CN204411380U - A kind of blood-lipoids material specific adsorption device - Google Patents
A kind of blood-lipoids material specific adsorption device Download PDFInfo
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- CN204411380U CN204411380U CN201520022421.4U CN201520022421U CN204411380U CN 204411380 U CN204411380 U CN 204411380U CN 201520022421 U CN201520022421 U CN 201520022421U CN 204411380 U CN204411380 U CN 204411380U
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Abstract
This utility model relates to medical instruments field, specifically, relate to a kind of blood-lipoids material specific adsorption device, its adsorption filtration can be disposed by the means of the blood-lipoids rubbish in hyperlipemia blood by naturopathy, after eventually passing through multiple times of filtration absorption, the blood-lipoids rubbish in blood is reduced, until return to one's perfect health.Comprise: cavity body, with heparin lithium layer on the inwall of cavity body; The inside of described cavity body is loaded with the resin sorbent granule that macroporous strong basic styrene series anion exchange resin is made, and the surface of described resin sorbent granule is coated with sodium acetate crystal peplos; The two ends of described cavity body are provided with blood and can pass through, and the described sealing device at two ends is communicated with blood catheter respectively with the intransitable sealing device of the absorbent particles inside established.Can not produce heavy burden to the body of patient in the process of the blood-lipoids material specific adsorption device treatment that this utility model provides, safety is high, Be very effective, instant effect.
Description
Technical field
This utility model relates to medical instruments field, in particular to a kind of blood-lipoids material specific adsorption device.
Background technology
Blood fat is the general name of neutral fat and lipoid in blood plasma, comprise triglyceride, cholesterol, phospholipid, glycolipid, sterin, steroid, in extensive existence and human body, it is the required material of human life cell base metabolism, if but human body blood lipid level exceeds standard, too high levels, will be formed various because the high disease brought of blood fat, as: hyperlipidemia, high blood viscosity, fatty liver, diabetes etc. disease.Hyperlipemia is also one of wherein comparatively serious patient's condition, and the disease of the serious harm health that it can cause, as atherosclerosis, coronary heart disease, pancreatitis etc.
Set forth for hyperlipidemia emphasis below: hyperlipemia can be divided into constitutional and Secondary cases two class.Constitutional is relevant with heredity with congenital, due to single-gene defect or polygenes defect, make the receptor of the transhipment of participation lipoprotein and metabolism, enzyme or apolipoprotein caused by abnormal, or cause due to environmental factors (diet, nutrition, medicine) with by unknown mechanism.Secondary cases is multiple is born in metabolic disorder disease (diabetes, hypertension, myxedema, hypothyroidism, obesity, hepatorenal disease, adrenal cortex function are hyperfunction), or with other factor age, sex, season, drink, smoking, diet, physical exertion, psychentonia, emotional activity etc. be relevant.The clinical manifestation of hyperlipemia is the xanthoma of lipid caused by intradermal deposition and the arteriosclerosis of lipid caused by blood vessel endothelium deposition mainly.Although hyperlipemia can cause xanthoma, its incidence rate is also not bery high; And atherosclerotic generation and development are a kind of slowly progressive processes.Therefore under normal conditions, most of patients non-evident sympton and abnormal sign.Many people raise owing to just finding that there is blood plasma lipoprotein level when other reasons carries out blood biochemical inspection.
The above-mentioned disease means of current treatment comprise:
1. control the many epidemiologic data displays of ideal body weight, mean plasma cholesterol and the serum triglyceride level of obese people are significantly higher than non-obese person of the same age.Except Body Mass Index (BMI) and blood lipid level are except obvious positive correlation, the distribution of body fat is also in close relations with blood plasma lipoprotein level.In general, more easily there is hyperlipemia in centric obesity person.After the losing weight of overweight people, blood fat disorder also can recover normal.
2. motion exercise sports not only can strengthen cardio-pulmonary function, improve insulin resistant and glucose tolerance, but also can lose weight, reduce blood plasma triacylglycerol and cholesterol levels, raises HDL cholesterol level.
