CN204911002U - Aseptic filteration device of preparation brain protein hydrolysis thing preparation - Google Patents
Aseptic filteration device of preparation brain protein hydrolysis thing preparation Download PDFInfo
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- CN204911002U CN204911002U CN201520712886.2U CN201520712886U CN204911002U CN 204911002 U CN204911002 U CN 204911002U CN 201520712886 U CN201520712886 U CN 201520712886U CN 204911002 U CN204911002 U CN 204911002U
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Abstract
The utility model provides an aseptic filteration device of preparation brain protein hydrolysis thing preparation, including reservoir, titanium stick filter and sterilization filter, the lateral wall of titanium stick filter be equipped with with the inlet that the reservoir is connected, titanium stick filter top be equipped with with the liquid outlet that sterilization filter connects, the sewer pipe that is equipped with the stop valve is connected to titanium stick filter bottom, sterilization filter includes the barrel, the barrel transversely is equipped with carbon granules filtering component and membrane filtering component by top to bottom in proper order, the barrel top be equipped with with the liquid inlet that titanium stick filter is connected, the flowing back pipe is connected to sterilization filter's bottom. The utility model provides an aseptic filteration device passes through the double -deck of titanium stick filter and aseptic filteration ware and filters, has reached thorough degerming, fast, the difficult purpose of blockking up of filter equipment of filter speed, has effectively improved the preparation efficiency of brain protein hydrolysis thing preparation, has guaranteed the quality of brain protein hydrolysis thing preparation simultaneously, and the practicality is strong.
Description
Technical field
The utility model relates to filter plant technical field, particularly a kind of sterilization filter device preparing pharmaceutics of hydrolysate of brain protein.
Background technology
In medical science, pharmaceutics of hydrolysate of brain protein is peptidergic nerve nutrient drug specific to a kind of brain, can act on nervous centralis in many ways; regulate and improve neuronic metabolism; promote the formation of cynapse, the differentiation of Induction of neuronal, and further neuroprotective cell from the infringement of various ischemic and neurotoxin; in addition; said preparation, by blood-brain barrier, promotes the synthesis of brain internal protein, affects respiratory chain; there is the protective capability of anti anoxia, improve the metabolism of brain self-energy.Therefore, in clinical medicine, pharmaceutics of hydrolysate of brain protein is mainly used in craniocerebral trauma, apoplexy sequela improves with the symptom of hypomnesia and visual cognitive ability obstacle.
In view of pharmaceutics of hydrolysate of brain protein is to the outstanding contributions of clinical practice, its use amount when clinical treatment is large, therefore, produces pharmaceutics of hydrolysate of brain protein in a large number for satisfying the demands needs.Patent publication No. is a kind of Cerebrolysin Vial and freeze-dried powder thereof disclosed in CN1303142991A, disclose the method preparing Cerebrolysin Vial, its method comprises: (1) gets fresh healthy swine brain, remove fat, homogenate, is then evacuated to 5 ~ 10Pa, keeps pressure 5 ~ 15min, after to pass into carbon dioxide to pressure be 10 ~ 18MPa, keep pressure 20 ~ 25min; (2) under rotating speed 300 ~ 500rpm, degrease brains saturated for carbon dioxide slowly being joined volume is in the liquid CO 2 of degrease brains weight 5 ~ 8 times, finish, stir 20-60min, be cooled to-70 ~-80 DEG C, keep 2 ~ 4h, then 5 ~ 10min is by temperature to 40 ~ 50 DEG C, by carbon dioxide gasification; (3) add the water for injection of 2-4 times of weight in the freeze thawing brains obtained to step 2, stir, then add the papain or pepsin that are equivalent to freeze thawing brains weight 0.5 ~ 1%, be hydrolyzed 3 ~ 4h at 30 ~ 40 DEG C, obtain zymolyte; (4) zymolyte is centrifugal, get supernatant, add medical active carbon by supernatant weight 0.1-0.5%, stirred at ambient temperature 10-20min, with 0.4 ~ 0.5 μm of filtering with microporous membrane de-carbon, then with 0.22 ~ 0.30 μm of filtering with microporous membrane and get final product.Can be produced by said method and obtain Cerebrolysin Vial, but in process of production, active carbon aseptic filtration can only remove relatively oarse-grained impurity in solution, can not really accomplish degerming, its bacteria-eliminating efficacy is bad, in addition, Cerebrolysin Vial freeze-dried powder generally adopts 0.22 micron membrane filter to filter, it is slower to there is the rate of filtration in this filter membrane, and it is not degerming thoroughly etc. not enough, therefore, people are badly in need of one and can be specifically designed to and prepare pharmaceutics of hydrolysate of brain protein, and fast, the degerming sterilization filter device thoroughly of its filtration.
