CN204500833U - Inhibitors of metalloproteinase coating degradable intestinal stent - Google Patents
Inhibitors of metalloproteinase coating degradable intestinal stent Download PDFInfo
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- CN204500833U CN204500833U CN201420811129.6U CN201420811129U CN204500833U CN 204500833 U CN204500833 U CN 204500833U CN 201420811129 U CN201420811129 U CN 201420811129U CN 204500833 U CN204500833 U CN 204500833U
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- metalloproteinase
- inhibitors
- siphunculus
- colon
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- 230000000968 intestinal effect Effects 0.000 title claims abstract description 17
- 102000005741 Metalloproteases Human genes 0.000 title claims abstract description 14
- 108010006035 Metalloproteases Proteins 0.000 title claims abstract description 14
- 239000003112 inhibitor Substances 0.000 title claims abstract description 12
- 239000011248 coating agent Substances 0.000 title claims abstract description 7
- 238000000576 coating method Methods 0.000 title claims abstract description 7
- 210000001072 colon Anatomy 0.000 claims abstract description 11
- 210000000988 bone and bone Anatomy 0.000 claims abstract description 5
- 239000000463 material Substances 0.000 claims abstract description 5
- 239000002861 polymer material Substances 0.000 claims abstract description 4
- 230000035876 healing Effects 0.000 abstract description 8
- 102000008186 Collagen Human genes 0.000 description 12
- 108010035532 Collagen Proteins 0.000 description 12
- 229920001436 collagen Polymers 0.000 description 12
- 238000000034 method Methods 0.000 description 12
- 230000003872 anastomosis Effects 0.000 description 8
- SGKRLCUYIXIAHR-AKNGSSGZSA-N (4s,4ar,5s,5ar,6r,12ar)-4-(dimethylamino)-1,5,10,11,12a-pentahydroxy-6-methyl-3,12-dioxo-4a,5,5a,6-tetrahydro-4h-tetracene-2-carboxamide Chemical compound C1=CC=C2[C@H](C)[C@@H]([C@H](O)[C@@H]3[C@](C(O)=C(C(N)=O)C(=O)[C@H]3N(C)C)(O)C3=O)C3=C(O)C2=C1O SGKRLCUYIXIAHR-AKNGSSGZSA-N 0.000 description 7
- 229960003722 doxycycline Drugs 0.000 description 7
- 230000000694 effects Effects 0.000 description 6
- 102000002274 Matrix Metalloproteinases Human genes 0.000 description 4
- 108010000684 Matrix Metalloproteinases Proteins 0.000 description 4
- 230000002980 postoperative effect Effects 0.000 description 4
- 206010050456 Anastomotic leak Diseases 0.000 description 3
- 230000015556 catabolic process Effects 0.000 description 2
- 238000006731 degradation reaction Methods 0.000 description 2
- 239000000835 fiber Substances 0.000 description 2
- 229920002521 macromolecule Polymers 0.000 description 2
- 230000035755 proliferation Effects 0.000 description 2
- 102000010911 Enzyme Precursors Human genes 0.000 description 1
- 108010062466 Enzyme Precursors Proteins 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 239000004100 Oxytetracycline Substances 0.000 description 1
- 206010068676 Pneumoretroperitoneum Diseases 0.000 description 1
- 208000005727 Retropneumoperitoneum Diseases 0.000 description 1
- 239000004098 Tetracycline Substances 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 206010003246 arthritis Diseases 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000001523 electrospinning Methods 0.000 description 1
- 238000010041 electrostatic spinning Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 210000002950 fibroblast Anatomy 0.000 description 1
- 210000003736 gastrointestinal content Anatomy 0.000 description 1
- 210000001035 gastrointestinal tract Anatomy 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 238000001746 injection moulding Methods 0.000 description 1
- 210000000936 intestine Anatomy 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000003771 matrix metalloproteinase inhibitor Substances 0.000 description 1
- 229940121386 matrix metalloproteinase inhibitor Drugs 0.000 description 1
- IWVCMVBTMGNXQD-PXOLEDIWSA-N oxytetracycline Chemical compound C1=CC=C2[C@](O)(C)[C@H]3[C@H](O)[C@H]4[C@H](N(C)C)C(O)=C(C(N)=O)C(=O)[C@@]4(O)C(O)=C3C(=O)C2=C1O IWVCMVBTMGNXQD-PXOLEDIWSA-N 0.000 description 1
- 229960000625 oxytetracycline Drugs 0.000 description 1
- 235000019366 oxytetracycline Nutrition 0.000 description 1
- 201000001245 periodontitis Diseases 0.000 description 1
- 229920000747 poly(lactic acid) Polymers 0.000 description 1
- 239000004626 polylactic acid Substances 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 238000010254 subcutaneous injection Methods 0.000 description 1
- 239000007929 subcutaneous injection Substances 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 210000004876 tela submucosa Anatomy 0.000 description 1
- IWVCMVBTMGNXQD-UHFFFAOYSA-N terramycin dehydrate Natural products C1=CC=C2C(O)(C)C3C(O)C4C(N(C)C)C(O)=C(C(N)=O)C(=O)C4(O)C(O)=C3C(=O)C2=C1O IWVCMVBTMGNXQD-UHFFFAOYSA-N 0.000 description 1
- 235000019364 tetracycline Nutrition 0.000 description 1
- 150000003522 tetracyclines Chemical class 0.000 description 1
- 229940040944 tetracyclines Drugs 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
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- Materials For Medical Uses (AREA)
- Prostheses (AREA)
Abstract
Inhibitors of metalloproteinase coating degradable intestinal stent, comprise the intestinal stent body made with degradable high polymer material, described stake body is siphunculus shape, the middle part of described siphunculus is straight tube-like, two ends are the flare openings expanded gradually, the middle part of described straight tube-like and the connecting portion of flare openings have the bulge loop for tying up one of both sides colon to be anastomosed, the outer surface at the middle part of described siphunculus forms the identical section of creeping of the colon broken ends of fractured bone of both sides, and the surface coverage of described stake body has inhibitors of metalloproteinase material layer.The healing rate of anastomotic stoma can be accelerated.
