CN204318949U

CN204318949U - Maxillary sinus biogel implantation body

Info

Publication number: CN204318949U
Application number: CN201420613828.XU
Authority: CN
Inventors: 耿建平; 陈锐; 郭峰; 邓斌
Original assignee: NANJING XINGJIE MEDICAL TECHNOLOGY Co Ltd
Current assignee: NANJING XINGJIE MEDICAL TECHNOLOGY Co Ltd
Priority date: 2014-10-22
Filing date: 2014-10-22
Publication date: 2015-05-13
Anticipated expiration: 2024-10-22

Abstract

This utility model provides a kind of maxillary sinus biogel implantation body, comprises implanting portion, base station, screw, gel and sterile packaging bottle, and implanting portion is hollow structure, and top, implanting portion and base station are linked together by screw.Wherein, implantation body and gel are packaged in sterile packaging bottle jointly, the top of implanting portion is provided with outer cap, the cervical region of implanting portion is provided with micro-screw thread, the lower surface of implanting portion is loose structure, and its hole wall has grain surface, and loose structure is connected with hollow structure inside, in loose structure and hollow structure, storage has the biogel in a large number with bone-inducing factor, is far superior to its concentration and release time current biological coating implantation body.This utility model has can induce osseous tissue initiatively to grow into the similar skeleton hollow structure of implantation body, can increase substantially implantation body-Xin bone and merges area and become bone strength, be applicable to the maxillary sinus implant operation under osteoporosis condition.

Description

Maxillary sinus biogel implantation body

Technical field

This utility model relates to a kind of dentistry implant, is specifically related to a kind of dentistry implant with the porous surface hollow structure inside of BMP gel solved under maxillary sinus osteoporosis condition, belongs to oral cavity implanting tooth field.

Background technology

In antral area, itself be hole cavity configuration be main, the bone quality and quantity at the bottom of hole is generally not good enough.Sinus floor is with the disappearance of backteeth, and alveolar process and alveolar bone basilar part serious absorption or absorb completely, decline at the bottom of hole, severe patient can be changed into consistent with residual alveolar ridge level thereupon, causes upper jaw bone severe atrophy.Carry out in the world after first Dental Implant from nineteen sixty-five, maxillary sinus plantation is excluded outside the strict indication formulated founder professor Branmark, is regarded as forbidden zone of performing the operation for a long time.1980, Boyne and James first reported the outer lift technique of maxillary sinus, and the doctor grasping oral maxillofacial surgery skill starts to dabble this field, but usually all needs the artificial bone meal of a large amount of filling.But Sinus floor sclerotin, based on the soft sclerotin of third and fourth class, very easily forms osteoporosis, under maxillary sinus osteoporosis condition, the easily failure of non-coating implantation body, various coating implantation bodys long-term effect are not good.

For non-coating implantation body, because surperficial bone syncretizing effect is not good, under osteoporosis condition, be difficult to form stable retention, cause most implantation body will be failed at about 1 year.At present, non-coating implantation body has been prohibited to be applied to the soft bony region of third and fourth class of maxillary sinus.

For coating implantation body, in order to improve bone fusion rate, nano-apatite or bone morphogenetic protein(BMP) surface BMP are combined with non-coating implantation body, its bone syncretizing effect is obviously better than non-coating implantation body, as the design that the patents such as CN1903140A, CN 201119919Y disclose.Under normal circumstances, coating implantation body can obtain preferably long-term effect, but coating implantation body long-term effect is still not good under osteoporosis condition, this is mainly because coating is only limited to solid implant surface, its limited use, the new bone limited amount of formation, becomes bone strength limited.Particularly BMP, its concentration and limited amount are comparatively large, are difficult to play better drug action.Although current paid examination transforming growth factor-β (TGF-β), insulin-like growth factor-i (IGF-1), miRNA, siRNA are as plantation coating, as the design that the patents such as CN102579145A disclose, but all by the same token, is difficult to play better drug action; The biological coating implantation bodys such as BMP also have a significant shortcoming, be exactly the holding time of coating generally in 9 months, expired use will cause the remarkable decline of self-bone grafting ability, loses efficiency and function.

In addition, once someone had trial hollow implant, it is inner to wish to grow into osseous tissue, as patent US 6918766B1, US 20070292820A1, US 2004081941A1, US 2003224328A1, US2006014120A1, JP 2005342157A, the design that CN 101366664B etc. disclose, but owing to lacking bone inductive factor support, passive osseous tissue is only relied on to grow into, be difficult to apply under osteoporosis condition, thus still fail to form commercial growth body, or be eliminated now, as the cylindric ITI implantation body of hollow open of Switzerland Schroeder and Sutter development in 1974.And, above hollow implant, even if employing hollow design, as shown in the patent such as CN 101366664B, CN 202875504U, but only adopt CNC (Digit Control Machine Tool) manufacturing technology due to it, the hollow structure of tight curves cannot be formed, a large amount of bone inductive factors cannot be stored, therefore, commercially produce even if achieve, also there is higher risk of failure.

