CN205333577U - Stratographic pre -column of liquid chromatogram ion device of deriving - Google Patents
Stratographic pre -column of liquid chromatogram ion device of deriving Download PDFInfo
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- CN205333577U CN205333577U CN201521136519.9U CN201521136519U CN205333577U CN 205333577 U CN205333577 U CN 205333577U CN 201521136519 U CN201521136519 U CN 201521136519U CN 205333577 U CN205333577 U CN 205333577U
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Abstract
The utility model discloses a stratographic pre -column of liquid chromatogram ion device of deriving, include: the liquid phase solution, pump, reaction unit, injector, insulation can chromatographic column, the detector that connect gradually, reaction unit include casing, reacting chamber and accuse temperature unit, and casing interior and one end and pump intercommunication are located to the reacting chamber, and the other end communicates with the injector, just reaction chamber outer wall is equipped with the heat preservation, and accuse temperature unit is including accuse temperature panel and temperature control circuit board, and the reacting chamber bottom face is equipped with a recess that is used for holding accuse temperature panel, and accuse temperature panel is fixed in in the recess and carries out temperature control to the reacting chamber, still includes agitating unit, and agitating unit includes motor and flabellum, and the reacting chamber outside is located to the motor, in the reacting chamber is located to the flabellum, and the output crown of roll of motor is stretched in the reacting chamber and fan blade connected, agitating unit is used for reaction liquid intensive mixing. The utility model discloses a temperature and reaction time controlled strong, derive efficient.
Description
Technical field
This utility model relates to chemical derivatization technical field, particularly relates to the column front derivation device of a kind of liquid chromatograph chromatography of ions。
Background technology
Derivatization is a kind of to utilize chemical transformation that converting compounds is become the material of similar chemical constitution。In general, the compound of a specific function participates in derivatization reaction, dissolubility, boiling point, fusing point, and state of aggregation or chemical composition can produce deviation。Consequent new chemical property can be used for quantifying or separating。The effect of the derivatization of sample is mainly similar to its chemical constitution the Substance Transformation being difficult to analyze but is prone to the material analyzed, it is simple to quantifies and separates。When detecting material and being not easy detected, as without uv absorption etc., it is possible to process, as plus chromophore etc., generated the material that can be detected。Instrumental Analysis is widely used。In gas chromatogram, applied chemistry derivatization reaction is to increase the volatility of sample or improving detection sensitivity, and the chemical derivatization of high performance liquid chromatography refers to and utilizes certain reagent (being generally called chemically derived reagent or labelled reagent) and sample component to carry out chemical reaction under certain condition, the product of reaction is conducive to chromatograph detection or separates。General chemical derivatization mainly has following purpose: improve the sensitivity of sample detection；Improve the separating degree of sample mixture；It is suitable for doing further Structural Identification, such as mass spectrum, infrared or nuclear magnetic resonance, NMR etc.。Carry out chemically derived reaction and should meet following requirement: reaction condition is required not harsh, and can rapidly, carry out quantitatively；Certain component in sample only generates a kind of derivant, and byproduct of reaction and excessive derivative reagent do not disturb separation and the detection of test sample product；Chemically derived reagent is conveniently easy to get, and versatility is good。
In Liquid Detection, in order to improve the detectability of determinand, the detection of some object needs determinand elder generation derivatization, then makes reactant realize separation on analytical column and detects, the content of indirect reaction thing to be detected。Wherein, column front derivation and post-column derivation two kinds, pre-column derivatization and post-column derivation method are respectively arranged with its pluses and minuses。The advantage of pre-column derivatization is: relatively free to selective response condition；It is absent from the restriction of kinetics；The by-product of derivatization can carry out pretreatment to reduce or to eliminate its interference；Easily allow the carrying out of multistep reaction；More derivatization reagent is had to may select；Do not need complicated instrument and equipment。Shortcoming is: the by-product of formation is likely to chromatographic isolation is caused bigger difficulty；In derivatization process, it is easy to introduce impurity or Interference Peaks, or make sample loss。Having the advantages of of post-column derivation method: forming by-product inessential, product is also without high stability, it is only necessary to the repeatability having had；Analyte can be easily separated under its original form, it is easy to selects existing analysis method。Shortcoming is: need extra equipment, and instrument requirements is higher；Reactor can cause peak stretching, reduces resolution；Excessive reagent is had to interfere。
Utility model content
The purpose of this utility model is to provide the column front derivation device of a kind of liquid chromatograph chromatography of ions that can accurately response time, reaction temperature be controlled。
