CN204702685U - A kind of serialization preparation facilities of N-pyrrolidone acetate - Google Patents
A kind of serialization preparation facilities of N-pyrrolidone acetate Download PDFInfo
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- CN204702685U CN204702685U CN201520110450.6U CN201520110450U CN204702685U CN 204702685 U CN204702685 U CN 204702685U CN 201520110450 U CN201520110450 U CN 201520110450U CN 204702685 U CN204702685 U CN 204702685U
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- tubular type
- reactor
- pyrrolidone
- preparation facilities
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- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
The utility model discloses a kind of serialization preparation facilities of N-pyrrolidone acetate, this preparation facilities comprises: material mixer (1), tubular type salt-forming reactor (2), reactive distillation column (3), supplementary solvent mixing tank (4), tubular type condensation reactor (5), equipment room connection line, control instruments and annex; Material mixer (1), tubular type salt-forming reactor (2), to supplement solvent mixing tank (4), tubular type condensation reactor (5) be tube type apparatus with or without chuck, and arranging in pipe or not arranging has moving and static mixing element of disturbance mixing effect to material.It is that starting raw material prepares salify in Piracetam (piracetam) technique, condensation reaction N-pyrrolidone acetate realizes serialization and prepares that the utility model can make by pyrrolidone.Mass transfer effect is good, and fully, speed of response is fast in material contact; Heat-transfer effect is good, and temperature of reaction controls precisely, to be conducive to improving the quality of products.
Description
Technical field
The utility model relates to a kind of chemical plant installations, particularly relates to a kind of serialization preparation facilities of N-pyrrolidone acetate.
Background technology
in formula, R is CH
3or C
2h
5
N-pyrrolidone acetate is the intermediate of Piracetam (piracetam).Piracetam (piracetam) is a kind of drugs for nervous, there is the effect promoting brain memory function, old memory to be gone down and the intelligence of some mentally handicapped youngster improves effectively, the memory that cerebral trauma, cerebrovascular accident, epilepsy sequela, carbon monoxide and alcohol or drug poisoning are caused and the disturbance of thought also effective in cure, be widely used in clinical at present.
The preparation method preparing Piracetam (piracetam) has multiple, comparative maturity and industrialized method be take pyrrolidone as starting raw material, through salify, condensation, reaction obtains N-pyrrolidone acetate, obtain product through aminating reaction again, preparation process is batch process procedures.
Summary of the invention
It is starting raw material with pyrrolidone that the purpose of this utility model is to provide a kind of, prepares the serialization preparation facilities of Piracetam (piracetam) intermediate N pyrrolidone acetate through salify, condensation.
the technical solution of the utility model is as follows:
A serialization preparation facilities for N-pyrrolidone acetate, described preparation facilities comprises: material mixer, tubular type salt-forming reactor, reactive distillation column, supplementary solvent mixing tank, tubular type condensation reactor, equipment room connection line, control instruments and annex; Material mixer, tubular type salt-forming reactor, to supplement solvent mixing tank, tubular type condensation reactor be tube type apparatus with or without chuck, and arranging in pipe or not arranging has the dynamic of disturbance mixing effect and static mixing element to material.
The serialization preparation facilities of described a kind of N-pyrrolidone acetate, described reactive distillation column or be conventional distillation still.
The utility model has the advantages that:
1. can make by pyrrolidone is that starting raw material prepares salify in Piracetam (piracetam) technique, condensation reaction N-pyrrolidone acetate realizes serialization and prepares.
2. adopt peripheral hardware chuck, inside establish tubular type salt-forming reactor and the tubular type condensation reactor of turbulent element, mass transfer effect is good, and fully, speed of response is fast in material contact; Heat-transfer effect is good, and temperature of reaction controls precisely, to be conducive to improving the quality of products.
3. adopt pipe reaction to combine with tower reactive distillation, can improve speed of response, the methyl alcohol that sharp separation goes out to generate, be conducive to reaction and carry out to positive dirction, reaction is carried out completely, good product quality, and raw material availability is high;
4. process operation is convenient stable, and preparation efficiency is high, and turndown ratio is large.
Accompanying drawing explanation
Accompanying drawing 1 is employing tubular type salt-forming reactor, reactive distillation column completes salt-forming reaction and separation of methanol; Tubular type tubular type condensation reactor is adopted to complete condensation reaction, the preparation facilities sketch of the obtained N-pyrrolidone acetate of serialization preparation.
Embodiment
Embodiment 1
The serialization preparation facilities of N-pyrrolidone acetate comprises material mixer 1, tubular type salt-forming reactor 2, reactive distillation column 3, supplements solvent mixing tank 4, tubular type condensation reactor 5, equipment room connection line, control instruments and annex.Material mixer 1, tubular type salt-forming reactor 2, supplementary solvent mixing tank 4, tubular type condensation reactor 5 are connected by straight tube and curved tube, fill the tube type apparatus of chemical filler in straight tube.
Embodiment 2
Embodiment 2 is substantially the same manner as Example 1, and difference is that material mixer 1, tubular type salt-forming reactor 2, supplementary solvent mixing tank 4, tubular type condensation reactor 5 straight length adopt commercially available static mixer, and curved tube section is blank pipe.
Embodiment 3
Embodiment 3 is substantially the same manner as Example 1, and difference is that in system, two strands of material meets arrange injector, aspirate another strand of material by one material.
Embodiment 4
Embodiment 4 is substantially the same manner as Example 1, and difference is with the still kettle surrogate response rectifying tower 3 with whipping appts.
Claims (2)
1. a serialization preparation facilities for N-pyrrolidone acetate, is characterized in that described device comprises material mixer (1), tubular type salt-forming reactor (2), reactive distillation column (3), supplements solvent mixing tank (4), tubular type condensation reactor (5), equipment room connection line, control instruments and annex; Material mixer (1), tubular type salt-forming reactor (2), to supplement solvent mixing tank (4), tubular type condensation reactor (5) be tube type apparatus with or without chuck, and arranging in pipe or not arranging has moving and static mixing element of disturbance mixing effect to material.
2. the serialization preparation facilities of a kind of N-pyrrolidone acetate according to claim 1, is characterized in that reactive distillation column (3) is for conventional distillation still.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201520110450.6U CN204702685U (en) | 2015-02-16 | 2015-02-16 | A kind of serialization preparation facilities of N-pyrrolidone acetate |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201520110450.6U CN204702685U (en) | 2015-02-16 | 2015-02-16 | A kind of serialization preparation facilities of N-pyrrolidone acetate |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN204702685U true CN204702685U (en) | 2015-10-14 |
Family
ID=54282317
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201520110450.6U Active CN204702685U (en) | 2015-02-16 | 2015-02-16 | A kind of serialization preparation facilities of N-pyrrolidone acetate |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN204702685U (en) |
-
2015
- 2015-02-16 CN CN201520110450.6U patent/CN204702685U/en active Active
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant |