CN204709073U - A kind of coaxial electrically spun silk device for the preparation of artificial nerve catheter - Google Patents
A kind of coaxial electrically spun silk device for the preparation of artificial nerve catheter Download PDFInfo
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- CN204709073U CN204709073U CN201520127915.9U CN201520127915U CN204709073U CN 204709073 U CN204709073 U CN 204709073U CN 201520127915 U CN201520127915 U CN 201520127915U CN 204709073 U CN204709073 U CN 204709073U
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- syringe
- liquid storage
- silica gel
- mouthfuls
- storage syringe
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Abstract
The utility model discloses a kind of coaxial electrically spun silk device for the preparation of artificial nerve catheter, it comprises the first liquid storage syringe, the second liquid storage syringe, syringe pump, two silica gel tubes, little syringe needle, three mouthfuls of shower nozzles, large syringe needle, high voltage power supply and receiving system; Wherein, first liquid storage syringe and the second liquid storage syringe are separately fixed on syringe pump, first liquid storage syringe is connected with the second liquid storage syringe by silica gel tube, second liquid storage syringe is connected with three mouthfuls of shower nozzles by silica gel tube, through silica gel tube and three mouthfuls of shower nozzles and be connected directly between the second liquid storage syringe is little syringe needle, large syringe needle is connected to one end of three mouthfuls of shower nozzles, the positive pole of high voltage power supply is connected with large syringe needle, and the negative pole of high voltage power supply connects on the reception device; Described receiving system is can the roller of adjusting rotary speed.This utility model novel structure, device is simple, and be easy to operation, size is controlled, reproducible.
Description
Technical field
This utility model relates to a kind of coaxial electrically spun silk device for the preparation of artificial nerve catheter.
Background technology
Nerve injury is a kind of more common disease.When neurologic defect length is less than 5mm, nerve can automatically engage and repair; When neurologic defect is larger, medically normal employing is transplanted sensorineural method and is repaired at present, but this exists again the coupling of neural length scale, the problem such as limited of originating, so artificial nerve catheter arises at the historic moment.
So-called nerve trachea is exactly ultimate principle and method by using tissue engineering, and according to the biological characteristics of neuranagenesis, that is made up of the biology or non-biological material with good biocompatibility has specific tubular structure and bioactive complex.
Method at present for the preparation of artificial nerve catheter mainly contains: phase separation method, mould water method for making, solution casting-percolation etc., also have many publications in addition to this has been research.Chinese patent (application number 201320815134.X) discloses the mould that a kind of twice molding builds multichannel sponge nerve trachea, but the method needs just can obtain nerve trachea by twice processing; Chinese patent (application number 200620056384.X) discloses a kind of particular manufacturing craft can preparing different-diameter degradable absorption aliphatic polyester nerve trachea; Chinese patent (application number 200910034583.9) discloses a kind of method and apparatus utilizing electrostatic spinning to prepare artificial nerve graft, and this patent can obtain catheter-like artificial nerve graft.But the nerve trachea that above-mentioned three patents obtain is single-wall structure conduit mostly, but CO2 laser weld is very complicated biological question, be only difficult to reach perfect repairing of neural injury by single structure.
Utility model content
The purpose of this utility model is for the above-mentioned shortcoming prepared in artificial nerve catheter method, devises a kind of coaxial electrically spun silk device for the preparation of artificial nerve catheter.
For the preparation of a coaxial electrically spun silk device for artificial nerve catheter, it is characterized in that: it comprises the first liquid storage syringe (1), the second liquid storage syringe (2), syringe pump (3), silica gel tube (4), silica gel tube (5), little syringe needle (6), three mouthfuls of shower nozzles (7), large syringe needle (8), high voltage power supply (9) and receiving system (10); wherein, first liquid storage syringe (1) and the second liquid storage syringe (2) are fixed on syringe pump (3), shell layer spinning solution and sandwich layer spinning liquid is respectively equipped with in first liquid storage syringe (1) and the second liquid storage syringe (2), by the motive force of syringe pump (3), the solution in the first liquid storage syringe (1) and the second liquid storage syringe (2) can be pushed into large syringe needle (8) place, first liquid storage syringe (1) is connected with the second liquid storage syringe (2) by silica gel tube (4), second liquid storage syringe (2) is connected with three mouthfuls of shower nozzles (7) by silica gel tube (5), in silica gel tube (5) and three mouthfuls of shower nozzles (7) and be connected directly between the second liquid storage syringe (2) is little syringe needle (6), large syringe needle (8) is connected to one end of three mouthfuls of shower nozzles (7), the positive pole of high voltage power supply (9) is connected with large syringe needle (8), the negative pole of high voltage power supply (9) is connected on receiving system (10).
Preferably, described receiving system is can the roller of adjusting rotary speed.
The beneficial effects of the utility model are: 1. this utility model is novel in design, and simple to operate, reproducible, cost is low, and the nerve trachea obtained has core shell structure and core shell can be regulated according to actual needs to form; 2. adopt the roller of scalable rotating speed as receiving system, Electrospun orientation deposition on the reception device can be made, be beneficial to the oriented growth of neurocyte; 3. the tube wall of the artificial nerve catheter obtained has the three dimensional structure enriching micropore, and the nutrient substance conveying needed for nerve growth process provides approach, for the growth of neurocyte provides space.
Accompanying drawing illustrates:
Fig. 1 is structural representation of the present utility model.
