CN205434507U - Ultrapure hemodialysis concentrate manufacturing system - Google Patents
Ultrapure hemodialysis concentrate manufacturing system Download PDFInfo
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- CN205434507U CN205434507U CN201521117538.7U CN201521117538U CN205434507U CN 205434507 U CN205434507 U CN 205434507U CN 201521117538 U CN201521117538 U CN 201521117538U CN 205434507 U CN205434507 U CN 205434507U
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- ultrapure
- endotoxin
- hemodialysis
- manufacturing system
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Abstract
The utility model relates to a hemodialysis liquid manufacturing system and manufacturing process, concretely relates to endotoxin <= 0.03euml and colony formation number <= 0.1cfuml's ultrapure hemodialysis concentrate manufacturing system and manufacturing process. Ultrapure hemodialysis concentrate manufacturing system includes: dissolving tank 1, activated carbon adsorber 2, modified resin adsorber 3, precision filter 4, liquid storage pot 5 are mixed to developments, developments are mixed the dissolving tank and are had the heating function. The beneficial effects of the utility model are that: having increased active carbon adsorption and modified resin and having adsorbed technology, it is endotoxin and the bacterial colony that is arranged in adsorbing the product specially to add this technology, has obtained cleaing away through adsorbing back endotoxin and bacterial colony.
Description
Technical field:
This utility model relates to a kind of blood dialysis solution and manufactures system, is specifically related to endotoxin≤0.03eu/ml and bacterium colony forms the ultrapure hemodialysis concentrated solution manufacture system of number≤0.1cfu/ml.
Background technology:
In prior art, the technological process of production of hemodialysis concentrated solution is as shown in Figure 1.The material used is: sodium chloride, potassium chloride, calcium chloride, magnesium chloride, glacial acetic acid, sodium bicarbonate;Manufacture process includes: material mixed dissolution, constant volume, the inspection of semifinished product.Because composition blood dialysis solution is made up of multiple raw and auxiliary material, these raw and auxiliary materials are not super cleans, inherently contain endotoxin and the clump count (for ultrapure blood dialysis solution) of higher level;Process of manufacture also has contaminated risk.
Endotoxin and clump count in hemodialysis concentrated solution are to cause dialysis patient chronic injury, topmost stealthy killer.Through long-term hemodialysis, in dialysis solution, endotoxin and the bacterium colony of higher level form number (for super clean dialysis solution) and can impact kidney, liver and the hemogram of patient.So developing super clean hemodialysis concentrated solution and using in medical institutions, the toxic and side effects that hemodialysis can be improved, the quality of life improving dialysis patient, prolongation patient's life-span.
Summary of the invention:
The purpose of this utility model is that the ultrapure hemodialysis concentrated solution providing a kind of endotoxin≤0.03eu/ml and bacterium colony to form number≤0.1cfu/ml manufactures system and manufacturing process.
Ultrapure hemodialysis concentrated solution manufactures system, including: dynamically mixed dissolution tank 1, active carbon adsorber 2, modified resin absorption device 3, accurate filter 4, fluid reservoir 5;Described dynamic mixed dissolution tank has heating function.Dynamically the mixed dissolution of mixed dissolution tank, molten material dynamic response hybrid system use the scheme described in open source literature (CN102228814A).The ultrapure hemodialysis concentrated solution manufacturing process realized in above-mentioned manufacture system, the material of use is: sodium chloride, potassium chloride, calcium chloride, magnesium chloride, glacial acetic acid, sodium bicarbonate;Manufacture process includes: material mixed dissolution, constant volume, the inspection of semifinished product;Subsequent technique process is followed successively by: activated carbon adsorption, resin absorption, secondary filter;Temperature during described material mixed dissolution controls at 35 DEG C ± 1.5 DEG C;Described accurate filter filtering accuracy is :≤0.12 μm.
Preferably, also include: the first pressure regulating pump 6 being arranged between dynamic mixed dissolution tank and active carbon adsorber, be arranged on the second pressure regulating pump 7 between modified resin absorption device and accurate filter;The operating pressure of described activated carbon adsorption and resin absorption controls all at 0.1MPa ± 0.05MPa.
As one of further preferred scheme, described activated carbon iodine number >=1000;In described active carbon absorption technology, activated carbon is filled into the 2/3 of activated carbon container volume.
As the two of further preferred scheme, the model of the modified resin used by described resin absorption is HB-H-7, and modified resin is filled into the 2/3 of modified plastic holding device volume.
The beneficial effects of the utility model are:
(1) adding activated carbon adsorption and modified resin absorption technique, add endotoxin and bacterium colony that this technique is used exclusively in adsorption production, after absorption, endotoxin and bacterium colony are removed.
