CN205073351U - Take off oral cavity patch in cell matrix source - Google Patents
Take off oral cavity patch in cell matrix source Download PDFInfo
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- CN205073351U CN205073351U CN201520728875.3U CN201520728875U CN205073351U CN 205073351 U CN205073351 U CN 205073351U CN 201520728875 U CN201520728875 U CN 201520728875U CN 205073351 U CN205073351 U CN 205073351U
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- oral cavity
- sticking patch
- collagen protein
- weaker zone
- exasperate
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Abstract
The utility model relates to a take off oral cavity patch in cell matrix source, include biomembrane stratum basale and the collagen weaker zone that has the hole in certain porosity, aperture, the biomembrane stratum basale has the structural feature on exasperate and plain noodles, and the collagen weaker zone passes through the mode of physical absorption or bioprotein glue bond to be fixed on the stratum basale exasperate, during the use, the plain noodles of oral cavity patch is closely attached in the damaged district of oral cavity tissue. The utility model discloses simple structure, convenient to use has with the oral cavity soft tissue closely attachedly, and histocompatibility is good, can realize the vascularization fast, and the postsurgical can progressively be degraded and thickness advantage such as suitable, and the use is extensive, and it is damaged to can be used to repair clinical common oral cavity soft tissue, can regard as the choke material of the back alveolus nest of having tooth pulled out to implant the protection film in the preceding damaged district of bone with the tooth planting body simultaneously.
Description
Technical field
This utility model relates to field of medical products, specifically, relates to a kind of oral cavity sticking patch that can be used for the multipurpose acellular matrix source of repairing oral soft tissue defect, filling tooth socket and protection tooth defective region bone bed.
Background technology
Maxillofacial Trauma or tumor resection can cause oral mucosa larger area defect, and oral mucosa restorative procedure transplants by Topical oral mucosal flap or autologous split-thickness skin graft is transplanted.It is current optimal restorative procedure that local mucosal flap is transplanted, but exists for the limited shortcoming in district.And although split-thickness skin graft is drawn materials conveniently, abundant for district, owing to lacking effective dermal components, after the healing of graft area skin graft, there is contracture in various degree; And skin graft has adnexal structure, need before using additionally to dispose it; Split-thickness skin graft is transplanted in oral cavity and is shown different keratinization processes, and namely split-thickness skin graft can only effectively be repaired, but does not reach the function effectively substituting oral mucosa.In addition, intraoral wet environment easily brings out skin graft and occurs as pain, infection for district or form the pathological changes such as hypertrophic scars, even causes skin graft maceration or causes skin grafing and mending failure because skin graft infects.Adopt allogeneic skin grafting dermepenthesis to solve above-mentioned Topical oral mucosal flap in the past to transplant or autologous split-thickness skin graft is implanted in the defect that oral soft tissue defect repair exists, but because there is certain rejection graft failure.
Extraction is one of the most common operation of Oral and Maxillofacial Surgery, postoperatively may occur the complication such as hemorrhage, pain, swelling and dry socket (bone wound infects), thus has influence on the quality of life of patient.And local alveolar bone reconstruction occurs and absorbs after exodontia, bone amount reduces, and causes later phase clinical repairing effect not good.How to reduce and the absorption of alveolar bone and postexodontic complication are Oral and Maxillofacial Surgery doctor and focus of attention always after preventing to have tooth pulled out focus, confirmed by a large amount of clinical trials, the Local treatment of teeth socked, particularly by inserting soft-tissue patch in tooth socket, the absorption of Post operation alveolar bone and the incidence rate of postexodontic complication can be reduced.
