CN204832102U - Biological detection sheet - Google Patents
Biological detection sheet Download PDFInfo
- Publication number
- CN204832102U CN204832102U CN201520190911.5U CN201520190911U CN204832102U CN 204832102 U CN204832102 U CN 204832102U CN 201520190911 U CN201520190911 U CN 201520190911U CN 204832102 U CN204832102 U CN 204832102U
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- China
- Prior art keywords
- biological detection
- carbon
- gold
- carried
- detection sheet
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- 238000001514 detection method Methods 0.000 title claims abstract description 63
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims abstract description 53
- 229910052799 carbon Inorganic materials 0.000 claims abstract description 47
- 239000010931 gold Substances 0.000 claims abstract description 42
- 229910052737 gold Inorganic materials 0.000 claims abstract description 41
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 claims abstract description 40
- 238000006243 chemical reaction Methods 0.000 claims description 22
- 239000000758 substrate Substances 0.000 claims description 22
- 239000012620 biological material Substances 0.000 claims description 16
- 238000000034 method Methods 0.000 claims description 12
- 230000001681 protective effect Effects 0.000 claims description 12
- 239000000463 material Substances 0.000 claims description 8
- -1 acticarbon Chemical compound 0.000 claims description 6
- XMWRBQBLMFGWIX-UHFFFAOYSA-N C60 fullerene Chemical compound C12=C3C(C4=C56)=C7C8=C5C5=C9C%10=C6C6=C4C1=C1C4=C6C6=C%10C%10=C9C9=C%11C5=C8C5=C8C7=C3C3=C7C2=C1C1=C2C4=C6C4=C%10C6=C9C9=C%11C5=C5C8=C3C3=C7C1=C1C2=C4C6=C2C9=C5C3=C12 XMWRBQBLMFGWIX-UHFFFAOYSA-N 0.000 claims description 5
- 108010015776 Glucose oxidase Proteins 0.000 claims description 5
- 239000004366 Glucose oxidase Substances 0.000 claims description 5
- 239000011248 coating agent Substances 0.000 claims description 5
- 238000000576 coating method Methods 0.000 claims description 5
- 229910003472 fullerene Inorganic materials 0.000 claims description 5
- 229940116332 glucose oxidase Drugs 0.000 claims description 5
- 235000019420 glucose oxidase Nutrition 0.000 claims description 5
- 229920000139 polyethylene terephthalate Polymers 0.000 claims description 5
- 239000005020 polyethylene terephthalate Substances 0.000 claims description 5
- 108090000790 Enzymes Proteins 0.000 claims description 3
- 102000004190 Enzymes Human genes 0.000 claims description 3
- 239000000427 antigen Substances 0.000 claims description 3
- 108091007433 antigens Proteins 0.000 claims description 3
- 102000036639 antigens Human genes 0.000 claims description 3
- 239000006229 carbon black Substances 0.000 claims description 3
- 238000005137 deposition process Methods 0.000 claims description 3
- 229940088598 enzyme Drugs 0.000 claims description 3
- 229910021389 graphene Inorganic materials 0.000 claims description 3
- 229910002804 graphite Inorganic materials 0.000 claims description 3
- 239000010439 graphite Substances 0.000 claims description 3
- 238000005470 impregnation Methods 0.000 claims description 3
- 238000001556 precipitation Methods 0.000 claims description 3
- 238000007639 printing Methods 0.000 claims description 3
- 238000001228 spectrum Methods 0.000 claims description 3
- 239000007921 spray Substances 0.000 claims description 3
- 238000010023 transfer printing Methods 0.000 claims description 3
- 239000004800 polyvinyl chloride Substances 0.000 claims description 2
- 229920000915 polyvinyl chloride Polymers 0.000 claims 1
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 abstract description 7
- 239000010410 layer Substances 0.000 abstract 3
- 239000007788 liquid Substances 0.000 abstract 2
- 229910052709 silver Inorganic materials 0.000 abstract 1
- 239000004332 silver Substances 0.000 abstract 1
- 239000002356 single layer Substances 0.000 abstract 1
- 239000008280 blood Substances 0.000 description 4
- 210000004369 blood Anatomy 0.000 description 4
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 4
- 208000017667 Chronic Disease Diseases 0.000 description 2
- LEHOTFFKMJEONL-UHFFFAOYSA-N Uric Acid Chemical compound N1C(=O)NC(=O)C2=C1NC(=O)N2 LEHOTFFKMJEONL-UHFFFAOYSA-N 0.000 description 2
- TVWHNULVHGKJHS-UHFFFAOYSA-N Uric acid Natural products N1C(=O)NC(=O)C2NC(=O)NC21 TVWHNULVHGKJHS-UHFFFAOYSA-N 0.000 description 2
- 235000012000 cholesterol Nutrition 0.000 description 2
- 239000004020 conductor Substances 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 229940116269 uric acid Drugs 0.000 description 2
- 206010038743 Restlessness Diseases 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
Abstract
The subject of the utility model is a biological detection sheet. The present invention relates to a biological detection sheet, and more particularly to a novel biological detection sheet with a simple structure. The utility model provides a novel and simple structure's biological detection piece, it can replace traditional electrically conductive silver thick liquid layer and electrically conductive carbon thick liquid layer in the conducting layer of carbon with the nanometer gold load of single layer, makes the utility model discloses a biological detection piece possesses the detection accuracy of preferred, and stability is good, and then improves biological detection's utilization and value.
