CN204147442U - A kind of biomim betatic assembly for heating ablation curative effect evaluation - Google Patents
A kind of biomim betatic assembly for heating ablation curative effect evaluation Download PDFInfo
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- CN204147442U CN204147442U CN201420434579.8U CN201420434579U CN204147442U CN 204147442 U CN204147442 U CN 204147442U CN 201420434579 U CN201420434579 U CN 201420434579U CN 204147442 U CN204147442 U CN 204147442U
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Abstract
This utility model provides a kind of biomim betatic assembly for heating ablation curative effect evaluation, comprises P (NIPA-CO-AA) gelinite, and is positioned at the lean pork taken under the spinal column of a hog of P (NIPA-CO-AA) gelinite; And lean pork taken under the spinal column of a hog Surface coating has wax layer.Of the present utility model in the biomim betatic assembly of heating ablation curative effect evaluation, the acoustic characteristic of P (NIPA-CO-AA) gelinite should, the acoustic characteristic of thermal characteristic and human body soft tissue is close, be can be formed to have highly similar bionical build to human body, simultaneously density and the velocity of sound of its hydrogel all have the similarity of extreme with human body; And combine to have with muscular tumor tissue very close to the lean pork taken under the spinal column of a hog of acoustical behavior as muscular tumor analogue body, the energy variation of hydrogel can be observed while effectively observing the energy variation of muscular tumor body, thus realize bionical assessment; And gelinite this as transparent, can Real Time Observation to the carrier of focus ultrasonic focus size form and position, while this carrier media can repeatedly, reuse, visualization is high.
Description
Technical field
This utility model belongs to bionic technical field, is specifically related to a kind of biomim betatic assembly for heating ablation curative effect evaluation.
Background technology
High strength supersonic focus is the new technique that a kind of non-invasive, conformal heat " excision " treats tumor, and its mechanism is mainly by producing high heat after focusing ultrasonic wave, aligning target area, affected part is carried out tumor cell and killed.But this high heat is simultaneously also along with the security risk such as scald of normal tissue, therefore when clinical practice is treated, in order to ensure effectiveness and the safety for the treatment of, the focusing performance that HIFU (High Intensity Focused Ultrasound, high intensity focused ultrasound) treats head must be evaluated.But owing to being the tissue acting on live body in treatment, the biological tissue of therefore very difficult nonstandardized technique up to now evaluates the focusing performance that HIFU treats head, and the focusing performance of difference treatment head is compared.
The existing size research mostly carrying out focusing spot in the treatment of supersonic focus therapeutic is more carry out based on in vitro tissue, but in vitro organizing loses the condition such as temperature sensitive, active of live body after all, and the result of assessment is inaccurate; And need to carry out real-time monitoring and observation to the focus of focus ultrasonic in the process of assessment, be convenient to therapeutic scheme and the metering of formulating supersonic focus therapeutic, to not possessing function that is visual and that can not repeatedly reuse due in vitro tissue in traditional sense, therefore, on the platform of mass data data output, efficiently data statistics and observation can not be carried out.
Utility model content
The object of this utility model embodiment is the above-mentioned deficiency overcoming prior art, provides the biological properties such as a kind of every calorifics, acoustics can substitute the biomim betatic assembly of biological tissue for heating ablation curative effect evaluation.
In order to realize above-mentioned utility model object, the technical scheme of this utility model embodiment is as follows:
For a biomim betatic assembly for heating ablation curative effect evaluation, comprise P (NIPA-CO-AA) gelinite, and be positioned at the lean pork taken under the spinal column of a hog of described P (NIPA-CO-AA) gelinite; Described lean pork taken under the spinal column of a hog Surface coating has wax layer.
Of the present utility model in the biomim betatic assembly of heating ablation curative effect evaluation, the acoustic characteristic of P (NIPA-CO-AA) gelinite should, the acoustic characteristic of thermal characteristic and human body soft tissue is close, be can be formed to have highly similar bionical build to human body, simultaneously density and the velocity of sound of its hydrogel all have the similarity of extreme with human body; And combine to have with muscular tumor tissue very close to the lean pork taken under the spinal column of a hog of acoustical behavior as muscular tumor analogue body, the energy variation of hydrogel can be observed while effectively observing the energy variation of muscular tumor body, thus realize bionical assessment; And gelinite this as transparent, can Real Time Observation to the carrier of focus ultrasonic focus size form and position, while this carrier media can repeatedly, reuse, visualization is high.
Accompanying drawing explanation
Below in conjunction with drawings and Examples, the utility model is described in further detail, in accompanying drawing:
Fig. 1 is the structural representation of this utility model embodiment for the biomim betatic assembly of heating ablation curative effect evaluation.
