CN204890945U - Silk fibroin slowly -releasing micropin - Google Patents
Silk fibroin slowly -releasing micropin Download PDFInfo
- Publication number
- CN204890945U CN204890945U CN201520641227.4U CN201520641227U CN204890945U CN 204890945 U CN204890945 U CN 204890945U CN 201520641227 U CN201520641227 U CN 201520641227U CN 204890945 U CN204890945 U CN 204890945U
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- medicine
- storing bag
- storage chamber
- medicine storing
- drug storage
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0046—Solid microneedles
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- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Dermatology (AREA)
- Medical Informatics (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
Abstract
The utility model provides a silk fibroin slowly -releasing micropin, including substrate layer and long gluey vesicular medicine storage bag, medicine storage bag is made by silk fibroin, press the buttress shaft that the array set up on the substrate layer, medicine storage bag one end is provided with the capillary cavity for storage medicine who extends to the other end, capillary cavity for storage medicine is in medicine storage bag's one end forms the opening, be provided with corresponding medicament in the capillary cavity for storage medicine, medicine storage bag passes through the opening with capillary cavity for storage medicine part nested in on the buttress shaft, the utility model discloses the medicine storage bag memory action medicine that contains capillary cavity for storage medicine that utilizes that silk fibroin makes, capillary cavity for storage medicine is getting into human back because internal flow nature is relatively poor simultaneously, and the medicine is done benefit to the absorption of skin to the medicine by slow capillary cavity for storage medicine that releases.
Description
Technical field
This utility model relates to health-care medical Material Field, especially, is a kind of fibroin albumen slow release micropin.
Background technology
Beauty treatment micropin utilizes many small syringe needles on micropin roller, chafe, and within very short time, micropin can be made more than 200,000 microtubule, by the regeneration of stimulation collagen, reaches the object of beauty treatment.Along with the development of micro-processing technology, a kind ofly sting expelling pathogenic factors from the exterior skin but do not injure corium and neural micropin technology was come out, for transdermal administration brings new thinking before the more than ten years.Size pierces through the skin surface (horny layer) of permeability extreme difference at micron-sized micropin dot matrix in the mode of reversible Wicresoft, causes biomacromolecule to be able to the mechanical passage passed through, and does not but produce pain and skin trauma.Thrust preferably to change skin permeation sexuality though conventional metals, glass, siliceous micropin possess, but generally medicine is applied in microneedle surface, drug loading is little, is difficult to reach therapeutic effect.Therefore, there is the empty micropin structure of coating medicine in micropin inside, the medicine of q.s can be made to enter the skin corium of skin by empty micropin.Above method all adopts short time instantaneous raising drug dose to reach the object of administration, brings huge pressure to the absorbability of cell, and can be absorbed totally in the medicine short time simultaneously, curative effect reduces gradually along with increasing progressively of time.
Utility model content
In order to solve the problem, the purpose of this utility model is to provide a kind of fibroin albumen slow release micropin, and this fibroin albumen slow release micropin slowly can carry out drug delivery uniformly.
This utility model solves the technical scheme that its technical problem adopts:
This fibroin albumen slow release micropin comprises the medicine storing bag of substrate layer and long capsule shape, described medicine storing bag is made up of fibroin albumen, described substrate layer is pressed the buttress shaft that array is arranged, described medicine storing bag one end is provided with the capillary drug storage chamber extended to the other end, described capillary drug storage chamber forms opening in one end of described medicine storing bag, described capillary drug storage intracavity is provided with corresponding medicament, and capillary drug storage cavity segment is nested on described buttress shaft by described opening by described medicine storing bag.
As preferably, the root of described buttress shaft is provided with the projection matched with the opening diameter of medicine storing bag, and the external diameter of described projection is identical with the external diameter of described opening.
As preferably, the length that described buttress shaft stretches into described capillary drug storage chamber is less than 1/2nd of capillary drug storage chamber total length.
As preferably, the diameter of described medicine storing bag successively decreases gradually to the direction of opening bottom described capillary drug storage chamber.
As preferably, the periphery wall of described medicine storing bag is provided with the agnail tilted to described open at one end.
As preferably, described buttress shaft is made up of the affine material of elasticity.
As preferably, material that described elasticity is affine is artificial spider silk material.
As preferably, the diameter of described buttress shaft successively decreases along root to the direction of head.