At present, Integrated implant formula tooth implant has been used successfully to and has repaired defect of dentition or disappearance.Traditional dental implant, in order to reach the synostosis of implantation body and surrounding socket bone, 9 ~ 12 months ability must be implemented usually after exodontia.In order to shorten tooth implant Implantation Time and the quick absorption preventing alveolar bone, people start the immediate implant attempting tooth implant, are namely implanted into tooth implant at fresh teeth socked.A large amount of clinical practice and experimental studies results show, guide tissue regeneration (guidedbone/tissueregeneration, GBR/GTR) there is the effect guiding skeletonization and promote the formation of bone regeneration around implant synostosis, its principle is different according to all kinds of different tissues cell migration rates, i.e. epithelial cell, fibrohistiocytic is than forming cementum, the cell migration rates of periodontal ligament and osseous tissue is fast, therefore, adopt the biomembrane of band micropore can play good barrier action, surrounding tissue can be stoped to form cell and epithelial cell as knot to grow into Cranial defect district simultaneously, avoid these cells and have the cell of osteogenesis ability to compete suppressing, protection clot is stablized, maintain the gap of clot filling, the cell of osteogenesis ability is made slowly to enter Cranial defect district, be conducive to the synostosis of implantation body and surrounding socket bone, the object before tooth implant is implanted, tooth defective region bone bed protected can be realized.
For above three kinds of clinical indications, had corresponding Oral Repair film products application in the market in clinical, but in Clinical practice, still there is many deficiencies in the design of existing product and performance.Existing Oral Repair film is the biomembrane of single structure, and its porosity and pore diameter range are all limited to raw material, and recipient epithelial cells etc. are difficult to move wherein and participate in tissue reconstruction; In addition, existing repair membrane product and receptor oral soft tissue adhesiveness poor, easily there is cavity after implantation, be unfavorable for creeping and growing of recipient cell and tissue.For deficiency and the limitation of existing product, this utility model is optimized and perfect.
Utility model content
The purpose of this utility model is to solve above-mentioned prior art deficiency and circumscribed defect; there is provided a kind of can be used for the tooth socket after repairing defect of oral mucosa, filling exodontia and implant the protecting film of prebone defective region as tooth implant, good biocompatibility, degradable absorb, can oral cavity, the multipurpose acellular matrix source sticking patch of vascularization fast.
For solving above-mentioned technical problem, this utility model adopts following technical scheme:
A kind of oral cavity sticking patch of acellular matrix source, comprise biomembrane base bottom and collagen protein weaker zone, described biomembrane base bottom has exasperate and bright finish, and described collagen protein weaker zone is fixed on biomembrane base bottom exasperate, and wherein said collagen protein weaker zone has hole.During use, the bright finish of oral cavity sticking patch is closely attached to defect of oral tissues district, can effectively play a protective role.
Described collagen protein weaker zone is fixed on the exasperate of biomembrane base bottom by physical absorption.
Described collagen protein weaker zone is adhesively fixed on the exasperate of biomembrane base bottom by biological fibrin glue.
The porosity of described collagen protein weaker zone is 65 ~ 86%.
The aperture of the hole of described collagen protein weaker zone is 50 ~ 300 μm.
The thickness of described collagen protein weaker zone is 0.05 ~ 1.50mm.
Described oral cavity sticking patch is square membrane-like structure.
The length of described oral cavity sticking patch is 20 ~ 80mm, and width is 10 ~ 60mm, and thickness is 0.1 ~ 1.5mm.
Compared with prior art; this utility model has following beneficial effect: structure is simple; easy to use; have and closely attach with oral soft tissue, histocompatibility is good, can realize vascularization fast; postoperatively can progressively to degrade and the advantage such as appropriate thickness; and of many uses, can be used for repairing clinical common oral soft tissue defect, the protecting film of prebone defective region can be implanted simultaneously as the choke material of tooth socket after exodontia and tooth implant.
Accompanying drawing explanation
Fig. 1 is cross-sectional view of the present utility model;
Fig. 2 is the scanning electron microscope (SEM) photograph of collagen protein weaker zone of the present utility model.
