CN204939350U - A kind of refining production system of intermediate of capecitabine - Google Patents
A kind of refining production system of intermediate of capecitabine Download PDFInfo
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- CN204939350U CN204939350U CN201520655210.4U CN201520655210U CN204939350U CN 204939350 U CN204939350 U CN 204939350U CN 201520655210 U CN201520655210 U CN 201520655210U CN 204939350 U CN204939350 U CN 204939350U
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Abstract
A kind of refining production system of intermediate of capecitabine, comprise dissolving vessel, strainer, crystallizer and filtration, washing, drying three-in-one device, dissolving vessel, strainer, crystallizer and filter, washing, between drying three-in-one device successively by pipeline communication, described pipeline is provided with control valve; Also be communicated with the organic solvent storage tank of outside, workshop by suction channel at filtration, washing, drying three-in-one device; Also be connected with negative pressure device at the top of filtration, washing, drying three-in-one device, negative pressure device is communicated with exhaust gas absorption device with dust.System that employs integrally closed structure, the dissolving crude product of the intermediate of capecitabine, filtration, crystallization all complete to being separated, drying in an airtight equipment, reduce the pollution that personnel and production environment cause product, improve quality product, reduce the harm that organic solvent, dust, waste gas etc. cause personnel and environment simultaneously.
Description
Technical field
The utility model relates to medical equipment technical field, particularly a kind of refining production system of intermediate (2', 3'-bis--O-ethanoyl-5'-deoxidation-5-fluorine cytidine) of capecitabine.
Background technology
2', 3'-bis--O-ethanoyl-5'-deoxidation-5-fluorine cytidine be the key intermediate of capecitabine, at present, this intermediate international market demand is in continuous increase, and the demand of European & American Market is particularly considerable.But because this intermediate product quality does not reach the specification of quality of drug act about starting material and advanced intermediate, have impact on the export sales of this product.Therefore, be meeting the market requirement, need to refine this intermediate, to improve the quality of products.The process for purification of capecitabine intermediate 2', 3'-bis--O-ethanoyl-5'-deoxidation-5-fluorine cytidine, for carry out recrystallization with dehydrated alcohol, is separated and obtains wet product, then drying obtains 2', 3'-bis--O-ethanoyl-5'-deoxidation-5-fluorine cytidine fine work.What current separation and drying course adopted mostly is that whizzer and Hotaircirculatingoven carry out operation; the usual method used is; 2'; 3'-bis--O-ethanoyl-5'-deoxidation-5-fluorine cytidine is after reactor crystallization; being discharged to whizzer carries out centrifugal, then the wet product of centrifugal gained is placed and carries out drying in an oven.In this process, Problems existing is: 2', 3'-bis--O-ethanoyl-5'-deoxidation-5-fluorine cytidine is capecitabine key intermediate, be exposed in production environment in a large number in centrifugal and drying course, personnel and the quality of production environment on product have potential impact; 2' simultaneously; 3'-bis--O-ethanoyl-5'-deoxidation-5-fluorine cytidine dust recycling is in production environment; and this process also has a large amount of organic solvent effusions; all cause the injury of personnel and the pollution of workshop condition; the possibility that next a large amount of organic solvent of simultaneously overflowing is blasted in the time existence running into naked light; so need the design carrying out again to it, improve the quality of products, improve operating environment.
Utility model content
For overcoming problems of the prior art, the utility model provides the refining production system of the intermediate of the capecitabine of high, the enclosed environmentally safe of a kind of quality product.
The technical scheme in the invention for solving the technical problem is: the refining production system of the intermediate of this kind of capecitabine, it is characterized in that: comprise dissolving vessel, strainer, crystallizer and filtration, washing, drying three-in-one device, wherein dissolving vessel is communicated with by pipe-and-filter, strainer is communicated with crystallizer by pipeline, crystallizer is communicated with filtration, washing, drying three-in-one device by pipeline, and described pipeline is provided with control valve; Also be communicated with the organic solvent storage tank of outside, workshop by suction channel at filtration, washing, drying three-in-one device; Also be connected with negative pressure device at the top of filtration, washing, drying three-in-one device, negative pressure device is communicated with exhaust gas absorption device with dust.
