CN204789498U - Admission valve chromatographic device - Google Patents
Admission valve chromatographic device Download PDFInfo
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- CN204789498U CN204789498U CN201520620245.4U CN201520620245U CN204789498U CN 204789498 U CN204789498 U CN 204789498U CN 201520620245 U CN201520620245 U CN 201520620245U CN 204789498 U CN204789498 U CN 204789498U
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Abstract
(B, ) the utility model discloses an admission valve chromatographic device makes a valve realize four kinds of different functions, and functional. When the sample state, do not disturb between the load of sample and the system's flow path, can realize advancing at any time appearance, guarantee not loss of sample, the sample pump is direct when advancing kind washes the waste liquid port switch -on with the pump, and this state can carry out the sample pump at any time and wash, and when the pump washed the state, transfer pump and direct design that links to each other of waste liquid output channel can realize the function that the pump washed, when the appearance state directly is gone up to the sample pump, can realize that the sample pump is direct in a large number upward kind, can carry out the pump again and wash to the sample encircled a termination waste liquid output channel this moment, and the other end is sealed, and the sample in the sample ring can not be in loss under the siphon action at this moment. The utility model discloses admission valve chromatographic device design guarantees that pollution each other is little many times when advancing in succession kind, and the status switching of valve can be through the switching of software intelligence. (B, )
Description
Technical field
the utility model relates to a kind of sampling valve chromatographic apparatus.
Background technology
liquid chromatography instrument is exactly utilize the difference of the affinity such as the partition factor of various materials in two-phase, adsorptive power to be separated to be separated.The then instrument of Analysis and Identification or preparation.When utilizing liquid chromatography instrument sample being analyzed or prepare, design path is needed to enable to realize following functions: 1. sample, 2. sample in sample loop is injected analytical instrument or apparatus for preparation, 3. system stream rinses, and 4. directly sample is injected analytical instrument or apparatus for preparation by sample pump.And sampling valve chromatographic apparatus of the prior art, can not realize namely can sample loop loading, a large amount of loading (i.e. sample pump loading) can be realized again, and when those skilled in the art are when carrying out multiple experiment continuously, sometimes be a small amount of loading, sometimes be a large amount of loading, can only dismounting sample loop be back and forth passed through, or increase valve realizes.Dismounting sample loop easily causes system stream to pollute back and forth, and increase valve and then increase cost, therefore this problem needs solution badly.
Utility model content
in order to solve the problem, the purpose of this utility model is to provide a kind of sampling valve chromatographic apparatus, can not change parts, only realize above-mentioned difference in functionality by the state switching of valve.
in order to reach above object, the technical solution adopted in the utility model is: sampling valve chromatographic apparatus, and it comprises sampling valve, the systems pumps be connected with sampling valve, the sample loop be connected with sampling valve, the post position valve be connected with sampling valve, the chromatographic column be connected with post position valve, the detecting device that is connected with post position valve;
sampling valve comprises sampling valve stator, to rotate the sampling valve rotor be connected with sampling valve stator, sampling valve stator has sampling valve one hole be connected with sample pump, sampling valve two hole be connected with waste liquid output channel and sampling valve three hole, sampling valve four hole be connected with one end of sample loop, sampling valve five hole be connected with post position valve, sampling valve six hole be connected with the other end of sample loop, the sampling valve seven apertures in the human head be connected with systems pumps, the axial line of sampling valve seven apertures in the human head and the pivot center of sampling valve rotor coincide, sampling valve one hole, sampling valve two hole, sampling valve three hole, sampling valve four hole, sampling valve five hole, centered by the axial line of sampling valve six hole and sampling valve seven apertures in the human head angularly and distribute successively equidistantly, sampling valve rotor have sampling valve one groove, sampling valve two groove, sampling valve three groove and blind hole,
sampling valve has sampling state, sample introduction state, pump rinse state and by the direct loading state of sample pump, when it is in the state of sampling, sampling valve one hole is connected by sampling valve one groove with sampling valve six hole, sampling valve five hole is connected by sampling valve two groove with sampling valve seven apertures in the human head, sampling valve two hole is connected by sampling valve three groove with sampling valve four hole, and blind hole is connected with sampling valve three hole; When sampling valve is in sample introduction state, sampling valve five hole is connected by sampling valve one groove with sampling valve six hole, sampling valve four hole is connected by sampling valve two groove with sampling valve seven apertures in the human head, and sampling valve one hole is connected by sampling valve three groove with sampling valve three hole, and blind hole is connected with sampling valve two hole; When sampling valve rinses state at pump, sampling valve four hole is connected by sampling valve one groove with sampling valve five hole, sampling valve three hole is connected by sampling valve two groove with sampling valve seven apertures in the human head, and sampling valve two hole is connected by sampling valve three groove with sampling valve six hole, and blind hole is connected with sampling valve one hole; When sampling valve is in loading state direct by sample pump, sampling valve three hole is connected by sampling valve one groove with sampling valve four hole, sampling valve two hole is connected by sampling valve two groove with sampling valve seven apertures in the human head, sampling valve one hole is connected by sampling valve three groove with sampling valve five hole, and blind hole is connected with sampling valve six hole.