Utility model content
Relatively oarse-grained impurity in solution can only be removed to solve the active carbon aseptic filtration existed in prior art, can not really accomplish degerming, its bacteria-eliminating efficacy is bad, in addition, Cerebrolysin Vial freeze-dried powder generally adopts 0.22 micron membrane filter to filter, it is slower to there is the rate of filtration in this filter membrane, and the degerming problem such as not thorough, the utility model provides one can filter pharmaceutics of hydrolysate of brain protein continuously in enormous quantities, and filters fast, the degerming sterilization filter device preparing pharmaceutics of hydrolysate of brain protein thoroughly.
The concrete technical scheme of the utility model is as follows:
The utility model provides a kind of sterilization filter device preparing pharmaceutics of hydrolysate of brain protein, comprises the reservoir, titanium rod filter and the sterilizing filter that are sequentially connected in series by pipeline, wherein,
The sidewall of described titanium rod filter is provided with the inlet be connected with described reservoir, and described titanium rod filter top is provided with the liquid outlet be connected with described sterilizing filter, and described titanium rod filter bottom is connected with the sewer pipe of stop valve;
Described sterilizing filter comprises cylindrical shell, carbon granules filter assemblies and membrane filtration module is laterally provided with successively by top to bottom in described cylindrical shell, described cylindrical shell top is provided with the liquid inlet be connected with described titanium rod filter, the bottom connected drainage pipe of described sterilizing filter.
Further, described titanium rod filter comprises cartridge filter, and described cartridge filter top cross is provided with baffler, is longitudinally provided with multiple titanium rod bottom described baffler.
Further, described carbon granules filter assemblies is superposed by distribution plate, microporous barrier and forms, and the aperture of described microporous barrier is 0.4 μm ~ 0.5 μm, fills carbon granules layer between described distribution plate and described microporous barrier;
Described distribution plate is connected to form by the fixed head axially arranged by the annulus of multiple different radii, and the sidewall slope angle of described annulus is 30 ° ~ 60 °.
Further, described membrane filtration module is made up of the first deflector, filter membrane and the second deflector successively lateral stacking, and the aperture of described filter membrane is 0.22 μm ~ 0.30 μm.
Further, described first deflector, the second deflector are connected to form by the baffle plate axially arranged by the concentric ring of multiple different radii, the sidewall slope angle of the described concentric ring of described first deflector is 30 ° ~ 60 °, and the sidewall slope angle of the described concentric ring of described second deflector is 120 ° ~ 150 °.
Further, this sterilization filter device also comprises receipts flow container, and described receipts flow container is connected with described discharging tube.
Further, this sterilization filter device also comprises waste liquid tank, and described waste liquid tank is connected with described sewer pipe.
Preferably, the pipeline between described titanium rod filter and described sterilizing filter is provided with centrifugal pump.
Preferably, the pipeline between described reservoir and described titanium rod filter is provided with liquid delivery pump.
Preferably, the pipeline between described reservoir and described titanium rod filter is also provided with check valve.
The beneficial effects of the utility model are as follows: the sterilization filter device that the utility model provides is specifically designed to prepares pharmaceutics of hydrolysate of brain protein, this sterilization filter device passes through the double medium filtration of titanium rod filter and sterilizing filter, reach thoroughly degerming object, the rate of filtration of this sterilization filter device is very fast simultaneously, after multiple filtration, filter membrane or microporous barrier all not easily block, effectively improve the preparation efficiency of pharmaceutics of hydrolysate of brain protein, ensure that the quality of pharmaceutics of hydrolysate of brain protein simultaneously, practical.