Summary of the invention

For the defect of prior art, this utility model provides a kind of implantation body that can store the porous surface hollow structure inside of a large amount of BMP gel, greatly can improve implantation body merge area with new bone and become bone strength, solve the global problem that various implantation bodys long-term effect under current maxillary sinus osteoporosis condition is not good.

The technical solution of the utility model is as follows:

Maxillary sinus biogel implantation body, implantation body comprises implanting portion, base station, screw, gel and sterile packaging bottle, implanting portion is hollow structure, top, implanting portion and base station are linked together by screw, described implantation body and gel are packaged in sterile packaging bottle jointly, the top of described implanting portion is provided with outer cap, the cervical region of implanting portion is provided with micro-screw thread, the lower surface of implanting portion is loose structure, its hole wall has grain surface, described loose structure is connected with hollow structure inside, and in loose structure and hollow structure, storage has and has BMP gel in a large number.

Described implanting portion is first generated by 3D printing technique, and then the top of implanting portion and screw and base station junction adopt CNC method secondary to process.

The pH value of described gel is 6-8.

Overall diameter >=the 5mm of described implanting portion, the length >=11mm of implanting portion; Footpath difference between the diameter of described outer cap and implanting portion overall diameter is 0.625mm.

This utility model plants the maxillary sinus interior lifting operating theater instruments of above-mentioned implantation body, and have micro-stepping and only stop function, the nose shape of lifting arm is consistent with the lower shape of described implantation body.

Further, the head of described lifting arm is provided with multiple.

Compared to existing technology, the beneficial effects of the utility model are as follows:

1. this utility model have employed the porous hollow of the similar skeleton that can store gel: existing coating implantation body, and play the coating of bone inductive effect, be only confined to implant surface, its concentration and quantity are limited to, and the new bone thus formed is very limited.This utility model, by 3D printing technique, devises special loose structure, by this intensive class haversian canaliculi design, increases considerably area and the volume in hole, and can store gel.

2. have employed the gel technique containing bone-inducing factor in conjunction with loose structure of the present utility model, but not coating technology.Gel technique is at concentration and quantitative aspects far away higher than coating technology, and gel more easily preserves biological activity, and existing coating technology can lose efficacy by biological activity in 9 months.Gel containing bone-inducing factor can induce the formation of new bone, strengthen the fusion of bone-implantation body, particularly merges with the bone of new bone formation on porous wall surface, and with the new bone formation of outside integrally, drastically increase implantation body and merge area with new bone and become bone strength.In addition, its separation and purification product of BMP gel of the present utility model, in conjunction with enzymolysis, vacuum concentration, the quantitatively technology such as mixing and precise and tiny ultrafiltration, is stored in special PH neutral gel, between pH value 6-8, can preserve for a long time under normal temperature condition, and keep comparatively high bioactivity.

3., with existing Technical comparing, the self-bone grafting ability of implantation body by strong extremely weak sequence is successively: biogel implantation body of the present utility model >=biological coating implantation body >=physics or immersion coating implantation body >=non-coating implantation body.

4. implantation body of the present utility model must coordinate lifting operating theater instruments in the Microstep maxillary sinus of special construction just can complete implant operation.Routine operation apparatus cannot use in antral area, will damage hole film, produces serious complication.So far, promoting operating theater instruments in Microstep maxillary sinus is relatively safest operating theater instruments, can the minimizing damage hole film chance of minimum radius and the possibility of complication.Print implantation body for many 3D of the present utility model, must use in the maxillary sinus with bull of the present utility model and promote operating theater instruments, this is a kind of apparatus also do not had both at home and abroad at present.

Accompanying drawing explanation

Fig. 1 overall structure schematic diagram of the present utility model.

The overall schematic of the implanting portion in Fig. 2 this utility model.

The schematic surface of the middle and lower part, implanting portion (a) in Fig. 3 this utility model, (b) generalized section.

Fig. 4 this utility model completes postoperative overall generalized section in clinical.

Operating theater instruments is promoted in Fig. 5 specific customization Microstep maxillary sinus of the present utility model.

Wherein, 1-implanting portion, 2-base station, 3-center screw, 4-gel, 5-sterile packaging bottle, 6-outer cap, the micro-helicitic texture of 7-, the similar trabecular bone structure of 8-, 9-hollow structure, 10-loose structure, 11-ceramic crown, 12-gingiva, 13-upper jaw bone, the artificial bone meal of 14-, the head of 15-lifting arm.