In figure: 1-first liquid storage syringe; 2-second liquid storage syringe; 3-syringe pump; 4-silica gel tube; 5-silica gel tube; The little syringe needle of 6-; 7-tri-mouthfuls of shower nozzles; The large syringe needle of 8-; 9-high voltage power supply; 10-receiving system.
Detailed description of the invention:
As shown in Figure 1, this detailed description of the invention by the following technical solutions: it comprises the first liquid storage syringe 1, second liquid storage syringe 2, syringe pump 3, silica gel tube 4, silica gel tube 5, little syringe needle 6, three mouthfuls of shower nozzles 7, large syringe needle 8, high voltage power supply 9 and receiving system 10, wherein, first liquid storage syringe 1 and the second liquid storage syringe 2 are fixed on syringe pump 3, shell layer spinning solution and sandwich layer spinning liquid is respectively equipped with in first liquid storage syringe 1 and the second liquid storage syringe 2, by the motive force of syringe pump 3, the solution in first liquid storage syringe 1 and the second liquid storage syringe 2 can be pushed into large syringe needle 8 place, first liquid storage syringe 1 is connected with the second liquid storage syringe 2 by silica gel tube 4, second liquid storage syringe 2 is connected with three mouthfuls of shower nozzles 7 by silica gel tube 5, in silica gel tube 5 and three mouthfuls of shower nozzles 7 and be connected directly between the second liquid storage syringe 2 is little syringe needle 6, large syringe needle 8 is connected to one end of three mouthfuls of shower nozzles 7, the positive pole of high voltage power supply 9 is connected with large syringe needle 8, the negative pole of high voltage power supply 9 is connected on receiving system 10.
In the coaxial electrical spinning process preparing artificial nerve catheter, after injecting a certain amount of shell layer spinning solution and sandwich layer spinning liquid respectively in the first liquid storage syringe 1 and the second liquid storage syringe 2, first liquid storage syringe 1 and the second liquid storage syringe 2 are separately fixed on syringe pump 3, regulate electrospinning parameters, under the effect of syringe pump 3, shell layer spinning solution and sandwich layer spinning liquid merge into drop at large syringe needle 8 place, and be then communicated with power supply, spinning just can be carried out continuously and stably.
More than show and describe ultimate principle of the present utility model and principal character and advantage of the present utility model.The technical staff of the industry should understand; this utility model is not restricted to the described embodiments; what describe in above-described embodiment and description just illustrates principle of the present utility model; under the prerequisite not departing from this utility model spirit and scope; this utility model also has various changes and modifications, and these changes and improvements all fall within the scope of claimed this utility model.The claimed scope of this utility model is defined by appending claims and equivalent thereof.
Claims (2)
1. for the preparation of a coaxial electrically spun silk device for artificial nerve catheter, it is characterized in that: it comprises the first liquid storage syringe (1), the second liquid storage syringe (2), syringe pump (3), silica gel tube (4), silica gel tube (5), little syringe needle (6), three mouthfuls of shower nozzles (7), large syringe needle (8), high voltage power supply (9) and receiving system (10); wherein, first liquid storage syringe (1) and the second liquid storage syringe (2) are separately fixed on syringe pump (3), shell layer spinning solution and sandwich layer spinning liquid is respectively equipped with in first liquid storage syringe (1) and the second liquid storage syringe (2), by the motive force of syringe pump (3), the solution in the first liquid storage syringe (1) and the second liquid storage syringe (2) can be pushed into large syringe needle (8) place, first liquid storage syringe (1) is connected with the second liquid storage syringe (2) by silica gel tube (4), second liquid storage syringe (2) is connected with three mouthfuls of shower nozzles (7) by silica gel tube (5), in silica gel tube (5) and three mouthfuls of shower nozzles (7) and be connected directly between the second liquid storage syringe (2) is little syringe needle (6), large syringe needle (8) is connected to one end of three mouthfuls of shower nozzles (7), the positive pole of high voltage power supply (9) is connected with large syringe needle (8), the negative pole of high voltage power supply (9) is connected on receiving system (10).
2. a kind of coaxial electrically spun silk device for the preparation of artificial nerve catheter according to claim 1, is characterized in that: described receiving system (10) is can the roller of adjusting rotary speed.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201520127915.9U CN204709073U (en) | 2015-03-06 | 2015-03-06 | A kind of coaxial electrically spun silk device for the preparation of artificial nerve catheter |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201520127915.9U CN204709073U (en) | 2015-03-06 | 2015-03-06 | A kind of coaxial electrically spun silk device for the preparation of artificial nerve catheter |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN204709073U true CN204709073U (en) | 2015-10-21 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201520127915.9U Expired - Fee Related CN204709073U (en) | 2015-03-06 | 2015-03-06 | A kind of coaxial electrically spun silk device for the preparation of artificial nerve catheter |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN204709073U (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111317594A (en) * | 2020-02-28 | 2020-06-23 | 广州迈普再生医学科技股份有限公司 | Automatic artificial blood vessel production device |
-
2015
- 2015-03-06 CN CN201520127915.9U patent/CN204709073U/en not_active Expired - Fee Related
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111317594A (en) * | 2020-02-28 | 2020-06-23 | 广州迈普再生医学科技股份有限公司 | Automatic artificial blood vessel production device |
| CN111317594B (en) * | 2020-02-28 | 2023-10-20 | 广州迈普再生医学科技股份有限公司 | Automatic artificial blood vessel production device |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20151021 Termination date: 20160306 |