The utility model has the advantage of:
The medicine storing bag memory action medicine containing capillary drug storage chamber utilizing fibroin albumen to manufacture, simultaneously capillary drug storage chamber after entering human body because internal liquidity is poor, medicine is discharged capillary drug storage chamber slowly, the long-term of the dose uniformity of medicine is made to act on skin, reduce the zest of heavy dose of pharmaceutical through skin, be more conducive to the absorption of skin.
Accompanying drawing explanation
Fig. 1 is the structural representation of this fibroin albumen slow release micropin embodiment one.
Fig. 2 is the structural representation of this fibroin albumen slow release micropin embodiment two.
Fig. 3 is the structural representation of this fibroin albumen slow release micropin embodiment three.
Fig. 4 is the structural representation of this fibroin albumen slow release micropin embodiment four.
Fig. 5 is the structural representation of this fibroin albumen slow release micropin embodiment five.
Detailed description of the invention
Below in conjunction with drawings and Examples, this utility model is further illustrated:
Embodiment one:
In the present embodiment, consult Fig. 1, this fibroin albumen slow release micropin comprises the medicine storing bag 300 of substrate layer 120 and long capsule shape, described medicine storing bag 300 is made up of fibroin albumen, described substrate layer 120 is pressed the buttress shaft 100 that array is arranged, described medicine storing bag 300 one end is provided with the capillary drug storage chamber 200 extended to the other end, described capillary drug storage chamber 200 forms opening in one end of described medicine storing bag 300, be provided with corresponding medicament in described capillary drug storage chamber 200, capillary drug storage chamber 200 part is nested on described buttress shaft 100 by described opening by described medicine storing bag 300.
The root of described buttress shaft 100 is provided with the projection 110 matched with the opening diameter of medicine storing bag 300, and the described external diameter of protruding 110 is identical with the external diameter of described opening.In order to make medicine storing bag 300 thrust completely in skin corium, described projection can be good at medicine storing bag 300 to push in skin corium.
In order to keep the drug storage amount in capillary drug storage chamber 200, and the persistency of slow release, the length that described buttress shaft 100 stretches into described capillary drug storage chamber 200 is less than 1/2nd of capillary drug storage chamber 200 total length.
Embodiment two:
In the present embodiment, consult Fig. 2, this fibroin albumen slow release micropin comprises the medicine storing bag 300 of substrate layer 120 and long capsule shape, described medicine storing bag 300 is made up of fibroin albumen, described substrate layer 120 is pressed the buttress shaft 100 that array is arranged, described medicine storing bag 300 one end is provided with the capillary drug storage chamber 200 extended to the other end, described capillary drug storage chamber 200 forms opening in one end of described medicine storing bag 300, be provided with corresponding medicament in described capillary drug storage chamber 200, capillary drug storage chamber 200 part is nested on described buttress shaft 100 by described opening by described medicine storing bag 300.The root of described buttress shaft 100 is provided with the projection 110 matched with the opening diameter of medicine storing bag 300, and the described external diameter of protruding 110 is identical with the external diameter of described opening.The length that described buttress shaft 100 stretches into described capillary drug storage chamber 200 is less than 1/2nd of capillary drug storage chamber 200 total length.
The diameter of described medicine storing bag 300 successively decreases gradually to the direction of opening bottom described capillary drug storage chamber 200, because described medicine storing bag 300 is made up of fibroin albumen, fibroin albumen is just absorbed slowly after thrusting human body, due to the difference of medicine storing bag 300 diameter, therefore the position of thicker diameter required time that disappears because of absorption is longer, namely the medicine that medicine storing bag 300 leaves mouth nearer is released at first, and then mouth medicine far away is left in release gradually.
Embodiment three:
In the present embodiment, consult Fig. 3, this fibroin albumen slow release micropin comprises the medicine storing bag 300 of substrate layer 120 and long capsule shape, described medicine storing bag 300 is made up of fibroin albumen, described substrate layer 120 is pressed the buttress shaft 100 that array is arranged, described medicine storing bag 300 one end is provided with the capillary drug storage chamber 200 extended to the other end, described capillary drug storage chamber 200 forms opening in one end of described medicine storing bag 300, be provided with corresponding medicament in described capillary drug storage chamber 200, capillary drug storage chamber 200 part is nested on described buttress shaft 100 by described opening by described medicine storing bag 300.The root of described buttress shaft 100 is provided with the projection 110 matched with the opening diameter of medicine storing bag 300, and the described external diameter of protruding 110 is identical with the external diameter of described opening.The length that described buttress shaft 100 stretches into described capillary drug storage chamber 200 is less than 1/2nd of capillary drug storage chamber 200 total length.The diameter of described medicine storing bag 300 successively decreases gradually to the direction of opening bottom described capillary drug storage chamber 200.The periphery wall of described medicine storing bag 300 is provided with the agnail 310 tilted to described open at one end, agnail 310 can better make medicine storing bag 300 stay in skin corium by volume, described agnail 310 can at medicine storing bag 300 after micropin Making mold completes, rubbed by grinding tool and generate, also can directly shape in a mold.
