CN204752570U - Purification device of l -cn - Google Patents
Purification device of l -cn Download PDFInfo
- Publication number
- CN204752570U CN204752570U CN201520425321.6U CN201520425321U CN204752570U CN 204752570 U CN204752570 U CN 204752570U CN 201520425321 U CN201520425321 U CN 201520425321U CN 204752570 U CN204752570 U CN 204752570U
- Authority
- CN
- China
- Prior art keywords
- carnitine
- reation kettle
- decoloration
- desalination
- whizzer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
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- 238000000746 purification Methods 0.000 title claims abstract description 20
- 238000010612 desalination reaction Methods 0.000 claims abstract description 17
- 238000000909 electrodialysis Methods 0.000 claims abstract description 13
- 238000000967 suction filtration Methods 0.000 claims abstract description 10
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims abstract description 7
- 239000011780 sodium chloride Substances 0.000 claims abstract description 5
- PHIQHXFUZVPYII-ZCFIWIBFSA-N (R)-carnitine Chemical compound C[N+](C)(C)C[C@H](O)CC([O-])=O PHIQHXFUZVPYII-ZCFIWIBFSA-N 0.000 claims description 35
- 238000006243 chemical reaction Methods 0.000 claims description 17
- 230000004044 response Effects 0.000 claims description 16
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 6
- 238000004519 manufacturing process Methods 0.000 claims description 4
- 239000012670 alkaline solution Substances 0.000 claims description 3
- 230000002631 hypothermal effect Effects 0.000 claims description 3
- 239000000843 powder Substances 0.000 claims description 3
- 238000005507 spraying Methods 0.000 claims description 3
- 239000012535 impurity Substances 0.000 abstract description 12
- 230000000694 effects Effects 0.000 abstract description 4
- 238000012824 chemical production Methods 0.000 abstract description 2
- 239000012045 crude solution Substances 0.000 abstract 1
- 238000010410 dusting Methods 0.000 abstract 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 13
- 239000000243 solution Substances 0.000 description 10
- 238000000034 method Methods 0.000 description 9
- 239000012043 crude product Substances 0.000 description 7
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 6
- 239000000126 substance Substances 0.000 description 5
- 239000000047 product Substances 0.000 description 4
- GETQZCLCWQTVFV-UHFFFAOYSA-N trimethylamine Chemical compound CN(C)C GETQZCLCWQTVFV-UHFFFAOYSA-N 0.000 description 4
- DPDMMXDBJGCCQC-UHFFFAOYSA-N [Na].[Cl] Chemical compound [Na].[Cl] DPDMMXDBJGCCQC-UHFFFAOYSA-N 0.000 description 3
- 238000005576 amination reaction Methods 0.000 description 3
- 238000005516 engineering process Methods 0.000 description 3
- 230000008569 process Effects 0.000 description 3
- LRWZZZWJMFNZIK-UHFFFAOYSA-N 2-chloro-3-methyloxirane Chemical compound CC1OC1Cl LRWZZZWJMFNZIK-UHFFFAOYSA-N 0.000 description 2
- 239000012141 concentrate Substances 0.000 description 2
- 238000001816 cooling Methods 0.000 description 2
- 239000000428 dust Substances 0.000 description 2
- 235000013305 food Nutrition 0.000 description 2
- 238000006460 hydrolysis reaction Methods 0.000 description 2
- 239000006210 lotion Substances 0.000 description 2
- 230000007935 neutral effect Effects 0.000 description 2
- 230000020477 pH reduction Effects 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- 235000011121 sodium hydroxide Nutrition 0.000 description 2
- LRWZZZWJMFNZIK-NFJMKROFSA-N (2R)-2-chloro-3-methyloxirane Chemical compound CC1O[C@@H]1Cl LRWZZZWJMFNZIK-NFJMKROFSA-N 0.000 description 1
- AOSFMYBATFLTAQ-UHFFFAOYSA-N 1-amino-3-(benzimidazol-1-yl)propan-2-ol Chemical compound C1=CC=C2N(CC(O)CN)C=NC2=C1 AOSFMYBATFLTAQ-UHFFFAOYSA-N 0.000 description 1
- XFXPMWWXUTWYJX-UHFFFAOYSA-N Cyanide Chemical compound N#[C-] XFXPMWWXUTWYJX-UHFFFAOYSA-N 0.000 description 1
- 208000008589 Obesity Diseases 0.000 description 1
- 239000005703 Trimethylamine hydrochloride Substances 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- 210000000577 adipose tissue Anatomy 0.000 description 1
- 239000003513 alkali Substances 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- 229960004203 carnitine Drugs 0.000 description 1
- 239000003054 catalyst Substances 0.000 description 1
- 230000003197 catalytic effect Effects 0.000 description 1
- 238000006555 catalytic reaction Methods 0.000 description 1
- 239000003518 caustics Substances 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 230000000295 complement effect Effects 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 239000000498 cooling water Substances 0.000 description 1
- 230000007797 corrosion Effects 0.000 description 1
- 238000005260 corrosion Methods 0.000 description 1
- 238000002425 crystallisation Methods 0.000 description 1
- 230000008025 crystallization Effects 0.000 description 1
- 230000002328 demineralizing effect Effects 0.000 description 1
- 210000003298 dental enamel Anatomy 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- 230000002255 enzymatic effect Effects 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 239000012467 final product Substances 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 230000007062 hydrolysis Effects 0.000 description 1
