CN204931669U - EEG signals amplification system - Google Patents
EEG signals amplification system Download PDFInfo
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- CN204931669U CN204931669U CN201520705809.4U CN201520705809U CN204931669U CN 204931669 U CN204931669 U CN 204931669U CN 201520705809 U CN201520705809 U CN 201520705809U CN 204931669 U CN204931669 U CN 204931669U
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Abstract
The utility model discloses a kind of EEG signals amplification system, comprise brain electrode cap, EEG signals amplification module and parallel acquisition module, described brain electrode cap is arranged on head surface, and it receives the brain electricity of cortex and exports brain electric analoging signal; The brain electric analoging signal differential amplification that described EEG signals amplification module will receive, it comprises 36 unipolar signal amplifiers and 4 bipolar signal amplifiers; Described parallel acquisition module comprises 40 a/d converter, a/d converter described in any one with and only lead with a unipolar signal amplifier or bipolar signal amplifier, brain electric analoging signal real-time parallel after amplifying 40 tunnels gathers, and converts brain electricity digital signal to.This utility model can improve the acquisition range of EEG signals further, more careful observation brain district.
Description
Technical field
This utility model relates to a kind of EEG signals amplification system, and more particularly, this utility model relates to and is a kind ofly applied to the schizoid EEG signals amplification system possessing 40 channel parallel collections, amplification of direct current.
Background technology
Electroencephalogram (EEG) is cranial nerve cell bioelectrical activity in the overall reflection of cerebral cortex or scalp surface.Contain a large amount of physiology and disease information in EEG signals, in clinical medicine, EEG Processing not only can be some disease of brain and provides diagnosis basis, but also provides effective treatment means for some disease of brain.In engineer applied, people also attempt utilizing EEG signals to realize torsion free modules (BCI), utilizing people to the difference of the brain electricity of different sensations, motion or cognitive activities, controlling object by reaching certain to the effective extraction of EEG signals and classification.But because EEG signals does not possess ergodic nonstationary random signal, and its background noise is also very strong, and therefore the treatment and analysis of EEG signals is very attractive but is the research topic with suitable difficulty always.This utility model provides efficient EEG signals and amplifies scheme, and the supervision and analysis technology be intended to for people's cerebral biological electricity provides new method.Schizophrenia is the not bright major psychosis of one group of cause of disease, many person between twenty and fifty slow or subacute onset, often show as the different syndrome of symptom clinically, relate to the inharmonious of many-sided obstacles such as sensory perception, thinking, emotion and behavior and ergasia.The general Clear consciousness of patient, intelligence is normal, but some patients there will be the infringement of cognitive function in lysis.The course of disease is generally delayed, and in recurrent exerbation, increases the weight of or worsens, and decline and mental handicap finally appear in some patients, but some patients can keep recovery from illness or the state that is almost recovered after treatment.
Utility model content
An object of the present utility model solves at least the problems referred to above and defect, and the advantage will illustrated after providing.
This utility model also has an object to be to provide a kind of EEG signals amplification system, by arranging 40 40 brain electrodes, can improve the acquisition range of EEG signals further, more careful observation brain district.
This utility model also has an object to be by arranging 36 unipolarity amplifiers and 4 bipolar amplifiers, because the distance of bipolar electrode should not be cancelled at more than 3-6cm guarantee signal, therefore the spacing of electrode cap top electrode can not be too short, again because the electrode on electrode cap is symmetrical design, the number of amplifier is necessary for even number, and the design considering selection 36 unipolarity amplifiers and 4 bipolar amplifiers is optimum.
This utility model also has an object to be by arranging magnetic coupling isolator between the first microprocessor and the second microprocessor of main control module, and Magnetic isolation is not only faster than light isolation speed, also has circuit design more succinct, the features such as integrated level is high, low-power consumption.