Description
Technical field
The utility model about a kind of biological detection sheet, the espespecially a kind of novel and simple biological detection sheet of structure.
Background technology
Along with the progress of medical science and technology, the mean lifetime of compatriots increases gradually, and chronic disease replaces communicate illness gradually, becomes one of compatriots' main causes of death.Wherein, the numerical value such as blood sugar, cholesterol, uric acid are higher, are common chronic diseases.
In order to promote the convenience of patient's self-monitoring, developing the pick-up unit of many houses simple type at present, having allowed patient regularly detect blood sugar, cholesterol, uric acid isoconcentration voluntarily.At home biological detecting test piece have cost low, simple to operate, portable good, analyze the advantages such as quick.
Please refer to shown in Fig. 5, the biological detection sheet generally used at present is from bottom to top sequentially stacking substrate 50, conductive silver slurry layer 51, conductive carbon paste layer 52, protective seam 53 and layer of biological material 54.But, the mode of this biological detection sheet, the problem such as easily have the uneven or electrical conductivity of conduction too low, and then be difficult to metrical error value to control within ± 15%.
So, for overcoming the defect existing for current biological detection sheet, need the biological detection sheet developing a novel structure badly.
Utility model content
The purpose of this utility model is to provide one novel and the simple biological detection sheet of structure, its conductive layer that can be carried on carbon (nanometer Au/C) with the nm of gold of simple layer replaces traditional conductive silver slurry layer and conductive carbon paste layer, biological detection sheet of the present utility model is possessed and preferably detects the advantage such as degree of accuracy, stability, and then improve usability and the value of biological detection.
For reaching above-mentioned purpose, the utility model provides a kind of biological detection sheet, and it comprises: a substrate; One nm of gold is carried on the conductive layer of carbon, and it is arranged on described substrate; And a protective seam; it is directly covered in described substrate and described nm of gold is carried on the wherein a part of of the conductive layer of carbon; and described substrate and the described nano-gold loaded conductive layer in carbon are not formed a reaction zone disconnected from each other and a bonding pad by the remainder that described protective seam covers, and the conductive layer of the exposed part in described reaction zone and described bonding pad.
Specifically, the material of substrate can be polyethylene terephthalate (PET), or Polyvinylchloride (PVC), but is not limited only to this.
Specifically, nm of gold is carried on the conductive layer of carbon, is nm of gold be carried on carbon.Carbon can be graphite, Graphene, acticarbon, CNT, carbon black, fullerene (Fullerene) etc., or wherein two or more mixing.Gold is carried on the method for carbon, comprises impregnation method, separates out the modes such as the precipitation method, vapour deposition process, Graft Method, but be not limited only to this.