- 238000009413 insulation Methods 0.000 description 1
- 229960001518 levocarnitine Drugs 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 235000012054 meals Nutrition 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 150000002825 nitriles Chemical class 0.000 description 1
- 231100000957 no side effect Toxicity 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 235000020824 obesity Nutrition 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 230000035790 physiological processes and functions Effects 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 230000006340 racemization Effects 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 235000020989 red meat Nutrition 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 238000013517 stratification Methods 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 230000002194 synthesizing effect Effects 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- SZYJELPVAFJOGJ-UHFFFAOYSA-N trimethylamine hydrochloride Chemical compound Cl.CN(C)C SZYJELPVAFJOGJ-UHFFFAOYSA-N 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Landscapes
- Separation Using Semi-Permeable Membranes (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Water Treatment By Electricity Or Magnetism (AREA)
Abstract
The utility model discloses a purification device of l -cn belongs to chemical production equipment technical field. The device includes concentrated reation kettle (1), desalination centrifugal separator (2), pH value adjustment reation kettle (3), suction filtration machine (4), electrodialysis structure (5), triple effect concentrator (6), decoloration reation kettle (7) and the decoloration centrifugal separator (8) that connects gradually through the pipeline, and concentrated reation kettle (1) is connected with apparatus for producing (9) of l -cn, and the centrifugate export of decoloration centrifugal separator (8) is connected with the structure of dusting (10). Wherein, concentrated reation kettle and desalination centrifugal separator are used for getting rid of sodium chloride, and pH value adjustment reation kettle and suction filtration machine are in getting rid of partial impurity, and the concentration of crude solution not only can be realized to electrodialysis structure mainly used desalination, triple effect concentrator can also detach easy volatile impurity, and decoloration reation kettle is used for getting rid of once more partial impurity with the decoloration centrifugal separator, and the purity of the l -cn that obtains at last is greater than 90%, and does not have variegatedly.
Description
Technical field
The utility model relates to technical field of chemical production equipment, particularly a kind of purification devices of L-carnitine, particularly relates to a kind of purification devices adopting chemical resolution method to produce L-carnitine.
Background technology
L-carnitine (English name L-camitine), also known as VBT or transliteration Carnitine, be a kind of adipose conversion that impels be the amino acid of energy, red meat is the main source of L-carnitine, to human non-toxic's side effect.The L-carnitine of dissimilar diet containing 5-100 milligram, but common people can only take in 50 milligrams every day from meals, and vegetarian takes in less.The main Physiological Function of L-carnitine promotes that adipose conversion becomes energy, taking L-carnitine can while minimizing body fat, reduction body weight, do not reduce moisture and muscle, within 2003, L-carnitine is regarded as the safest fat-reducing nutrient complementary goods had no side effect by International Obesity health tissues.
The preparation method of L-carnitine conventional at present has following several: one, Split Method, domestic and international synthetic l-carnitine adopts Split Method mostly, comprises chemical resolution and Enzymatic Resolution.Two, the asymmetric chemistry synthesis of VBT, namely utilizes chemical asymmetry catalysis, only needs the chiral material of catalytic amount can induce optically active substance new in a large number, be considered to the method for synthesizing chiral compound most development prospect.
Our company mainly adopts chemical resolution method to produce L-carnitine, comprises the following steps:
1 splits: epoxy chloropropane reacts under the existence of catalyzer, organic solvent and water, splits, distill to obtain S-epoxy chloropropane to racemization epoxy chloropropane (in the presence of a catalyst selective hydrolysis R-epoxy chloropropane), then stratification removing moisture.
2 amination reactions: S-epoxy chloropropane step 1 obtained and trimethylamine hydrochloride, trimethylamine aqueous solution carry out amination reaction.
3 cyanogenations: the product of amination reaction step 2 obtained and prussiate carry out cyanogenation.
4 acidification reactions: the product of cyanogenation step 3 obtained and a small amount of hydrochloric acid reaction obtain nitrile in intermediate card [L-(-)-chlorination-3-cyano group-2-carboxypropyl Trimethylamine 99], crystallization, centrifugal intermediate.