In order to realize, according to these objects of the present utility model and other advantage, providing a kind of EEG signals amplification system, comprise brain electrode cap, EEG signals amplification module and parallel acquisition module:
Described brain electrode cap is arranged on scalp, and it arranges 40 brain electrodes, and brain electrode described in any one receives the brain electricity of cortex, and exports brain electric analoging signal;
The brain electric analoging signal differential amplification that described EEG signals amplification module will receive, it comprises 36 unipolar signal amplifiers and 4 bipolar signal amplifiers, any one unipolar signal amplifier described or bipolar signal amplifier and described 40 brain electrode one_to_one corresponding;
Described parallel acquisition module comprises 40 a/d converter, a/d converter described in any one with and only lead with a unipolar signal amplifier or bipolar signal amplifier, brain electric analoging signal real-time parallel after amplifying 40 tunnels gathers, and converts brain electricity digital signal to.
Preferably, described EEG signals amplification system is also included in line impedence Sampling network, and it, by applying alternating current to described brain electrode cap, regulates the voltage of electrode-skin interface reaction, make impedance reach 5-80 milliohm.
Preferably, described EEG signals amplification system also comprises main control module, it comprises first microprocessor and the second microprocessor, wherein said first microprocessor is to parallel acquisition module transmitting control commands, judge whether to receive brain electricity digital signal from described parallel acquisition module according to resistance value, subsequently the 40 road brain electricity digital signals received are transferred to described second microprocessor through magnetic coupling isolator.
Preferably, described EEG signals amplification system also comprises USB2.0 data transmission module and Butterworth Filtering Processing module, described USB2.0 data transmission module synchronously receives the brain electricity digital signal that described second microprocessor exports, and to described Butterworth Filtering Processing module transfer, described Butterworth Filtering Processing module installation single order high pass, step low-pass two kinds of wave filter carry out filtering to gathered EEG signals data, complete the enlarging function of display EEG signals.
Preferably, described EEG signals amplification system also comprises the stimulating module be arranged on scalp, described stimulating module comprises and is evenly pasted on head electrode everywhere, be preferably on the acupuncture point of head, skull barrier stimulation brain is penetrated from the outer hurtless measure of cranium with imitative bio electricity, described stimulating module is connected with described main control module, and under the stimulation order that described main control module sends, described stimulating module carries out the bionical electricity irritation of brain electricity to scalp;
Wherein, described main control module also comprises the 3rd microprocessor, it carries out subregion to scalp, and described stimulating module is sent to the stimulation order of specific region, contrast the EEG signals that cerebral cortex sends after electricity irritation, record sends the conversion zone of the strongest EEG signals and the most weak EEG signals simultaneously.
Preferably, the input of described unipolar signal amplifier is to diode, and outfan is the operational amplifier of accurate skin peace level input current.
Preferably, the electric current of described bipolar signal amplifier is 1.3mA, and input imbalance is 50uV, and input bias current is 1nA, and CMRR is 100dB, and input noise is 0.28uV.
Preferably, the resolution of described a/d converter is 22bit, and dynamic range is 105dB, and non-linear is ± 0.003%.
Preferably, the interface of described parallel acquisition module is spi bus interface.
Preferably, the bionical electricity irritation frequency of described brain electricity is 0.5Hz, and stimulating current intensity is 20-400 μ A.This utility model at least comprises following beneficial effect:
1, by arranging 40 40 brain electrodes, the acquisition range of EEG signals can be improved further, more careful observation brain district.
2, by arranging 36 unipolarity amplifiers and 4 bipolar amplifiers, because the distance of bipolar electrode should not be cancelled at more than 3-6cm guarantee signal, therefore the spacing of electrode cap top electrode can not be too short, again because the electrode on electrode cap is symmetrical design, the number of amplifier is necessary for even number, and the design considering selection 36 unipolarity amplifiers and 4 bipolar amplifiers is optimum.
3, by arranging magnetic coupling isolator between the first microprocessor and the second microprocessor of main control module, Magnetic isolation is not only faster than light isolation speed, also has circuit design more succinct, the features such as integrated level is high, low-power consumption.
Part is embodied by explanation below by other advantage of the present utility model, target and feature, part also will by research and practice of the present utility model by those skilled in the art is understood.