Detailed description of the invention
In order to make the purpose of this utility model, technical scheme and advantage clearly understand, below in conjunction with drawings and Examples, this utility model is further elaborated.Should be appreciated that specific embodiment described herein only in order to explain this utility model, and be not used in restriction this utility model.
This utility model embodiment provides a kind of biomim betatic assembly for heating ablation curative effect evaluation, see Fig. 1, comprise a P (NIPA-CO-AA) gelinite 10, and the lean pork taken under the spinal column of a hog 20 be arranged in this P (NIPA-CO-AA) gelinite 10, the outer surface of this lean pork taken under the spinal column of a hog 20 is coated with wax layer.
Be beneficial to molding in order to the structure and shape that ensure P (NIPA-CO-AA) gelinite 10 and stablize, P (NIPA-CO-AA) gelinite 10 shape is preferably the regular geometrical body such as cuboid, square, although also irregular shape can be made, but the visuality that the solid of rule is beneficial in processing and bionical assessment is more observed, and overall acoustics, the more irregular body of thermal property will be got well.
In this utility model, its advantageous refinements of P (NIPA-CO-AA) gelinite 10 is simulation human body soft tissue, the combined density 1.058g/cm of its hydrogel combination body
3with the average density 1.050g/cm of Liver Tissue
3close, in focus ultrasonic, focal regions central temperature ascensional range can reach (70 DEG C ± 5 DEG C), target area central authorities maximum temperature reaches 130 DEG C, and in this utility model, P (NIPA-CO-AA) gelinite fusing point reaches 150 DEG C, meets the requirement of the high heat in HIFU focus place; Therefore overall performance is stablized, and its acoustic attenuation coefficient is 0.615dB/cm when 1.2MHz, slightly low compared with the attenuation quotient (0.75dB/cm, 1.2MHz) of hepatic tissue, with the attenuation quotient (0.61dB/cm, 1.2MHz) of cerebral tissue closely; The prior acoustic characteristic being P (NIPA-CO-AA) gelinite should, the acoustic characteristic of thermal characteristic and human body soft tissue is close, can be formed to have highly similar bionical build to human body, simultaneously density and the velocity of sound of its hydrogel all have the similarity of extreme with human body, and the lower critical solution temperature of its PNIPA hydrogel is 50 DEG C.With the copolymer hydrogel that N-isopropylacrylamide monomer and acrylamide monomer make, there is higher LCST (lower critical solution temperature), closer to biologic soft tissue thermal denaturation temperature than PNIPA hydrogel.
Therefore, on above-mentioned gelinite basis, can realize emulating the thermal ablation therapy of simulated tissue, combine simultaneously to have with muscular tumor tissue very close to the lean pork taken under the spinal column of a hog of acoustical behavior as muscular tumor analogue body, using intelligent bionical body mould as tissues such as body of uterus, cattle crystalline lenses, the energy variation of hydrogel can be observed while making effectively to observe the energy variation of muscular tumor body in dosage is considered, thus realize bionical assessment; And gelinite this as transparent, can Real Time Observation to the carrier of focus ultrasonic focus size form and position, while this carrier media can repeatedly, reuse, visualization is high.
This utility model also proposes a kind of preparation method of the biomim betatic assembly for heating ablation curative effect evaluation further, comprises the steps:
Obtain raw material, comprise: NIPA (NIPA), Bis (methylene diacrylamide), AAm (acrylamide), APS (Ammonium persulfate .), TEMED (N, N, N ', N '-tetramethylethylenediamine), sodium metabisulfite, high-quality lean pork taken under the spinal column of a hog, normal saline, wax and deionised degassed water standardize solution 400ml;
S10, is dissolved in deionised degassed water by NIPA monomer, stirs and forms NIPA solution;
S20 is that the ratio of 1:10 ~ 20 adds Bis to NIPA solution according to Bis:NIPA, and is that the ratio of 1:3 ~ 4 adds AAm to NIPA solution according to AAm:NIPA, and stirring to dissolve forms monomer mixed solution;
S30 is that 0.02 ~ 0.027:1 gets APS and is dissolved into APS solution according to amount than APS:NIPA, and by sodium metabisulfite: NIPA is that 0.015 ~ 0.02:1 gets sodium metabisulfite deionised degassed water and is dissolved into sodium metabisulfite solution;
S40, the ratio being 200 ~ 267g:1ml according to NIPA:TEMED is got TEMED and is dissolved in deionised degassed water, forms TEMED solution;
S50, using lean pork taken under the spinal column of a hog as embedded body, the size and dimension according to required muscular tumor analogue body carries out cutting process;
S60, by normal saline and the deionised degassed water proportions soak according to 1:2, and cryopreservation, storage temperature can control about 10 DEG C.