Embodiment four:
In the present embodiment, consult Fig. 4, this fibroin albumen slow release micropin comprises the medicine storing bag 300 of substrate layer 120 and long capsule shape, described medicine storing bag 300 is made up of fibroin albumen, described substrate layer 120 is pressed the buttress shaft 100 that array is arranged, described medicine storing bag 300 one end is provided with the capillary drug storage chamber 200 extended to the other end, described capillary drug storage chamber 200 forms opening in one end of described medicine storing bag 300, corresponding medicament is provided with in described capillary drug storage chamber 200, capillary drug storage chamber 200 part is nested on described buttress shaft 100 by described opening by described medicine storing bag 300, the root of described buttress shaft 100 is provided with the projection 110 matched with the opening diameter of medicine storing bag 300, the described external diameter of protruding 110 is identical with the external diameter of described opening.The length that described buttress shaft 100 stretches into described capillary drug storage chamber 200 is less than 1/2nd of capillary drug storage chamber 200 total length.The diameter of described medicine storing bag 300 successively decreases gradually to the direction of opening bottom described capillary drug storage chamber 200, the periphery wall of described medicine storing bag 300 is provided with the agnail 310 tilted to described open at one end.
Described buttress shaft 100 material is artificial spider silk material, spider silk has high strength, high resiliency, high work to break, low-density, good heatproof and the excellent properties such as UV resistant performance, good biocompatibility, its elasticity as rich as Croesus, article one, diameter only has the spider silk of ten thousand/millimeter, more than twice can be extended just can break, because buttress shaft 100 is elastic material, therefore when stretching buttress shaft 100, the stretching position diameter of buttress shaft diminishes, and is more conducive to depart from described capillary drug storage chamber 200.
Embodiment five:
In the present embodiment, consult Fig. 5, in any embodiment, the diameter of described buttress shaft 100 can be successively decreased along root to the direction of head, be more conducive to depart from described capillary drug storage chamber 200.
The mechanism of action of the fibroin albumen slow release micropin in two above-mentioned embodiments:
Fibroin albumen contains 18 seed amino acids and various trace elements, has stronger affinity with human body skin, is easy to be absorbed by human skin.The medicine storing bag 300 memory action medicine containing capillary drug storage chamber 200 utilizing fibroin albumen to manufacture, simultaneously capillary drug storage chamber 200 after entering human body because internal liquidity is poor, medicine is discharged capillary drug storage chamber 200 slowly, simultaneously, in embodiment three, make the outlet in capillary drug storage chamber 200 constantly close to bottom because of the continuous absorption of medicine storing bag 300 especially, be beneficial to the release of drug substance stable.
Describedly be only preferred embodiment of the present utility model, not in order to limit this utility model, all within spirit of the present utility model and principle, any amendment done, equivalent replacement, improvement etc., all should be included in protection domain of the present utility model.
Claims (8)
1. a fibroin albumen slow release micropin, it is characterized in that: the medicine storing bag (300) comprising substrate layer (120) and long capsule shape, described medicine storing bag (300) is made up of fibroin albumen, the upper buttress shaft (100) pressed array and arrange of described substrate layer (120), described medicine storing bag (300) one end is provided with the capillary drug storage chamber (200) extended to the other end, described capillary drug storage chamber (200) forms opening in one end of described medicine storing bag (300), corresponding medicament is provided with in described capillary drug storage chamber (200), capillary drug storage chamber (200) part is nested on described buttress shaft (100) by described opening by described medicine storing bag (300).
2. fibroin albumen slow release micropin according to claim 1, it is characterized in that: the root of described buttress shaft (100) is provided with the projection (110) matched with the opening diameter of medicine storing bag (300), and the external diameter of described projection (110) is identical with the external diameter of described opening.
3. fibroin albumen slow release micropin according to claim 1, is characterized in that: the length that described buttress shaft (100) stretches into described capillary drug storage chamber (200) is less than 1/2nd of capillary drug storage chamber (200) total length.
4. fibroin albumen slow release micropin according to claim 1, is characterized in that: the diameter of described medicine storing bag (300) successively decreases along described capillary drug storage chamber (200) bottom gradually to the direction of opening.