further, if the distance between sampling valve one hole and sampling valve two hole is m, distance between sample introduction one valve opening and sampling valve seven apertures in the human head is n, one end of sampling valve one groove is m to the distance of its other end, and the distance between one end of sampling valve one groove and the pivot center of its other end and sampling valve rotor is n.
further, one end of sampling valve two groove is positioned at the pivot center place of sampling valve rotor, and one end of sampling valve two groove is n to the distance between its other end, and the distance between the other end of sampling valve two groove and the other end of sampling valve one groove is m.
further, distance between one end of sampling valve three groove and the pivot center of its other end and sampling valve rotor is n, distance between one end of sampling valve three groove and one end of sampling valve one groove is m, and the distance between the other end of sampling valve three groove and the other end of sampling valve two groove is also m.
further, post position valve comprises post position stator valve, rotate with post position stator valve the post position valve rotor be connected, post position stator valve to have centered by the pivot center of post position valve rotor angularly and valve one hole, post position distributed successively equidistantly, valve two hole, post position, valve three hole, post position, valve four hole, post position, valve two hole, post position is connected with the two ends of chromatographic column respectively with valve four hole, post position, valve one hole, post position is connected with the fluid hole of sampling valve, valve three hole, post position is connected with detecting device, post position valve rotor has post position valve one groove and two post position valve two grooves
post position valve has at least three duties, when post position valve is in the first duty, valve one hole, post position is connected by two post position valve two grooves with valve two hole, post position, and valve three hole, post position is connected by another in two post position valve two grooves with valve four hole, post position; When post position valve is in the second duty, valve one hole, post position is connected by two post position valve two grooves with valve four hole, post position, and valve two hole, post position is connected by another in two post position valve two grooves with valve three hole, post position; When post position valve is in the 3rd duty, valve one hole, post position is connected by post position valve one groove with valve three hole, post position.
further, if the distance between the pivot center of valve one hole, post position and post position valve rotor is R, the length direction of post position valve one groove is vertical and crossing with the pivot center of post position valve rotor, and the distance between one end of post position valve one groove and the pivot center of its other end and post position valve rotor is R.
further, two post position valve two grooves are arranged on the both sides of post position valve one groove respectively symmetrically, and the distance between one end of each post position valve two groove and the pivot center of its other end and post position valve rotor is R.
further, valve four hole, post position is connected with the forward end of chromatographic column, and valve two hole, post position is connected with the backward end of chromatographic column.
further, systems pumps comprises the pump assembly of one group of pump assembly or at least two group parallel connections.
further, pump assembly comprises pump, liquid inlet tee joint valve, the solenoid valve of connecting successively.
owing to adopting technique scheme, sampling valve in the utility model sampling valve chromatographic apparatus is under sampling state, sample enters sample loop by sampling valve one hole by sampling valve six hole, unnecessary sample or waste liquid are discharged by sampling valve two hole by sampling valve four hole, systems pumps is directly connected the post position valve being connected with chromatographic column by sampling valve five hole by sampling valve seven apertures in the human head, sampling valve three hole is closed; Sampling valve in this case, by post position Vavle switching to the second duty or the 3rd duty, can rinse chromatographic column or walk balance;
sampling valve is passing through under sample loop sample introduction state, systems pumps is by sampling valve seven apertures in the human head, be communicated with sample loop by sampling valve four hole, the other end of sample loop is by sampling valve six hole, the post position valve being connected with chromatographic column is connected in sampling valve five hole, can the sample preserved in sample loop be pushed in chromatographic column via post position valve, then detecting device is arrived, the other end due to sample loop directly receives post position valve to chromatographic column, centre does not connect other accessories, even if the sample like this in sample loop is discontented with, sample also directly can enter chromatographic column, the design in this respect of this valve ensure that sample can realize non-full ring sample introduction when sample introduction state, sample pump connects waste liquid output channel by sampling valve one hole by sampling valve three hole, can carry out sample pump flushing at any time, and sampling valve two hole is closed, sampling valve in this case, by post position Vavle switching to the second duty or the 3rd duty, can carry out forward and reverse loading to chromatographic column,
sampling valve is under pump flushing state, and systems pumps directly connects a waste liquid output channel by sampling valve seven apertures in the human head by sampling valve three hole, and can realize the function that pump rinses, five holes are connected in sample loop one end, another termination waste liquid output channel, and sample pump is closed; In this case, mobile phase (damping fluid) is directly flowed out from waste liquid output channel by sampling valve three hole sampling valve, can not enter next active section again;
sampling valve is when loading state direct by sample pump, sample pump directly will connect post position valve by sampling valve one hole by sampling valve five hole, can loading in a large number, sample loop one end connects waste liquid output channel by sampling valve three hole, the other end is closed, systems pumps connects waste liquid output channel by sampling valve two hole, now if necessary, also can carry out systems pumps flushing; Sampling valve in this case, by post position Vavle switching to the second duty or the 3rd duty, can carry out forward and reverse a large amount of loading to chromatographic column.