3. giving up smoking smoking can elevate plasma cholesterol and serum triglyceride level, reduces HDL-cholesterol levels.Stop smoking 1 year, plasma HDL-cholesterol can rise to the level of non-smoker, and the degree of danger of coronary heart disease can reduce by 50%, even close to non-smoker.
4. Diet Therapy blood plasma lipide is mainly derived from food, by keeping on a diet, blood plasma cholesterol level can be made to reduce by 5% ~ 10%, contribute to fat-reducing simultaneously.And make fat-reducing medicament give play to best effect.Most broad beta disease patient, by Diet Therapy, corrects the metabolism disorder that other coexist simultaneously, blood lipid level often can be made to be down to normally.
The Diet Therapy of hyperlipemia is the method by keeping on a diet, and while maintenance ideal body weight, reduces the LDL-cholesterol levels in blood plasma.Dietary structure directly can affect the height of blood lipid level.Blood plasma cholesterol level is subject to the impact of cholesterol intake in diet, and a large amount of satisfied fatty acid of taking food also can increase the synthesis of cholesterol.Usually, the cholesterol in the foods (particularly egg yolk and pluck) such as carnivorous, egg and milk product and saturated fatty acid content more, limes reacting dose is taken food.Edible oil should based on vegetable oil, and consumption is advisable with 25 ~ 30g for each person every day.Familial HypercholesterolemicPatients Patients should cholesterol in strict erstricted diet and fatty acid be taken in.
5. Drug therapy has Statins and resinae based on what reduce serum total cholesterol and LDL-C.The special class of shellfish and nicotinic acid class is had based on the medicine reducing serum triacylglycerol.
6. the patient of the non-drug therapy part dyslipidemia of severe dyslipidemia passes through the blood lipid regulation effect that adjustment diet all can reach more satisfactory with mode of making the life better, there is only a few blood lipid very high, be more common in the patient of gene genetic exception, can be treated by plasma purification, surgical intervention.Gene therapy will likely capture the genetic dyslipidemia of intractable in future.
Existing treatment means its produce little effect, and it is slow to take effect, and for various reasons, individual cannot adhere to for a long time, and causes Endodontic failure.
In view of more than, special this utility model is proposed.
Utility model content
The purpose of this utility model is to provide a kind of blood-lipoids material specific adsorption device, by the sodium acetate peplos of this adsorber and wherein the macroporous strong basic styrene series anionic exchange resin adsorbent that contains and adsorbent, by the unnecessary blood fat adsorption filtration in blood, the effect reducing blood fat in patient body fast can be reached by the means of naturopathy.
In order to realize above-mentioned purpose of the present utility model, spy by the following technical solutions::
A kind of blood-lipoids material specific adsorption device, comprising: cavity body, with heparin lithium layer on the inwall of cavity body;
The inside of described cavity body is loaded with the resin sorbent granule that macroporous strong basic styrene series anion exchange resin is made, and the surface of described resin sorbent granule is coated with sodium acetate crystal peplos;
The two ends of described cavity body are provided with blood and can pass through, and the described sealing device at two ends is communicated with blood catheter respectively with the intransitable sealing device of the absorbent particles inside established.
Usually the patient of hyperlipidemia is suffered from; the blood rubbish of blood-lipoids is mixed with all to some extent in its blood; these blood rubbish can cause the blood circulation in patient body not smooth; even produce the symptoms such as arteriosclerosis; the blood-lipoids material specific adsorption device that this utility model provides; its object is exactly the means of the blood-lipoids rubbish in hyperlipemia blood by naturopathy its adsorption filtration disposed; after eventually passing through multiple times of filtration absorption, the blood-lipoids rubbish in blood is reduced, until return to one's perfect health.Can not produce heavy burden to the body of patient in the process for the treatment of, safety is high, Be very effective, instant effect.
