CN204864514U - Be used for uterine medicine sustained -release devices that takes - Google Patents
Be used for uterine medicine sustained -release devices that takes Download PDFInfo
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- CN204864514U CN204864514U CN201520546017.7U CN201520546017U CN204864514U CN 204864514 U CN204864514 U CN 204864514U CN 201520546017 U CN201520546017 U CN 201520546017U CN 204864514 U CN204864514 U CN 204864514U
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- mesh bag
- gelinite
- uterus
- medicine
- delayed release
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Abstract
The utility model discloses a be used for uterine medicine sustained -release devices that takes, it includes pocket and gelinite, but the gelinite mainly comprises with the medicine of treatment uterine disease absorption liquid expanded gel materials, the side of pocket is formed with a plurality of micropores, the inside of pocket is formed with and is used for the holding the holding chamber of gelinite, when the concrete roof tile is used, gel materials is in holding intracavity absorption moisture inflation struts the pocket, the medicine sees through the micropore and externally releases. The utility model discloses an implantation process is earlier to the pocket will in sending into the uterus again the gelinite pours into into inside the pocket. The utility model discloses a pocket under the user state is from the inflation to according to the ambient pressure that receives, compliance ground supports the geometry by irregularly organizing the wall, forms great support contact surface, and 360 degrees all -round doses to play and disinfect thoroughly, avoids the micropore on the pocket to be blockked up simultaneously, realizes the long -term slowly -releasing function of dosing.
Description
Technical field
This utility model relates to the technical field of the Design for Medical Device of hysteropathy treatment, particularly relates to a kind of band medicine delayed release device for uterus.
Background technology
Inflammation of uterus is common gynaecopathia, brings great puzzlement to female patient.The scheme of current treatment inflammation of uterus has: oral medicine and vaginal plugging.
The advantage of oral medicine is taking convenience, and shortcoming is that part needs the patient of accurate administration indication be but forced to because of oral through whole body circulation medicine and do not have targeting, specific aim and the large heavy discount of therapeutic effect.
The advantage of vaginal plugging is easy to use and have relative targeting, and shortcoming is owing to not having support after filling, and cause just absorbing or flowing out external for one day to two days, part needs the patient of long-term sustained release administration, needs weekly medicine-feeding for several times, and effect is bad and very inconvenient.
The applicant is found by patent retrieval, has following patent application in prior art.
No. 200410050861.7th, Chinese patent discloses a kind of Novel pessulum, can be implemented in the method for vagina holding medicine treatment cervicitis, but can not reach long-term sustained-release administration effect.
Chinese patent CN102860895B discloses a kind of pessulum with slow release stent, the technical scheme adopted is can the support of slow releasing pharmaceutical by being provided with in the inside of ring pessary, this support is isolated by microporous membrane with extraneous, this microporous membrane forms several micropore, pass through for microgranule, vagina administration effect can be played.But its Problems existing is, this micropore administering mode is more limited, is only limitted to the medicine between 0.1nm-10nm, and the too little easy blocking of micro-pore diameter, is unfavorable for the metabolism circulation of inside and outside material; The implantation of pessulum, also can cause secondary damage to a certain degree to patient.
Chinese patent CN2936292Y discloses a kind of intrauterine administration device with sustained-release and controlled release drug form, and the scheme of employing is the hollow reticulate body being placed with medicine by arranging an inside, is placed into intrauterine and carries out sustained-release administration.The volume of this device is comparatively large, in implantation process, easily cause damage to patient, and its inner medicine placed easily is dropped by port, and body adaptive ability is poor, cannot provide suitable support force to intrauterine wall.
Therefore, the applicant is devoted to develop a kind of band medicine delayed release device for uterus, and realization can have long-term sustained release administration functions, simultaneously easy to use, damages little to patient.
Utility model content
The purpose of this utility model, propose a kind of band medicine delayed release device for uterus exactly, realization can have long-term sustained release administration functions, simultaneously easy to use, damages little to patient.
