CN204699077U - A kind of RTP container and online sterilizing and online dry device - Google Patents
A kind of RTP container and online sterilizing and online dry device Download PDFInfo
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- CN204699077U CN204699077U CN201520419035.9U CN201520419035U CN204699077U CN 204699077 U CN204699077 U CN 204699077U CN 201520419035 U CN201520419035 U CN 201520419035U CN 204699077 U CN204699077 U CN 204699077U
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Abstract
The utility model discloses a kind of RTP container and comprise online sterilizing and the online dry device of this RTP container.Current RTP container wholely must be put in sterilizing cabinet and do off-line sterilizing, and the drying system carried by sterilizing cabinet is just difficult to accomplish bone dry, can not meet and have the strict technological requirement controlled to article aridity.The feature of this utility model RTP container is, on the cavity of passive door, have an air inlet and connect an air inlet diaphragm valve, the bottom of cavity has an air vent and connects an air vent diaphragm valve; The lateral wall of described cavity covers a detachable heat-insulating layer, described passive door is stamped the pressure protect lid of a high pressure resistant steam sterilization pressure.RTP container of the present utility model is applicable to carrying out online sterilizing and online dry.
Description
Technical field
This utility model relates to pharmaceutical machine steam sterilization techniques field, is specifically a kind ofly applied to the RTP container of the aseptic material transmission of the industries such as pharmacy, biology, food and comprises online sterilizing and the online dry device of this RTP container.
Background technology
In the process of producing product of the industries such as pharmacy, biology, food, frequent needs are under non-sterile production environment, article after sterilizing are passed to another sterilized space from a sterilized space, in transmittance process, also need the aseptic condition maintaining article, such as the aseptic material in sterilizing cabinet is delivered in sterile filling isolator.
At present, most extensive use is RTP (Rapid Transfer Port) fast transfer gate technique.The RTP door of complete set is made up of alpha door (also claiming active door) and beta door (also claiming passive door), wherein alpha door is generally arranged on the wall of isolator, RABS or Biohazard Safety Equipment, beta door is then arranged on the discharging opening of the container holding article, and therefore this container is also referred to as RTP container.
The bottom of RTP container is provided with an aseptic level filter of hydrophobicity, can allow saturated vapor through, therefore whole RTP container just can put into sterilizing in sterilizing cabinet.
The disinfecting action flow process of current RTP container is as follows: first, by needing the article of sterile transfer (comprise the tool of production, glass drying oven, packaging material etc. any can the article of steam sterilization) to load in RTP container, covers beta door;
Secondly, whole RTP container is put into devaporation sterilizing in sterilizing cabinet;
Then, take out the RTP container that sterilizing is good, the beta door of its discharging opening is docked to (isolator sterilizing is in advance good, stand-by) on the alpha door of isolator, and locks;
Finally, by the glove on isolator, open a whole set of RTP door in isolator inside, thus be communicated with two sterilized spaces, sterilizing article is transferred in isolator fast in RTP container.
Although said method is widely used, but its defect is that RTP container must wholely be put in sterilizing cabinet and does off-line sterilizing, this needs for some the article (such as plug and vial etc.) doing finish-drying process after sterilization, the drying system carried by sterilizing cabinet is just difficult to accomplish bone dry, can not meet and have the strict technological requirement controlled to article aridity.
Utility model content
Technical problem to be solved in the utility model is the defect overcoming the existence of above-mentioned prior art, provides the RTP container that a kind of structure is improved, makes RTP container can be applicable to carrying out online sterilizing and online dry.
For this reason, this utility model adopts following technical scheme: a kind of RTP container, comprise the cavity of high pressure resistant steam sterilization pressure and be arranged on the passive door of cavity discharge outlet, it is characterized in that, on the cavity of passive door, have an air inlet and connect an air inlet diaphragm valve, the bottom of cavity has an air vent and connects an air vent diaphragm valve;
The lateral wall of described cavity covers a detachable heat-insulating layer, described passive door is stamped the pressure protect lid of a high pressure resistant steam sterilization pressure.
This utility model eliminates the filter being arranged on RTP container bottom in existing RTP structure of container, and aerofluxus and draining are all undertaken by air vent diaphragm valve.Cavity of the present utility model and pressure protect lid need resistance to more than 0.1MPa saturated vapor sterilization pressure.