Accompanying drawing explanation
Fig. 1 is a kind of structural representation preparing the sterilization filter device of pharmaceutics of hydrolysate of brain protein described in embodiment 1;
Fig. 2 is a kind of structural representation preparing titanium rod filter in the sterilization filter device of pharmaceutics of hydrolysate of brain protein described in embodiment 2;
Fig. 3 is a kind of structural representation preparing sterilizing filter in the sterilization filter device of pharmaceutics of hydrolysate of brain protein described in embodiment 2;
Fig. 4 is a kind of top view preparing distribution plate in the sterilization filter device of pharmaceutics of hydrolysate of brain protein described in embodiment 2;
Fig. 5 is a kind of top view preparing the second deflector in the sterilization filter device of pharmaceutics of hydrolysate of brain protein described in embodiment 2;
Fig. 6 is a kind of front view preparing the first deflector in the sterilization filter device of pharmaceutics of hydrolysate of brain protein described in embodiment 2;
Fig. 7 is a kind of front view preparing the second deflector in the sterilization filter device of pharmaceutics of hydrolysate of brain protein described in embodiment 2;
Fig. 8 is a kind of structural representation preparing the sterilization filter device of pharmaceutics of hydrolysate of brain protein described in embodiment 3.
Wherein: 1, reservoir; 2, titanium rod filter; 201, inlet; 202, liquid outlet; 203, stop valve; 204, sewer pipe; 205, cartridge filter; 206, baffler; 207, titanium rod; 3, sterilizing filter; 301, cylindrical shell; 302, liquid inlet; 303, discharging tube; 4, carbon granules filter assemblies; 401, distribution plate; 402, microporous barrier; 403, carbon granules layer; 404, annulus; 405, fixed head; 5, membrane filtration module; 501, the first deflector; 502, filter membrane; 503, the second deflector; 504, concentric ring; 505, baffle plate; 6, flow container is received; 7, waste liquid tank; 8, centrifugal pump; 9, liquid delivery pump.
Detailed description of the invention
Below in conjunction with accompanying drawing and following examples, the utility model is described in further detail.
Embodiment 1
As shown in Figure 1, the utility model example 1 provides a kind of sterilization filter device preparing pharmaceutics of hydrolysate of brain protein, this sterilization filter device is specifically designed to the aseptic filtration prepared in pharmaceutics of hydrolysate of brain protein, this filter comprises the reservoir 1 be sequentially connected in series by pipeline, titanium rod filter 2 and sterilizing filter 3, the structure and the annexation that define described titanium rod filter 2 in the technical program are: the sidewall of described titanium rod filter 2 is provided with the inlet 201 be connected with described reservoir 1, described titanium rod filter 2 top is provided with the liquid outlet 202 be connected with described sterilizing filter 3, the sewer pipe 204 of stop valve 203 is connected with bottom described titanium rod filter 2, because titanium rod filter 2 is for filtering macromolecular substances, so be connected with the sewer pipe 204 of stop valve 203 bottom titanium rod filter 2, can despumation by sewer pipe 204, the large molecular impurity of effective filtration, in addition, titanium rod filter 2 production cost is lower, through being often used as the deep bed filter of serious offense filter amount, titanium rod filter 2 can as the pre-filtering program prepared in pharmaceutics of hydrolysate of brain protein, effective raising filter effect, prevent later stage sterilizing filter 3 from blocking in filter process, effectively improve filter efficiency.
Described sterilizing filter 3 comprises cylindrical shell 301, carbon granules filter assemblies 4 and membrane filtration module 5 is laterally provided with successively by top to bottom in described cylindrical shell 301, described cylindrical shell 301 top is provided with the liquid inlet 302 be connected with described titanium rod filter 2, the bottom connected drainage pipe 303 of described sterilizing filter 3.Carbon granules filter assemblies 4 and membrane filtration module 5 serve the object of secondary filter, and that is in this device, tool haves three layers filtration system, effectively plays filter effect.