During use, the blood extracted out in patient body enters from one end of adsorber, flows out feed back back in patient body again from its other end.The blood rubbish of blood-lipoids is all present in blood plasma, when the blood plasma with blood-lipoids blood rubbish is by adsorber, because plasma protein positively charged, this just determines blood plasma positively charged, and the resin sorbent granule band basic group included is positive electricity, so after blood plasma contacts with absorbent particles, two like magnetic poles repel each other, the blood plasma of positively charged can be ostracised and be pushed the inwall direction of cavity body to, now can be attracted by the electronegative heparin lithium layer on inwall, at this moment after in blood plasma, blood-lipoids rubbish contacts because of the sodium acetate crystal peplos coated with absorbent particles top layer, it can expand, sour variable expansion met by blood-lipoids rubbish, volume becomes and cannot pass through from the drainage screen of adsorber bottom greatly, be forced to stay in adsorber.Not only because plus-minus electric gravitation cannot be greater than not containing the blood plasma of blood lipid rubbish but also together flowing out from adsorber with hemocyte of blood filtration impulsive force simultaneously after being first attracted, flow back to human body.Blood plasma enters adsorber and to be attracted by negative electricity and this flash be flushed away meets to lipid rubbish in blood plasma the response time that acid plumping reserves exactly.Finally, blood is in the process be filtered, and the blood rubbish of blood-lipoids is wherein by adsorption filtration, and the blood plasma of the health after only having hemocyte and being filtered flows back to human body again by adsorber, reach cleaning blood, alleviate or cure completely the effect of hyperlipidemia.
Meanwhile, be coated in the heparin lithium layer on the inwall of cavity body, it is a kind of anticoagulant, is the polymer be alternately formed by connecting by two kinds of polysaccharide, has blood coagulation resisting function in vivo and in vitro.Because heparin has the effect stoping thrombin to be formed, thus prevents platelet aggregation, thrombosis can not be formed in adsorber.And the general adsorber used time, must rush in advance after multipass makes its heparinization and could use with heparin solution, and this adsorber exempts from pre-punching.
Meanwhile, Lithium acid heparin is conventional anticoagulant heparin agent, and the sodium of heparin, potassium, lithium, ammonium salt are wherein best with Lithium acid heparin.Evenly with heparin lithium layer on the inwall of cavity body, heparin compositions in heparin lithium layer is a kind of mucopolysaccharide containing sulfate group, with powerful negative charge, the blood rubbish of the blood-lipoids of positively charged can be adsorbed, make it meet acid plumping if having time, prevent it from flowing out adsorber with blood.
Can realize in the process of adsorbing in order to cavity body can be made, resin sorbent granule wherein can not be dropped out, and can resin sorbent granule be loaded in cavity body, what cavity body can be sealed is fine simultaneously, be provided with blood at the two ends of cavity body and by, the intransitable sealing device of resin sorbent granule, the sealing device at two ends can be communicated with respectively the transmission that blood catheter carries out blood.
The blood-lipoids material specific adsorption device provided by this utility model effectively by the blood-lipoids rubbish adsorption removal in blood, finally can be reached cleaning blood, alleviates or cure completely the effect of hyperlipidemia.
Further, the thickness of described heparin lithium layer is 0.5-1mm.
Further, the particle diameter of each described resin sorbent granule is equal.
Further, the thicknesses of layers of described sodium acetate crystal peplos is 100-150nm.
Further, described sealing device comprises drainage screen and seal cover, and described seal cover is provided with blood access;
Described drainage screen is wrapped in the two ends of described cavity body, and described seal cover is located at the outermost at the two ends of described cavity body, and the inwall of described seal cover and the outer wall of described cavity body are tightly connected; Described blood catheter is communicated with described blood access respectively.
Further, the cumulative volume of described resin sorbent granule is greater than or equal to 1/2 of described cavity body volume.
Further, described resin sorbent granule is layered distribution in described cavity body.
Further, each described resin sorbent granule is uniform round shaped grain or the side's of being grain.
Further, the inwall welding of described blood catheter and described blood access.
Further, the inwall of described blood access is provided with the binding thread for being fastenedly connected with blood catheter.
Compared to the prior art, this utility model tool has the following advantages:
1) treatment of the various diseases that hyperlipidemia causes is applicable to;
2) take stopgap measures and effect a permanent cure, to human non-toxic's side effect, therapeutic effect is remarkable.