Aforementioned process is intermediate workshop section.
5 acidification reactions: intermediate step 4 obtained and a large amount of hydrochloric acid reactions, have reacted rear cooling, centrifugal desalination, reconcentration demineralizing acid.
6 hydrolysis reaction: first concentrated solution step 5 obtained reacts with ammonium bisulfite and sodium hydroxide, react with gac after reaction for some time again, have reacted rear cooling, centrifugal, have namely obtained the crude product solution of L-carnitine.
Aforementioned process is product workshop section.
7 purifying: purification process is carried out to the crude product solution that step 6 obtains.
8 dust: dust to the liquid after step 7 purification process, obtain food grade L-carnitine.
Applicant finds in the production process realizing L-carnitine, and at purification section, in the crude product solution of L-carnitine, foreign matter content is high, and especially salts contg is very high, and cause the purity of the finished product low, economic worth is not high.
Summary of the invention
The purification devices of a kind of L-carnitine of the utility model embodiment, this device is used for carrying out purification process to L-carnitine crude product solution, can obtain highly purified L-carnitine (food grade).Described technical scheme is as follows:
The utility model embodiment provides a kind of purification devices of L-carnitine, this device comprises the concentration response still 1, desalination whizzer 2, pH value adjustment reactor 3, suction filtration machine 4, electrodialysis structure 5, Three-effect concentration device 6, decoloring reaction still 7 and the decolouring whizzer 8 that are connected successively by pipeline, described concentration response still 1 is connected with the production equipment 9 of L-carnitine, and the centrifugate outlet of described decolouring whizzer 8 is connected with powder spraying structure 10.
Wherein, the concentration response still 1 in the utility model embodiment comprises reactor body and the outer sheathed chuck of reactor body, and described chuck is connected with vapour pipe and hypothermic saline pipe.
Wherein, the pH value adjustment reactor 3 in the utility model embodiment is provided with pure water feed mouth and alkaline solution opening for feed.
The beneficial effect of the purification devices of the L-carnitine that the utility model embodiment provides is: the utility model embodiment provides a kind of purification devices of L-carnitine, this device comprises the concentration response still connected successively by pipeline, desalination whizzer, pH value adjustment reactor, suction filtration machine, electrodialysis structure, Three-effect concentration device, decoloring reaction still and decolouring whizzer etc., concentration response still and desalination whizzer are for removing sodium-chlor, pH value adjustment reactor and suction filtration machine are for removing partial impurities, electrodialysis structure is mainly used in desalination, Three-effect concentration device not only can realize the concentrated of crude product solution can also remove easy volatile impurity (example hydrochloric acid), decoloring reaction still and decolouring whizzer are used for again removing partial impurities, the purity of the L-carnitine finally obtained is greater than 90%, and non-variegation.
Accompanying drawing explanation
In order to be illustrated more clearly in the technical scheme in the utility model embodiment, below the accompanying drawing used required in describing embodiment is briefly described, apparently, accompanying drawing in the following describes is only embodiments more of the present utility model, for those of ordinary skill in the art, under the prerequisite not paying creative work, other accompanying drawing can also be obtained according to these accompanying drawings.
Fig. 1 is the structured flowchart of the purification devices of the L-carnitine that the utility model embodiment provides.
Embodiment
For making the purpose of this utility model, technical scheme and advantage clearly, below in conjunction with accompanying drawing, the utility model embodiment is described in further detail.
See Fig. 1, the utility model embodiment provides a kind of purification devices of L-carnitine, and this device comprises concentration response still 1, desalination whizzer 2, pH value adjustment reactor 3, suction filtration machine 4, electrodialysis structure 5, Three-effect concentration device 6, decoloring reaction still 7 and the decolouring whizzer 8 etc. that are connected successively by pipeline.Wherein, concentration response still 1 is connected with the production equipment 9 (specifically adopting the method described in detail in background technology) of L-carnitine, and the centrifugate outlet of decolouring whizzer 8 is connected with powder spraying structure 10.Wherein, concentration response still 1 concentrates L-carnitine crude product solution for first high temperature, then subcooling precipitated sodium chloride; The sodium-chlor that desalination whizzer 2 is separated out for centrifugal removing concentration response still 1; PH value adjustment reactor 3 is adjusted to neutrality for the pH value of the centrifugate exported by desalination whizzer 2 or close to neutral, have partial impurities to separate out, create good condition simultaneously for follow-up electrodialysis under this pH value condition; The impurity that suction filtration machine 4 is separated out for separating of pH value adjustment reactor 3; Electrodialysis structure 5, for removal of impurities, is mainly used in desalination, is common electrodialysis structure; Three-effect concentration device 6 both can concentrate the solution after electrodialysis, can remove again volatile substances (example hydrochloric acid), can be common Three-effect concentration device, also can adopt the triple effect concentrating unit that application number 201410671271.X provides; Decoloring reaction still 7, for carrying out desolventing technology to final product, is common structure, adds a small amount of gac and carries out decolour (can supplement a small amount of alkali).Decolouring whizzer 8 is for separating of the gac after decolouring.