This sterilization filter device preparing pharmaceutics of hydrolysate of brain protein is by three layer filtration system, impurity in effective removal preparation, really accomplish degerming, in addition, after two-layer filtration, impurity screening in sterilizing filter 3 is less, be not easy to block filter membrane 502, so the rate of filtration is very fast, thoroughly degerming, can use continuously, practical.
Embodiment 2
The utility model embodiment 2 provides a kind of sterilization filter device preparing pharmaceutics of hydrolysate of brain protein, and this sterilization filter device as different from Example 1, further defines the structure of described titanium rod filter 2, sterilizing filter 3 in the technical program.
As shown in Figure 2, in order to improve filter effect, further define described titanium rod filter 2 in the technical program and comprise cartridge filter 205, described cartridge filter 205 top cross is provided with baffler 206, is longitudinally provided with multiple titanium rod 207 bottom described baffler 206.Titanium rod 207 is as filtration core, play preliminary object of filtering, the titanium filter filter core that carbon-point filter core selects high purity titanium or titanium alloy irregular powder to process, be mainly used in middle separation and the filtration of the industries such as petrochemical industry, the manufacture of liquid medicine, water treatment, utensil has high temperature resistant, acid-alkali-corrosive-resisting, by force anti-oxidant, and be suitable for multiple environment, anti-microbe ability is strong, do not have an effect with microorganism, can in bioengineering and medical domain application.
As shown in Figure 2, in order to improve filter effect further, define described carbon granules filter assemblies 4 in the technical program to be made up of distribution plate 401, microporous barrier 402 superposition, the aperture of described microporous barrier 402 is 0.4 μm ~ 0.5 μm, fills carbon granules layer 403 between described distribution plate 401 and described microporous barrier 402.
As shown in Figure 4, described distribution plate 401 is connected to form by the fixed head 405 axially arranged by the annulus 404 of multiple different radii, and the sidewall slope angle of described annulus 404 is 30 ° ~ 60 °.The sidewall slope angle of annulus 404 more easily makes liquid flow in annulus 404 within the scope of 30 ° ~ 60 °, if angle is excessive or too small being all not easy to makes liquid flow in distribution plate 401, can not liquid flow be hindered in this angular range, liquid can not be caused to block, achieve staggered flowing.
In the technical program, annulus 404 on distribution plate 401 achieves liquid flow and moves along specific runner, liquid can be made to flow by its incline direction, and evenly by carbon granules layer 403, rear evenly to filter through microporous barrier 402 is filtered by carbon granules layer 403, when liquid arrives microporous barrier 402, the parallel direction formed along film flows, thus realize cross-flow filtration, easy to use, uniform liquid can flow and uniform filtering by the existence of this distribution plate 401, liquid can not be made to focus on carbon granules layer 403, thus make liquid can not focus on microporous barrier 402, improve filter efficiency, liquid can not cause larger pressure to microporous barrier 402, extend the service life of microporous barrier 402, practical.
As shown in Figure 3, it should be noted that, further describe described membrane filtration module 5 in the technical program to be made up of the first deflector 501501, filter membrane 502 and the second deflector 503 successively lateral stacking, the aperture of described filter membrane 502 is 0.22 μm ~ 0.30 μm.Membrane filtration module 5 is for the last one deck filtration system in pharmaceutics of hydrolysate of brain protein, the first deflector 501501 in this assembly plays the effect that dispense liquid flows to, alleviate the hydraulic shock power that filter membrane 502 is subject to, thus make filter membrane 502 reach the effect of uniform filtering, not only increase the filter efficiency of filter membrane 502 like this, and extend the service life of filter membrane 502, practical.In addition, the aperture of filter membrane 502 is fully can play bacteria-eliminating efficacy in the scope of 0.22 μm ~ 0.30 μm.