Detailed description of the invention

In order to more clearly describe this utility model, below in conjunction with accompanying drawing, the utility model is described in further detail.

As shown in Figure 1, implantation body of the present utility model comprises implanting portion 1, base station 2, center screw 3, gel 4 and sterile packaging bottle 5.Top, implanting portion 1 and base station 2 are linked together by center screw 3, implanting portion 1 and gel 4 are packaged in sterile packaging bottle 5 jointly, bubble is got rid of by agitator, gel 4 is made to infiltrate the similar skeleton hollow structure of whole implantation body, and be stored in inside loose structure 10 and hollow structure 9, when using, uncork and use, improve greatly than the concentration of coating implantation body and quantity.Implantation body is in human body, and the BMP in gel 4 can slowly release, and induction osseous tissue is initiatively grown in class skeleton hollow structure, and form the tight fusion of new bone and implantation body, this design drastically increases new bone and merges area with implantation body and become bone strength.

The pH value of gel best shelf-life is 6-8, and early stage, fluidity was higher, and through 24 to 48 hours, fluidity step-down, can preserve at least 2 years, and keep comparatively high bioactivity under normal temperature condition with implantation body is combined time.Compare the pot-life that existing BMP biological coating only has 9 months, improve practicality.

As shown in Figure 2, implanting portion 1, its middle and lower part is by 3D printing technique, and titanium alloy powder is generated the support of similar trabecular bone structure 8 at 1500-1600 DEG C, the surface of trabecular bone structure 8 has texture structure, and forms many hollow structures 9 storing gel; Its cervical region is processed into micro-helicitic texture 7 by traditional CNC; There is difference outer, 0.625mm footpath cap 6 on its top, and when can prevent from performing the operation, implantation body accidentally falls into maxillary sinus chamber and causes surgical error.

As shown in Figure 3, (a) schematic surface shows similar trabecular bone structure 8 and similar haversian canaliculi (i.e. loose structure 10); B () generalized section shows similar trabecular bone structure 8, similar haversian canaliculi (i.e. loose structure 10), storage Jiao Chi (i.e. hollow structure 9).Containing gel 4 in hollow structure 9, containing abundant BMP in gel 4; BMP in gel 4 can induce the formation of new bone, strengthens the fusion of new bone-implantation body, particularly merges with the bone of new bone formation on hollow wall surface, and with the new bone formation of outside integrally.

As shown in Figure 4, that implantation body of the present utility model completes postoperative situation clinical: form primarily of implanting portion 1, base station 2, ceramic crown 11, gingiva 12, upper jaw bone 13, artificial bone meal 14, implanting portion 1 is connected with ceramic crown 11 by base station 2, and the middle and lower part of implanting portion 1 is goed deep in upper jaw bone 13.

More than the overall diameter 5mm of implanting portion 1, length more than 11mm, adopt single or many designs, need to adopt lifting operating theater instruments in the Microstep maxillary sinus of specific customization just can complete implant operation, the design of more long thicker implantation body can ensure larger gmatjpdumamics, the success rate of longer-term, is applicable to the maxillary sinus implant operation under osteoporosis condition.The structural representation of operating theater instruments is promoted as shown in Figure 5 in the maxillary sinus that this utility model dentistry implant needs, the head 15 of lifting arm can be set to multiple (the present embodiment adopts two), to meet the requirement that implanting portion 1 is implant operation under many root conditions.Head 15 shape is consistent with the lower shape of implantation body 1.This maxillary sinus interior lifting operating theater instruments has micro-stepping and only stops function, and the concrete structure of lifting arm can be recorded see the patent documentation of WO2011/116517A1.

Claims

1. maxillary sinus biogel implantation body, implantation body comprises implanting portion, base station, screw, gel and sterile packaging bottle, implanting portion is hollow structure, top, implanting portion and base station are linked together by screw, it is characterized in that, described implantation body and gel are packaged in sterile packaging bottle jointly, the top of described implanting portion is provided with outer cap, the cervical region of implanting portion is provided with micro-screw thread, the lower surface of implanting portion is loose structure, its hole wall has grain surface, described loose structure is connected with hollow structure inside, in loose structure and hollow structure, storage has a large amount of BMP gel.

2. maxillary sinus biogel implantation body according to claim 1, is characterized in that, described implanting portion is first generated by 3D printing technique, and then the top of implanting portion and screw and base station junction adopt CNC method secondary to process.

3. maxillary sinus biogel implantation body according to claim 1, is characterized in that, the pH value of described gel is 6-8.

4. according to the maxillary sinus biogel implantation body one of claims 1 to 3 Suo Shu, it is characterized in that, the overall diameter >=5mm of described implanting portion, the length >=11mm of implanting portion; Footpath difference between the diameter of described outer cap and implanting portion overall diameter is 0.625mm.