Wherein, the concentration response still 1 in the utility model embodiment comprises reactor body and the outer sheathed chuck etc. of reactor body, and chuck is connected with vapour pipe and hypothermic saline pipe, can realize the concentrated of solution, can separate out salt by low temperature again.Preferably, concentration response still 1 high-temperature steam outlet and HCl recovery structure or hydrochloric acid tail gas process anatomical connectivity.
Wherein, the pH value adjustment reactor 3 in the utility model embodiment is provided with pure water feed mouth and alkaline solution (being specially caustic soda soln) opening for feed, and the pH value for the centrifugate exported by desalination whizzer 2 is adjusted to neutrality or close neutral.
Preferably, this purification devices is also provided with washing structure, washes, collect water lotion, and water lotion is sent into Three-effect concentration device 6 for the filter residue exported decolouring whizzer 8.
In aforementioned structure, each structure connects in turn essentially by pipeline, and pipeline arranges the structures such as power-driven pump, valve and flow valve as required.Meanwhile, aforementioned each structure is all acidproof or caustic corrosion structure, and reactor is enamel reaction still or glass reaction still, and each reactor arranges stirring, thermometer, weather gauge, insulation jacket, cooling water jecket etc. as required or is connected with exhaust treatment system.
The utility model embodiment provides a kind of purification devices of L-carnitine, this device comprises the concentration response still connected successively by pipeline, desalination whizzer, pH value adjustment reactor, suction filtration machine, electrodialysis structure, Three-effect concentration device, decoloring reaction still and decolouring whizzer etc., concentration response still and desalination whizzer are for removing sodium-chlor, pH value adjustment reactor and suction filtration machine are for removing partial impurities, electrodialysis structure is mainly used in desalination, Three-effect concentration device not only can realize the concentrated of crude product solution can also remove easy volatile impurity (example hydrochloric acid), decoloring reaction still and decolouring whizzer are used for again removing partial impurities, the purity of the L-carnitine finally obtained is greater than 90%, and non-variegation.
The above embodiment of the present utility model, does not form the restriction to the utility model protection domain.Any various other made according to technical conceive of the present utility model change and distortion accordingly, all should be included in the protection domain of the utility model claim.
Claims (3)
1. the purification devices of a L-carnitine, it is characterized in that, comprise connected successively by pipeline concentration response still (1), desalination whizzer (2), pH value adjustment reactor (3), suction filtration machine (4), electrodialysis structure (5), Three-effect concentration device (6), decoloring reaction still (7) and decolour whizzer (8), described concentration response still (1) is connected with the production equipment (9) of L-carnitine, and the centrifugate outlet of described decolouring whizzer (8) is connected with powder spraying structure (10).
2. the purification devices of L-carnitine according to claim 1, is characterized in that, described concentration response still (1) comprises reactor body and the outer sheathed chuck of reactor body, and described chuck is connected with vapour pipe and hypothermic saline pipe.
3. the purification devices of L-carnitine according to claim 1, is characterized in that, described pH value adjustment reactor (3) is provided with pure water feed mouth and alkaline solution opening for feed.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201520425321.6U CN204752570U (en) | 2015-06-19 | 2015-06-19 | Purification device of l -cn |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201520425321.6U CN204752570U (en) | 2015-06-19 | 2015-06-19 | Purification device of l -cn |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN204752570U true CN204752570U (en) | 2015-11-11 |
Family
ID=54467299
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201520425321.6U Expired - Fee Related CN204752570U (en) | 2015-06-19 | 2015-06-19 | Purification device of l -cn |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN204752570U (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106957238A (en) * | 2017-04-19 | 2017-07-18 | 黄冈华阳药业有限公司 | A kind of preparation technology of carnitine |
| CN108299217A (en) * | 2017-01-13 | 2018-07-20 | 南京红杉生物科技有限公司 | A kind of process and system producing D-phenylalanine |
-
2015
- 2015-06-19 CN CN201520425321.6U patent/CN204752570U/en not_active Expired - Fee Related
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108299217A (en) * | 2017-01-13 | 2018-07-20 | 南京红杉生物科技有限公司 | A kind of process and system producing D-phenylalanine |
| CN106957238A (en) * | 2017-04-19 | 2017-07-18 | 黄冈华阳药业有限公司 | A kind of preparation technology of carnitine |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20151111 |