As illustrated in figs. 5-7, in order to improve filter effect, improve the service life of filter membrane 502, further define described first deflector 501501, second deflector 503 in the technical program to be connected to form by the baffle plate 505 axially arranged by the concentric ring 504 of multiple different radii, the sidewall slope angle of the described concentric ring 504 of described first deflector 501501 is 30 ° ~ 60 °, and the sidewall slope angle of the described concentric ring 504 of described second deflector 503 is 120 ° ~ 150 °.Described first deflector 501501 is for dispense liquid runner, liquid is made evenly to flow on filter membrane 502 along the sidewall of concentric ring 504, this design, the everywhere of filter membrane 502 can be made all can to play filter effect, increase the filter area of filter membrane 502, thus achieve cross-flow filtration, effectively improve filter efficiency; In addition, described second deflector 503 plays the effect that liquid is collected rapidly, the sidewall slope angle of the described concentric ring 504 of described second deflector 503 is 120 ° ~ 150 °, in this range of tilt angles, the liquid after filtration can be made fully to concentrate and be poured out by discharging tube 303, improve practicality.
Embodiment 3
The utility model embodiment 3 provides a kind of sterilization filter device preparing pharmaceutics of hydrolysate of brain protein, and this sterilization filter device as different from Example 1, further defines the structure of described sterilization filter device in the technical program.
As shown in Figure 8, in order to be got up by the liquid collection after sterilizing filter 3 inner filtration, further define this sterilization filter device in the technical program and also comprise receipts flow container 6, described receipts flow container 6 is connected with described discharging tube 303.Receive flow container 6 for sealing receipts flow container 6, the liquid after effectively preventing the impurity in air from again entering into filtration.
In the technical program, in order to by waste liquid or Slag recovering, define this sterilization filter device and also comprise waste liquid tank 7 in the technical program, described waste liquid tank 7 is connected with described sewer pipe 204.The waste liquid that waste liquid tank 7 is collected or residue can utilize by Recovery and recycle.
Preferably, the pipeline between described titanium rod filter 2 and described sterilizing filter 3 is provided with centrifugal pump 8.The existence of centrifugal pump 8 can improve power, is extracted in sterilizing filter 3 by the liquid in titanium rod filter 2, effectively improves filter efficiency.
Preferably, the pipeline between described reservoir 1 and described titanium rod filter 2 is provided with liquid delivery pump 9.Liquid in reservoir 1 fully can be transported to titanium rod filter 2 by liquid delivery pump 9, improves filter efficiency, can not make to there is liquid residue in reservoir 1.
Preferably, the pipeline between described reservoir 1 and described titanium rod filter 2 is also provided with check valve.The existence liquid that can control in reservoir 1 of check valve flow into the amount in titanium rod filter 2, prevents the liquid in titanium rod filter 2 from overstocking, effectively controls liquid filtering amount and improve filter effect.
The utility model is not limited to above-mentioned preferred forms; anyone can draw other various forms of products under enlightenment of the present utility model; no matter but any change is done in its shape or structure; every have identical with the application or akin technical scheme, all drops within protection domain of the present utility model.
Claims (10)
1. prepare a sterilization filter device for pharmaceutics of hydrolysate of brain protein, it is characterized in that, comprise the reservoir (1), titanium rod filter (2) and the sterilizing filter (3) that are sequentially connected in series by pipeline, wherein,
The sidewall of described titanium rod filter (2) is provided with the inlet (201) be connected with described reservoir (1), described titanium rod filter (2) top is provided with the liquid outlet (202) be connected with described sterilizing filter (3), and described titanium rod filter (2) bottom is connected with the sewer pipe (204) of stop valve (203);
Described sterilizing filter (3) comprises cylindrical shell (301), carbon granules filter assemblies (4) and membrane filtration module (5) is laterally provided with successively by top to bottom in described cylindrical shell (301), described cylindrical shell (301) top is provided with the liquid inlet (302) be connected with described titanium rod filter (2), bottom connected drainage pipe (303) of described sterilizing filter (3).