the utility model sampling valve chromatographic apparatus makes a valve achieve four kinds of difference in functionalitys, and functional.When the state of sampling, between the loading of sample and system stream, not interference, can realize sample introduction at any time, ensures that sample does not lose; During sample introduction sample pump directly and pump flushing waste mouth connect, this state can carry out sample pump flushing at any time, when pump rinses state, the design that infusion pump and a waste liquid output channel are directly connected can realize the function that pump rinses, and when loading state direct by sample pump, can realize sample pump directly a large amount of loading, pump flushing can be carried out again, and now sample loop one termination waste liquid output channel, the other end seals, and the sample now in sample loop can not in loss under syphonic effect.The design of the utility model sampling valve chromatographic apparatus ensures that pollution is each other little when repeatedly continuous sample introduction, and the state of valve switches can by the switching of software intelligence.
Accompanying drawing explanation
accompanying drawing 1 is the structural representation of the utility model sampling valve chromatographic apparatus, and wherein sampling valve is in sampling state, and post position valve is in the first duty;
accompanying drawing 2 is the structural representation of the utility model sampling valve chromatographic apparatus, and wherein sampling valve is in sampling state, and post position valve is in the second duty;
accompanying drawing 3 is the structural representation of the utility model sampling valve chromatographic apparatus, and wherein sampling valve is in sampling state, and post position valve is in the 3rd duty;
accompanying drawing 4 is the structural representation of the utility model sampling valve chromatographic apparatus, and wherein sampling valve is in sample introduction state, and post position valve is in the first duty;
accompanying drawing 5 is the structural representation of the utility model sampling valve chromatographic apparatus, and wherein sampling valve is in sample introduction state, and post position valve is in the second duty;
accompanying drawing 6 is the structural representation of the utility model sampling valve chromatographic apparatus, and wherein sampling valve is in sample introduction state, and post position valve is in the 3rd duty;
accompanying drawing 7 is the structural representation of the utility model sampling valve chromatographic apparatus, and wherein sampling valve rinses state at pump, post position valve in the first duty;
accompanying drawing 8 is the structural representation of the utility model sampling valve chromatographic apparatus, and wherein sampling valve rinses state at pump, and post position valve is in the second duty;
accompanying drawing 9 is the structural representation of the utility model sampling valve chromatographic apparatus, and wherein sampling valve rinses state at pump, and post position valve is in the 3rd duty;
accompanying drawing 10 is the structural representation of the utility model sampling valve chromatographic apparatus, and wherein sampling valve is by the direct loading state of sample pump, and post position valve is in the first duty;
accompanying drawing 11 is the structural representation of the utility model sampling valve chromatographic apparatus, and wherein sampling valve is by the direct loading state of sample pump, and post position valve is in the second duty;
accompanying drawing 12 is the structural representation of the utility model sampling valve chromatographic apparatus, and wherein sampling valve is by the direct loading state of sample pump, and post position valve is in the 3rd duty;
accompanying drawing 13 is the structural representation of the stator of sampling valve in the utility model sampling valve chromatographic apparatus;
accompanying drawing 14 is the structural representation of another angle of the stator of sampling valve in the utility model sampling valve chromatographic apparatus;
accompanying drawing 15 is the structural representation of the rotor of sampling valve in the utility model sampling valve chromatographic apparatus.
number in the figure is:
10, systems pumps; 11, pump; 12, sample introduction T-valve; 13, solenoid valve; 14, air bubble sensor; 15, filtrator; 16, damping fluid bottle; 17, mixing tee valve; 18, mixer; 19, pot strainer;
20, sampling valve; 201, sampling valve stator; 202, sampling valve rotor; 21, sampling valve one hole; 22, sampling valve two hole; 23, sampling valve three hole; 24, sampling valve four hole; 25, sampling valve five hole; 26, sampling valve six hole; 27, sampling valve seven apertures in the human head; 281, sampling valve one groove; 282, sampling valve two groove; 283, sampling valve three groove; 29, blind hole;
30, sample loop;
40, post position valve; 401, post position stator valve; 402, post position valve rotor; 403, pipeline; 41, post position valve one hole; 42, post position valve
twohole; 43, post position valve three hole; 44, post position valve four hole; 45, post position valve five hole; 46, post position valve six hole; 47, post position valve one groove; 48, post position valve two groove;
50, chromatographic column;
60, detecting device;
70, sample pump; 71, sample bottle;
80, waste liquid bottle.