Another object of the present utility model is to provide the online sterilizing and online dry device that comprise above-mentioned RTP container, the device of online sterilizing and online dry can be carried out to RTP container, it can carry out finish-drying process to article after sterilizing, has the strict technological requirement controlled to meet to the aridity of article after sterilizing.
For this reason, the technical scheme that another object of this utility model adopts is as follows: the online sterilizing of RTP container and online dry device, comprise above-mentioned RTP container, it is characterized in that, it also comprises conveyance conduit, clean steam system, clean pressure air system, vacuum system, air heating system, sterile air filtration system, safe pressure relief device and hydrophobic, draining and gas extraction system, and described hydrophobic, draining and gas extraction system comprise discharge tube;
The air vent diaphragm valve of described RTP container by silica gel hose with connect clip soon and be connected with discharge tube;
The input of described conveyance conduit establishes described vacuum system and clean pressure air system, the outfan of conveyance conduit by silica gel hose with connect clip soon and be connected with the air inlet diaphragm valve of RTP container, establish described air heating system, sterile air filtration system, clean steam system and safe pressure relief device between the input of conveyance conduit and outfan successively;
Described clean pressure air system is used for providing clean compressed air to RTP container, described air heating system heats clean compressed air, sterile air filtration system carries out aseptic filtration to the clean compressed air after heating, described clean steam system is used for providing clean steam to RTP container and sterile air filtration system, described is hydrophobic, draining and gas extraction system are used for the condensed water will produced during the sterilizing of sterile air filtration system, the clean compressed air passed into when the condensed water produced during sterilizing in RTP container and drying in RTP container is discharged, described vacuum system carries out vacuum drying for the vacuum in control RTP container, described safe pressure relief device is used for pressure release during superpressure, ensures safety when the online sterilizing of RTP container and online dry device use.
Further, described clean pressure air system comprises clean compressed air conveyance conduit and the air relief valve be arranged on clean compressed air conveyance conduit and the first diaphragm valve.
Further, described vacuum system comprises vacuum handling pipeline and is arranged on vacuum pump, check-valves and the second diaphragm valve on vacuum handling pipeline.
Further, the Pressure gauge that described sterile air filtration system comprises stainless steel filter housing, is placed in the degerming level hydrophobicity filter element in housing and is arranged on housing.
Further, described clean steam system comprises clean steam conveyance conduit and is arranged on the steam rates control valve on clean steam conveyance conduit.
Further, described hydrophobic, draining and gas extraction system also comprise condensed water drain water piping, be arranged on the first drain valve on condensed water drain water piping and the 3rd diaphragm valve and the drain valve be arranged on discharge tube and the second drain valve, and described sterile air filtration system is connected with discharge tube by described condensed water drain water piping.
Further, described online sterilizing and online dry device also comprise a switch board, this switch board band PLC, man machine operation interface and control software design, described conveyance conduit is provided with pressure probe and pressure transducer, described discharge tube and condensed water drain water piping are respectively equipped with temperature probe and sensor, and the whole operation of the online sterilizing of RTP container and online dry device controls valves such as (adopt air-driven type) all diaphragm valves, drain valve, control valves automatically by PLC.
The beneficial effect that this utility model has is as follows: the online sterilizing and the online dry that achieve RTP container, and sterilization effect is better; Sterilizing intensification and temperature-fall period shorten, and sterilizing speed is faster; Vacuum drying and hot air blowing can hocket, and drying is more thorough, is suitable for technique article aridity being had to strict demand; Whole operating process can be controlled automatically by PLC, more meets the requirement of drugs manufacture equipment automatization.
Accompanying drawing explanation
Fig. 1 is the structural representation of this utility model RTP container.
In figure, 100-cavity, 101-passive door (i.e. Beta door), 102-pressure protect lid, 103-air inlet diaphragm valve, 104-air vent diaphragm valve, 105-detachable heat-insulating layer.
Fig. 2 is the schematic diagram of the online sterilizing of this utility model RTP container and online dry device.
In figure, 200-conveyance conduit, 201-silica gel hose, 202-pressure transducer, 203-safe pressure relief device, 204-clean steam conveyance conduit, 205-sterile air filtration system, 206-clean compressed air conveyance conduit, 207-vacuum system, 208-air heating system, 209-temperature probe and sensor, 210-is hydrophobic, draining and gas extraction system, 211-clean pressure air system, 212-clean steam system, 213-discharge tube, 214-connects clip soon, 215-air relief valve, 216-first diaphragm valve, 217-vacuum handling pipeline, 218-vacuum pump, 219-check-valves, 220-second diaphragm valve, 221-steam rates control valve, 222-condensed water drain water piping, 223-first drain valve, 224-the 3rd diaphragm valve, 225-drain valve, 226-second drain valve.