Detailed description of the invention
In order to make the purpose of this utility model, technical scheme and beneficial effect clearly understand, below in conjunction with drawings and Examples, the oral cavity sticking patch in a kind of acellular matrix source of this utility model is described in detail.Specific embodiment described herein only for explaining this utility model, and is not used in restriction this utility model.
With reference to shown in Fig. 1, the oral cavity sticking patch in a kind of acellular matrix source of this utility model, comprise biomembrane base bottom 1 and there is the collagen protein weaker zone 2 of hole in certain porosity, aperture, biomembrane base bottom 1 has the construction features of exasperate and bright finish, collagen protein weaker zone 2 is fixed on the exasperate of biomembrane base bottom 1, in use, the sticking patch bright finish of oral cavity sticking patch is closely attached to defect of oral tissues district.
Described collagen protein weaker zone 2 is fixed on the exasperate of biomembrane base bottom 1 by modes such as physical absorption or bioprotein glue bonds.
The oral cavity sticking patch in a kind of acellular matrix source of this utility model is the quadrangular membrane laminated structure with plurality of specifications, and the specification of length has 20 ~ 80m, and the specification of width has 10 ~ 60mm, and the specification of thickness has 0.1 ~ 1.5mm.And object can be repaired selecting suitable specification according to the defect area of patient's oral soft tissue during clinical repair operation, also meeting operation demand by the means such as cutting out.Preferably, the specification of the length of the oral cavity sticking patch in a kind of acellular matrix source of this utility model has 30 ~ 60mm, and the specification of width has 20 ~ 40mm, and the specification of thickness has 0.05 ~ 1.0mm.Most preferred, the length specification of the oral cavity sticking patch in a kind of acellular matrix source of this utility model is 50mm, and the specification of width is 30mm, and the specification of thickness is 0.8mm.
The porosity specification of the collagen protein weaker zone 2 of the oral cavity sticking patch in a kind of acellular matrix source of this utility model has 65 ~ 86%, and the specification in the aperture of hole has 50 ~ 300 μm, and the specification of thickness has 0.05 ~ 1.50mm.Preferably, the porosity of collagen protein weaker zone 2 is 70%, and the specification in the aperture of hole is 180 μm, and the specification of thickness is 0.50mm.
Having that this utility model is selected two-sided (bright finish and exasperate) and the biomembrane base bottom of compact structure are from animal membrane materials such as Cor Sus domestica peplos, animal peritoneal, and these animal membrane materials are translucent, in appearance in uniform milky or light yellow.
Fresh animal membrane material is easily degraded by microorganisms or decomposes, if for tissue repairing, this material need make it crosslinked fixing with fixative.Traditional method uses to have the glutaraldehyde of residual toxicity as fixative, and this utility model to be selected as epoxide, two acid diamides, vulcabond, Polyethylene Glycol or carbodiimides etc. easily with protein molecule generation cross-linking reaction and the no-aldehyde fixative of non-residual toxicity is crosslinked fixes.Biomembrane base bottom is after cross-linking agents is fixing.Its compact structure and more stable, can, better for oral soft tissue defective region provides protection and mechanical support, can protect tooth defective region to avoid being grown into by surrounding tissue better.
The biomembrane base bottom that this utility model is selected also needs to carry out antigen process after crosslinked fixing, theoretical according to Immunology Today, the antigenicity of animal tissue is mainly caused by the active group of some specific position in protein and particular conformation, these active groups mainly-OH ,-NH
2,-SH etc.; And particular conformation is mainly because some special hydrogen bond of collagen molecules coiled strand causes.When processing animal membrane and organizing, be easily combined with these groups with the activating agent (as anhydride, acyl chlorides, amide, epoxide or halomethane etc.) that these groups react with one or more, be closed, effectively can remove antigen.
The collagen protein weaker zone that this utility model is selected is to the animal of purification processes of hanging oneself (pig, cattle) tendon, and this collagen protein weaker zone is made up of I type, type III or I/III Collagen Type VI.