Embodiment
below in conjunction with accompanying drawing, preferred embodiment of the present utility model is described in detail, can be easier to be readily appreciated by one skilled in the art to make advantage of the present utility model and feature.
as can be seen from the structural representation of accompanying drawing 1 to accompanying drawing 15, present embodiments provide a kind of sampling valve chromatographic apparatus, it comprises sampling valve 20, the systems pumps 10 be connected with sampling valve 20, the sample loop 30 be connected with sampling valve 20, the post position valve 40 be connected with sampling valve 20, the chromatographic column 50 be connected with post position valve 40, the detecting device 60 that is connected with post position valve 40.
systems pumps 10 comprises the pump assembly of one group of pump assembly or at least two group parallel connections.Pump assembly comprises pump 11, liquid inlet tee joint valve 12, solenoid valve 13, the damping fluid bottle 15 of connecting successively, and wherein, pump 11 is at one end one end of the close sampling valve 20 of pump assembly.Solenoid valve 13 with the syndeton of damping fluid bottle 15 is: the one end of the pipeline be connected with solenoid valve 13 is inserted in damping fluid bottle 15, and one end of this pipeline is connected with filtrator 16.Pump assembly in the present embodiment has two groups, two groups of pump assemblies by after mixing tee valve 17 parallel connection again and between sampling valve 20, be in series with mixer 18 and pot strainer 19, wherein, pot strainer 19 comparatively mixer 18 closer to sampling valve 20.The pipeline that solenoid valve 13 wherein in one group of pump assembly connects damping fluid bottle 15 is connected with air bubble sensor 14.
sampling valve 20 comprises sampling valve stator 201, to rotate the sampling valve rotor 202 be connected with sampling valve stator 201, sampling valve stator 201 has sampling valve one hole 21 be connected with sample pump 70, sampling valve two hole 22 be connected with waste liquid output channel and sampling valve three hole 23, sampling valve four hole 24 be connected with one end of sample loop 30, sampling valve five hole 25 be connected with post position valve 40, sampling valve six hole 26 be connected with the other end of sample loop 30, the sampling valve seven apertures in the human head 27 be connected with systems pumps 10, the axial line of sampling valve seven apertures in the human head 27 and the pivot center of sampling valve rotor coincide, sampling valve one hole 21, sampling valve two hole 22, sampling valve three hole 23, sampling valve four hole 24, sampling valve five hole 25, centered by the axial line of sampling valve six hole 26 and sampling valve seven apertures in the human head 27 angularly and distribute successively equidistantly, sampling valve rotor have sampling valve one groove 281, sampling valve two groove 282, sampling valve three groove 283 and blind hole 29.
sampling valve one hole 21, sampling valve two hole 22, sampling valve three hole 23, sampling valve four hole 24, sampling valve five hole 25, sampling valve six hole 26 and sampling valve seven apertures in the human head 27 are through hole.
if the distance between sampling valve one hole 21 and sampling valve two hole 22 is m, distance between sampling valve one hole 21 and sampling valve seven apertures in the human head 27 is n, one end of sampling valve one groove 281 is m to the distance of its other end, and the distance between one end of sampling valve one groove 281 and the pivot center of its other end and sampling valve rotor is n.One end of sampling valve two groove 282 is positioned at the pivot center place of sampling valve rotor, and one end of sampling valve two groove 282 is n to the distance between its other end, and the distance between the other end of sampling valve two groove 282 and the other end of sampling valve one groove 281 is m.Distance between one end of sampling valve three groove 283 and the pivot center of its other end and sampling valve rotor is n, distance between one end of sampling valve three groove 283 and one end of sampling valve one groove 281 is m, and the distance between the other end of sampling valve three groove 283 and the other end of sampling valve two groove 282 is also m.Preferably, sampling valve one groove 281 is arc, and sampling valve two groove 282 and sampling valve three groove 283 are linear.
in the present embodiment, the other end that the one end that is connected with sampling valve 20 of sample pump 70 is contrary connects sample bottle 71, and sample bottle 71 is built with sample, and the sample in sample bottle 71 is injected sampling valve 20 by sample pump 70, flows into next stage by sampling valve 20.