This utility model is for solving the problems of the technologies described above, provide a kind of band medicine delayed release device for uterus, it comprises mesh bag and gelinite, the gel rubber material that described gelinite expands primarily of fluid-absorbing forms with the medicine for the treatment of hysteropathy, the side of described mesh bag is formed with some micropores, and the inside of described mesh bag is formed with the containing cavity for accommodating described gelinite.
In a state of use, described gel rubber material absorbs moisture expansion and struts described mesh bag in described containing cavity, and described in described agent permeates therethrough, micropore externally discharges.
This utility model forms support by gel rubber material imbibition to mesh bag, realize mesh bag self-expanding in a state of use, this self-expanding can according to suffered ambient pressure, compliance ground is against the geometry of irregular tissue wall, be conducive to forming larger support contact surface with inside, uterus, 360 degree of comprehensive administrations play sterilization thoroughly, avoid the micropore on mesh bag blocked simultaneously, what the medicine be convenient in gelinite was continued by the micropore on mesh bag spreads to mesh bag surrounding, realizes long-term sustained release administration functions.
And owing to there is good biomechanical property after gel rubber material imbibition, can with inner space, uterus automatic adaptation, device can not be caused to form excessive isolation, also can not cause excess pressure to intrauterine wall, effectively avoid after expanding and produce pain and sense of discomfort.
Preferably, described gel rubber material is gel sponge material or injecting fluid gel rubber material.
Preferably, described gel rubber material is mixed by gel sponge material and injecting fluid gel rubber material.
Preferably, described medicine is one or both or three kinds in analgesic, antibiotic medicine and biological preparation.
Preferably, described mesh bag internal preset has sponge material layer.
Preferably, described mesh bag is combined by lateral plate more than two panels or two panels or integrally formed, and the edge of described lateral plate is interconnected and fixed, and innerly forms the containing cavity being used for accommodating described gelinite, described lateral plate offers respectively multiple described micropore.
Mesh bag of the present utility model is further designed to two sides combination or many lateral plates combine or integrally formed inside has the pad form of containing cavity, easy to make and be more convenient to the implantation of mesh bag.
Preferably, described mesh bag is made up of degradable high polymer material.
Preferably, described degradable high polymer material comprises one or more in following material: polycaprolactone, PGA, poly(hydrobutyl ester), plastic starch material, polyether-ether-ketone, zein, polylactic acid, PPDO, lactic acid/co-glycolic acid, collagen protein and methylcellulose.
This utility model adopts degradable high polymer material to make mesh bag further, mainly utilizes the feature of degradable material, and degraded timeliness is synchronous, avoids occurring that bulk/hard material is dissociated.
This utility model also proposes a kind of method for implantation with medicine delayed release device, and described band medicine delayed release device is the above-mentioned band medicine delayed release device for uterus, and implantation process comprises the steps:
Step 1, described mesh bag is sent into intrauterine;
Step 2, described gelinite to be injected described mesh bag inner.
The method for implantation of the band medicine delayed release device that the utility model proposes is different from the overall method for implantation of conventional device, but ingenious be divided into mesh bag and gelinite two parts by band medicine delayed release device are implanted respectively, the final band medicine delayed release device forming assembled state in patient body, and play effectiveness, implantation process is more convenient, and it is little to have wound, simple to operate, be implanted to the better advantage of power.
Preferably, described step 1 be specially described mesh bag carried out folding after through conduit hysteroscope auxiliary under send to intrauterine, then withdraw from described conduit, described mesh bag launch to recover its folding before state.
Preferably, described step 2 is specially and modulates described gelinite in advance, by external pressure devices, described gelinite is injected the sponge material layer of described mesh bag internal preset, it (can be the moisture in body that described gelinite absorbs water within the border gradually at body of uterus pendular ring, also can be injecting fluid) expanding struts mesh bag, and the medicine in described gelinite externally continues slow dispersal events by micropore on described mesh bag.
Preferably, method for implantation of the present utility model also comprises step 3: toward mesh bag internal injection liquid, make gelinite absorb described injecting fluid fast and realize self-expanding.