Itself and autologous patient soft tissue are fixed together by operation suture thread by this utility model, and stitch points spacing controls at 2 ~ 4mm, also can adopt traditional or 6 fixations at 4.After stitching, bundle can be used to carry out pressurization to patch area and to fix, to enable the tissue of oral cavity sticking patch and restoring area better and quickly merge, be conducive to the Quick-climbing of autologous epithelial, and implant the quick vascularization of sticking patch.
The oral cavity sticking patch tool in a kind of acellular matrix source of this utility model has the following advantages:
The first, be adhered fixed collagen protein weaker zone at the exasperate of biomembrane base bottom, not only increase the adhesive force between biomembrane base bottom and collagen protein weaker zone, and can realize preferably having complementary advantages.Biomembrane base fabric is fine and close and stable; there is certain mechanical property and biodegradability; structural intergrity and the mechanical support function of oral soft tissue defective region can be given; the shortcoming that simple collagen support poor mechanical property, degradation rate are too fast can be overcome; simultaneously as physical barriers; can prevent from around tying and form cell and epithelial tissue and to grow into tooth defective region, play a very good protection.
The second, collagen protein weaker zone has natural three dimensional pore structures, can promote the creeping of host epithelial cells, proliferation and growth, be conducive to the quick vascularization of realization of sticking patch, induces and promotes reparation and the regeneration of defective region.
3rd, aperture and the porosity of collagen protein weaker zone are suitable for, and are conducive to creeping, breed and breaking up of host epithelial cells, are conducive to the quick vascularization of sticking patch, accelerate and promote that the 26S Proteasome Structure and Function of oral soft tissue defective region recovers.
4th, implanting 3 ~ 6 months periods, along with the regeneration of cambium, oral cavity sticking patch can be degraded gradually, participates in the regeneration of cambium, and noresidue in vivo, and finally complete structural remodeling and the functional rehabilitation of whole defective region.
The preparation method of the oral cavity sticking patch in a kind of acellular matrix source of this utility model, concrete steps comprise:
(1) select materials
Obtain fresh Cor Sus domestica peplos or peritoneum, and the raw material such as tendon.
(2) pretreatment
Animal membrane material and tendon are cleaned, sterilization, prune, remove unnecessary fatty tissue, fiber or fine hair.
(3) defat
With the fat that may exist in organic solvent extracting animal membrane material and tendon and oil-soluble impurities.
(4) de-cell
Use surfactant and associated proteins enzyme, and the cell washed away under ultrasound condition in animal membrane material and tendon and fragment.
(5) crosslinked fixing
Under normal temperature condition, use the collagen molecules in epoxy crosslinked fixing animal membrane material.
(6) antigen is removed
With the specific activity group-OH or-NH2 or-SH in activating agent closing membrane material collagen molecules, and with the special hydrogen bond in the Tris solution replacement film material of guanidine hydrochloride and tendon collagen molecules coiled strand, change particular conformation, obtain biomembrane base bottom 1 and tendon tissue.
(7) collagen protein extracts and purification
Acid solution is used to dissolve de-cell and the tendon tissue after removing antigen, smash to pieces through tissue mashing machine again, under sour environment, then use protease to continue to dissolve, separate out collagen protein, re-use surfactant process after filtration, after washing, obtain collagen protein sterling.Use pulverizer to pulverize after lyophilized collagen albumen, ball mill is milled, and sieves, and obtains the collagen protein powder of different-grain diameter.
(8) composite collagen
Collagen protein powder is dissolved into certain density collagen solution, and with physisorphtion by active type I collagen, type III collagen, or both blends are fixed on the exasperate of biomembrane base bottom 1, form collagen protein weaker zone 2.Meanwhile, also can first by collagen solution lyophilizing, use biological fibrin glue the collagen film after lyophilizing is adhesively fixed in biomembrane base bottom 1 exasperate on.