Further, described control valve is stopping valve.
Further, described dissolving vessel and crystallizer are glassed steel reaction vessels.
Further, the pipeline between dissolving vessel and strainer is provided with a stopping valve, and the pipeline between the pipeline between strainer and crystallizer, crystallizer and filtration, washing, drying three-in-one device is equipped with two stopping valve.
Further, strainer and filtration, washing, drying three-in-one device are 304 stainless steels.
To sum up, the beneficial effect of technique scheme of the present utility model is as follows:
By in dissolving vessel to carrying out 2'; the dissolving crude product of 3'-bis--O-ethanoyl-5'-deoxidation-5-fluorine cytidine; enter in crystallizer after the filteration of strainer and carry out crystallization; then by carrying out being separated and drying with the filtration of the closed connection of crystallizer, washing, drying three-in-one device, improve quality product.
Focus on additionally by the organic solvent storage tank at suction channel isolated organic solvent being directly evacuated to outside, workshop by suction channel, the organic solvent decreasing effusion, to the injury of personnel and workshop condition and pollution, avoids the danger that organic solvent meets naked light blast simultaneously.Simultaneously by filtering, washing, the dust that produced by drying course of negative pressure device that arranges of top of drying three-in-one device and waste gas is drawn in dust and exhaust gas absorption device and focuses on, and avoids dust and waste gas to the pollution of environment.
Accompanying drawing explanation
Fig. 1 is structural representation of the present utility model.
In figure:
1 dissolving vessel, 2 strainers, 3 crystallizers, 4 filtrations, washing, drying three-in-one device, 5 organic solvent storage tanks, 6 negative pressure devices, 7 dust and exhaust gas absorption device, 8 control valves, 9 pipelines, 10 suction channels.
Embodiment
Be described in detail to characteristic sum principle of the present utility model below in conjunction with accompanying drawing, illustrated embodiment, only for explaining the utility model, not limits protection domain of the present utility model with this.
As shown in Figure 1, this utility model comprise dissolving vessel 1, strainer 2, crystallizer 3 and filter, washing, drying three-in-one device 4.Wherein dissolving vessel is communicated with by pipe-and-filter, 2', 3'-bis--O-ethanoyl-5'-deoxidation-5-fluorine cytidine mainly slightly dissolve in dissolving vessel.2' after thick dissolving, 3'-bis--O-ethanoyl-5'-deoxidation-5-fluorine cytidine entered into 304 stainless steels by pipeline 9 strainer in filter.Solution pipeline 9 between dissolving vessel and strainer is provided with after a control dissolving enters the control valve 8 in strainer, can select stopping valve.
Strainer is communicated with crystallizer by pipeline 9, and 2', 3'-bis--O-ethanoyl-5'-deoxidation-5-fluorine cytidines crystallization in crystallizer, obtains the crystal after crystallization and solution.The mixture of crystal and solution and wet product entered into by pipeline filter, wash, drying three-in-one device (this equipment existing structure, for general designation vocabulary in the industry, personnel can know the structure of this equipment in the art) in, enter filtration, washing, drying three-in-one device wet product dried.
Pipeline 9 between dissolving vessel and strainer is provided with a stopping valve, in order to improve the quality of product, pipeline 9 between the pipeline 9 between strainer and crystallizer, crystallizer and filtration, washing, drying three-in-one device being equipped with two stopping valve, preventing one of them stopping valve from damaging the impact caused producing tablet quality.
Filtration, washing, drying three-in-one device are also communicated with the organic solvent storage tank 5 of outside, workshop by suction channel 10, the organic solvent of the generation in sepn process is evacuated in organic solvent storage tank by suction channel 10, prevent the organic solvent of overflowing to the injury of personnel and workshop condition and pollution, avoid the danger that organic solvent meets naked light blast simultaneously.