Accompanying drawing explanation
Fig. 1 is the system block diagram of embodiment 1 in this utility model.
Detailed description of the invention
Below in conjunction with accompanying drawing, this utility model is described in further detail, can implements according to this with reference to description word to make those skilled in the art.
Should be appreciated that used hereinly such as " to have ", other element one or more do not allotted in " comprising " and " comprising " term or the existence of its combination or interpolation.
A kind of EEG signals amplification system, comprises brain electrode cap, EEG signals amplification module and parallel acquisition module:
Described brain electrode cap is arranged on scalp, and it arranges 40 brain electrodes, and brain electrode described in any one receives the brain electricity of cortex, and exports brain electric analoging signal;
The brain electric analoging signal differential amplification that described EEG signals amplification module will receive, it comprises 36 unipolar signal amplifiers and 4 bipolar signal amplifiers, any one unipolar signal amplifier described or bipolar signal amplifier and described 40 brain electrode one_to_one corresponding;
Described parallel acquisition module comprises 40 a/d converter, a/d converter described in any one with and only lead with a unipolar signal amplifier or bipolar signal amplifier, brain electric analoging signal real-time parallel after amplifying 40 tunnels gathers, and converts brain electricity digital signal to.
Described EEG signals amplification system is also included in line impedence Sampling network, and it, by applying alternating current to described brain electrode cap, regulates the voltage of electrode-skin interface reaction, make impedance reach 5-80 milliohm.
Described EEG signals amplification system also comprises main control module, it comprises first microprocessor and the second microprocessor, wherein said first microprocessor is to parallel acquisition module transmitting control commands, judge whether to receive brain electricity digital signal from described parallel acquisition module according to resistance value, subsequently the 40 road brain electricity digital signals received are transferred to described second microprocessor through magnetic coupling isolator.
Described EEG signals amplification system also comprises USB2.0 data transmission module and Butterworth Filtering Processing module, described USB2.0 data transmission module synchronously receives the brain electricity digital signal that described second microprocessor exports, and to described Butterworth Filtering Processing module transfer, described Butterworth Filtering Processing module installation single order high pass, step low-pass two kinds of wave filter carry out filtering to gathered EEG signals data, complete the enlarging function of display EEG signals.
The input of described unipolar signal amplifier is to diode, and outfan is the operational amplifier of accurate skin peace level input current.
The electric current of described bipolar signal amplifier is 1.3mA, and input imbalance is 50uV, and input bias current is 1nA, and CMRR is 100dB, and input noise is 0.28uV.
The resolution of described a/d converter is 22bit, and dynamic range is 105dB, and non-linear is ± 0.003%.
The interface of described parallel acquisition module is spi bus interface.
The bionical electricity irritation frequency of described brain electricity is 0.5Hz, and stimulating current intensity is 20-400 μ A, and efficient output current amount is little, little to skin irritation, the acceptance level of user is high, and owing to being stimulate scalp, do not need to implant in brain, strengthen the satisfaction of user.
As shown in Figure 1, a kind of EEG signals amplification system is by online impedance detection network, direct current amplification module, parallel acquisition module, buffer circuit, USB2.0 transport module, Triger circuit, digital Butterworth Filtering Processing display module, and totally 7 parts form;
Online impedance detection network:
The size of electrode-skin contact impedance affects the quality of the physiological signals such as brain electricity, electrocardio, and excessive easy introducing 50Hz disturbs, and the amplitude of physiological signal also reduces.Online impedance detection is by applying alternating current to electrode one skin contact, and the voltage signal of detecting electrode one skin contact reaction, calculates R=U/I.If impedance is excessive in implantation process, process will be adjusted, to reduce contact resistance.Online impedance detection network can realize the resistance value size that real-time show electrode cap contacts with scalp layer.
Direct current amplification module:
Direct current amplifies, and reacting wider physiological signal can record, can the composition of reaction signal more realistically.EEG electro-physiological signals is generally picked up by metal, can produce polarization DC potential when contacting with meninges, generally at hundred more than mV, and analog digital conversion scope ± 2.5V, thus adopt low range to amplify.Low range is amplified, and the stability of amplification system is high, and reaction is fast, does not have AC amplification time constant.