In sum, this utility model includes following or several somes beneficial effects for the band medicine delayed release device in uterus:
1, band medicine delayed release device of the present utility model can realize long-term sustained release administration, is particularly useful for meeting intrauterine long-term SM demand.
2, band medicine delayed release device of the present utility model is easy to use, damages little to patient.
3, the micropore on band medicine delayed release device of the present utility model not easily blocks, and can not affect the metabolism circulation of inside and outside material.
4, band medicine delayed release device of the present utility model in use, and the biomechanical property have well, be suitable for, can form the isolation of appropriateness, and form inside and outside mass exchange and metabolism, prevents material from going bad and harmful substance accumulation.
5, method for implantation of the present utility model achieves Wicresoft's implantation, damages little, simple to operate, is implanted to power high.
Accompanying drawing explanation
Below in conjunction with the drawings and specific embodiments, this utility model is described in further detail:
Fig. 1 is the cross section structure schematic diagram of specific embodiment for the band medicine delayed release device in uterus.
Fig. 2 is the perspective view of specific embodiment mesh bag.
Fig. 3 is the structural representation of a lateral plate of specific embodiment mesh bag.
Drawing reference numeral illustrates:
Mesh bag 1, gelinite 2, micropore 3, lateral plate 4.
Detailed description of the invention
As shown in Figure 1, present embodiment discloses a kind of band medicine delayed release device for uterus, it comprises mesh bag 1 and gelinite 2.
The gel rubber material that the described gelinite of the present embodiment expands primarily of fluid-absorbing forms with the medicine for the treatment of hysteropathy.
Exemplary, the gel rubber material of the present embodiment selects injecting fluid gel rubber material, described choice of drug antibiotic medicine.
Described injecting fluid gel rubber material and described antibiotic medicine can be carried out mixing preparation gelinite by the present embodiment by a certain percentage in advance, described antibiotic medicine adopts the medicine of liquid form or powder morphology, both ratios and concrete consumption, can adjust by suitable carrying out as the case may be, also other adjuvants can be added, to meet different treatment needs and expanding needs.
As shown in Figure 2, the side of the mesh bag 1 of the present embodiment is formed with some micropores 3, and the inside of mesh bag 1 is formed with the containing cavity for accommodating gelinite 2.
The present embodiment in a state of use, is with medicine delayed release device as shown in Figure 1: described gel rubber material absorbs moisture expansion and struts mesh bag 1 in described containing cavity, and described agent permeates therethrough micropore 3 externally discharges.
It should be noted that, the band medicine delayed release device of the present embodiment is under unused state, and mesh bag 1 and gelinite 2 can be prefabricated separately respectively, do not combine.Be likely by the instruction of different manufacturers according to the present embodiment, make mesh bag, gel rubber material and medicine respectively, then undertaken supportingly forming one group of band medicine delayed release device completed by another producer, supply third party uses.
Exemplary, the mesh bag 1 of the present embodiment is specifically combined by two lateral plates 4 as shown in Figure 3, the edge of two lateral plates 4 mutually bonds as shown in Figure 2 and is connected and fixed, the inner described containing cavity formed for accommodating described gelinite, and be preset with sponge material layer (not shown) at the described containing cavity of mesh bag 1 inside, on two lateral plates 4, offer multiple micropore 3 respectively simultaneously.
Wherein, pore size and the quantity of micropore 3 adjust according to practical situation, the present embodiment selects the micropore 3 of suitable aperture and quantity to make gelinite 2 be unlikely to be extruded in mesh bag 1 under wall pressure power in uterus, and medicine wherein also can effectively be disengaged by micropore 3 simultaneously.
In different specific embodiment, the concrete form of mesh bag also can be arranged according to practical situation, the mesh bag etc. of cuboid or square is combined to form as adopted six lateral plates, so described mesh bag also can be combined by other many lateral plates or integrally formed, be interconnected and fixed by the edge of described lateral plate, the inner containing cavity formed for accommodating described gelinite, and multiple described micropore is offered respectively on each described lateral plate, repeat no more herein.