Detailed description of the invention
Below in conjunction with specification drawings and specific embodiments, this utility model is further described.
RTP container as shown in Figure 1, cavity 100 discharge outlet of high pressure resistant steam sterilization pressure is equipped with passive door 101, on the cavity of passive door, have air inlet and connect air inlet diaphragm valve 103, the bottom of cavity has air vent and connects air vent diaphragm valve 104.The lateral wall of cavity 100 covers detachable heat-insulating layer 105, described passive door is stamped the pressure protect lid 102 of high pressure resistant steam sterilization pressure.Described cavity 100 and pressure protect lid 102 all above saturated vapor sterilization pressure of ability 0.1MPa.Described detachable heat-insulating layer 105 is common heat-insulation layer or electric heating type heat-insulation layer.
The online sterilizing of RTP container as shown in Figure 2 and online dry device, hydrophobic, draining and gas extraction system 210 by discharge tube 213, condensed water drain water piping 222, be arranged on the first drain valve 223 on condensed water drain water piping and the 3rd diaphragm valve 224 and the drain valve 225 be arranged on discharge tube and the second drain valve 226 and form.
Air vent diaphragm valve 104 by silica gel hose 201 with connect clip 214 soon and be connected with discharge tube 213.The input of conveyance conduit 200 is provided with vacuum system 207 and clean pressure air system 211, the outfan of conveyance conduit 200 by silica gel hose 201 with connect clip 214 soon and be connected with the air inlet diaphragm valve 103 of RTP container, be provided with air heating system 208, sterile air filtration system 205, clean steam system 212 and safe pressure relief device 203 between the input of conveyance conduit 200 and outfan successively.
Sterile air filtration system 205 is connected with discharge tube 213 by condensed water drain water piping 222.Described sterile air filtration system 205 by stainless steel filter housing, be placed in degerming level hydrophobicity filter element in housing and the Pressure gauge be arranged on housing forms.
Described clean pressure air system 211 provides clean compressed air for giving RTP container, described air heating system 208 pairs of clean compressed airs heat, sterile air filtration system 205 carries out aseptic filtration to the clean compressed air after heating, described clean steam system 212 provides clean steam for giving RTP container and sterile air filtration system, described is hydrophobic, draining and the condensed water of gas extraction system 210 for producing during the sterilizing of sterile air filtration system, the clean compressed air passed into when the condensed water produced during sterilizing in RTP container and drying in RTP container is discharged, described vacuum system 207 carries out vacuum drying for the vacuum in control RTP container, described safe pressure relief device 203, for pressure release during superpressure, ensures safety when the online sterilizing of RTP container and online dry device use.
Described clean pressure air system 211 is made up of clean compressed air conveyance conduit 206 and the air relief valve 215 be arranged on clean compressed air conveyance conduit and the first diaphragm valve 216.Clean compressed air can adopt clean nitrogen to replace, and the inert gas of other cleanings also can be adopted to replace.
Described vacuum system 207 is made up of vacuum handling pipeline 217 and vacuum pump 218, check-valves 219 and the second diaphragm valve 220 be arranged on vacuum handling pipeline.Described air heating system 208 adopts steam indirect heat exchange mode to carry out heating or directly carrying out electrical heating.
Described clean steam system 212 is made up of clean steam conveyance conduit 204 and the steam rates control valve 221 be arranged on clean steam conveyance conduit.Described safe pressure relief device 203 is relief valve or rupture disk.
Described online sterilizing and online dry device also comprise a switch board, this switch board band PLC, man machine operation interface and control software design, described conveyance conduit 200 is provided with pressure probe and pressure transducer 202, described discharge tube 213 and condensed water drain water piping 222 are respectively equipped with temperature probe and sensor 209, and the whole operation of online sterilizing and online dry device controls valves such as (adopt air-driven type) all diaphragm valves, drain valve, control valves automatically by PLC.
The using method of the online sterilizing of above-mentioned RTP container and online dry device is as follows:
A. by needing the article of sterile transfer (comprise the tool of production, glass drying oven, packaging material etc. any can the article of steam sterilization) to load in the cavity 100 of RTP container, covering beta door 101, covering pressure protect lid 102, wrapping detachable heat-insulating layer 105.
