CN205041980U - Experimental device for verify that near infrared is to sick treatment of A erzihaimo - Google Patents

Experimental device for verify that near infrared is to sick treatment of A erzihaimo Download PDF

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Publication number
CN205041980U
CN205041980U CN201520692323.1U CN201520692323U CN205041980U CN 205041980 U CN205041980 U CN 205041980U CN 201520692323 U CN201520692323 U CN 201520692323U CN 205041980 U CN205041980 U CN 205041980U
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experiment
infrared
experimental provision
near infrared
infrared light
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魏勋斌
曾宇晖
黄勇
索元震
孟庆强
韩盟盟
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Zhejiang lai'en Hass Medical Technology Co.,Ltd.
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黄勇
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Abstract

The utility model relates to an experimental device for verify that near infrared is to sick treatment of A erzihaimo, include the experiment container, set up at experiment container top and constitute airtight near -infrared of testing the cavity jointly with the experiment container and shine the unit and shine the circuit control unit that the unit electricity is connected with the near -infrared, during the experiment, will test the mouse and arrange airtight experiment cavity in, and shine the opening of unit, shut -in time point and illumination frequency through the circuit control unit automatically regulated near -infrared, the experiment mouse is accepted near infrared and shines the treatment in airtight experiment cavity, treat that near infrared shines the treatment after, take out and test the mouse to carry out subsequent verification experiment to it. Compared with the prior art, the utility model discloses simple structure, economical and practical, convenient operation can realize that near infrared shines the intelligent control of treatment, can effectively reduce experimental error to reduce the experimenter's work load, the experiment accuracy is high, and safe and reliable has fine application prospect.