Specifically, biological detection sheet also comprises a layer of biological material, and it is arranged in reaction zone, and is carried on the conductive layers make contact of carbon with the nm of gold in described reaction zone.Layer of biological material can comprise a pair thing to be detected and have narrow spectrum enzyme, antigen or antibody.More specifically, layer of biological material can comprise the biological detection material as glucose oxidase (glucoseoxidase, GOD).Because the biological detection material in layer of biological material can contact with the conductive material be arranged in reaction zone, therefore biological detection sheet of the present utility model can be used for the blood sugar concentration measuring thing to be detected.
Specifically, biological detection sheet of the present utility model possesses and preferably detects degree of accuracy, and error amount controls within ± 8%, and the error amount that more traditional conductive silver paste adds the two-layer electrode of conductive carbon paste is low.
More specifically, nm of gold is carried on the conductive layer of carbon, can form the structure of two pole formulas, and it comprises a working electrode and a reference electrode of mutually insulated.Wherein reaction zone is exposed one end of working electrode and one end of reference electrode; And bonding pad is exposed the other end of working electrode and the other end of reference electrode.
More specifically, nm of gold is carried on the conductive layer of carbon, can form the structure of a three-pole, and it comprises a working electrode, a reference electrode of mutual insulating, and an auxiliary electrode.Wherein, reaction zone is exposed one end of working electrode and one end of reference electrode; And bonding pad is exposed the other end of working electrode, the other end of reference electrode, and auxiliary electrode.
More specifically, nm of gold is carried on the conductive layer of carbon, can wire mark, spray printing, impression, transfer printing or coating mode formed, but be not limited to this.
More specifically, biological detection sheet of the present utility model possesses and preferably detects degree of accuracy, and error amount controls within ± 8%, and error amount ± 15% that more traditional conductive silver paste adds the two-layer electrode of conductive carbon paste is low.
In sum, the utility model provides one novel and the simple biological detection sheet of structure, its conductive layer that can be carried on carbon with the nm of gold of simple layer replaces traditional conductive silver slurry layer and conductive carbon paste layer, biological detection sheet of the present utility model is possessed and preferably detects the advantage such as degree of accuracy, stability, and then improve usability and the value of biological detection.
Accompanying drawing explanation
Fig. 1 is the exploded view of the biological detection sheet of the first embodiment of the utility model.
Fig. 2 is the upward view of the biological detection sheet of the first embodiment of the utility model.
Fig. 3 is the exploded view of the biological detection sheet of the utility model the second embodiment.
Fig. 4 is the upward view of the biological detection sheet of the utility model the second embodiment.
Fig. 5 is the exploded view of the biological detecting test piece of prior art.
Embodiment
Refer to Fig. 1 and Fig. 2, the first embodiment of the utility model provides a kind of three-pole biological detection sheet 1.
In the present embodiment, biological detection sheet 1 from bottom to top comprises: substrate 10, nm of gold are carried on the conductive layer 20 of carbon, protective seam 30 and layer of biological material 40.
In the present embodiment, substrate is polyethylene terephthalate (PET) substrate.
The conductive layer 20 that described nm of gold is carried on carbon is arranged on described substrate 10.Nm of gold is carried on the conductive layer 10 of carbon, is to be carried on carbon by nm of gold, and carbon can be graphite, Graphene, acticarbon, CNT, carbon black, fullerene (Fullerene) etc., or wherein two or more mixing.
Nm of gold is carried on the method for carbon, comprises impregnation method, separates out the precipitation method, vapour deposition process, Graft Method etc., but be not limited only to this.More specifically, the grain size of nm of gold, between 1 to 100 nanometer, is preferably between 2 to 50 nanometers.
Nm of gold is carried on the conductive layer 20 of carbon, can wire mark, spray printing, impression, transfer printing or coating mode be formed on substrate 10, but be not limited to this.
As shown in Figure 2, described protective seam 30 is covered in a wherein part for substrate 10 and conductive layer 20, and described substrate 10 and conductive layer 20 are not formed reaction zone 31 and a bonding pad 32 disconnected from each other by the remainder that described protective seam 30 covers.Wherein, described reaction zone is exposed one end of working electrode 21 and one end of reference electrode 22; And bonding pad 32 is exposed the other end of working electrode 21, the other end of reference electrode 22 and auxiliary electrode 23.It can comprise a upper cover further, is covered on protective seam 30 and layer of biological material 40 (not shown), and covers layer of biological material 40 at least completely.