This utility model direct current amplification module comprises unipolar signal amplifier and bipolarity amplifying signal amplifier.Overall channel number is 40, and wherein unipolarity port number is 36, and ambipolar port number is 4.Unipolarity amplifies employing homophase structure for amplifying, and this structure has high input impedance.Structure is simple, is easy to parameter consistency, is easy to carry out software difference, improves common mode rejection ratio.Input takes diode, can effectively to antistatic, and protect accurate skin to pacify level input current amplifying device and do not damaged by electrostatic, amplification can reach 19 times.Bipolarity amplifies the instrument amplifier adopting classics, Circuit Classical, A/D chip, is easy to realize.The feature of A/D chip: low-power consumption: 1.3mA, input imbalance: 50uV, input bias current: InA, CMRR:100dB.Input noise: 0.28uV, amplification can reach 10 times.
Impedance detection, by the 30Hz sinusoidal signal of 10M Ω, is loaded between electrode and ground, after collection, through the IIR band filter of 28 to 8Hz, detects its amplitude Vx.By the contact impedance between the tested passage of formulae discovery and reference.
Parallel acquisition module:
Parallel acquisition module is the EEG signals in order to record scalp, is made up of 40 a/d converter, can carry out Synchronization Control, collection, realize the synchronicity between event channel to 40 road signals, can realize adding of signal to cut algorithm.Its feature is comprise 4 independently analog digital conversion inside each module.Spi bus interface is also easy to daisy chain structure design cascade.Designed by daisy chain structure, realize gathering the data of 40 passages.Acquisition rate, by software control, can reach 1000Hz.
After data syn-chronization EOC, by CASCIN, the SDATA starting sheet #1 exports data, and the SDATA of sheet #2 forbids exporting, and when sheet #1 data end of output, its CASCOUT notifies sheet #2, allows No. 2 outputs.Daisy chain structure that Here it is designs, and so repeatedly carries out cascade, meets Multi-Channel Parallel Acquisition demand.
Buffer circuit:
The function of buffer circuit is restraint speckle interference.In order to reach national safety standard, buffer circuit adopts high speed magnetic isolation technology, faster than light isolation speed, and reach 10MHz, isolation voltage is up to 5000V.It is more succinct that Magnetic isolation also has circuit design, the features such as integrated level is high, low-power consumption (being only the 1/10-1/6 of optocoupler).
USB2.0 data are transmitted:
Data transmission adopts USB2.0 agreement.Traffic rate is up to 480MHz, and CY7C68013 selected by device.By usb2.0 transmission means, the EEG signals collected is transferred to computer.
Triger circuit:
Triger circuit is stimulation circuit again, and function is the code sending stimulus object.Stimulate code and reaction code receiving circuit to comprise serial ports, parallel port form, reaction button receiving circuit is 4bit mode.Wherein serial ports receives baud rate is 115.2kbps, 10bit, start bit, position of rest agreement.
Butterworth Filtering Processing module:
Filtering Processing is to remove interference.Modern digital filtering technique is ripe, no matter is real-time or afterwards, can extract the signal that institute needs easily.Design basis ground motion low order iir filter, uses software engineering, realizes multiband, various filters, the multichannel physiological single processing ability of acceleration.
1. impedance detection is by the 30Hz sinusoidal signal of 10M Ω, is loaded between electrode and ground, after collection, through the IIR band filter of 28 to 8Hz, detects its amplitude Vx.By the contact impedance between the tested passage of formulae discovery and reference.This utility model direct current amplification module comprises unipolarity and amplifies and bipolarity amplification.Overall channel number is 40, and wherein unipolarity port number is 36, and ambipolar port number is 4.One pole amplification can reach 19 times.Bipolar amplification can reach 10 times.
2. parallel acquisition module is made up of 40 AD, can carry out Synchronization Control, collection, realize the synchronicity between event channel to 40 road signals, can realize adding of signal to cut algorithm.