S70, after wax being melt into wax liquid, being placed in wax liquid and carrying out soaking stagnant process by lean pork taken under the spinal column of a hog, the processing time takes out and the wax liquid on lean pork taken under the spinal column of a hog surface is solidified after being about 0.5s; Again the lean pork taken under the spinal column of a hog of sealing wax is placed in soak to soak.
S80, joins in monomer mixed solution by TEMED solution, unidirectionally stirs;
S90, adds in monomer mixed solution by APS solution and sodium metabisulfite solution, stirs and forms gel stock solution;
S100, by the lean pork taken under the spinal column of a hog immersion precipitation stock solution after soak, and adopts in vitro tissue fixture to carry out position to fix, and leaves standstill more than 30s and gel stock solution is solidified, and namely obtains biomim betatic assembly of the present utility model after cleaning sealer.
In cutting selected lean pork taken under the spinal column of a hog in above-mentioned steps S50, shape is mainly formulated according to the morphosis of muscular tumor.According to the degree of accuracy of Evaluated effect in this utility model, the specifications control after lean pork taken under the spinal column of a hog cuts is at 1cm
3~ 20cm
3, first can ensure that group muscular tumor parody is with truly similar, further processes and processes convenient; Secondly compare on the whole in this specification and be easy to visual observation, the susceptiveness changed after the hot spot focusing for the treatment of head is also more excellent.
In bionical Gel Compositions body, need to control the rate of set of gel and lean pork taken under the spinal column of a hog activity, by the gel stock solution of solidifying that exceeds the speed limit in this utility model, wherein TEMED and APS combinationally uses, promote the condensation of gel monomers hypervelocity, promote its setting time to tens second; Behind the position of fixing lean pork taken under the spinal column of a hog, the gel type of slow coagulation due to before condensing completely its molecular structure to have very high flowing random, between condensation Middle molecule, power can cause the lean pork taken under the spinal column of a hog fixed that position skew occurs.And in preparation, adopt unidirectional stirring, ensure the regular linking of monomer, avoid occurring mixed and disorderly situation, cause its character not reach expection.
And in above-mentioned steps S70, lean pork taken under the spinal column of a hog is carried out process of sealing with wax, waxiness is closed and lean pork taken under the spinal column of a hog can be made to be in by airtight state, thus be beneficial to its active and various physiological property of maintenance, avoid it that degeneration etc. occurs; And it can also be conducive to the isolation of lean pork taken under the spinal column of a hog in gel, avoid molecule infiltration that overall bionical performance is changed; Blood red pigment also making it possible to isolated lean pork taken under the spinal column of a hog etc. produces the color of gel and pollutes simultaneously, ensures the pure transparent visual of gel, ensures the observability in bionical assessment.Wherein wax preferably adopts paraffin, its waxiness Stability Analysis of Structures.And by the soak immersion treatment of normal saline dilution after sealing with wax, wax surface ion is after solidification distributed and osmotic balance, more close to the performance of biological tissue.Further, further in this utility model in implementation process according to the effect of bionical assessment, the thickness of wax layer is preferably controlled at 0.8mm ~ 1.2mm, in order to be effective like this best.Because when the thickness of wax layer thickeies again, the heat energy of the part of the hot spot that treatment head focuses on will be absorbed by wax, correspondingly increases the error of assessment result.
In above-mentioned preparation process, in order to prevent the loss of its moisture, can also add agar in gel, for solid water, in gel, agar forms the solid water structure of cross-linked network, be beneficial to and keep hydrone in a large number, and itself does not have an impact to the performance of gel; In general agarose gel, agar can affect rate of set and the answer to a riddle structure of gel, and rate of set own be can't help agar and controlled in this utility model, therefore to add after agar only solid water, and on condensation and the impact of overall structure performance very little; Therefore adopt in this utility model and add agar, be more beneficial to the persistency maintaining each performance.
Adopt in above-mentioned preparation method of the present utility model, similar with live body in its acoustics of biomim betatic assembly prepared and the physiological parameter of calorifics, and by the control of many factors in preparation process, ensure that it is more close to physiological condition further, combined density is 1.058g/cm
3with the average density 1.050g/cm of Liver Tissue
3close, can directly be used as simulation human body soft tissue, thus realize visual heating ablation curative effect evaluation.
