (1) connects emulsifying systems (3), and described continuous phase preparation system (2) connects emulsifying systems (3), described emulsifying systems
(3) connecting solvent recovering system (4), described solvent recovering system (4) connects separation drying system (5)；Prepared by described dispersion phase
System (1) includes C2H2Cl2Storage tank (11), dispersal device (12) and GE/EC storage tank (13), described C2H2Cl2Storage tank (11) and GE/
EC storage tank (13) connects with dispersal device (12) respectively；Described continuous phase preparation system (2) includes distilled water storage tank (21), PVA
Storage tank (22) and dissolver (23), described distilled water storage tank (21) and PVA storage tank (22) are connected with dissolver (23) respectively；
Described emulsifying systems (3) is emulsifier unit (31)；Described solvent recovering system (4) include vaporising device (41), vacuum pump (42),
Condensing unit (43) and solvent recovery tank (44), described vaporising device (41) connects with emulsifier unit (31) and condensing unit (43)
Connecing, described vacuum pump (42) is connected with condensing unit (43) upper end outlet, described solvent recovery tank (44) and condensing unit (43)
Outlet connects；Described separation drying system (5) includes segregation apparatus (51), devil liquor recovery tank (52), drying device (53) and produces
Product storage tank (54), the outlet of described devil liquor recovery tank (52) and segregation apparatus (51) lower end is connected, described drying device (53) with divide
Connecting from device (51) outlet, described product storage tank (54) is connected with the outlet of drying device (53) lower end.
Genistein the most according to claim 1/EC-PVA slow release composite particles preparation system, it is characterised in that: described
Dispersal device (12) is constant-temperature ultrasonic dispersion machine.
Genistein the most according to claim 1/EC-PVA slow release composite particles preparation system, it is characterised in that: described
GE/EC storage tank (13) is double-layer storage tank, and every layer is equipped with individually outlet.
Genistein the most according to claim 1/EC-PVA slow release composite particles preparation system, it is characterised in that: described
Dissolver (23) is constant temperature blender with magnetic force.
Genistein the most according to claim 1/EC-PVA slow release composite particles preparation system, it is characterised in that: described
Emulsifier unit (31) is ultrasonic homogenizer.
Genistein the most according to claim 1/EC-PVA slow release composite particles preparation system, it is characterised in that: described
Vaporising device (41) is single effect evaporator.
Genistein the most according to claim 1/EC-PVA slow release composite particles preparation system, it is characterised in that: described
Segregation apparatus (51) is GZX-1 high speed separator.
Genistein the most according to claim 1/EC-PVA slow release composite particles preparation system, it is characterised in that: described
Drying device (53) is frozen vacuum dryer.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201620413083.1U CN205729803U (en) | 2016-05-09 | 2016-05-09 | A kind of genistein/EC PVA slow release composite particles preparation system |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201620413083.1U CN205729803U (en) | 2016-05-09 | 2016-05-09 | A kind of genistein/EC PVA slow release composite particles preparation system |
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| Publication Number | Publication Date |
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| CN205729803U true CN205729803U (en) | 2016-11-30 |
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|---|---|---|---|
| CN201620413083.1U Expired - Fee Related CN205729803U (en) | 2016-05-09 | 2016-05-09 | A kind of genistein/EC PVA slow release composite particles preparation system |
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| CN (1) | CN205729803U (en) |
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2016
- 2016-05-09 CN CN201620413083.1U patent/CN205729803U/en not_active Expired - Fee Related
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| Date | Code | Title | Description |
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| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20161130 Termination date: 20190509 |
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| CF01 | Termination of patent right due to non-payment of annual fee |