B. connect clean steam, industrial steam, clean compressed air and instrument gas, connect control system power supply;
C. by sanitation-grade silica gel hose 201, the air inlet diaphragm valve 103 and air vent diaphragm valve 104 that are mounted with the RTP container cavity 100 of article subject to sterilization being connected respectively to the outfan of conveyance conduit 200 and the incoming end of discharge tube 213, clamping with connecing clip 214 soon;
D. the online sterilizing of RTP container and online dry program is started:
D1) open clean pressure air system 206 and respective valves, carry out air-leakage test to whole device, it is qualified to guarantee;
D2) start vacuum system 207, setting value is evacuated down to RTP container 100 and sterile air filtration system 205;
D3) open the ratio adjusting valve 221 on clean steam conveyance conduit 204, setting value is pressurized to RTP container cavity 100 and filter 205;
D4) d2 is repeated)-d3) process 3 times, get rid of the non-condensing gas in RTP container 100 and sterile air filtration system 205;
D5) open the ratio adjusting valve 221 on clean steam conveyance conduit 204, pass into steam and RTP container cavity 100 and sterile air filtration system 205 are heated up; When starting sterilometer after being warmed up to 121 DEG C;
D6), after terminating during sterilometer, start vacuum system 207, evacuation drying is carried out to RTP container cavity 100;
D7) start clean pressure air system 211 and air heating system 208, hot air blowing is carried out to RTP container cavity 100;
D8) d6-d7 process 3 times are repeated, the article in finish-drying RTP container cavity 100;
E. drying terminates all valves of rear closedown, takes apart and connects clip soon and disconnect silica gel hose 201, takes off sterilized RTP container, stand-by.
Below be only described with regard to this utility model preferred embodiment, but can not be interpreted as it is limitations on claims.This utility model is not only confined to above embodiment, and its concrete structure allows to change.All various changes done in the protection domain of this utility model independent claims are all in protection domain of the present utility model.
Claims (8)
1. a RTP container, comprise the cavity (100) of high pressure resistant steam sterilization pressure and be arranged on the passive door (101) of cavity discharge outlet, it is characterized in that, on the cavity of passive door, have an air inlet and connect an air inlet diaphragm valve (103), the bottom of cavity has an air vent and connects an air vent diaphragm valve (104);
The lateral wall of described cavity (100) covers a detachable heat-insulating layer (105), described passive door is stamped the pressure protect lid (102) of a high pressure resistant steam sterilization pressure.
The online sterilizing of 2.RTP container and online dry device, comprise RTP container according to claim 1, it is characterized in that, it also comprises conveyance conduit (200), clean steam system (212), clean pressure air system (211), vacuum system (207), air heating system (208), sterile air filtration system (205), safe pressure relief device (203) and hydrophobic, draining and gas extraction system (210), and described hydrophobic, draining and gas extraction system (210) comprise discharge tube (213);
The air vent diaphragm valve (104) of described RTP container by silica gel hose (201) with connect clip (214) soon and be connected with discharge tube (213);
The input of described conveyance conduit (200) establishes described vacuum system (207) and clean pressure air system (211), the outfan of conveyance conduit (200) by silica gel hose (201) with connect clip (214) soon and be connected with the air inlet diaphragm valve (103) of RTP container, establish described air heating system (208), sterile air filtration system (205), clean steam system (212) and safe pressure relief device (203) between the input of conveyance conduit (200) and outfan successively;
Described clean pressure air system (211) provides clean compressed air for giving RTP container, described air heating system (208) heats clean compressed air, sterile air filtration system (205) carries out aseptic filtration to the clean compressed air after heating, described clean steam system (212) provides clean steam for giving RTP container and sterile air filtration system (205), described is hydrophobic, draining and the condensed water of gas extraction system (210) for producing during sterile air filtration system (205) sterilizing, the clean compressed air passed into when the condensed water produced during sterilizing in RTP container and drying in RTP container is discharged, described vacuum system (207) carries out vacuum drying for the vacuum in control RTP container, described safe pressure relief device (203), for pressure release during superpressure, ensures safety when the online sterilizing of RTP container and online dry device use.
3. the online sterilizing of RTP container according to claim 2 and online dry device, it is characterized in that, described clean pressure air system (211) comprises clean compressed air conveyance conduit (206) and the air relief valve (215) that is arranged on clean compressed air conveyance conduit and the first diaphragm valve (216).