In order to make above-mentioned preparation method of the present utility model clearly and easy to understand, below by way of multiple embodiment, aforesaid way is illustrated:
Embodiment 1
S10, gets NIPA monomer 30g and is dissolved in 350ml deionised degassed water, stir about 10min on magnetic stirring apparatus; After NIPA monomer dissolves, add Bis, 10g Aam of quality 2g; Stir about 3min treats that it dissolves and forms monomer mixed solution:
S20, is respectively dissolved in 0.8gAPS and 0.6g sodium metabisulfite in 5ml deionised degassed water respectively and obtains APS solution and sodium metabisulfite solution, leaves standstill;
S30, that gets that 1.5mlTEMED is dissolved in 5ml degass in water, after stirring, leaves standstill;
S40, carries out machining by fresh homogeneous lean pork taken under the spinal column of a hog according to the shape of body of uterus mould, then is fallen by tenterloin wattle as fixing cord binding with nylon fine rule;
S50, with medical saline and the deionised degassed water proportions soak according to 1:2, then places refrigerator the soak prepared, solution temperature is reduced to about 10 DEG C;
S60, uses constant temperature pot to dissolve paraffin, rear rapidly lean pork taken under the spinal column of a hog is placed in wax liquid about 0.5s after mention, naturally dry after solidifying about 10s, be put in the soak of above-mentioned preparation and soak 30s;
S70, joins in monomer mixed solution by TEMED solution, and unidirectional, low speed fully stirs; Again APS solution and sodium metabisulfite solution are added in monomer mixed solution, stir rapidly as gel polymerisation reaction stock solution, inject 400ml transparent plastic cup;
S80, by nylon rope in lean pork taken under the spinal column of a hog immersion precipitation polyreaction stock solution, by vitro tissue fixture need position upper be set up fixing, rest on reaction stock solution in, natural coagulation after about 30s, obtains biomim betatic assembly;
S90, after solidifying rear 10Min, by biomim betatic assembly surface at room temperature through 5 washings (soak surface 6 hours with deionized water, then outwell water and dry 12 hours) at every turn, to remove remained on surface monomer; Final gel surface coverage preservative film, preserves.
Embodiment 2
S10, gets NIPA monomer 40g and is dissolved in 350ml deionised degassed water, stir about 10min on magnetic stirring apparatus; After NIPA monomer dissolves, add Bis, 10g Aam of quality 3g; Stir about 3min treats that it dissolves and forms monomer mixed solution:
S20, is respectively dissolved in 0.8gAPS and 0.6g sodium metabisulfite in 5ml deionised degassed water respectively and obtains APS solution and sodium metabisulfite solution, leaves standstill;
S30, that gets that 1.5mlTEMED is dissolved in 5ml degass in water, after stirring, leaves standstill;
S40, carries out machining by fresh homogeneous lean pork taken under the spinal column of a hog according to the shape of body of uterus mould, then is fallen by tenterloin wattle as fixing cord binding with nylon fine rule;
S50, with medical saline and the deionised degassed water proportions soak according to 1:2, then places refrigerator the soak prepared, solution temperature is reduced to about 10 DEG C;
S60, uses constant temperature pot to dissolve paraffin, rear rapidly lean pork taken under the spinal column of a hog is placed in wax liquid about 0.5s after mention, naturally dry after solidifying about 10s, be put in the soak of above-mentioned preparation and soak 30s;
S70, joins in monomer mixed solution by TEMED solution, and unidirectional, low speed fully stirs; Again APS solution and sodium metabisulfite solution are added in monomer mixed solution, stir rapidly as gel polymerisation reaction stock solution, inject 400ml transparent plastic cup;
S80, by nylon rope in lean pork taken under the spinal column of a hog immersion precipitation polyreaction stock solution, by vitro tissue fixture need position upper be set up fixing, rest on reaction stock solution in, natural coagulation after about 30s, obtains biomim betatic assembly;
S90, after solidifying rear 10Min, by biomim betatic assembly surface at room temperature through 5 washings (soak surface 6 hours with ionized water, then outwell water and dry 12 hours) at every turn, to remove remained on surface monomer; Final gel surface coverage preservative film, preserves.