Description

Checking near infrared light is to the experimental provision of AD therapy effect
Technical field
This utility model belongs near infrared light according to treatment technology field, relates to checking near infrared light to the experimental provision of AD therapy effect.
Background technology
Alzheimer disease is commonly called as senile dementia, be a kind of Development process slowly, the persistence delayed ischemic neurological deficits constantly to worsen along with the time.Its cardinal symptom is impaired memory function, irritability, aggressiveness, cannot normal speech, be difficult to take care of oneself and dystropy etc., finally lose normal body function, die from the complication such as infection.Alzheimer disease is more common in more than 70 years old old man, have an appointment in over-65s old man 6% incidence rate.Along with prolongation and the population aging gradually of the average life span, alzheimer patient is being on the increase at globally and China.It also brings huge burden on society and financial burden simultaneously.
The cause of disease of alzheimer disease so far still among exploration, but medically generally believes that it is relevant with Tau albumen with kind of starch sample protein plaque deposition in brain.There is no effective AD therapy method clinically at present.Traditional Therapeutic Method mainly Drug therapy, as acetylcholine amylase blocker, improves medicine as cognition and is used to treat alzheimer disease.Neuroprotective Agents is in current sole therapy, the medicine of severe dementia, and it can the exitotoxicity of blocked glutamic acid, slows down the disappearance gradually of living skill whereby.But Drug therapy can only delay advancing of disease process, and therapeutic effect is limited.In addition Drug therapy also has larger side effect.
In recent years, several physical therapy modalities occurred in the world likely reverse alzheimer disease process, and do not have side effect, as near-infrared irradiation with through cranium magnetic, through cranium electro ultrafiltration etc.Wherein, near-infrared light exposure treatment is considered to the therapeutic modality most possibly pushing clinical practice to, its possible mechanism of action is stimulated brain by the near infrared light that penetrance is stronger, thus promote the metabolism of kind of starch sample protein in brain, reverses the disease process of alzheimer disease.At present, progressively start in the world to launch research to the mechanism of near-infrared light exposure treatment alzheimer disease, use a kind of easy portable equipment to carry out near-infrared light exposure treatment to Transgenic studies mice in these researchs, verify the cure mechanism of near infrared light to alzheimer disease with this.The transgenic mice that the experiment of this class uses needs to raise under strict illumination condition, ensures the white-light illuminating of 12 hours every days and the dark surrounds of 12 hours.The experiment parameters such as the time of near-infrared light exposure treatment and irradiation frequency need strict control, and often regulate different parameters to carry out irradiation treatment.
But current used experimental facilities needs experimenter to test separately every experiment mice, the time and efforts of meeting at substantial like this, especially regulates during irradiation treatment parameter at needs and seems more difficult.In addition, the error that different illumination points action time and anthropic factor cause also easily reduces the credibility of experimental result.Therefore, be necessary to design a kind of experimental provision, the workload of experimenter can be reduced, and improve the accuracy of experimental result.
Utility model content
The purpose of this utility model is exactly the experimental provision dependence manual operation in order to overcome existing checking near-infrared light exposure treatment alzheimer disease, the technological deficiency wasted time and energy, and provide a kind of structure simple, economical and practical, effectively can realize Automated condtrol, in order to reduce the workload of experimenter, and the checking near infrared light that can improve experimental result accuracy is to the experimental provision of AD therapy effect.
The purpose of this utility model can be achieved through the following technical solutions:
Checking near infrared light is to the experimental provision of AD therapy effect, and this experimental provision comprises experiment container, be arranged on experiment container top and the near-infrared illumination unit jointly forming airtight laboratory with experiment container and the circuit control unit be electrically connected with near-infrared illumination unit;
When testing, experiment mice is placed in airtight laboratory, by the unlatching of the automatic regulating near-infrared illumination unit of circuit control unit, shut-in time point and illumination frequency, experiment mice accepts near-infrared light exposure treatment in airtight laboratory, after near-infrared light exposure treatment terminates, take out experiment mice, and follow-up confirmatory experiment is carried out to it.
Described experiment container is open-topped interior empty cuboid container.
At least one side of described cuboid container offers ventilation mouth, and this ventilation mouth is provided with the gauze for lucifuge, a side of described cuboid container also offers the connector for installing food groove and the water inlet for feeding water.
Preferably, three sides of described cuboid container all offer ventilation mouth, this ventilation mouth is provided with the black gauze for lucifuge, and the connector the 4th of described cuboid container the side offered for installing food groove and the water inlet for feeding water.
Described connector is rectangle connector, and this rectangle connector is provided with the gauze for lucifuge, and described rectangle connector place is provided with food groove.
Described water inlet is circular port, and this circular port is communicated with external source, and the water of external source is entered in cuboid container by circular port.
The on and off switch that described near-infrared illumination unit comprises circuit board, be evenly laid in near-infrared luminous diode in circuit board bottom surface and white light emitting diode in array, be arranged on the Control architecture on board top surface and be arranged on Control architecture, described Control architecture is electrically connected with near-infrared luminous diode, white light emitting diode and circuit control unit respectively by circuit.