3.Triger circuit (stimulation circuit) stimulates code and reaction code receiving circuit to comprise serial ports, parallel port form, and reaction button receiving circuit is 4bit mode.
4. buffer circuit adopts high speed magnetic isolation technology, and reach 10MHz, isolation voltage is up to 5000V.
5. transport module adopts high speed USB 2.0 to transmit.
6. adopt digital Butterworth Filtering Processing, design basis ground motion low order iir filter, use software engineering to realize multiband, various filters, the multichannel physiological single processing ability of acceleration.
Unipolarity and ambipolar advantage
Theoretically, if health there is a zero-potential point (in electricity will the earth be set to zero-potential point), and puts with this and be linked with the exploring electrode on scalp, measured potential difference is then the absolute value of cerebral biological electricity potential change under exploring electrode.In fact human body can not have this point, therefore affect the Relative Zero potential point arrangement electrode of two minimum ear-lobes as imagination farthest and by other bio electricity using apart from brain, this electrode is called indifferent electrode or claims reference electrode, and exploring electrode is also known as float electrode.Generally when combining unipolar lead, using float electrode as negative pole, be connected with G1, indifferent electrode is as positive pole.
The method of attachment of unipolar lead method:
1., the float electrode of every side hemisphere is linked with electrode of picking up the ears.
2., two ear poles be connected after as a public reference electrode, then form with float electrode and lead.
3., be connected with ground wire again after two ear electrodes connections, as a public reference electrode, then form with float electrode and lead.
4., to pick up the ears the common electrode of electrode as both sides hemisphere float electrode using one.
The feature of unipolar lead method:
1. the roughly absolute value of cerebral biological electricity potential change under float electrode can, be recorded to.
2., therefore, the E.E.G that the impact scope that cortex, cortex deep focus produce is wider, unipolar lead is easy to find than bipolar lead.
3., due to the span between float electrode and indifferent electrode comparatively large, therefore more weak, compared with zonule property E.E.G easily by more large regions, stronger cerebral biological electricity cover and can not be found.
4., due to ear electrode ground connection, easily 50Hz alternating current disturbance is produced.
5., because two ears are extremely near temples, the special E.E.G of Gu Niequ often can make ear electrode by the impact of its electric field.Cause indifferent electrode mobilization.
Other physiologic information of bipolar essential record, comprises ECG, EOG, EMG etc.Physiological signal is weak signal, and common mode is relatively more serious, in order to obtain good information, all adopts Differential Input pattern
Unipolarity and bipolar electrode distribution method
Second: apportion design Main Basis 10-20 system electrode placement methods.
10---20 system electrode placement methods and international electroencephalogram association specified standard electrode placement methods.
1., front and back sagittal line: get a line from the nasion to external occipital protuberance, on this line, mark 5 points, successively called afters from front to back: antinion mid point (Fpz), metopion (Fz), central point (Cz), summit (Pz), pillow point (Oz).Antinion mid point respectively accounts for 10% of this line total length to the Distance geometry pillow point of the nasion to the distance of external occipital protuberance, and all the other each points are all separated by with 20% of this line total length.Here it is 10---the source of 20 systematic names
2., transverse presentation: get a line from left preauricular point (before tragus roots of zygoma recess) by central point to right preauricular point, mark (T4) in (T3) in left temporo, right temporo, left centre (C3), right median (C4) in the left and right sides symmetry of this line.The distance of T3, T4 point and preauricular point respectively accounts for 10% of this line total length, and all the other each points (comprising Cz point) are all separated by with 20% of this line total length.
40 meanings of leading and selectivity use feasibility.
40 lead resolution, mainly can improve spatial resolution further, can careful observation brain district difference in functionality.Develop into now 256 to lead or 512 to lead.
40 lead and can screen, can independent assortment, by an addition and subtraction that leads, and the different characteristic of analytic signal.Instrument is all kinds of computational science software, as matlab etc.
