CN205146165U - Reation kettle for drug manufacturing - Google Patents
Reation kettle for drug manufacturing Download PDFInfo
- Publication number
- CN205146165U CN205146165U CN201520979621.9U CN201520979621U CN205146165U CN 205146165 U CN205146165 U CN 205146165U CN 201520979621 U CN201520979621 U CN 201520979621U CN 205146165 U CN205146165 U CN 205146165U
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- kettle
- pharmaceutical production
- production reactor
- utility
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Abstract
The utility model relates to the technical field of medical equipment, especially, relate to a reation kettle for drug manufacturing, including the feed inlet at the cauldron body, cauldron body top, the discharge gate and the agitating unit of cauldron body bottom, cauldron body top still is equipped with nitrogen gas import and the manometer that is used for nitrogen gas to get into, the utility model discloses a having restrained and easily firing volatilizing of explosive gas or harmful gas to letting in nitrogen gas in the reation kettle, the security that has improved drug manufacturing has to a certain extent prevented air pollution, has guaranteed the isolation of raw materials and oxygen in the reation kettle, and furtherly has improved drug manufacturing's security, the utility model discloses different viscosity according to raw materials for production set up the three -layer agitator, make raw materials for production stir, react more abundant in reation kettle.
Description
Technical field
The utility model relates to technical field of medical instruments, particularly relates to a kind of pharmaceutical production reactor.
Background technology
Reactor is combined reaction container, according to reaction condition to reactor structure function and the design configuring annex.From charging-reaction-discharging all can complete pre-set reactions steps with higher automaticity, the temperature in course of reaction, pressure, mechanics are controlled to the important parameter such as (stirring, air blast etc.), reactant/product concentration and carry out strict regulation and control.
At present, when producing Dapoxetine hydrochloride, Atorvastatin, rosuvastatin, Pitavastatin Calcium and intermediate series of products thereof, due to the reason of raw materials for production chemical property, when stirring in reactor, when likely can contact with oxygen, be oxidized, the dangerous situation such as blast, and due to the viscosity of raw materials for production different, cause and stir insufficient situation.
Just based on above-mentioned consideration, the utility model devises a kind of pharmaceutical production reactor.
Utility model content
The purpose of this utility model is to overcome the deficiencies in the prior art, adapts to reality need, provides a kind of pharmaceutical production reactor.
In order to realize the purpose of this utility model, the technical solution adopted in the utility model is:
The utility model discloses a kind of pharmaceutical production reactor, comprise kettle, the charging aperture at kettle top, the discharging opening of autoclave body bottom and agitating device, described kettle top is also provided with the nitrogen inlet and Pressure gauge that enter for nitrogen.
Described agitating device comprises and is arranged on the motor above kettle, the shaft being connected to motor output end and at least two agitators be arranged on shaft.
Described agitator is divided into three layers, is followed successively by dasher, general energy formula agitator, anchor agitator from top to bottom.
Discharging opening is connected with branch pipe, and the parting of described branch pipe is connected by three-way valve, and an arm of described branch pipe is nitrogen tube.
Described kettle is also evenly provided with multiple mixing baffle and for mixing baffle being fixed on the baffle plate connecting plate on inner wall of kettle.
Described baffle plate connecting plate and inner wall of kettle are in spending angle.
Described kettle outer wall is also provided with cooling jacket, and described cooling jacket top is provided with cooling water intake, and bottom is provided with cooling water outlet.
The beneficial effects of the utility model are:
1. the utility model by passing into the volatilization that nitrogen inhibits flammable explosive gas or pernicious gas in reactor, improve the security of pharmaceutical production to a certain extent, prevent air pollution, ensure that the isolation of raw material in reactor and oxygen, further increasing the security of pharmaceutical production;
2. the utility model arranges three layers of agitator according to the different viscosities of raw materials for production, raw materials for production is stirred in reactor, reacts more abundant.
Accompanying drawing explanation
Fig. 1 is the structural representation of the utility model pharmaceutical production reactor;
Fig. 2 is kettle internal structure schematic diagram in the utility model pharmaceutical production reactor.
In figure, 1 kettle, 2 charging apertures, 3 discharging openings, 4 agitating devices, 41 motors, 42 shafts, 5 nitrogen inlet, 6 Pressure gauges, 71 dashers, 72 general energy formula agitators, 73 anchor agitators, 8 discharge nozzles, 9 three-way valves, 10 nitrogen tube, 11 mixing baffles, 12 baffle plate connecting plates, 13 cooling jackets, 14 cooling water intakes, 15 cooling water outlets.
Detailed description of the invention
Below in conjunction with drawings and Examples, the utility model is further illustrated:
See Fig. 1-Fig. 2.
The utility model discloses a kind of pharmaceutical production reactor, comprise kettle 1, the charging aperture 2 at kettle 1 top, discharging opening 3 bottom kettle 1 and agitating device 4, described kettle 1 top is also provided with the nitrogen inlet 5 and Pressure gauge 6 that enter for nitrogen, the operation principle of the present embodiment: raw materials for production are entered in kettle 1 by charging aperture 3 and carries out stirring reaction by agitating device 4, simultaneously, nitrogen is made to enter in described kettle 1 by nitrogen inlet 5, owing to there being passing into of nitrogen, the air pressure in kettle 1 is made to be malleation, inhibit the volatilization of flammable explosive gas or pernicious gas to a certain extent, improve the security of pharmaceutical production to a certain extent, prevent air pollution, ensure that the isolation of raw material in kettle 1 and oxygen, further increasing the security of pharmaceutical production.