Described Control architecture is also provided with power line and attaching plug, for connecing 220 volt AC power.
On and off switch on described Control architecture controls the opening and closing of whole experimental provision.
The number of described near-infrared luminous diode is greater than the number of white light emitting diode, and described near-infrared luminous diode is array is evenly laid in around white light emitting diode.
Described board top surface is also arranged with a pair radiator fan.
Described circuit control unit comprises the programming device and computer that are electrically connected with Control architecture successively.
In use, described circuit control unit controls the time point of the opening and closing of near-infrared luminous diode by programming device, thus control the time span of near infrared light treatment, simultaneously, also pulse generating circuit is provided with in circuit control unit, can regulate illumination frequency, within every 0.25 second, open and close once as controlled near-infrared luminous diode, and then realize the irradiation frequency of 2Hz.
Described circuit control unit realizes controlling with the independence of near-infrared luminous diode same illumination parameter to white light emitting diode by programming device.
Described programming device is selected from single-chip microcomputer or digital signal processor, and needs to have the interface carrying out communication with computer.
The software matched with hardware is housed in described computer, software interface is selected different parameters irradiate.
During embody rule, when carrying out near infrared light according to Experiment on therapy, first by the unlatching of the good near-infrared luminous diode of computer installation and white light emitting diode, shut-in time point and illumination frequency experiment parameter, experiment mice is placed in the airtight laboratory that circuit board and cuboid container are formed jointly, open the on and off switch on Control architecture, infrarede emitting diode and white light emitting diode irradiate according to the test parameters set, experiment mice accepts near infrared light treatment, at treatments period, subsisted and water to experiment mice by food groove and circular port, after near infrared light treatment terminates, on and off switch in closing control template, take out experiment mice, and follow-up confirmatory experiment is carried out to it.
In this utility model, the wavelength of near infrared light mainly concentrates on 780 ~ 2526nm, the centre wavelength of the near-infrared luminous diode of employing can be selected from 810nm, 880nm, 950nm, 1050nm or 1070nm one or more.
Compared with prior art, this utility model has following characteristics:
1) due to circuit control unit is combined with near-infrared illumination unit, irradiation time length and the illumination frequency of near-infrared illumination unit can be controlled quickly and easily by circuit control unit, easy to operate, intelligentized control method can be realized, compared to existing experimental provision, human intervention can be reduced further, and then effectively improve efficiency and the accuracy of experiment;
2) owing to offering ventilation mouth on experiment container, and arrange gauze on ventilation mouth, structural design is simple, while guarantee experiment container breathability, effectively can also eliminate the impact of ambient light on experiment mice, and then improve the accuracy of experiment;
3) due in the design of near-infrared illumination unit, adopt circuit board, this circuit board both may be used for installing near-infrared luminous diode and white light emitting diode, again can as the lid of experiment container, airtight laboratory is jointly formed with experiment container, effectively can save design space, simplified design component constructs;
4) overall structure is simple, economical and practical, easy to operate, the intelligentized control method of near-infrared light exposure treatment can be realized, effectively can reduce the experimental error because different light action time and anthropic factor cause, and reduce the workload of experimenter, experiment accuracy is high, safe and reliable, there is good application prospect.
Accompanying drawing explanation
Fig. 1 is experiment container structural representation in embodiment 1;
Fig. 2 is near-infrared illumination unit and circuit control unit mounting structure schematic diagram in embodiment 1;
Fig. 3 is circuit board bottom surface structural representation in near-infrared illumination unit in embodiment 1;
Description of symbols in figure:
1, experiment container, 2, ventilation mouth, 3, connector, 4, gauze, 5, food groove, 6, water bottle, 7, water inlet, 8, circuit board, 9, Control architecture, 10, on and off switch, 11, radiator fan, 12, power line, 13, attaching plug, 14, data wire, 15, computer, 16, USB interface, 17, near-infrared luminous diode, 18, white light emitting diode, 19, support.
Detailed description of the invention
Below in conjunction with the drawings and specific embodiments, this utility model is described in detail.
Embodiment 1:
As shown in Figure 1, the material of experiment container 1 is conventional polythene material, and long and wide ratio is 2:1, and the ventilation mouth 2 of three sides is all arranged on its long and high centre 1/3rd place, and hides ensure lucifuge and breathe freely with black gauze 4.4th side is opened a water inlet 7 and a connector 3, this connector 3 is rectangle connector, and connector 3 place is provided with food groove 5, and water inlet 7 is circular port, and water bottle 6 support 19 supports.
As shown in Figure 2, circuit board 8 is equipped with radiator fan 11, the accumulation of heat preventing lamp pearl from producing impacts device.Control architecture 9 to be installed on circuit board 8 and to be connected with computer 15 by the usb 16 on data wire 14, carry out control hardware by software and realize corresponding function, the time point of opening and closing, the frequency of illumination as controlled near-infrared luminous diode 17 and white light emitting diode 18 regulate etc.Control architecture 9 connects the special alternating current power supply of 220V by another power line 12 and attaching plug 13, and the on and off switch 10 on Control architecture 9 controls the opening and closing of whole device.Whole circuit board 8 as the lid of experiment container 1, can form airtight box with experiment container 1 again jointly.