the end of the waste liquid output channel in the present embodiment is connected with waste liquid bottle 80, and waste liquid is entered in waste liquid bottle 80 by waste liquid output channel.Sampling valve two hole 22 is respectively connected a waste liquid bottle 80 with sampling valve three hole 23 respectively by a waste liquid output channel.
post position valve 40 in the present embodiment comprises post position stator valve 401, to rotate the post position valve rotor 402 be connected with post position stator valve 401, post position stator valve 401 to have centered by the pivot center of post position valve rotor 402 angularly and valve one hole, post position 41 distributed successively equidistantly, valve two hole, post position 42, valve three hole, post position 43, valve four hole, post position 44, valve two hole, post position 42 is connected with the two ends of chromatographic column 50 respectively with valve four hole, post position 44, valve one hole, post position 41 is connected with the fluid hole of sampling valve 20, valve three hole, post position 43 is connected with detecting device 60, post position valve rotor 402 has post position valve one groove 45 and two post position valve two grooves 46.
valve one hole, post position 41, valve two hole, post position 42, valve three hole, post position 43 and valve four hole, post position 44 are through hole.
if the distance between valve one hole, post position 41 and the pivot center of post position valve rotor 402 is R, the length direction of post position valve one groove 45 is vertical and crossing with the pivot center of post position valve rotor 402, and the distance between one end of post position valve one groove 45 and the pivot center of its other end and post position valve rotor 402 is R.Two post position valve two grooves 46 are arranged on the both sides of post position valve one groove 45 respectively symmetrically, and the distance between one end of each post position valve two groove 46 and the pivot center of its other end and post position valve rotor 402 is R.Preferably, post position valve one groove 45 and two post position valve two grooves 46 are linear.
in the present embodiment, valve four hole, post position 44 is connected with the forward end of chromatographic column 50, and valve two hole, post position 42 is connected with the backward end of chromatographic column 50.
post position valve 40 has at least three duties: when post position valve 40 is in the first duty, valve one hole, post position 41 is connected by two post position valve two grooves 46 with valve two hole, post position 42, valve three hole, post position 43 is connected by another in two post position valve two grooves 46 with valve four hole, post position 44, in this case, mobile phase under the promotion of systems pumps 10 through sampling valve 20, post position valve 40 is entered by valve one hole, post position 41, again through valve two hole, post position 42, by the filler reverses through chromatographic column 50 li, again through valve four hole, post position 44, valve three hole, post position 43, enter detecting device 60 to detect, finally discharge whole chromatographic apparatus, counterflush chromatographic column can be realized simultaneously, when post position valve 40 is in the second duty, valve one hole, post position 41 is connected by two post position valve two grooves 46 with valve four hole, post position 44, valve two hole, post position 42 is connected by another in two post position valve two grooves 46 with valve three hole, post position 43, in this case, mobile phase under the promotion of systems pumps 10 through sampling valve 20, post position valve 40 is entered by valve one hole, post position 41, again through valve four hole, post position 44, by the filler of forward through chromatographic column 50 li, again through valve two hole, post position 42, valve three hole, post position 43, enter detecting device 60 to detect, finally discharge whole chromatographic apparatus, forward can be realized simultaneously and rinse chromatographic column, when post position valve is in the 3rd duty, valve one hole, post position 41 is connected by post position valve one groove 45 with valve three hole, post position 43, in this case, mobile phase is without chromatographic column 50, by systems pumps 10 through valve one hole, post position 41 of sampling valve 20, post position valve 40 and valve three hole, post position 43, directly enter detecting device 60 to detect, finally discharge whole chromatographic apparatus, thus realize the function of Bypass.