2. prepare the sterilization filter device of pharmaceutics of hydrolysate of brain protein as claimed in claim 1, it is characterized in that, described titanium rod filter (2) comprises cartridge filter (205), described cartridge filter (205) top cross is provided with baffler (206), and described baffler (206) bottom is longitudinally provided with multiple titanium rod (207).
3. prepare the sterilization filter device of pharmaceutics of hydrolysate of brain protein as claimed in claim 1, it is characterized in that, described carbon granules filter assemblies (4) is superposed by distribution plate (401), microporous barrier (402) and forms, the aperture of described microporous barrier (402) is 0.4 μm ~ 0.5 μm, fills carbon granules layer (403) between described distribution plate (401) and described microporous barrier (402);
Described distribution plate (401) is connected to form by the fixed head (405) axially arranged by the annulus (404) of multiple different radii, and the sidewall slope angle of described annulus (404) is 30 ° ~ 60 °.
4. prepare the sterilization filter device of pharmaceutics of hydrolysate of brain protein as claimed in claim 1, it is characterized in that, described membrane filtration module (5) is made up of the first deflector (501), filter membrane (502) and the second deflector (503) successively lateral stacking, and the aperture of described filter membrane (502) is 0.22 μm ~ 0.30 μm.
5. prepare the sterilization filter device of pharmaceutics of hydrolysate of brain protein as claimed in claim 4, it is characterized in that, described first deflector (501), the second deflector (503) are connected to form by the baffle plate (505) axially arranged by the concentric ring (504) of multiple different radii, the sidewall slope angle of the described concentric ring (504) of described first deflector (501) is 30 ° ~ 60 °, and the sidewall slope angle of the described concentric ring (504) of described second deflector (503) is 120 ° ~ 150 °.
6. prepare the sterilization filter device of pharmaceutics of hydrolysate of brain protein as claimed in claim 1, it is characterized in that, this sterilization filter device also comprises receives flow container (6), and described receipts flow container (6) is connected with described discharging tube (303).
7. prepare the sterilization filter device of pharmaceutics of hydrolysate of brain protein as claimed in claim 1, it is characterized in that, this sterilization filter device also comprises waste liquid tank (7), and described waste liquid tank (7) is connected with described sewer pipe (204).
8. prepare the sterilization filter device of pharmaceutics of hydrolysate of brain protein as claimed in claim 1, it is characterized in that, the pipeline between described titanium rod filter (2) and described sterilizing filter (3) is provided with centrifugal pump (8).
9. prepare the sterilization filter device of pharmaceutics of hydrolysate of brain protein as claimed in claim 1, it is characterized in that, the pipeline between described reservoir (1) and described titanium rod filter (2) is provided with liquid delivery pump (9).
10. the sterilization filter device preparing pharmaceutics of hydrolysate of brain protein as described in any one of claim 1-9, is characterized in that, the pipeline between described reservoir (1) and described titanium rod filter (2) is also provided with check valve.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201520712886.2U CN204911002U (en) | 2015-09-15 | 2015-09-15 | Aseptic filteration device of preparation brain protein hydrolysis thing preparation |
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| CN201520712886.2U CN204911002U (en) | 2015-09-15 | 2015-09-15 | Aseptic filteration device of preparation brain protein hydrolysis thing preparation |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109666590A (en) * | 2019-01-29 | 2019-04-23 | 大连民族大学 | A kind of method of microorganism in collection fresh-cut fruit and vegetable |
| CN109731107A (en) * | 2019-01-26 | 2019-05-10 | 临海市科晶生物科技有限公司 | A kind of compound disposable high-efficiency quick liquid sterilization purification device and its application method |
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2015
- 2015-09-15 CN CN201520712886.2U patent/CN204911002U/en active Active
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109731107A (en) * | 2019-01-26 | 2019-05-10 | 临海市科晶生物科技有限公司 | A kind of compound disposable high-efficiency quick liquid sterilization purification device and its application method |
| CN109666590A (en) * | 2019-01-29 | 2019-04-23 | 大连民族大学 | A kind of method of microorganism in collection fresh-cut fruit and vegetable |
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