To achieve these goals, the technical scheme that this utility model provides is: provide the column front derivation device of a kind of liquid chromatograph chromatography of ions, including: the liquid solution being sequentially connected with, pump, reaction unit, injector, couveuse chromatographic column, detector, described reaction unit includes housing, reative cell and control temperature unit, described reative cell is located in described housing and one end connects with described pump, the other end connects with described injector, and described reacting outdoor wall is provided with heat-insulation layer, described control temperature unit includes temperature control panel and temperature-adjusting circuit plate, and described reative cell bottom face is provided with one for holding the groove of described temperature control panel, described temperature control panel is fixed in described groove and described reative cell is carried out temperature control, also include agitating device, described agitating device includes motor and flabellum, described motor is located at outside described reative cell, described flabellum is located in described reative cell, and the output shaft of described motor convexedly stretches in described reative cell and is connected with described flabellum, described agitating device is for being sufficiently mixed reactant liquor。
Bottom described reative cell and top is respectively equipped with entrance and the outlet of liquid, and described entrance connects with described pump, and described outlet connects with described injector。
Described temperature control panel includes rectangular-shaped main body sheet material, and described main body sheet material is fixed with some semiconductor chilling plates, and by some described semiconductor chilling plates and the close contact of described reative cell lower surface, and the part of described reative cell lower surface and the close contact of described semiconductor chilling plate is the metallic plate that heat conductivility is good。
In some described semiconductor chilling plates, it is divided into two groups, first group is that the one side heated is in close contact with described reative cell lower surface, and second group is that the one side of refrigeration is in close contact with described reative cell lower surface, and first group of semiconductor chilling plate and second group of spaced laying of semiconductor chilling plate。
It is additionally provided with temperature sensing device in described reative cell。
Also including control unit, described temperature-adjusting circuit plate and described temperature sensing device are all connected with described control unit, the temperature information that described control unit is fed back by described temperature sensing device, and then control the work of described temperature-adjusting circuit plate。
Also including speed change gear, described control unit is connected with described motor by described speed change gear, and is used for controlling described motor speed。
Described speed change gear is converter or controllable silicon。
Described housing upper surface is located at by described motor, and the output shaft of described motor is connected through described housing and reacting outdoor wall with described flabellum。
Being additionally provided with air inlet and air outlet on described housing, described air inlet is located at described housing upper surface, and described air outlet is located at described housing lower surface, and described air outlet place is additionally provided with exhaust blower。
It is additionally provided with various way solenoid valve between described liquid solution and described pump, and described various way solenoid valve is electrically connected with described control unit。
Compared with prior art, in the column front derivation device of this utility model liquid chromatograph chromatography of ions, including control temperature unit, additionally include agitating device, described agitating device includes motor and flabellum, and described motor is located at outside described reative cell, and described flabellum is located in described reative cell, and the output shaft of described motor convexedly stretches in described reative cell and is connected with described flabellum, described agitating device is for being sufficiently mixed reactant liquor。The temperature of derivative solution can be efficiently controlled by described control temperature unit, then can be effectively improved derivative efficiency by described agitating device。
By description below and in conjunction with accompanying drawing, this utility model will become more fully apparent, and these accompanying drawings are used for explaining embodiment of the present utility model。
Accompanying drawing explanation
Fig. 1 is the column front derivation apparatus structure schematic diagram of this utility model liquid chromatograph chromatography of ions。
Fig. 2 is the structural representation of the reaction unit of the column front derivation device of liquid chromatograph chromatography of ions as shown in Figure 1。
Fig. 3 is the structural representation of the temperature control panel of the column front derivation device of liquid chromatograph chromatography of ions as shown in Figure 1。
Fig. 4 is the circuit theory module map of the temperature control panel of the column front derivation device of liquid chromatograph chromatography of ions as shown in Figure 1。
Detailed description of the invention
With reference now to accompanying drawing, describing embodiment of the present utility model, element numbers similar in accompanying drawing represents similar element。As mentioned above, such as Fig. 1, shown in 2, the column front derivation device 100 of the liquid chromatograph chromatography of ions that this utility model embodiment provides, including: the liquid solution 1 being sequentially connected with, pump 2, reaction unit 3, injector 4, couveuse chromatographic column 5, detector 6, described reaction unit 3 includes housing 7, reative cell 8 and control temperature unit 9, described reative cell 8 is located in described housing 7 and one end connects with described pump 2, the other end connects with described injector 4, and described reative cell 8 outer wall is provided with heat-insulation layer 10, described control temperature unit 9 includes temperature control panel 91 and temperature-adjusting circuit plate 92, and described reative cell 8 bottom face is provided with one for holding the groove of described temperature control panel 91, described temperature control panel 91 is fixed in described groove and described reative cell 8 is carried out temperature control, also include agitating device 11, described agitating device 11 includes motor 12 and flabellum 13, it is outside that described reative cell 8 is located at by described motor 12, specifically, described housing 7 upper surface is located at by described motor 12, and the output shaft 14 of described motor 12 is connected through described housing 7 and reative cell 8 outer wall with described flabellum 13。Described heat-insulation layer 10 is asbestos material layer。