Described layer of biological material 40, it is arranged in reaction zone 31, and is carried on the conductive layers make contact of carbon with nm of gold in described reaction zone.Layer of biological material can comprise a pair thing to be detected and have narrow spectrum enzyme, antigen or antibody.More specifically, layer of biological material can comprise the biological detection material as glucose oxidase (glucoseoxidase, GOD).Because the biological detection material in layer of biological material can contact with the conductive material be arranged in reaction zone, therefore biological detection sheet of the present utility model can be used for the blood sugar concentration measuring thing to be detected.
Reaction zone 31 described in present embodiment is reacted in order to provide biological detection material and determinand to produce in this region, relends the change being detected electric current by working electrode 21 and reference electrode 22.The working electrode 21 of described bonding pad 32, reference electrode 22 and auxiliary electrode 23 are connected with a biological monitor, curent change and ground unrest to be passed to biological monitor (non-icon), to obtain biological detection result.
Please refer to Fig. 3 and Fig. 4, the two pole formula biological detection sheet 1A that the utility model the second embodiment provides a kind of structure to simplify.
As the first embodiment aforementioned, the biological detection sheet 1A of the present embodiment from bottom to top comprises: substrate 10A, nm of gold are carried on conductive layer 20A, protective seam 30A and the layer of biological material 40A of carbon.The difference of the biological detection sheet of the present embodiment and the first embodiment is, the conductive layer that nm of gold is carried on carbon is two pole formula electrode patterns.
Two described pole formula electrode patterns comprise and are separated from each other and the working electrode 21A insulated an and reference electrode 22A.Protective seam 30A is the part coating substrate 10A, and wherein said substrate 10A is not formed by the part that described protective seam 30A covers the reaction zone 31A and a bonding pad 32A that are separated from each other, as shown in Figure 4.Wherein, reaction zone 31A is exposed one end of working electrode 21A and one end of reference electrode 22A, and bonding pad 32A is then exposed the other end of working electrode 21A and the other end of reference electrode 22A.
Described in the first embodiment, the conductive layer 20A that the present embodiment also can be carried on carbon by nm of gold detects the curent change that biological detection material and thing to be detected cause in the 31A of reaction zone, and via working electrode 21A and reference electrode 22A, curent change is passed to the biological monitor (non-icon) that the working electrode 21A in the 32A of bonding pad is connected with reference electrode 22A, to obtain a biological detection result.
In sum, the utility model provides one novel and the simple biological detection sheet of structure, it can be carried on carbon-coating with the nm of gold of simple layer and replace traditional conductive silver slurry layer and conductive carbon paste layer, biological detection sheet of the present utility model is possessed and preferably detects the advantage such as degree of accuracy, stability, and then improve usability and the value of biological detection.
The foregoing is only preferred embodiment of the present utility model, and be not used to limit claim of the present utility model; Under all other does not depart from the spirit that invention discloses, the equivalence that completes changes or modifies, and all should be included in claim.
Claims (14)
1. a biological detection sheet, is characterized in that, described biological detection sheet comprises: a substrate; One nm of gold is carried on the conductive layer of carbon, and it is arranged on described substrate; And a protective seam; it is directly covered in described substrate and described nm of gold is carried on the wherein a part of of the conductive layer of carbon; and the conductive layer that described substrate and described nm of gold are carried on carbon is not formed the reaction zone and a bonding pad that are separated from each other by the remainder that described protective seam covers, and described reaction zone and described bonding pad some nm of gold exposed is carried on the conductive layer of carbon.
2. biological detection sheet as claimed in claim 1, it is characterized in that, described biological detection sheet also comprises a layer of biological material, and it is arranged in described reaction zone, and is carried on the conductive layers make contact of carbon with the nm of gold in described reaction zone.
3. biological detection sheet as claimed in claim 1, it is characterized in that, the conductive layer that described nm of gold is carried on carbon comprises a working electrode and a reference electrode of mutual insulating, exposed one end having one end of described working electrode and described reference electrode in described reaction zone, and the exposed other end having the other end of described working electrode and described reference electrode in described bonding pad.
4. biological detection sheet as claimed in claim 3, it is characterized in that, the conductive layer that described nm of gold is carried on carbon also has an auxiliary electrode, and described auxiliary electrode and described working electrode and described reference electrode insulate, and are exposed in described bonding pad.