Exemplary, the mesh bag 1 of the present embodiment is made up of degradable high polymer material, described degradable high polymer material comprise in following material one or more: polycaprolactone (PCL), PGA (PGA), poly(hydrobutyl ester) (PHB), plastic starch material, polyether-ether-ketone (PEEK), zein, polylactic acid (PLA), PPDO (PDO), lactic acid/co-glycolic acid (PLGA), collagen protein and methylcellulose.
Exemplary, the present embodiment can according to make need to select as follows by biological degradability or one or more in biocompatible material, make fluid-absorbing (moisture, body fluid or blood etc.) expanding forms the gel rubber material of gel state: polycaprolactone (PCL), PGA (PGA), poly(hydrobutyl ester) (PHB), plastic starch material, animal derived cellular matrix, gelatin, chitosan, platelet rich plasma, polyether-ether-ketone (PEEK), poly-methyl acid methyl ester, alginate, zein, de-cellular cartilage material, polylactic acid (PLA), PPDO (PDO) and lactic acid/co-glycolic acid (PLGA), collagen protein and/or methylcellulose.
The described gel rubber material of the present embodiment can shift to an earlier date mixing preparation with described medicine and make semigel shape, is injected in mesh bag by pressure apparatus, then absorbs moisture further by gel rubber material and become gel completely and realize expanding completely.
Of course, in other specific embodiments, gel rubber material selected by band medicine delayed release device of the present utility model can also be gel sponge material etc. other meet medical water swellability gel rubber material, also can be the compound of gel sponge material and injecting fluid gel rubber material.Described medicine also can adopt the other drug such as analgesic or biological preparation according to practical situation, in the multi-medicaments such as analgesic, antibiotic medicine and biological preparation two or three also can be adopted to carry out used in combination, repeat no more herein.
The band medicine delayed release device of the present embodiment is particularly applicable in the treatment of inflammation of uterus, its concrete method for implantation is also different from conventional overall method for implantation, what the method for implantation of the band medicine delayed release device of the present embodiment adopted is split implantation, and its implantation process comprises the steps:
Step 1, mesh bag 1 is sent into intrauterine;
Step 2, gelinite 2 to be injected described mesh bag inner;
Step 3, past mesh bag internal injection liquid (as normal saline), make gelinite absorb described injecting fluid fast and realize self-expanding.
Mesh bag 1 is first implanted by described step 1 by the present embodiment, because mesh bag 1 inside does not exist the support substances such as gelinite, so small volume, and convenient implantation; The gelinite 2 of appropriate amount is injected again by described step 2, complete the assembling of band medicine delayed release device in uterus, neither affect result of use, Wicresoft can also be realized simultaneously and implant, reduce the loss that implantation process brings for patient, and improve the success rate implanted further; Step 3 provides sufficient liquid to gel rubber material, absorbs to expand to form gel state fast for it.
It should be noted that, in other specific embodiments, above-mentioned steps 3 is also omissible, can by the body fluid of inside, uterus for gel rubber material provides the required liquid that expands, and gel rubber material also can realize imbibition and form gel state.
Exemplary, in concrete practical operation, the concrete implantation process of method for implantation of the band medicine delayed release device for uterus of the present embodiment is as follows:
Concrete steps 1: mesh bag 1 is carried out folding after through conduit hysteroscope auxiliary under send to intrauterine, then withdraw from described conduit, described mesh bag 1 launch to recover its folding before state.
Concrete steps 2: modulate gelinite 2 in advance, by external pressure devices, gelinite 2 is injected the described sponge material layer of mesh bag 1 internal preset, it (can be the moisture in body that gelinite 2 absorbs water within the border gradually at body of uterus pendular ring, also can be injecting fluid) expanding mesh bag 1 to strut forms good support force, and the medicine in gelinite 2 externally continues slow dispersal events by micropore 3 on mesh bag 1.Whether implement above-mentioned steps 3 further, select according to practical situation.