As shown in Figure 3, the opposite side of circuit board 8 is evenly provided with light emitting diode matrix, and what wherein diameter was less is near-infrared luminous diode 17, and what diameter was larger is white light emitting diode 18.During experiment, white light-emitting diode 18 opens 12 hours, close 12 hours again, constantly circulate with this, this is that environment facies in order to be in 12 h light and 12 h dark when raising with experiment mice are consistent, or regulate its working time according to special requirement, and near-infrared luminous diode 17 remains opening in whole experimentation.
During experiment, alzheimer disease experiment mice is put into experiment container 1, make experiment mice freely movable wherein.Computer 15 is connected with Control architecture 9 by data wire 14, and the software of computer 15 sets parameters, starts to irradiate.After starting irradiation, computer 15 can be removed, near-infrared luminous diode 17 and white light emitting diode 18 can irradiate according to the parameter set.In experimentation, ensure that experiment mice can normally be taken food and drink water, namely water inlet 7 and food groove 5 will ensure sufficient water and food.
According to raising requirement, after irradiation treatment terminates, switch 10 of cutting off the electricity supply, takes out checking therapeutic effect such as carrying out Behaviors survey by experiment mice, and by experiment container 1 scrub to test next time.After device power-off, various parameter is kept in Control architecture 9 all the time, reopens on and off switch 10 next time, can proceed near infrared light Experiment on therapy according to the parameter set last time.
Embodiment 2:
The present embodiment checking near infrared light to the experimental provision of AD therapy effect, the near-infrared illumination unit comprising experiment container 1, be arranged on experiment container 1 top and jointly form airtight laboratory with experiment container 1 and the circuit control unit be electrically connected with near-infrared illumination unit;
When testing, experiment mice is placed in airtight laboratory, by the unlatching of the automatic regulating near-infrared illumination unit of circuit control unit, shut-in time point and illumination frequency, experiment mice accepts near-infrared light exposure treatment in airtight laboratory, after near-infrared light exposure treatment terminates, take out experiment mice, and follow-up confirmatory experiment is carried out to it.
Wherein, experiment container 1 is open-topped interior empty cuboid container, the side that two of this cuboid container are relative offers ventilation mouth 2 respectively, and ventilation mouth 2 is provided with the gauze 4 for lucifuge, another side of cuboid container also offers the connector 3 for installing food groove 5 and the water inlet 7 for feeding water.Connector 3 is rectangle connector, and this rectangle connector is provided with the gauze 4 for lucifuge, and rectangle connector place is provided with food groove 5; Water inlet 7 is circular port, and this circular port is communicated with external source, and the water of external source is entered in cuboid container by circular port.
The on and off switch 10 that near-infrared illumination unit comprises circuit board 8, be evenly laid in near-infrared luminous diode 17 on circuit board 8 bottom surface and white light emitting diode 18 in array, be arranged on the Control architecture 9 on circuit board 8 end face and be arranged on Control architecture 9, Control architecture 9 is electrically connected with near-infrared luminous diode 17, white light emitting diode 18 and circuit control unit respectively by circuit.Control architecture 9 is also provided with power line 12 and attaching plug 13, for connecing 220 volt AC power.On and off switch 10 on Control architecture 9 controls the opening and closing of whole experimental provision.The number of near-infrared luminous diode 17 is greater than the number of white light emitting diode 18, and near-infrared luminous diode 17 is evenly laid in white light emitting diode 18 around in array.Circuit board 8 end face is also arranged with a pair radiator fan 11.
Circuit control unit comprises the programming device and computer 15 that are electrically connected with Control architecture 9 successively.In use, circuit control unit controls the time point of the opening and closing of near-infrared luminous diode 17 by programming device, thus control the time span of near infrared light treatment, simultaneously, also pulse generating circuit is provided with in circuit control unit, can regulate illumination frequency, within every 0.25 second, open and close once as controlled near-infrared luminous diode 17, and then realize the irradiation frequency of 2Hz.Circuit control unit realizes controlling with the independence of near-infrared luminous diode 17 same illumination parameter to white light emitting diode 18 by programming device.
In the present embodiment, programming device is single-chip microcomputer, and needs to have the interface carrying out communication with computer 15.The software matched with hardware is housed in computer 15, software interface is selected different parameters irradiate.
When carrying out near infrared light according to Experiment on therapy, the unlatching of near-infrared luminous diode 17 and white light emitting diode 18 is first set by computer 15, shut-in time point and illumination frequency experiment parameter, experiment mice is placed in the airtight laboratory that circuit board 8 is formed jointly with cuboid container, open the on and off switch 10 on Control architecture 9, infrarede emitting diode 17 and white light emitting diode 18 irradiate according to the test parameters set, experiment mice accepts near infrared light treatment, at treatments period, subsisted and water to experiment mice by food groove 5 and circular port, after near infrared light treatment terminates, on and off switch 10 in closing control template 9, take out experiment mice, and follow-up confirmatory experiment is carried out to it.
During specific experiment, the wavelength of near infrared light mainly concentrates on 780 ~ 2526nm, the centre wavelength of the near-infrared luminous diode of employing can be selected from 810nm, 880nm, 950nm, 1050nm or 1070nm one or more.
Embodiment 3:
A side of the experiment container 1 of the present embodiment experimental provision is provided with ventilation mouth 2, and another side is corresponding thereto provided with the connector 3 for installing food groove 5 and the water inlet 7 for feeding water, and all the other are with embodiment 2.