4. the online sterilizing of RTP container according to claim 2 and online dry device, it is characterized in that, described vacuum system (207) comprises vacuum handling pipeline (217) and is arranged on vacuum pump (218), check-valves (219) and the second diaphragm valve (220) on vacuum handling pipeline.
5. the online sterilizing of RTP container according to claim 2 and online dry device, it is characterized in that, the Pressure gauge that described sterile air filtration system (205) comprises stainless steel filter housing, is placed in the degerming level hydrophobicity filter element in housing and is arranged on housing.
6. the online sterilizing of RTP container according to claim 2 and online dry device, it is characterized in that, described clean steam system (212) comprises clean steam conveyance conduit (204) and is arranged on the steam rates control valve (221) on clean steam conveyance conduit.
7. the online sterilizing of RTP container according to claim 2 and online dry device, it is characterized in that, described hydrophobic, draining and gas extraction system (210) also comprise condensed water drain water piping (222), be arranged on the first drain valve (223) on condensed water drain water piping and the 3rd diaphragm valve (224) and the drain valve (225) be arranged on discharge tube and the second drain valve (226), and described sterile air filtration system (205) is connected with discharge tube (213) by described condensed water drain water piping (222).
8. the online sterilizing of RTP container according to claim 2 and online dry device, it is characterized in that, it also comprises a switch board, this switch board band PLC, man machine operation interface and control software design, described conveyance conduit (200) is provided with pressure probe and pressure transducer (202), described discharge tube (213) and condensed water drain water piping (222) are respectively equipped with temperature probe and sensor (209), and the whole operation of the online sterilizing of RTP container and online dry device is controlled automatically by PLC.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201520419035.9U CN204699077U (en) | 2015-06-17 | 2015-06-17 | A kind of RTP container and online sterilizing and online dry device |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201520419035.9U CN204699077U (en) | 2015-06-17 | 2015-06-17 | A kind of RTP container and online sterilizing and online dry device |
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| CN204699077U true CN204699077U (en) | 2015-10-14 |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105423740A (en) * | 2015-11-30 | 2016-03-23 | 桂林斯壮微电子有限责任公司 | Baking oven with double-protection function |
| CN105823307A (en) * | 2016-03-24 | 2016-08-03 | 袁静 | Laboratory asphalt water content detecting quick dryer |
| CN106310302A (en) * | 2015-06-17 | 2017-01-11 | 浙江医药股份有限公司新昌制药厂 | RTP container and online sterilization and online drying device comprising RTP container and use method thereof |
| CN107846941A (en) * | 2015-07-21 | 2018-03-27 | Cj第制糖株式会社 | Article bactericidal unit including reinforcement |
| CN109620118A (en) * | 2018-11-17 | 2019-04-16 | 尹振华 | A kind of gynemetrics's clinic detects the integrated equipment for the treatment of |
-
2015
- 2015-06-17 CN CN201520419035.9U patent/CN204699077U/en active Active
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106310302A (en) * | 2015-06-17 | 2017-01-11 | 浙江医药股份有限公司新昌制药厂 | RTP container and online sterilization and online drying device comprising RTP container and use method thereof |
| CN107846941A (en) * | 2015-07-21 | 2018-03-27 | Cj第制糖株式会社 | Article bactericidal unit including reinforcement |
| CN107846941B (en) * | 2015-07-21 | 2020-12-25 | Cj第一制糖株式会社 | Sterilization device comprising reinforcing ribs |
| CN105423740A (en) * | 2015-11-30 | 2016-03-23 | 桂林斯壮微电子有限责任公司 | Baking oven with double-protection function |
| CN105823307A (en) * | 2016-03-24 | 2016-08-03 | 袁静 | Laboratory asphalt water content detecting quick dryer |
| CN109620118A (en) * | 2018-11-17 | 2019-04-16 | 尹振华 | A kind of gynemetrics's clinic detects the integrated equipment for the treatment of |
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Effective date of registration: 20171208 Address after: No. 125, Yue Zhong Road, Binhai New Town, Shaoxing, Zhejiang Province Patentee after: Zhejiang innovation biology Co., Ltd. Address before: No. 59, Chengguan Town, Xinchang County, Shaoxing, Zhejiang Province, around Chengguan East Road Patentee before: Xinchang Pharmaceutical Factory, Zhejiang Medicine Co., Ltd. |