sampling valve 20 in the present embodiment sampling valve chromatographic apparatus has sampling state, sample introduction state, pump rinse state and by sample pump 70 directly loading state: when sampling valve 20 is in the state of sampling, sampling valve one hole 21 is connected by sampling valve one groove 281 with sampling valve six hole 26, sampling valve five hole 25 is connected by sampling valve two groove 282 with sampling valve seven apertures in the human head 27, sampling valve two hole 22 is connected by sampling valve three groove 283 with sampling valve four hole 24, and blind hole 29 is connected with sampling valve three hole 23; In this case, sample enters sample loop 30 by sampling valve one hole 21 by sampling valve six hole 26 by sample injector, (joint connecting sample pump need be removed when doing this step, after sample loop completion of the sample, again sample pump being connected) unnecessary sample or waste liquid discharged from waste liquid output channel by sampling valve two hole 22 by sampling valve four hole 24, systems pumps 10 is directly connected the post position valve 40 being connected with chromatographic column 50 by sampling valve five hole 25 by sampling valve seven apertures in the human head 27, sampling valve three hole 23 is closed; Post position valve 40, under 20 these states, is switched to the second duty or the 3rd duty by sampling valve, can rinse or walk balance to chromatographic column 50;
when sampling valve 20 is in sample introduction state, sampling valve five hole 25 is connected by sampling valve one groove 281 with sampling valve six hole 26, sampling valve four hole 24 is connected by sampling valve two groove 282 with sampling valve seven apertures in the human head 27, sampling valve one hole 21 is connected by sampling valve three groove 283 with sampling valve three hole 23, and blind hole 29 is connected with sampling valve two hole 22, in this case, systems pumps 10 is communicated with sample loop 30 by sampling valve four hole 24 by sampling valve seven apertures in the human head 27, the other end of sample loop 30 is by sampling valve six hole 26, the post position valve 40 being connected with chromatographic column 50 is connected in sampling valve five hole 25, can the sample preserved in sample loop 30 be pushed in chromatographic column 50 via post position valve 40, then detecting device 60 is arrived, the other end due to sample loop 30 directly receives post position valve 40 to chromatographic column 50, centre does not connect other accessories, even if the sample like this in sample loop 30 is discontented with, sample also can directly enter chromatographic column 50, the design of this valve ensure that sampling valve 20 sample when sample introduction state can realize non-full ring sample introduction, sample pump 70 connects waste liquid output channel by sampling valve one hole 21 by sampling valve three hole 23, can carry out sample pump 70 at any time and rinse, and sampling valve two hole 22 is closed, post position valve 40 in this case, is switched to the second duty or the 3rd duty by sampling valve 20, can carry out forward and reverse a small amount of loading to chromatographic column 50,
when sampling valve 20 rinses state at pump, sampling valve four hole 24 is connected by sampling valve one groove 281 with sampling valve five hole 25, sampling valve three hole 23 is connected by sampling valve two groove 282 with sampling valve seven apertures in the human head 27, sampling valve two hole 22 is connected by sampling valve three groove 283 with sampling valve six hole 26, and blind hole 29 is connected with sampling valve one hole 21; In this case, systems pumps 10 directly connects a waste liquid output channel by sampling valve seven apertures in the human head 27 by sampling valve three hole 23, and can realize the function that pump rinses, sample loop 30 one end connects chromatographic column 50 by post position valve, another termination waste liquid output channel, sample pump 70 is closed; In this case, mobile phase is directly flowed out from waste liquid output channel by sampling valve three hole 23 sampling valve 20, can not enter next active section again;
when sampling valve 20 is in the direct loading state of sample pump 70, sampling valve three hole 23 is connected by sampling valve one groove 281 with sampling valve four hole 24, sampling valve two hole 22 is connected by sampling valve two groove 282 with sampling valve seven apertures in the human head 27, sampling valve one hole 21 is connected by sampling valve three groove 283 with sampling valve five hole 25, and blind hole 29 is connected with sampling valve six hole 26; When this state, sample pump 70 directly will connect post position valve 40 by sampling valve one hole 21 by sampling valve five hole 25, can loading in a large number, sample loop 30 one end connects waste liquid output channel by sampling valve three hole 23, the other end is closed, systems pumps 10 is connected sampling valve two hole 22 by sampling valve seven apertures in the human head 27 and is connect waste liquid output channel, now if necessary, also can carry out systems pumps flushing; Post position valve 40 in this case, is switched to the second duty or the 3rd duty by sampling valve 20, can carry out forward and reverse a large amount of loading to chromatographic column 50.
the utility model sampling valve chromatographic apparatus makes a sampling valve achieve four kinds of difference in functionalitys, and functional.When the state of sampling, between the loading of sample and system stream, not interference, can realize sample introduction at any time, ensures that sample does not lose; During sample introduction sample pump directly and pump flushing waste mouth connect, this state can carry out sample pump flushing at any time, when pump rinses state, the design that infusion pump and a waste liquid output channel are directly connected can realize the function that pump rinses, and when loading state direct by sample pump, can realize sample pump directly a large amount of loading, pump flushing can be carried out again, and now sample loop one termination waste liquid output channel, the other end seals, and the sample now in sample loop can not in loss under syphonic effect.The design of the utility model sampling valve chromatographic apparatus ensures that pollution is each other little when repeatedly continuous sample introduction, and the state of valve switches can by the switching of software intelligence.
above-described embodiment, only for technical conceive of the present utility model and feature are described, its object is to person skilled in the art can be understood content of the present utility model and implement according to this, can not limit protection domain of the present utility model with this.All equivalences done according to the utility model Spirit Essence change or modify, and all should be encompassed within protection domain of the present utility model.