Claims (9)

1. verify that near infrared light is to the experimental provision of AD therapy effect, it is characterized in that, this experimental provision comprises experiment container (1), be arranged on experiment container (1) top and the near-infrared illumination unit jointly forming airtight laboratory with experiment container (1) and the circuit control unit be electrically connected with near-infrared illumination unit.
2. checking near infrared light according to claim 1 is to the experimental provision of AD therapy effect, it is characterized in that, described experiment container (1) is open-topped interior empty cuboid container.
3. checking near infrared light according to claim 2 is to the experimental provision of AD therapy effect, it is characterized in that, at least one side of described cuboid container offers ventilation mouth (2), this ventilation mouth (2) is provided with the gauze (4) for lucifuge, a side of described cuboid container also offers the connector (3) for installing food groove (5) and the water inlet (7) for feeding water.
4. checking near infrared light according to claim 3 is to the experimental provision of AD therapy effect, it is characterized in that, described connector (3) is rectangle connector (3), this rectangle connector (3) is provided with the gauze (4) for lucifuge, and described rectangle connector (3) place is provided with food groove (5).
5. checking near infrared light according to claim 4 is to the experimental provision of AD therapy effect, it is characterized in that, described water inlet (7) is circular port, and this circular port is communicated with external source, and the water of external source is entered in cuboid container by circular port.
6. checking near infrared light according to claim 1 is to the experimental provision of AD therapy effect, it is characterized in that, described near-infrared illumination unit comprises circuit board (8), the near-infrared luminous diode (17) on circuit board (8) bottom surface and white light emitting diode (18) is evenly laid in array, the on and off switch (10) being arranged on the Control architecture (9) on circuit board (8) end face and being arranged on Control architecture (9), described Control architecture (9) by circuit respectively with near-infrared luminous diode (17), white light emitting diode (18) and circuit control unit electrical connection.
7. checking near infrared light according to claim 6 is to the experimental provision of AD therapy effect, it is characterized in that, the number of described near-infrared luminous diode (17) is greater than the number of white light emitting diode (18), and described near-infrared luminous diode (17) is evenly laid in white light emitting diode (18) around in array.
8. checking near infrared light according to claim 6 is to the experimental provision of AD therapy effect, it is characterized in that, described circuit board (8) end face is also arranged with a pair radiator fan (11).
9. checking near infrared light according to claim 6 is to the experimental provision of AD therapy effect, it is characterized in that, described circuit control unit comprises the programming device and computer (15) that are electrically connected with Control architecture (9) successively.
CN201520692323.1U 2015-09-08 2015-09-08 Experimental device for verify that near infrared is to sick treatment of A erzihaimo Active CN205041980U (en)

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105148411A (en) * 2015-09-08 2015-12-16 黄勇 Experimental device for verifying the treatment effect of near-infrared light on Alzheimer's disease and application of the device
CN106730396A (en) * 2017-02-26 2017-05-31 常州亚当生物技术有限公司 The therapeutic system of senile dementia and Parkinson's, therapeutic room and treatment glasses

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105148411A (en) * 2015-09-08 2015-12-16 黄勇 Experimental device for verifying the treatment effect of near-infrared light on Alzheimer's disease and application of the device
CN105148411B (en) * 2015-09-08 2018-03-06 黄勇 Verify experimental provision and application of the near infrared light to AD therapy effect
CN106730396A (en) * 2017-02-26 2017-05-31 常州亚当生物技术有限公司 The therapeutic system of senile dementia and Parkinson's, therapeutic room and treatment glasses

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Effective date of registration: 20201021

Address after: Room 610, 6 / F, Kechuang building, 128 Shuanglian Road, Haining Economic Development Zone, Jiaxing City, Zhejiang Province

Patentee after: Zhejiang lai'en Hass Medical Technology Co.,Ltd.

Address before: Liyang City, Jiangsu province 213300 Changzhou City Tai Cun No. 4

Patentee before: Huang Yong

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Address after: 310051 room 2601-6, building 3, Haiwei business center, Xixing street, Binjiang District, Hangzhou City, Zhejiang Province

Patentee after: Zhejiang lai'en Hass Medical Technology Co.,Ltd.

Address before: 314400 room 610, 6 / F, Kechuang building, 128 Shuanglian Road, Haining Economic Development Zone, Haining City, Jiaxing City, Zhejiang Province

Patentee before: Zhejiang lai'en Hass Medical Technology Co.,Ltd.