In one embodiment, as in figure 2 it is shown, described flabellum 13 is located in described reative cell 8, and the output shaft 14 of described motor 12 convexedly stretches in described reative cell 8 and is connected with described flabellum 13, and described agitating device 11 is for being sufficiently mixed reactant liquor。
In one embodiment, as in figure 2 it is shown, bottom described reative cell 8 and top is respectively equipped with entrance 15 and the outlet 16 of liquid, and described entrance 15 connects with described pump 2, and described outlet 16 connects with described injector 4。
In one embodiment, as shown in Figure 3, described temperature control panel 91 includes rectangular-shaped main body sheet material, and described main body sheet material offers six grooves 910, and each groove 910 is fixed with a semiconductor chilling plate 17, and by these six described semiconductor chilling plates 17 and the close contact of described reative cell 8 lower surface, and the part of described reative cell 8 lower surface and the close contact of described semiconductor chilling plate 17 is the metallic plate that heat conductivility is good。
In above-described embodiment, in six described semiconductor chilling plates 17, it is divided into two groups of quantity often organized to be three, first group is that the one side heated is in close contact with described reative cell 8 lower surface, second group is that the one side of refrigeration is in close contact with described reative cell 8 lower surface, and first group of semiconductor chilling plate 17 and second group of spaced laying of semiconductor chilling plate 17。It is thus desirable to when described reative cell 8 is heated, allows first group of semiconductor chilling plate 17 work, and second group of semiconductor chilling plate 17 do not work；When needing described reative cell 8 is freezed, allow second group of semiconductor chilling plate 17 work, and first group of semiconductor chilling plate 17 does not work。
In one embodiment, as in figure 2 it is shown, be additionally provided with temperature sensing device 18 in described reative cell 8。
In above-described embodiment, as shown in Figure 4, also include control unit 19, described temperature-adjusting circuit plate 92 and described temperature sensing device 18 are all connected with described control unit 19, the described control unit 19 temperature information by described temperature sensing device 18 feedback, and then control described temperature-adjusting circuit plate 92 and work, and described temperature-adjusting circuit plate 92 to be located at described housing 7 internal。
In above-described embodiment, as shown in Figure 4, also including speed change gear 20, described control unit 19 is connected with described motor 12 by described speed change gear 20, and is used for controlling described motor 12 rotating speed。
In above-described embodiment, described speed change gear 20 is converter or controllable silicon。
In one embodiment, as in figure 2 it is shown, be additionally provided with air inlet 30 and air outlet 31 on described housing 7, described air inlet 30 is located at described housing 7 upper surface, and described air outlet 31 is located at described housing 7 lower surface, and described air outlet 31 place is additionally provided with exhaust blower 32。
In one embodiment, described liquid solution 1 includes several different liquid solution, and connect with described pump 2 commonly through after various way solenoid valve 21, the flow velocity of described liquid solution 1 is by the power decision of described pump 2, additionally can select the electromagnetic valve of controllable flow speed size that the flow velocity of liquid solution is controlled。
Compared with prior art, in conjunction with Fig. 1～4, in the column front derivation device 100 of this utility model liquid chromatograph chromatography of ions, described control temperature unit 9 includes temperature control panel 91 and temperature-adjusting circuit plate 92, and described reative cell 8 bottom face is provided with one for holding the groove of described temperature control panel 91, described temperature control panel 91 is fixed in described groove and described reative cell 8 is carried out temperature control, also include agitating device 11, described agitating device 11 includes motor 12 and flabellum 13, it is outside that described reative cell 8 is located at by described motor 12, described flabellum 13 is located in described reative cell 8, and the output shaft 14 of described motor 12 convexedly stretches in described reative cell 8 and is connected with described flabellum 13, described agitating device 11 is for being sufficiently mixed reactant liquor。The temperature of derivative solution can be efficiently controlled by described control temperature unit 9, then can be effectively improved derivative efficiency by described agitating device。
Above disclosed it is only preferred embodiment of the present utility model, certainly can not limit the interest field of this utility model, the equivalent variations therefore made according to this utility model claim with this, still belong to the scope that this utility model is contained。
Claims (10)