Description
Technical field
This utility model relates to a kind of support for bowel anastomosis.
Background technology
Bowel anastomosis method mainly manual suture jacquard CAD and Anastomat hemorrhoidal circumcision method two kinds conventional at present.Manual suture jacquard CAD is time-honored identical method, adopts silk thread or absorbable thread to complete by hand, operates more loaded down with trivial details, the time of coincideing is long, have certain anastomotic leakage transmission rate, but this identical method cost being low, is that the primary bowel of economically less developed region coincide method.Anastomat hemorrhoidal circumcision method uses anastomat to complete bowel anastomosis, and method of coincideing is simple, and the time that coincide is short, but anastomat price is high, leaves metallic foreign body throughout one's life in gentle pneumoretroperitoneum, and needs to open anastomat insert port in addition, increases wound.Because in these identical methods, intestinal contents directly contacts with anastomotic stoma, the complication rates such as anastomotic leakage are high.
No. 2007100712082, patent of invention proposes a kind of " anastomosis bracket of colon bundling type ", solves the problems referred to above.But the healing rate of anastomotic stoma is still fast not.Anastomotic healing is the process that a collage synthesis and degradation dynamic balance.Collagen fiber are mainly positioned at tela submucosa, are the main components maintaining digestive tract intensity, can be degraded by matrix metalloproteinase
[5].Anastomotic position collagen content, through first reducing the change procedure raised afterwards, can be divided into collagen decomposition phase, Collagen Proliferation phase and collagen transformation phase.Postoperative wounded tissue matrix metalloproteinase locally immediately content increases, increased activity, and collagen decomposes in a large number, and content reduces gradually, and anastomotic stoma intensity reduces, and usually within postoperative 3rd day, reaches minimum
[6].From 5 days after operation, enter the Collagen Proliferation phase, anastomotic position fibroblast increases, and collagen content increases gradually, and reached peak in postoperative 10th day, anastomotic stoma intensity strengthens rapidly.Perform the operation 10 days is that collagen transforms the phase later, and collagen fiber are ripe gradually, and collagen selective absorbs restructuring, and anastomotic stoma intensity enters stable phase
[7 , 8].Matrix metalloproteinase comparatively obviously raises at other position of intestinal in the activity of stoma site
[9], especially after anastomotic leakage occurs, it is expressed and activity increases more obvious
[6].
Summary of the invention
This utility model will overcome the above-mentioned shortcoming of prior art, provides the bowel anastomosis support that a kind of healing rate of anastomotic stoma is fast.
Inhibitors of metalloproteinase coating degradable intestinal stent described in the utility model, comprise the intestinal stent body made with degradable high polymer material, described stake body is siphunculus shape, the middle part of described siphunculus is straight tube-like, two ends are the flare openings expanded gradually, the middle part of described straight tube-like and the connecting portion of flare openings have the bulge loop for tying up one of both sides colon to be anastomosed, the outer surface at the middle part of described siphunculus forms the identical section of creeping of the colon broken ends of fractured bone of both sides, it is characterized in that: the surface coverage of described stake body has doxycycline material layer.
Inhibitors of metalloproteinase doxycycline has another name called doxycycline, is a kind of semi-synthetic long-acting Tetracyclines broad ectrum antibiotic.Research finds that doxycycline is except antibacterial activity, is also the matrix metallo-proteinase inhibitor of wide spectrum, can play the effect suppressing matrix metalloproteinase in multiple links such as the secretion of proenzyme, activation and inhibitory enzyme activity
[1], at present in osteanagenesis
[2], periodontitis
[3], arthritis
[4]apply etc. in disease.
Existing research confirms to suppress the activity of metalloproteases to be the effective ways promoting anastomotic healing.Siemonsma etc. find subcutaneous injection doxycycline before rat intestine anastomosis, and postoperative 3rd day anastomotic stoma avulsion pressure comparatively matched group significantly improves
[10].
Adopt the methods combining of electrospinning in rack surface inhibitors of metalloproteinase doxycycline, after anastomotic stoma inserted by support, surface deoxidation oxytetracycline progressively discharges, and suppresses the metalloproteases that anastomotic stoma increases, thus suppress the degraded of collagen, be conducive to anastomotic healing.