Claims (10)
1. a sampling valve chromatographic apparatus, is characterized in that: it comprises sampling valve (20), the systems pumps (10) be connected with described sampling valve (20), the sample loop (30) be connected with described sampling valve (20), post position valve (40) be connected with described sampling valve (20), the chromatographic column (50) be connected with described post position valve (40), the detecting device (60) that is connected with described post position valve (40);
Described sampling valve (20) comprises sampling valve stator (201), to rotate the sampling valve rotor (202) be connected with described sampling valve stator (201), described sampling valve stator (201) has sampling valve one hole (21) be connected with sample pump (70), sampling valve two hole (22) be connected with waste liquid output channel and sampling valve three hole (23), sampling valve four hole (24) be connected with one end of described sample loop (30), sampling valve five hole (25) be connected with described post position valve (40), sampling valve six hole (26) be connected with the other end of described sample loop (30), the sampling valve seven apertures in the human head (27) be connected with systems pumps (10), the described axial line of sampling valve seven apertures in the human head (27) and the pivot center of sampling valve rotor coincide, described sampling valve one hole (21), sampling valve two hole (22), sampling valve three hole (23), sampling valve four hole (24), sampling valve five hole (25), centered by the axial line of sampling valve six hole (26) and sampling valve seven apertures in the human head (27) angularly and distribute successively equidistantly, described sampling valve rotor have sampling valve one groove (281), sampling valve two groove (282), sampling valve three groove (283) and blind hole (29),
Described sampling valve (20) has sampling state, sample introduction state, pump rinse state and by the direct loading state of sample pump, when it is in the state of sampling, described sampling valve one hole (21) is connected by sampling valve one groove (281) with sampling valve six hole (26), described sampling valve five hole (25) is connected by sampling valve two groove (282) with sampling valve seven apertures in the human head (27), described sampling valve two hole (22) is connected by sampling valve three groove (283) with sampling valve four hole (24), and described blind hole (29) is connected with sampling valve three hole (23); When sampling valve (20) is in sample introduction state, described sampling valve five hole (25) is connected by sampling valve one groove (281) with sampling valve six hole (26), described sampling valve four hole (24) is connected by sampling valve two groove (282) with sampling valve seven apertures in the human head (27), described sampling valve one hole (21) is connected by sampling valve three groove (283) with sampling valve three hole (23), and described blind hole (29) is connected with sampling valve two hole (22); When sampling valve (20) rinses state at pump, described sampling valve four hole (24) is connected by sampling valve one groove (281) with sampling valve five hole (25), described sampling valve three hole (23) is connected by sampling valve two groove (282) with sampling valve seven apertures in the human head (27), described sampling valve two hole (22) is connected by sampling valve three groove (283) with sampling valve six hole (26), and described blind hole (29) is connected with sampling valve one hole (21); When sampling valve (20) is in loading state direct by sample pump, described sampling valve three hole (23) is connected by sampling valve one groove (281) with sampling valve four hole (24), described sampling valve two hole (22) is connected by sampling valve two groove (282) with sampling valve seven apertures in the human head (27), described sampling valve one hole (21) is connected by sampling valve three groove (283) with sampling valve five hole (25), and described blind hole (29) is connected with sampling valve six hole (26).
2. sampling valve chromatographic apparatus according to claim 1, it is characterized in that: set distance between described sampling valve one hole (21) and sampling valve two hole (22) as m, distance between described sampling valve one hole (21) and sampling valve seven apertures in the human head (27) is n, one end of described sampling valve one groove (281) is m to the distance of its other end, and the distance between described one end of sampling valve one groove (281) and the pivot center of its other end and sampling valve rotor is n.
3. sampling valve chromatographic apparatus according to claim 2, it is characterized in that: one end of described sampling valve two groove (282) is positioned at the pivot center place of sampling valve rotor, one end of sampling valve two groove (282) is n to the distance between its other end, and the distance between the other end of sampling valve two groove (282) and the other end of sampling valve one groove (281) is m.
4. sampling valve chromatographic apparatus according to claim 3, it is characterized in that: the distance between described one end of sampling valve three groove (283) and the pivot center of its other end and sampling valve rotor is n, distance between one end of sampling valve three groove (283) and one end of sampling valve one groove (281) is m, and the distance between the other end of sampling valve three groove (283) and the other end of post position valve two groove (282) is also m.