Accompanying drawing explanation
In order to be illustrated more clearly in this utility model detailed description of the invention or technical scheme of the prior art, be briefly described to the accompanying drawing used required in detailed description of the invention or description of the prior art below, apparently, accompanying drawing in the following describes is embodiments more of the present utility model, for those of ordinary skill in the art, under the prerequisite not paying creative work, other accompanying drawing can also be obtained according to these accompanying drawings.
The cross-sectional view of a kind of blood-lipoids material specific adsorption device that Fig. 1 provides for this utility model embodiment;
The cross sectional representation of the cavity body in a kind of blood-lipoids material specific adsorption device that Fig. 2 provides for this utility model embodiment;
The generalized section of the resin sorbent granule in a kind of blood-lipoids material specific adsorption device that Fig. 3 provides for this utility model embodiment;
Reference numeral:
1, cavity body, 2, heparin lithium layer, 3, resin sorbent granule, 4, sodium acetate crystal peplos, 5, sealing device, 6, drainage screen, 7, blood access, 8, blood catheter.
Detailed description of the invention
Be clearly and completely described the technical solution of the utility model below in conjunction with accompanying drawing, obviously, described embodiment is this utility model part embodiment, instead of whole embodiments.Based on the embodiment in this utility model, those of ordinary skill in the art are not making the every other embodiment obtained under creative work prerequisite, all belong to the scope of this utility model protection.
In description of the present utility model, it should be noted that, orientation or the position relationship of the instruction such as term " " center ", " on ", D score, "left", "right", " vertically ", " level ", " interior ", " outward " they be based on orientation shown in the drawings or position relationship; be only this utility model and simplified characterization for convenience of description; instead of instruction or imply the device of indication or element must have specific orientation, with specific azimuth configuration and operation, therefore can not be interpreted as restriction of the present utility model.In addition, term " first ", " second ", " the 3rd " only for describing object, and can not be interpreted as instruction or hint relative importance.
A kind of blood-lipoids material specific adsorption device that this utility model provides, comprising: cavity body 1, with heparin lithium layer 2 on the inwall of cavity body 1;
The inside of described cavity body 1 is loaded with the resin sorbent granule that macroporous strong basic styrene series anion exchange resin is made, and the surface of described resin sorbent granule 3 is coated with sodium acetate crystal peplos 4;
The two ends of described cavity body 1 are provided with blood and can pass through, and the intransitable sealing device 5 of the absorbent particles inside established, the described sealing device 5 at two ends is communicated with blood catheter 8 respectively.
Usually the patient of hyperlipidemia is suffered from; the blood rubbish of blood-lipoids is mixed with all to some extent in its blood; these blood rubbish can cause the blood circulation in patient body not smooth; even produce the symptoms such as arteriosclerosis; the blood-lipoids material specific adsorption device that this utility model provides; its object is exactly the means of the blood-lipoids rubbish in hyperlipemia blood by naturopathy its adsorption filtration disposed; after eventually passing through multiple times of filtration absorption, the blood-lipoids rubbish in blood is reduced, until return to one's perfect health.Can not produce heavy burden to the body of patient in the process for the treatment of, safety is high, Be very effective, instant effect.
During use, the blood extracted out in patient body enters from one end of adsorber, flows out feed back back in patient body again from its other end.The blood rubbish of blood-lipoids is all present in blood plasma, when the blood plasma with blood-lipoids blood rubbish is by adsorber, because plasma protein positively charged, this just determines blood plasma positively charged, and resin sorbent granule 3 is with basic group to be positive electricity, after blood plasma contacts with absorbent particles, two like magnetic poles repel each other, the blood plasma of positively charged can be ostracised and be pushed the inwall direction of cavity body 1 to, now can be attracted by the electronegative heparin lithium layer 2 on inwall, after blood-lipoids rubbish in blood plasma contacts because of the sodium acetate crystal peplos 4 coated with absorbent particles top layer, it can expand, blood-lipoids rubbish is met acid and can be expanded, volume becomes and cannot pass through from the drainage screen 6 of adsorber bottom greatly, be forced to stay in adsorber.Blood plasma enters adsorber and is first attracted by negative electricity and cannot be greater than the impulsive force of blood filtration because of plus-minus electric gravitation and be flushed away, and so healthy blood plasma flows back to human body again with hemocyte.Blood plasma enters adsorber and first to be attracted by negative electricity and this flash be flushed away meets to blood-lipoids rubbish in blood plasma the time difference that acid reaction reserves exactly.Finally, blood is in the process be filtered, and the blood rubbish of hyperlipidemia class is wherein by adsorption filtration, and the healthy blood plasma after only having hemocyte and being filtered flows back to human body again by adsorption column, reach cleaning blood, alleviate or cure completely the effect of hyperlipidemia.