(9) subsequent treatment
Carry out vacuum lyophilization to the oral cavity sticking patch after composite collagen, sizing, packaging, sterilizing, finally obtains oral cavity sticking patch finished product.
In described step (3), organic solvent can be acetate esters, chloroform, carbon tetrachloride, ether, acetone, and dehydrated alcohol.
In described step (4), surfactant can refer in TritonX (Triton-100), NaTDC, carboxymethylamino methane (Tris), dodecyl sodium sulfate (SDS) or 3-[3-(gallbladder amido propyl) dimethylamino] propane sulfonic acid inner salt (CHAPS) one or more.
In described step (5), epoxide can be monoepoxide
also can be di-epoxide
here R=H, C
nh
2n+1-, n=0-10; Can also be low polyepoxide, as poly(propylene oxide).
In described step (6), activating agent can also be one or more in small molecular organic acid acid anhydride, acyl chlorides, amide, epoxide or halomethane; And strong hydrogen bonding reagent can be guanidine compound.
In described step (7), acid solution can be hydrochloric acid, acetic acid etc.
In described step (8), the mode of physical adherence or bioprotein glue bond of can passing through is by active type I collagen, type III collagen, or both blends are adhesively fixed on the exasperate of biomembrane base bottom 1, form collagen protein weaker zone 2.
In described step (9), the gamma-ray irradiation sterilizing of 25 ~ 40kGy irradiation dose can be used, effectively kill potential animal virus and pathogen.
This utility model epoxide replaces aldehydes fixating reagent.Because epoxide is very unstable, easily there is open loop cross-linking reaction, control reaction condition and the cross-linking products of the collagen protein of membrane tissue can be made very stable, do not degrade easily.Only when cross-linking products " silkworm erosion " that regenerating tissues growth, propagation need collagen protein, secrete under kallikrein, fibrinolysin and glucocorticoid work in coordination with collagenase effect, the cross-linking products of collagen protein slowly could be decomposed into polypeptide and aminoacid, and absorb.As can be seen here, this passive type degraded is synchronous with the regeneration of tissue, uses the collagen molecules in epoxy crosslinked fixed biofilm basal layer to be that the reproducibility being conducive to tissue is most repaired, and does not have aldehydes residual toxicity.
The foregoing is only preferred embodiment of the present utility model; but protection domain of the present utility model is not limited thereto; anyly be familiar with those skilled in the art in scope disclosed in the utility model; be equal to according to technical scheme and plan plot and replace or change, all belonged to protection domain of the present utility model.
Claims (8)
1. the oral cavity sticking patch in acellular matrix source, is characterized in that: comprise biomembrane base bottom and collagen protein weaker zone, and described biomembrane base bottom has exasperate and bright finish, and described collagen protein weaker zone is fixed on biomembrane base bottom exasperate; Wherein said collagen protein weaker zone has hole.
2. the oral cavity sticking patch in a kind of acellular matrix source according to claim 1, is characterized in that: described collagen protein weaker zone is fixed on the exasperate of biomembrane base bottom by physical absorption.
3. the oral cavity sticking patch in a kind of acellular matrix source according to claim 1, is characterized in that: described collagen protein weaker zone is adhesively fixed on the exasperate of biomembrane base bottom by biological fibrin glue.
4. the oral cavity sticking patch in a kind of acellular matrix source according to claim 1, is characterized in that: the porosity of described collagen protein weaker zone is 65 ~ 86%.
5. the oral cavity sticking patch in a kind of acellular matrix source according to claim 1, is characterized in that: the aperture of the hole of described collagen protein weaker zone is 50 ~ 300 μm.
6. the oral cavity sticking patch in a kind of acellular matrix source according to claim 1, is characterized in that: the thickness of described collagen protein weaker zone is 0.05 ~ 1.50mm.
7. the oral cavity sticking patch in a kind of acellular matrix source according to claim 1, is characterized in that: described oral cavity sticking patch is square membrane-like structure.