Embodiment 3
S10, gets NIPA monomer 35g and is dissolved in 350ml deionised degassed water, stir about 10min on magnetic stirring apparatus; After NIPA monomer dissolves, add Bis, 9g Aam of quality 2.6g; Stir about 3min treats that it dissolves and forms monomer mixed solution:
S20, is respectively dissolved in 0.8gAPS and 0.6g sodium metabisulfite in 5ml deionised degassed water respectively and obtains APS solution and sodium metabisulfite solution, leaves standstill;
S30, that gets that 1.5mlTEMED is dissolved in 5ml degass in water, after stirring, leaves standstill;
S40, carries out machining by fresh homogeneous lean pork taken under the spinal column of a hog according to the shape of body of uterus mould, then is fallen by tenterloin wattle as fixing cord binding with nylon fine rule;
S50, with medical saline and the deionised degassed water proportions soak according to 1:2, then places refrigerator the soak prepared, solution temperature is reduced to about 10 DEG C;
S60, uses constant temperature pot to dissolve paraffin, rear rapidly lean pork taken under the spinal column of a hog is placed in wax liquid about 0.5s after mention, naturally dry after solidifying about 10s, be put in the soak of above-mentioned preparation and soak 30s;
S70, joins in monomer mixed solution by TEMED solution, and unidirectional, low speed fully stirs; Again APS solution and sodium metabisulfite solution are added in monomer mixed solution, add the agar powder of 2.5g simultaneously, stir rapidly as gel polymerisation reaction stock solution, inject 400ml transparent plastic cup;
S80, by nylon rope in lean pork taken under the spinal column of a hog immersion precipitation polyreaction stock solution, by vitro tissue fixture need position upper be set up fixing, rest on reaction stock solution in, natural coagulation after about 30s, obtains biomim betatic assembly;
S90, after solidifying rear 10Min, by biomim betatic assembly surface at room temperature through 5 washings (soak surface 6 hours with ionized water, then outwell water and dry 12 hours) at every turn, to remove remained on surface monomer; Final gel surface coverage preservative film, preserves.
When adopting above-mentioned biomim betatic assembly of the present utility model to carry out bionical assessment, supersonic focus therapeutic head is carried out same step according in live body therapeutic process, over the course for the treatment of, treatment head is inserted in biomim betatic assembly on lean pork taken under the spinal column of a hog, is carried out similar treatment or excision operation.The bionical coagulation necrosis of in vitro tissue is made because focus ultrasonic can produce high temperature instantaneously at focus area, because in vitro tissue is red at normal temperatures, white is become after coagulation necrosis, the highly transparent of Bound moisture gelinite, the process that the in vitro tissue can observing focal position very soon degenerates, becomes white instantaneously by redness.Simultaneously again according to final change procedure and the result of biomim betatic assembly, just can assess the performance for the treatment of head.Thus compensate for the existing merely focus strength for the treatment of head assessment and treat the larger shortcoming of large deviations at live body.
The foregoing is only preferred embodiment of the present utility model; not in order to limit this utility model; all do within spirit of the present utility model and principle any amendment, equivalent to replace and improvement etc., all should be included within protection domain of the present utility model.
Claims (4)
1. for a biomim betatic assembly for heating ablation curative effect evaluation, it is characterized in that, comprise P (NIPA-CO-AA) gelinite, and be positioned at the lean pork taken under the spinal column of a hog of described P (NIPA-CO-AA) gelinite;
Described lean pork taken under the spinal column of a hog Surface coating has wax layer.
2., as claimed in claim 1 for the biomim betatic assembly of heating ablation curative effect evaluation, it is characterized in that, described P (NIPA-CO-AA) gelinite is cuboid or square.
3., as claimed in claim 1 or 2 for the biomim betatic assembly of heating ablation curative effect evaluation, it is characterized in that, the thickness of described wax layer is 0.8mm ~ 1.2mm.
4., as claimed in claim 1 or 2 for the biomim betatic assembly of heating ablation curative effect evaluation, it is characterized in that, described lean pork taken under the spinal column of a hog volume is 1cm
3~ 20cm
3.
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| CN104174122A (en) * | 2014-08-01 | 2014-12-03 | 深圳市普罗惠仁医学科技有限公司 | Bionic hydrogel assembly for assessment of thermal ablation curative effect, and preparation method |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104174122A (en) * | 2014-08-01 | 2014-12-03 | 深圳市普罗惠仁医学科技有限公司 | Bionic hydrogel assembly for assessment of thermal ablation curative effect, and preparation method |
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Address after: Two road 518000 Guangdong city of Shenzhen province Nanshan District high tech Industrial Park, Xili Street No. 28 North Howell technology building floor area on the north side of D Patentee after: Shenzhen municipal medical Limited by Share Ltd Address before: 518000 Guangdong city of Shenzhen province Nanshan District high tech Industrial Park, North Central Avenue, North Song Ping Road No. 1 building four North Yuanxing Technology Building Room 402 Patentee before: Puluohuiren Medicine Sci-Tech Co., Ltd., Shenzhen |