5. biological detection sheet as claimed in claim 2, it is characterized in that, the conductive layer that described nm of gold is carried on carbon comprises a working electrode and a reference electrode of mutual insulating, exposed one end having one end of described working electrode and described reference electrode in described reaction zone, and the exposed other end having the other end of described working electrode and described reference electrode in described bonding pad.
6. biological detection sheet as claimed in claim 5, it is characterized in that, the conductive layer that described nm of gold is carried on carbon also has an auxiliary electrode, and described auxiliary electrode and described working electrode and described reference electrode insulate, and are exposed in described bonding pad.
7. biological detection sheet as claimed in claim 2, it is characterized in that, described layer of biological material comprises a pair thing to be detected and has narrow spectrum enzyme, antigen or antibody.
8. biological detection sheet as claimed in claim 7, it is characterized in that, described layer of biological material comprises glucose oxidase.
9. biological detection sheet as claimed in claim 1, it is characterized in that, nm of gold is carried on the conductive layer of carbon, and carbon is graphite, Graphene, acticarbon, CNT, carbon black or fullerene.
10. biological detection sheet as claimed in claim 1, it is characterized in that, nm of gold is carried on the method for carbon, comprises impregnation method, separates out the precipitation method, vapour deposition process or Graft Method.
11. biological detection sheets as described in any one in claim 1 to 8, it is characterized in that, described nm of gold is carried on the conductive layer of carbon, is formed on substrate in the mode of wire mark, spray printing, impression, transfer printing or coating.
12. biological detection sheets as claimed in claim 1, it is characterized in that, nm of gold is carried on the conductive layer of carbon, the grain size of nm of gold, between 1 to 100 nanometer.
13. biological detection sheets as claimed in claim 1, it is characterized in that, nm of gold is carried on the conductive layer of carbon, and the grain size of nm of gold is between 2 to 50 nanometers.
14. biological detection sheets as described in any one in claim 1 to 8, it is characterized in that, the material of substrate is polyethylene terephthalate, or Polyvinylchloride.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| TW103205657 | 2014-04-03 | ||
| TW103205657U TWM488634U (en) | 2014-04-03 | 2014-04-03 | Organism detection sheet |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN204832102U true CN204832102U (en) | 2015-12-02 |
Family
ID=52109523
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201520190911.5U Expired - Fee Related CN204832102U (en) | 2014-04-03 | 2015-04-01 | Biological detection sheet |
Country Status (2)
| Country | Link |
|---|---|
| CN (1) | CN204832102U (en) |
| TW (1) | TWM488634U (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107064128A (en) * | 2017-04-26 | 2017-08-18 | 浙江欣叶健康管理有限公司 | A kind of urine detection reagent and the urine detection test paper prepared by it |
| WO2020000169A1 (en) * | 2018-06-26 | 2020-01-02 | Boe Technology Group Co., Ltd. | Sample analysis chip and fabricating method thereof |
| TWI752687B (en) * | 2020-10-26 | 2022-01-11 | 國立清華大學 | An sensor device and fabricating method thereof |
-
2014
- 2014-04-03 TW TW103205657U patent/TWM488634U/en not_active IP Right Cessation
-
2015
- 2015-04-01 CN CN201520190911.5U patent/CN204832102U/en not_active Expired - Fee Related
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107064128A (en) * | 2017-04-26 | 2017-08-18 | 浙江欣叶健康管理有限公司 | A kind of urine detection reagent and the urine detection test paper prepared by it |
| CN107064128B (en) * | 2017-04-26 | 2020-01-17 | 浙江欣叶健康管理有限公司 | Urine detection reagent and urine detection test paper prepared from same |
| WO2020000169A1 (en) * | 2018-06-26 | 2020-01-02 | Boe Technology Group Co., Ltd. | Sample analysis chip and fabricating method thereof |
| TWI752687B (en) * | 2020-10-26 | 2022-01-11 | 國立清華大學 | An sensor device and fabricating method thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| TWM488634U (en) | 2014-10-21 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20151202 Termination date: 20180401 |
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| CF01 | Termination of patent right due to non-payment of annual fee |