8. the oral cavity sticking patch in a kind of acellular matrix source according to claim 1, is characterized in that: the length of described oral cavity sticking patch is 20 ~ 80mm, and width is 10 ~ 60mm, and thickness is 0.1 ~ 1.5mm.
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| CN201520728875.3U CN205073351U (en) | 2015-09-18 | 2015-09-18 | Take off oral cavity patch in cell matrix source |
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| CN201520728875.3U CN205073351U (en) | 2015-09-18 | 2015-09-18 | Take off oral cavity patch in cell matrix source |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105935454A (en) * | 2015-09-18 | 2016-09-14 | 广州市美昊生物科技有限公司 | Decellularized matrix-source tissue engineering scaffold and preparation method and application thereof |
| CN108355172A (en) * | 2018-04-17 | 2018-08-03 | 上海市第六人民医院 | A kind of soft tissue repair bionical matrix of de- cell Java tilapia skin and its preparation method and application |
| CN108355171A (en) * | 2018-04-09 | 2018-08-03 | 青岛海洋生物医药研究院 | Acellular dermal matrix guide tissue regeneration film material and its preparation method and application |
| CN115025296A (en) * | 2022-06-15 | 2022-09-09 | 上海新华瑞思医疗科技有限公司 | Oral cavity repairing membrane for guiding tissue regeneration and preparation method and related kit thereof |
| CN115845116A (en) * | 2022-12-16 | 2023-03-28 | 山东隽秀生物科技股份有限公司 | Acellular matrix wound material and preparation method thereof |
| CN115970061A (en) * | 2023-01-31 | 2023-04-18 | 上海卓阮医疗科技有限公司 | Biological material for blood supply deficiency scene and preparation method and application thereof |
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2015
- 2015-09-18 CN CN201520728875.3U patent/CN205073351U/en active Active
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105935454A (en) * | 2015-09-18 | 2016-09-14 | 广州市美昊生物科技有限公司 | Decellularized matrix-source tissue engineering scaffold and preparation method and application thereof |
| CN108355171A (en) * | 2018-04-09 | 2018-08-03 | 青岛海洋生物医药研究院 | Acellular dermal matrix guide tissue regeneration film material and its preparation method and application |
| CN108355172A (en) * | 2018-04-17 | 2018-08-03 | 上海市第六人民医院 | A kind of soft tissue repair bionical matrix of de- cell Java tilapia skin and its preparation method and application |
| CN115025296A (en) * | 2022-06-15 | 2022-09-09 | 上海新华瑞思医疗科技有限公司 | Oral cavity repairing membrane for guiding tissue regeneration and preparation method and related kit thereof |
| CN115025296B (en) * | 2022-06-15 | 2024-06-11 | 上海新华瑞思医疗科技有限公司 | Oral cavity repairing film for guiding tissue regeneration, preparation method thereof and related kit |
| CN115845116A (en) * | 2022-12-16 | 2023-03-28 | 山东隽秀生物科技股份有限公司 | Acellular matrix wound material and preparation method thereof |
| CN115845116B (en) * | 2022-12-16 | 2024-05-03 | 山东隽秀生物科技股份有限公司 | Acellular matrix wound material and preparation method thereof |
| CN115970061A (en) * | 2023-01-31 | 2023-04-18 | 上海卓阮医疗科技有限公司 | Biological material for blood supply deficiency scene and preparation method and application thereof |
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Effective date of registration: 20200427 Address after: 510000 Yuyan Road, Whampoa District, Guangzhou, Guangdong Province, No. 12 Patentee after: GUANHAO BIOTECH Co.,Ltd. Address before: High tech Industrial Development Zone, Guangzhou city Guangdong province 510663 international business incubator Science City building D Room 401 Co-patentee before: GUANHAO BIOTECH Co.,Ltd. Patentee before: GUANGZHOU MEIHAO BIOTECHNOLOGY Co.,Ltd. |