The utility model has the advantages that: the healing rate that anastomotic stoma can be accelerated.
Accompanying drawing explanation
Fig. 1 is structural representation of the present utility model
Fig. 2 is the sectional view of Fig. 1
Detailed description of the invention
With reference to accompanying drawing 1,2:
Inhibitors of metalloproteinase coating degradable intestinal stent described in the utility model, comprise the intestinal stent body made with degradable high polymer material, described stake body is siphunculus shape, the middle part 1 of described siphunculus is in straight tube-like, two ends are the flare openings 2 expanded gradually, middle part 1 and the connecting portion of flare openings 2 of described straight tube-like have the bulge loop 3 for tying up one of both sides colon to be anastomosed, the outer surface at the middle part 1 of described siphunculus forms the identical section of creeping of the colon broken ends of fractured bone of both sides, the surface coverage of described stake body has inhibitors of metalloproteinase doxycycline material layer 4.
As shown in Figure 1, Figure 2, support intracavity footpath 20mm, central tubular, both sides flare, on support, the bulge loop (wide 1.5mm) of twice projection is in order to fixing intestinal tube for colon end to end anastomosis supporting structure of the present utility model.When coincideing, the both sides intestinal tube broken ends of fractured bone is enclosed within support both sides respectively, ties up fixing intestinal tube with silk thread in prominence.Both sides intestinal tube section, in the contact growth of longitudinal stent axis centre, completes colon end to end anastomosis after healing.
Manufacture degradable macromolecule intestinal stent by modes such as injection mouldings, then with the method for electrostatic spinning, inhibitors of metalloproteinase is coated above-mentioned rack surface, be made into coating stent of medicine.
Degradable macromolecule intestinal stent can select the degradation material comprising polylactic acid.
Claims (1)
1. inhibitors of metalloproteinase coating degradable intestinal stent, comprise the intestinal stent body made with degradable high polymer material, described stake body is siphunculus shape, the middle part of described siphunculus is straight tube-like, two ends are the flare openings expanded gradually, the middle part of described straight tube-like and the connecting portion of flare openings have the bulge loop for tying up one of both sides colon to be anastomosed, the outer surface at the middle part of described siphunculus forms the identical section of creeping of the colon broken ends of fractured bone of both sides, it is characterized in that: the surface coverage of described stake body has inhibitors of metalloproteinase material layer.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201420811129.6U CN204500833U (en) | 2014-12-18 | 2014-12-18 | Inhibitors of metalloproteinase coating degradable intestinal stent |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201420811129.6U CN204500833U (en) | 2014-12-18 | 2014-12-18 | Inhibitors of metalloproteinase coating degradable intestinal stent |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN204500833U true CN204500833U (en) | 2015-07-29 |
Family
ID=53698839
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|---|---|---|---|
| CN201420811129.6U Active CN204500833U (en) | 2014-12-18 | 2014-12-18 | Inhibitors of metalloproteinase coating degradable intestinal stent |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN204500833U (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106562844A (en) * | 2016-11-14 | 2017-04-19 | 东北农业大学 | Novel degradable supporter for intestinal canal anastomosis surgery |
| WO2017100977A1 (en) * | 2015-12-14 | 2017-06-22 | 北京阿迈特医疗器械有限公司 | Individualized polymer stent and manufacturing method therefor and use thereof |
| CN110327141A (en) * | 2019-07-22 | 2019-10-15 | 上海交通大学医学院附属仁济医院 | Degradable Colon and rectum internal bypass device and preparation method thereof |
| EP3785679A1 (en) * | 2019-08-27 | 2021-03-03 | Zhejiang University | A degradable intestinal diversion device |
-
2014
- 2014-12-18 CN CN201420811129.6U patent/CN204500833U/en active Active
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2017100977A1 (en) * | 2015-12-14 | 2017-06-22 | 北京阿迈特医疗器械有限公司 | Individualized polymer stent and manufacturing method therefor and use thereof |
| CN106562844A (en) * | 2016-11-14 | 2017-04-19 | 东北农业大学 | Novel degradable supporter for intestinal canal anastomosis surgery |
| CN110327141A (en) * | 2019-07-22 | 2019-10-15 | 上海交通大学医学院附属仁济医院 | Degradable Colon and rectum internal bypass device and preparation method thereof |
| EP3785679A1 (en) * | 2019-08-27 | 2021-03-03 | Zhejiang University | A degradable intestinal diversion device |
| US20210059676A1 (en) * | 2019-08-27 | 2021-03-04 | Zhejiang University | Degradable intestinal diversion device |
| WO2021036198A1 (en) * | 2019-08-27 | 2021-03-04 | 浙江大学 | Biodegradable enteric complete diversion stent |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20180521 Address after: 310058 zhe Da Road, Xihu District, Hangzhou, Zhejiang Province, No. 38 Patentee after: Zhejiang University Address before: 310016 Sir Run Run Shaw Hospital, 3 Qingchun East Road, Hangzhou, Zhejiang Patentee before: Cai Xiujun |
|
| TR01 | Transfer of patent right |