Described agitating device 4 comprises and is arranged on the motor 41 above kettle 1, the shaft 42 being connected to motor 41 output and at least two agitators be arranged on shaft 42, due in the production of medicine, the viscosity of raw materials for production is different, cause stirring insufficient uneven, by arranging at least two and different agitators, ensure that raw materials for production stir fully.
As preferably, described agitator is divided into three layers, be followed successively by dasher 71, general energy formula agitator 72, anchor agitator 73 from top to bottom, dasher 71 is suitable for low viscous upper strata and stirs, general energy formula agitator 72 adapt to very wide viscosity, owing to carrying out chemical reaction in kettle 1, good mixing effect can be had by formula agitator 72 so general, and lower floor adopts the full-bodied material of anchor agitator 73 Neng Shi lower floor to combine more fully.
Further, discharging opening 3 is connected with branch pipe 8, the parting of described branch pipe 8 is connected by three-way valve 9, an arm of described branch pipe 8 is nitrogen tube 10, in order to fully stir raw materials for production further, discharging opening 3 is connected branch pipe, two arms of branch pipe are respectively discharge nozzle 8 and nitrogen tube 10, and connected by three-way valve 9 at parting, when raw materials for production are deposited on the bad stirring of bottom stirrer in kettle 1, by three-way valve 9, discharge nozzle cuts out and nitrogen tube 10 is communicated with in kettle 1, now in kettle 1, passing into nitrogen by nitrogen tube 10 makes the raw materials for production be deposited on bottom kettle 1 seethe, thus it is more thorough to make raw materials for production stir, more abundant.
Described kettle 1 is also evenly provided with multiple mixing baffle 11 and for mixing baffle 11 being fixed on the baffle plate connecting plate 12 on kettle 1 inwall, more even by what arrange in kettle 1 that multiple mixing baffle 11 makes raw materials for production stir in kettle 1 further, and shear flow and the circulation ability of agitating device 4 can be increased by arranging mixing baffle 11.
As preferably, described baffle plate connecting plate 12 be 45 degree of angles with kettle 1 inwall, is 45 degree of angles, reduces stirring resistance, prevent from, at formation dead angle, mixing baffle 12 place, causing particle packing by baffle plate connecting plate 12 and kettle 1 inwall.
Described kettle 1 outer wall is also provided with cooling jacket 13, described cooling jacket 13 top is provided with cooling water intake 14, bottom is provided with cooling water outlet 15, because the corresponding temperature of raw materials for production reaction needed is carried out, cooling water enters in cooling jacket 13 by cooling water intake 14, can cool kettle 1.
The foregoing is only embodiment of the present utility model; not thereby the scope of the claims of the present utility model is limited; every equivalents utilizing the utility model description and accompanying drawing content to do; or be directly or indirectly used in relevant technical field, be all in like manner included in scope of patent protection of the present utility model.
Claims (7)
1. a pharmaceutical production reactor, comprise kettle (1), the charging aperture (2) at kettle (1) top, the discharging opening (3) of kettle (1) bottom and agitating device (4), it is characterized in that: described kettle (1) top is also provided with the nitrogen inlet (5) and Pressure gauge (6) that enter for nitrogen.
2. pharmaceutical production reactor according to claim 1, is characterized in that: described agitating device (4) comprises the motor (41) being arranged on kettle (1) top, the shaft (42) being connected to motor (41) output and at least two agitators be arranged on shaft (42).
3. pharmaceutical production reactor according to claim 2, is characterized in that: described agitator is divided into three layers, is followed successively by dasher (71), general energy formula agitator (72), anchor agitator (73) from top to bottom.
4. pharmaceutical production reactor according to claim 3, it is characterized in that: discharging opening (3) is connected with branch pipe, the parting of described branch pipe is connected by three-way valve (9), and an arm of described branch pipe is nitrogen tube (10), and another arm is discharge nozzle (8).
5. pharmaceutical production reactor according to claim 1, is characterized in that: described kettle (1) is also evenly provided with multiple mixing baffle (11) and for mixing baffle (11) being fixed on the baffle plate connecting plate (12) on kettle (1) inwall.
6. pharmaceutical production reactor according to claim 5, is characterized in that: described baffle plate connecting plate (12) and kettle (1) inwall are 45 degree of angles.
7. pharmaceutical production reactor according to claim 1, it is characterized in that: described kettle (1) outer wall is also provided with cooling jacket (13), described cooling jacket (13) top is provided with cooling water intake (14), and bottom is provided with cooling water outlet (15).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201520979621.9U CN205146165U (en) | 2015-12-01 | 2015-12-01 | Reation kettle for drug manufacturing |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201520979621.9U CN205146165U (en) | 2015-12-01 | 2015-12-01 | Reation kettle for drug manufacturing |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN205146165U true CN205146165U (en) | 2016-04-13 |
Family
ID=55681908
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201520979621.9U Expired - Fee Related CN205146165U (en) | 2015-12-01 | 2015-12-01 | Reation kettle for drug manufacturing |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN205146165U (en) |
-
2015
- 2015-12-01 CN CN201520979621.9U patent/CN205146165U/en not_active Expired - Fee Related
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20160413 Termination date: 20181201 |
|
| CF01 | Termination of patent right due to non-payment of annual fee |