Medical personnel adopt the band medicine delayed release device of the present embodiment and operate according to the method for implantation of the present embodiment, band medicine delayed release device can realize Wicresoft and implant, gelinite and sponge material layer realize mixing with inside, uterus, in uterus expand gradually under the effect of fluid environment certain hour, strut mesh bag formation and there is the adaptive support of good biological (mesh bag can form various shape under the restriction of outside intrauterine wall), gel rubber material is effectively limited in mesh bag, the medicine that gelinite includes then continues slow release through realizing to inwall place, surrounding uterus in mesh bag micropore.
With above-mentioned be only preferred implementation of the present utility model; it should be pointed out that for those skilled in the art, under the prerequisite not departing from this utility model principle; can also make some improvements and modifications, these improvements and modifications also should be considered as protection domain of the present utility model.
Claims (8)
1. the band medicine delayed release device for uterus, it is characterized in that, comprise: mesh bag and gelinite, the gel rubber material that described gelinite expands primarily of fluid-absorbing forms with the medicine for the treatment of hysteropathy, the side of described mesh bag is formed with some micropores, and the inside of described mesh bag is formed with the containing cavity for accommodating described gelinite;
In a state of use, described gel rubber material absorbing fluid in described containing cavity expands and struts described mesh bag, and described in described agent permeates therethrough, micropore externally discharges.
2., as claimed in claim 1 for the band medicine delayed release device in uterus, it is characterized in that: described gel rubber material is gel sponge material or injecting fluid gel rubber material.
3., as claimed in claim 1 for the band medicine delayed release device in uterus, it is characterized in that: described gel rubber material is mixed by gel sponge material and injecting fluid gel rubber material.
4. as claimed in claim 1 for the band medicine delayed release device in uterus, it is characterized in that: described medicine is one or both or three kinds in analgesic, antibiotic medicine and biological preparation.
5., as claimed in claim 1 for the band medicine delayed release device in uterus, it is characterized in that: described mesh bag internal preset has sponge material layer.
6. as claimed in claim 1 for the band medicine delayed release device in uterus, it is characterized in that: described mesh bag is combined by lateral plate more than two panels or two panels or integrally formed, the edge of described lateral plate is interconnected and fixed, the inner containing cavity formed for accommodating described gelinite, described lateral plate offers respectively multiple described micropore.
7. the band medicine delayed release device for uterus as described in any one of claim 1-6, is characterized in that: described mesh bag is made up of degradable high polymer material.
8., as claimed in claim 7 for the band medicine delayed release device in uterus, it is characterized in that: described degradable high polymer material comprise in following material one or more: polycaprolactone, PGA, poly(hydrobutyl ester), plastic starch material, polyether-ether-ketone, zein, polylactic acid, PPDO, lactic acid/co-glycolic acid, collagen protein and methylcellulose.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201520546017.7U CN204864514U (en) | 2015-07-24 | 2015-07-24 | Be used for uterine medicine sustained -release devices that takes |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201520546017.7U CN204864514U (en) | 2015-07-24 | 2015-07-24 | Be used for uterine medicine sustained -release devices that takes |
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| CN204864514U true CN204864514U (en) | 2015-12-16 |
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| CN201520546017.7U Active CN204864514U (en) | 2015-07-24 | 2015-07-24 | Be used for uterine medicine sustained -release devices that takes |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104998343A (en) * | 2015-07-24 | 2015-10-28 | 严聪颖 | Medicine-prefilled and sustained-release apparatus for uterus uses and implantation method |
| WO2019155321A1 (en) * | 2018-02-12 | 2019-08-15 | 香港科能有限公司 | Implant capable of releasing drug, and manufacturing and usage methods therefor |
-
2015
- 2015-07-24 CN CN201520546017.7U patent/CN204864514U/en active Active
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104998343A (en) * | 2015-07-24 | 2015-10-28 | 严聪颖 | Medicine-prefilled and sustained-release apparatus for uterus uses and implantation method |
| WO2019155321A1 (en) * | 2018-02-12 | 2019-08-15 | 香港科能有限公司 | Implant capable of releasing drug, and manufacturing and usage methods therefor |
| CN110151290A (en) * | 2018-02-12 | 2019-08-23 | 香港科能有限公司 | The implantation material of releasable medicaments and manufacture and application method |
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