Also be connected with negative pressure device 6 at the top of filtration, washing, drying three-in-one device, negative pressure device is communicated with exhaust gas absorption device 7 with dust.The dust that drying produces by negative pressure device and waste gas are drawn in dust and exhaust gas absorption device and focus on, and avoid dust and waste gas to the pollution of environment.
System that employs integrally closed structure; the intermediate 2' of capecitabine; the dissolving crude product of 3'-bis--O-ethanoyl-5'-deoxidation-5-fluorine cytidine, filtration, crystallization are all complete in an airtight equipment to being separated, drying; reduce the pollution that personnel and production environment cause product; improve quality product, reduce harm and pollution that organic solvent in production process, dust, waste gas etc. cause personnel and environment simultaneously.
Above-described embodiment is only the description carried out preferred implementation of the present utility model; not scope of the present invention is limited; under the prerequisite not departing from the utility model design spirit; relevant technical staff in the field, to various distortion of the present utility model and improvement, all should expand in the determined protection domain of the utility model claims.
Claims (5)
1. the refining production system of the intermediate of a capecitabine, it is characterized in that: comprise dissolving vessel, strainer, crystallizer and filtration, washing, drying three-in-one device, wherein dissolving vessel is communicated with by pipe-and-filter, strainer is communicated with crystallizer by pipeline, crystallizer is communicated with filtration, washing, drying three-in-one device by pipeline, and described pipeline is provided with control valve; Also be communicated with the organic solvent storage tank of outside, workshop by suction channel at filtration, washing, drying three-in-one device; Also be connected with negative pressure device at the top of filtration, washing, drying three-in-one device, negative pressure device is communicated with exhaust gas absorption device with dust.
2. the refining production system of the intermediate of a kind of capecitabine according to claim 1, is characterized in that: described control valve is stopping valve.
3. the refining production system of the intermediate of a kind of capecitabine according to claim 1, it is characterized in that: the pipeline between dissolving vessel and strainer is provided with a stopping valve, the pipeline between the pipeline between strainer and crystallizer, crystallizer and filtration, washing, drying three-in-one device is equipped with two stopping valve.
4. the refining production system of the intermediate of a kind of capecitabine according to claim 1, is characterized in that: described dissolving vessel and crystallizer are glassed steel reaction vessels.
5. the refining production system of the intermediate of a kind of capecitabine according to claim 1, is characterized in that: strainer and filtration, washing, drying three-in-one device are 304 stainless steels.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201520655210.4U CN204939350U (en) | 2015-08-27 | 2015-08-27 | A kind of refining production system of intermediate of capecitabine |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201520655210.4U CN204939350U (en) | 2015-08-27 | 2015-08-27 | A kind of refining production system of intermediate of capecitabine |
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| CN204939350U true CN204939350U (en) | 2016-01-06 |
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| CN201520655210.4U Active CN204939350U (en) | 2015-08-27 | 2015-08-27 | A kind of refining production system of intermediate of capecitabine |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114315786A (en) * | 2021-12-20 | 2022-04-12 | 上海晋瑄智能设备制造有限公司 | Process method for solid-liquid separation and recovery of vinylene carbonate reaction liquid |
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2015
- 2015-08-27 CN CN201520655210.4U patent/CN204939350U/en active Active
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114315786A (en) * | 2021-12-20 | 2022-04-12 | 上海晋瑄智能设备制造有限公司 | Process method for solid-liquid separation and recovery of vinylene carbonate reaction liquid |
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Address after: 251400 No. 12, Taixing East Street, Jibei Economic Development Zone, Jiyang District, Jinan City, Shandong Province Patentee after: Shandong Baoyuan Pharmaceutical Co.,Ltd. Address before: Strong in Jiyang County of Ji'nan City, 251400 North Street, Shandong Province Economic Development Zone Patentee before: SHANDONG BOYUAN PHARMACEUTICAL Co.,Ltd. |