Meanwhile, be coated in the heparin lithium layer 2 on the inwall of cavity body 1, it is a kind of anticoagulant, is the polymer be alternately formed by connecting by two kinds of polysaccharide, has blood coagulation resisting function in vivo and in vitro.Because heparin has the effect stoping thrombin to be formed, thus prevents platelet aggregation, thrombosis can not be formed in adsorber.And the general adsorber used time, must rush in advance after multipass makes its heparinization and could use with heparin solution, and this adsorber exempts from pre-punching.
Meanwhile, Lithium acid heparin is conventional anticoagulant heparin agent, and the sodium of heparin, potassium, lithium, ammonium salt are wherein best with Lithium acid heparin.Evenly with heparin lithium layer 2 on the inwall of cavity body 1, heparin compositions in heparin lithium layer 2 is a kind of mucopolysaccharide containing sulfate group, with powerful negative charge, the blood rubbish of the blood-lipoids of positively charged can be adsorbed, make it meet acid plumping, prevent it from flowing out adsorber with blood.
Can realize in the process of adsorbing in order to cavity body 1 can be made, resin sorbent granule 3 wherein can not be dropped out, and can resin sorbent granule 3 be loaded in cavity body 1, what cavity body 1 can be sealed is fine simultaneously, be provided with blood at the two ends of cavity body 1 and by, the intransitable sealing device 5 of resin sorbent granule 3, the sealing device 5 at two ends can be communicated with respectively the transmission that blood catheter 8 carries out blood.
The blood-lipoids material specific adsorption device provided by this utility model effectively by the blood-lipoids rubbish adsorption removal in blood, finally can be reached cleaning blood, alleviates or cure completely the effect of hyperlipidemia.
Preferably, the thickness of described heparin lithium layer 2 is 0.5-1mm.
In order to make between multiple resin sorbent granule 3 the more closely neat of arrangement, the particle diameter that can arrange each resin sorbent granule 3 is identical.Preferably, the particle diameter of each described resin sorbent granule 3 is equal.
Preferably, the thicknesses of layers of described sodium acetate crystal peplos 4 is 100-150nm.Preferably, described sealing device 5 comprises drainage screen 6 and seal cover, and described seal cover is provided with blood access 7;
Described drainage screen 6 is wrapped in the two ends of described cavity body 1, and described seal cover is located at the outermost at the two ends of described cavity body 1, and the inwall of described seal cover and the outer wall of described cavity body 1 are tightly connected; Described blood catheter 8 is communicated with described blood access 7 respectively.
In order to reach good adsorption efficiency, preferably, the cumulative volume of described resin sorbent granule 3 is greater than or equal to 1/2 of described cavity body 1 volume.
Preferably, described resin sorbent granule 3 is layered distribution in described cavity body 1.The particle diameter that also can arrange resin sorbent granule 3 is comparatively large, makes resin sorbent granule 3 in layered distribution.
Preferably, each described resin sorbent granule 3 is uniform round shaped grain or the side's of being grain.Preferably, conveniently process, each resin sorbent granule 3 is set and is uniform round shaped grain.Each resin sorbent granule 3 also can be set and be uniform side's grain.Or be the resin sorbent granule 3 of other any shape.
Preferably, the inwall welding of described blood catheter 8 and described blood access 7.In order to improve the seal be connected between cavity body 1 with blood catheter 8, the inwall welding of the blood access 7 on the outer wall of blood catheter 8 and cavity body 1 can be set.