Industrial applicibility of the present utility model
1, by arranging 40 40 brain electrodes, the acquisition range of EEG signals can be improved further, more careful observation brain district.
2, by arranging 36 unipolarity amplifiers and 4 bipolar amplifiers, because the distance of bipolar electrode should not be cancelled at more than 3-6cm guarantee signal, therefore the spacing of electrode cap top electrode can not be too short, again because the electrode on electrode cap is symmetrical design, the number of amplifier is necessary for even number, and the design considering selection 36 unipolarity amplifiers and 4 bipolar amplifiers is optimum.
3, by arranging magnetic coupling isolator between the first microprocessor and the second microprocessor of main control module, Magnetic isolation is not only faster than light isolation speed, also has circuit design more succinct, the features such as integrated level is high, low-power consumption.
4, the stimulating module that can send the bionical electricity irritation of brain electricity is set by scalp, and to arrange at main control module and control stimulating module to carry out electricity irritation the 3rd microprocessor in feature region, simultaneously, 3rd microprocessor also records the conversion zone of the strongest EEG signals and the most weak EEG signals, user can according to the information obtained, obtain the relatedness of stimulated zone and conversion zone, and then judge whether this relatedness meets routine, reduce the time and difficulty of detecting disease.
Although embodiment of the present utility model is open as above, it is not restricted to listed in description and embodiment utilization.It can be applied to various applicable field of the present utility model completely.For those skilled in the art, can easily realize other amendment.Therefore do not deviating under the general concept that claim and equivalency range limit, this utility model is not limited to specific details and illustrates here and the legend described.
Claims (8)
1. an EEG signals amplification system, comprises brain electrode cap, EEG signals amplification module and parallel acquisition module, it is characterized in that:
Described brain electrode cap is arranged on scalp, and it arranges 40 brain electrodes, and brain electrode described in any one receives the brain electricity of cortex, and exports brain electric analoging signal;
The brain electric analoging signal differential amplification that described EEG signals amplification module will receive, it comprises 36 unipolar signal amplifiers and 4 bipolar signal amplifiers, any one unipolar signal amplifier described or bipolar signal amplifier and described 40 brain electrode one_to_one corresponding;
Described parallel acquisition module comprises 40 a/d converter, a/d converter described in any one with and only lead with a unipolar signal amplifier or bipolar signal amplifier, by 40 tunnels amplify after brain electric analoging signal convert to brain electricity digital signal.
2. EEG signals amplification system as claimed in claim 1, it is characterized in that, be also included in line impedence Sampling network, it is connected with described brain electrode cap.
3. EEG signals amplification system as claimed in claim 2, it is characterized in that, also comprise main control module, it comprises first microprocessor and the second microprocessor, wherein said first microprocessor and described parallel acquisition model calling also receive brain electricity digital signal, are provided with magnetic coupling isolator between described second microprocessor and described first microprocessor.
4. EEG signals amplification system as claimed in claim 3, it is characterized in that, also comprise USB2.0 data transmission module and Butterworth Filtering Processing module, described USB2.0 data transmission module receives the brain electricity digital signal that described second microprocessor exports, and to described Butterworth Filtering Processing module transfer.
5. EEG signals amplification system as claimed in claim 1, it is characterized in that, the input of described unipolar signal amplifier is to diode, and outfan is the operational amplifier of accurate skin peace level input current.
6. EEG signals amplification system as claimed in claim 1, it is characterized in that, the electric current of described bipolar signal amplifier is 1.3mA, and input imbalance is 50uV, and input bias current is 1nA, and CMRR is 100dB, and input noise is 0.28uV.
7. EEG signals amplification system as claimed in claim 1, it is characterized in that, the resolution of described a/d converter is 22bit, and dynamic range is 105dB, and non-linear is ± 0.003%.
8. EEG signals amplification system as claimed in claim 1, it is characterized in that, the interface of described parallel acquisition module is spi bus interface.
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| CN114098762A (en) * | 2021-11-26 | 2022-03-01 | 江苏科技大学 | Electric model of de novo cortical electroencephalogram (BCG) |
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