1. the column front derivation device of a liquid chromatograph chromatography of ions, it is characterized in that, including: the liquid solution being sequentially connected with, pump, reaction unit, injector, couveuse chromatographic column, detector, described reaction unit includes housing, reative cell and control temperature unit, described reative cell is located in described housing and one end connects with described pump, the other end connects with described injector, and described reacting outdoor wall is provided with heat-insulation layer, described control temperature unit includes temperature control panel and temperature-adjusting circuit plate, and described reative cell bottom face is provided with one for holding the groove of described temperature control panel, described temperature control panel is fixed in described groove and described reative cell is carried out temperature control, also include agitating device, described agitating device includes motor and flabellum, described motor is located at outside described reative cell, described flabellum is located in described reative cell, and the output shaft of described motor convexedly stretches in described reative cell and is connected with described flabellum, described agitating device is for being sufficiently mixed reactant liquor。
2. the column front derivation device of liquid chromatograph chromatography of ions as claimed in claim 1, it is characterised in that bottom described reative cell and top is respectively equipped with entrance and the outlet of liquid, and described entrance connects with described pump, and described outlet connects with described injector。
3. the column front derivation device of liquid chromatograph chromatography of ions as claimed in claim 1, it is characterized in that, described temperature control panel includes rectangular-shaped main body sheet material, and described main body sheet material is fixed with some semiconductor chilling plates, and by some described semiconductor chilling plates and the close contact of described reative cell lower surface, and the part of described reative cell lower surface and the close contact of described semiconductor chilling plate is the metallic plate that heat conductivility is good。
4. the column front derivation device of liquid chromatograph chromatography of ions as claimed in claim 3, it is characterized in that, in some described semiconductor chilling plates, it is divided into two groups, first group is that the one side heated is in close contact with described reative cell lower surface, second group is that the one side of refrigeration is in close contact with described reative cell lower surface, and first group of semiconductor chilling plate and second group of spaced laying of semiconductor chilling plate。
5. the column front derivation device of liquid chromatograph chromatography of ions as claimed in claim 4, it is characterised in that be additionally provided with temperature sensing device in described reative cell。
6. the column front derivation device of liquid chromatograph chromatography of ions as claimed in claim 5, it is characterized in that, also include control unit, described temperature-adjusting circuit plate and described temperature sensing device are all connected with described control unit, the temperature information that described control unit is fed back by described temperature sensing device, and then control the work of described temperature-adjusting circuit plate。
7. the column front derivation device of liquid chromatograph chromatography of ions as claimed in claim 6, it is characterised in that also including speed change gear, described control unit is connected with described motor by described speed change gear, and is used for controlling described motor speed。
8. the column front derivation device of liquid chromatograph chromatography of ions as claimed in claim 7, it is characterised in that described speed change gear is converter or controllable silicon。
9. the column front derivation device of liquid chromatograph chromatography of ions as claimed in claim 1, it is characterised in that described housing upper surface is located at by described motor, and the output shaft of described motor is connected through described housing and reacting outdoor wall with described flabellum。
10. the column front derivation device of liquid chromatograph chromatography of ions as claimed in claim 1, it is characterized in that, described housing is additionally provided with air inlet and air outlet, and described air inlet is located at described housing upper surface, described air outlet is located at described housing lower surface, and described air outlet place is additionally provided with exhaust blower。
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201521136519.9U CN205333577U (en) | 2015-12-31 | 2015-12-31 | Stratographic pre -column of liquid chromatogram ion device of deriving |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201521136519.9U CN205333577U (en) | 2015-12-31 | 2015-12-31 | Stratographic pre -column of liquid chromatogram ion device of deriving |
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| CN205333577U true CN205333577U (en) | 2016-06-22 |
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| CN201521136519.9U Active CN205333577U (en) | 2015-12-31 | 2015-12-31 | Stratographic pre -column of liquid chromatogram ion device of deriving |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105510479A (en) * | 2015-12-31 | 2016-04-20 | 华测检测认证集团股份有限公司 | Pre-column derivatization device of liquid chromatography and ion chromatography |
| CN106644653A (en) * | 2017-02-07 | 2017-05-10 | 中国科学院寒区旱区环境与工程研究所 | Device and method for preparing and measuring frozen soil sample |
-
2015
- 2015-12-31 CN CN201521136519.9U patent/CN205333577U/en active Active
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105510479A (en) * | 2015-12-31 | 2016-04-20 | 华测检测认证集团股份有限公司 | Pre-column derivatization device of liquid chromatography and ion chromatography |
| CN105510479B (en) * | 2015-12-31 | 2019-04-16 | 上海华测品标检测技术有限公司 | The column front derivation device of liquid chromatogram ion chromatography |
| CN106644653A (en) * | 2017-02-07 | 2017-05-10 | 中国科学院寒区旱区环境与工程研究所 | Device and method for preparing and measuring frozen soil sample |
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| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20170601 Address after: 2 121 building, 450001 Indus street, hi tech Industrial Development Zone, Henan, Zhengzhou Patentee after: Henan Hua Testing Technology Co., Ltd. Address before: 518101 Guangdong, Shenzhen Province, Baoan District District, Wei Wei Industrial Park, building C, 70 Patentee before: CENTRE TESTING INTERNATIONAL GROUP CO., LTD. |
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| TR01 | Transfer of patent right |