Preferably, the inwall of described blood access 7 is provided with the binding thread for being fastenedly connected with blood catheter 8.In order to can at the initial stage arranging blood catheter 8, loose blood catheter 8 can not come off easily, the binding thread being used for being connected with blood catheter 8 can be set on the inwall of blood access 7, by this binding thread, blood catheter 8 and blood access 7 are fastenedly connected, carry out welding more afterwards.
Last it is noted that above each embodiment is only in order to illustrate the technical solution of the utility model, be not intended to limit; Although be described in detail this utility model with reference to foregoing embodiments, those of ordinary skill in the art is to be understood that: it still can be modified to the technical scheme described in foregoing embodiments, or carries out equivalent replacement to wherein some or all of technical characteristic; And these amendments or replacement, do not make the essence of appropriate technical solution depart from the scope of each embodiment technical scheme of this utility model.
Claims (10)
1. a blood-lipoids material specific adsorption device, is characterized in that, comprising: cavity body, with heparin lithium layer on the inwall of cavity body;
The inside of described cavity body is loaded with the resin sorbent granule that macroporous strong basic styrene series anion exchange resin is made, and the surface of described resin sorbent granule is coated with sodium acetate crystal peplos;
The two ends of described cavity body are provided with blood and can pass through, and the described sealing device at two ends is communicated with blood catheter respectively with the intransitable sealing device of the absorbent particles inside established.
2. blood-lipoids material specific adsorption device according to claim 1, is characterized in that,
The thickness of described heparin lithium layer is 0.5-1mm.
3. blood-lipoids material specific adsorption device according to claim 1, is characterized in that,
The particle diameter of each described resin sorbent granule is equal.
4. blood-lipoids material specific adsorption device according to claim 1, is characterized in that,
The thicknesses of layers of described sodium acetate crystal peplos is 100-150nm.
5. blood-lipoids material specific adsorption device according to claim 1, it is characterized in that, described sealing device comprises drainage screen and seal cover, and described seal cover is provided with blood access;
Described drainage screen is wrapped in the two ends of described cavity body, and described seal cover is located at the outermost at the two ends of described cavity body, and the inwall of described seal cover and the outer wall of described cavity body are tightly connected; Described blood catheter is communicated with described blood access respectively.
6. blood-lipoids material specific adsorption device according to claim 1, is characterized in that,
The cumulative volume of described resin sorbent granule is greater than or equal to 1/2 of described cavity body volume.
7. blood-lipoids material specific adsorption device according to claim 1, is characterized in that,
Described resin sorbent granule is layered distribution in described cavity body.
8. blood-lipoids material specific adsorption device according to claim 1, is characterized in that,
Each described resin sorbent granule is uniform round shaped grain or the side's of being grain.
9. blood-lipoids material specific adsorption device according to claim 1, is characterized in that,
The inwall welding of described blood catheter and described blood access.
10. blood-lipoids material specific adsorption device according to claim 1, is characterized in that,
The inwall of described blood access is provided with the binding thread for being fastenedly connected with blood catheter.
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| CN201520022421.4U CN204411380U (en) | 2015-01-13 | 2015-01-13 | A kind of blood-lipoids material specific adsorption device |
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| CN201520022421.4U CN204411380U (en) | 2015-01-13 | 2015-01-13 | A kind of blood-lipoids material specific adsorption device |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105771014A (en) * | 2016-03-29 | 2016-07-20 | 艾沃生物科技（苏州）有限公司 | Plasma filter capable of adsorbing OFR (oxygen free radical) |
| CN109045379A (en) * | 2018-07-12 | 2018-12-21 | 安陆恩彼饲料有限公司 | A kind of plasma purification method |
-
2015
- 2015-01-13 CN CN201520022421.4U patent/CN204411380U/en active Active
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105771014A (en) * | 2016-03-29 | 2016-07-20 | 艾沃生物科技（苏州）有限公司 | Plasma filter capable of adsorbing OFR (oxygen free radical) |
| CN109045379A (en) * | 2018-07-12 | 2018-12-21 | 安陆恩彼饲料有限公司 | A kind of plasma purification method |
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