5. fibroin albumen slow release micropin according to claim 1, is characterized in that: the periphery wall of described medicine storing bag 300 is provided with the agnail (310) tilted to described open at one end.
6. fibroin albumen slow release micropin according to claim 1, is characterized in that: described buttress shaft (100) is made up of the affine material of elasticity.
7. fibroin albumen slow release micropin according to claim 6, is characterized in that: material that described elasticity is affine is artificial spider silk material.
8. fibroin albumen slow release micropin according to claim 1, is characterized in that: the diameter of described buttress shaft (100) successively decreases along root to the direction of head.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201520641227.4U CN204890945U (en) | 2015-08-24 | 2015-08-24 | Silk fibroin slowly -releasing micropin |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201520641227.4U CN204890945U (en) | 2015-08-24 | 2015-08-24 | Silk fibroin slowly -releasing micropin |
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| Publication Number | Publication Date |
|---|---|
| CN204890945U true CN204890945U (en) | 2015-12-23 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201520641227.4U Expired - Fee Related CN204890945U (en) | 2015-08-24 | 2015-08-24 | Silk fibroin slowly -releasing micropin |
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| CN (1) | CN204890945U (en) |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105079953A (en) * | 2015-08-24 | 2015-11-25 | 苏州先蚕丝绸生物科技有限公司 | Silk fibroin slow release micro-needle |
| CN108325064A (en) * | 2018-03-02 | 2018-07-27 | 莆田学院 | A kind of sustained release micropin and preparation method thereof |
| CN110099714A (en) * | 2016-12-22 | 2019-08-06 | 强生消费者公司 | Microneedle array and its preparation and application |
| CN111317911A (en) * | 2020-02-28 | 2020-06-23 | 广东工业大学 | Novel microneedle and manufacturing method thereof |
| CN114209975A (en) * | 2021-12-14 | 2022-03-22 | 优微（珠海）生物科技有限公司 | Microneedle patch with easily torn substrate |
| CN114432587A (en) * | 2021-12-14 | 2022-05-06 | 优微（珠海）生物科技有限公司 | Microneedle patch |
| US11413440B2 (en) | 2018-06-29 | 2022-08-16 | Johnson & Johnson Consumer Inc. | Three-dimensional microfluidics devices for the delivery of actives |
| WO2023109633A1 (en) * | 2021-12-14 | 2023-06-22 | 优微（珠海）生物科技有限公司 | Microneedle patch, microneedle mold and manufacturing method |
-
2015
- 2015-08-24 CN CN201520641227.4U patent/CN204890945U/en not_active Expired - Fee Related
Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105079953A (en) * | 2015-08-24 | 2015-11-25 | 苏州先蚕丝绸生物科技有限公司 | Silk fibroin slow release micro-needle |
| CN110099714A (en) * | 2016-12-22 | 2019-08-06 | 强生消费者公司 | Microneedle array and its preparation and application |
| US11241563B2 (en) | 2016-12-22 | 2022-02-08 | Johnson & Johnson Consumer Inc. | Microneedle arrays and methods for making and using |
| CN108325064A (en) * | 2018-03-02 | 2018-07-27 | 莆田学院 | A kind of sustained release micropin and preparation method thereof |
| US11413440B2 (en) | 2018-06-29 | 2022-08-16 | Johnson & Johnson Consumer Inc. | Three-dimensional microfluidics devices for the delivery of actives |
| US11464955B2 (en) | 2018-06-29 | 2022-10-11 | Johnson & Johnson Consumer Inc. | Three-dimensional microfluidics devices for the delivery of actives |
| CN111317911A (en) * | 2020-02-28 | 2020-06-23 | 广东工业大学 | Novel microneedle and manufacturing method thereof |
| CN114209975A (en) * | 2021-12-14 | 2022-03-22 | 优微（珠海）生物科技有限公司 | Microneedle patch with easily torn substrate |
| CN114432587A (en) * | 2021-12-14 | 2022-05-06 | 优微（珠海）生物科技有限公司 | Microneedle patch |
| CN114209975B (en) * | 2021-12-14 | 2022-07-26 | 优微（珠海）生物科技有限公司 | Microneedle patch with easily torn substrate |
| WO2023109633A1 (en) * | 2021-12-14 | 2023-06-22 | 优微（珠海）生物科技有限公司 | Microneedle patch, microneedle mold and manufacturing method |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20151223 Termination date: 20160824 |
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| CF01 | Termination of patent right due to non-payment of annual fee |