5. sampling valve chromatographic apparatus according to claim 1, it is characterized in that: described post position valve (40) comprises post position stator valve (401), to rotate post position valve rotor (402) be connected with described post position stator valve (401), described post position stator valve (401) to have centered by the pivot center of post position valve rotor (402) angularly and valve one hole, the post position (41) distributed successively equidistantly, valve two hole, post position (42), valve three hole, post position (43), valve four hole, post position (44), valve two hole, post position (42) is connected with the two ends of described chromatographic column (50) respectively with valve four hole, post position (44), valve one hole, post position (41) is connected with the fluid hole of described sampling valve (20), valve three hole, post position (43) is connected with described detecting device (60), described post position valve rotor (402) has post position valve one groove (45) and two post positions valve two groove (46),
Described post position valve (40) has at least three duties, when described post position valve (40) is in the first duty, described valve one hole, post position (41) is connected by two post positions valve two groove (46) with valve two hole, post position (42), and described valve three hole, post position (43) is connected by another in two post positions valve two groove (46) with valve four hole, post position (44); When described post position valve (40) is in the second duty, described valve one hole, post position (41) is connected by two post positions valve two groove (46) with valve four hole, post position (44), and described valve two hole, post position (42) is connected by another in two post positions valve two groove (46) with valve three hole, post position (43); When post position valve (40) is in the 3rd duty, described valve one hole, post position (41) is connected by post position valve one groove (45) with valve three hole, post position (43).
6. post position according to claim 5 valve, it is characterized in that: set distance between described valve one hole, post position (41) and the pivot center of post position valve rotor (402) as R, the length direction of described post position valve one groove (45) is vertical and crossing with the pivot center of post position valve rotor (402), and the distance between the pivot center of one end of post position valve one groove (45) and its other end and post position valve rotor (402) is R.
7. sampling valve chromatographic apparatus according to claim 6, it is characterized in that: two described post positions valve two groove (46) are arranged on the both sides of post position valve one groove (45) respectively symmetrically, the one end of post position valve two groove (46) described in each and the distance between the pivot center of its other end and post position valve rotor (402) are R.
8. sampling valve chromatographic apparatus according to claim 5, is characterized in that: described valve four hole, post position (44) is connected with the forward end of chromatographic column (50), and described valve two hole, post position (42) is connected with the backward end of chromatographic column (50).
9. sampling valve chromatographic apparatus according to claim 1, is characterized in that: described systems pumps (10) comprises the pump assembly of one group of pump assembly or at least two group parallel connections.
10. sampling valve chromatographic apparatus according to claim 9, is characterized in that: described pump assembly comprises pump (11), liquid inlet tee joint valve (12), the solenoid valve (13) of connecting successively.
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| CN201520620245.4U CN204789498U (en) | 2015-08-18 | 2015-08-18 | Admission valve chromatographic device |
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| CN109395875A (en) * | 2018-12-11 | 2019-03-01 | 苏州英赛斯智能科技有限公司 | A kind of Beads enrichment mechanism, device and Beads enrichment method |
| CN113332752A (en) * | 2021-05-14 | 2021-09-03 | 北京华创精科生物技术有限公司 | Continuous flow chromatography assembly, system and method |
| CN114480115A (en) * | 2021-02-09 | 2022-05-13 | 启德医药科技（苏州）有限公司 | Coupling device and method for producing a conjugate |
| CN114545014A (en) * | 2022-04-22 | 2022-05-27 | 成都理工大学 | Double-channel sample introduction system |
| WO2022170676A1 (en) * | 2021-02-09 | 2022-08-18 | Genequantum Healthcare (Suzhou) Co., Ltd. | Conjugation device and method for producing conjugates |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN109395875A (en) * | 2018-12-11 | 2019-03-01 | 苏州英赛斯智能科技有限公司 | A kind of Beads enrichment mechanism, device and Beads enrichment method |
| CN109395875B (en) * | 2018-12-11 | 2023-10-20 | 苏州英赛斯智能科技有限公司 | Magnetic bead separation mechanism, device and magnetic bead separation method |
| CN114480115A (en) * | 2021-02-09 | 2022-05-13 | 启德医药科技（苏州）有限公司 | Coupling device and method for producing a conjugate |
| WO2022170676A1 (en) * | 2021-02-09 | 2022-08-18 | Genequantum Healthcare (Suzhou) Co., Ltd. | Conjugation device and method for producing conjugates |
| US11578297B2 (en) | 2021-02-09 | 2023-02-14 | Genequantum Healthcare (Suzhou) Co., Ltd. | Conjugation device and method for producing conjugates |
| US12012582B2 (en) | 2021-02-09 | 2024-06-18 | Genequantum Healthcare (Suzhou) Co., Ltd. | Conjugation device and method for producing conjugates |
| CN113332752A (en) * | 2021-05-14 | 2021-09-03 | 北京华创精科生物技术有限公司 | Continuous flow chromatography assembly, system and method |
| CN114545014A (en) * | 2022-04-22 | 2022-05-27 | 成都理工大学 | Double-channel sample introduction system |
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