(2) prescription and the haemodialysis control unit of hemodialysis concentrated solution matches, because the dilution ratio of dialysis machine is different so the concentrated solution ion concentration used also can be had any different.This utility model only relates to the adsorption removal of endotoxin and bacterium colony, and does not affect the ion concentration of product, it is possible to the product for various ion concentrations is purged processing.
Accompanying drawing illustrates:
Fig. 1 is the process chart of prior art.
Fig. 2 is process chart of the present utility model.
Fig. 3 is the structural representation that this utility model manufactures system;In figure, 1 represents dynamic mixed dissolution tank, and 2 represent active carbon adsorber, and 3 represent modified resin absorption device, and 4 represent accurate filter, and 5 represent fluid reservoir, 6 represents the first pressure regulating pump, 7 represents the second pressure regulating pump.
Detailed description of the invention:
Embodiment:
Below in conjunction with Figure of description 2,3, this utility model super clean hemodialysis concentrated solution is manufactured system and technique is described in detail:
As shown in Figure 3, ultrapure hemodialysis concentrated solution manufactures system, including: dynamically mixed dissolution tank, active carbon adsorber, modified resin absorption device, accurate filter, fluid reservoir, it is arranged on the first pressure regulating pump between dynamic mixed dissolution tank and active carbon adsorber, is arranged on the second pressure regulating pump between modified resin absorption device and accurate filter;Described dynamic mixed dissolution tank has heating function;The material used is: sodium chloride, potassium chloride, calcium chloride, magnesium chloride, glacial acetic acid, sodium bicarbonate;Manufacture process includes: material mixed dissolution, constant volume, the inspection of semifinished product;Subsequent technique process is followed successively by: activated carbon adsorption, resin absorption, secondary filter;Temperature during described material mixed dissolution controls at 35 DEG C ± 1.5 DEG C;Described accurate filter filtering accuracy is :≤0.12 μm.
The mixed dissolution of described dynamic mixed dissolution tank, molten material dynamic response hybrid system use the scheme described in open source literature (CN102228814A).
The internal activated carbon of described active carbon adsorber 2 is filled at the 2/3 of volume.
Described resin absorption device 3 inter-modification resin is filled at the 2/3 of volume.
Described first pressure regulating pump 6 and the second pressure regulating pump 7 take automatically to compensate linkage work, remain that active carbon adsorber and modified pressure within resin absorption device are maintained at 0.1MPa ± 0.05MPa during work
Manufacture process comprises the steps:
(1) pure water being put into dynamic mixed dissolution tank, amount of water is the 2/3 of the amount of producing;Open heater;
(2) open the agitating function of dynamic mixed dissolution tank, feed intake by proportioning;Continue stirring until whole material dissolutions;
(3) after temperature reaches 35 DEG C, stirring is stopped, open the first pressure regulating pump and the second pressure regulating pump, by the dialysis solution for preparing through active carbon adsorber and modified resin absorption device, the Stress control of active carbon adsorber and modified resin absorption device is at 0.1MPa ± 0.05MPa;
(4) product through absorption carries out filtration treatment through accurate filter again;Accurate filter filter sizes≤0.12 μm;
(5) final products enter fluid reservoir.
Hemodialysis concentrated solution at a temperature of appropriate, apply to be fully contacted with activated carbon and modified resin under certain pressure condition, adsorption effect dramatically increases.When arriving the outlet of resin absorption device, endotoxin and the bacterium colony of concentrated solution form number and can meet: endotoxin≤0.03eu/ml, bacterium colony form number≤0.1cfu/ml.
Claims (2)
- The most ultrapure hemodialysis concentrated solution manufactures system, it is characterized in that, including: dynamically mixed dissolution tank (1), active carbon adsorber (2), modified resin absorption device (3), accurate filter (4), fluid reservoir (5);Described dynamic mixed dissolution tank has heating function.
- 2. manufacture system according to the most ultrapure hemodialysis concentrated solution, its feature, also include: the first pressure regulating pump (6) being arranged between dynamic mixed dissolution tank and active carbon adsorber, be arranged on the second pressure regulating pump (7) between modified resin absorption device and accurate filter.
Priority Applications (1)
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CN201521117538.7U CN205434507U (en) | 2015-12-28 | 2015-12-28 | Ultrapure hemodialysis concentrate manufacturing system |
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CN201521117538.7U CN205434507U (en) | 2015-12-28 | 2015-12-28 | Ultrapure hemodialysis concentrate manufacturing system |
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CN205434507U true CN205434507U (en) | 2016-08-10 |
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Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
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CN105641764A (en) * | 2015-12-28 | 2016-06-08 | 天津市标准生物制剂有限公司 | Ultra-pure hemodialysis concentrated solution manufacturing system and manufacturing technology |
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Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
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CN105641764A (en) * | 2015-12-28 | 2016-06-08 | 天津市标准生物制剂有限公司 | Ultra-pure hemodialysis concentrated solution manufacturing system and manufacturing technology |
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