CN204111767U - A kind of novel tumor cell electromagnetic sieve screening device - Google Patents
A kind of novel tumor cell electromagnetic sieve screening device Download PDFInfo
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- CN204111767U CN204111767U CN201420567663.7U CN201420567663U CN204111767U CN 204111767 U CN204111767 U CN 204111767U CN 201420567663 U CN201420567663 U CN 201420567663U CN 204111767 U CN204111767 U CN 204111767U
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- magnet case
- slide glass
- biochip
- tumor cell
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Abstract
The utility model provides a kind of novel tumor cell electromagnetic sieve screening device, be mainly used in the clinical laboratory of the medical institutions such as hospital in the screening of tumour cell, the utility model is based on electro-magnet principle, electro-magnet case is connected with resistance box by electric wire, wherein, several by-pass cockes are provided with above resistance box, the turn on angle of solenoids different in electro-magnet case can be controlled respectively, and then regulate the intensity in magnetic field to screen tumour cell, the two ends of electro-magnet case are connected with clamp by spring, slide glass can be fixed on a surface of electro-magnet case by clamp, slide glass is closely placed on the upper surface of biochip, the upper surface of biochip is provided with a microchannel, by liquid-inlet pipe and drain pipe, fluid to be screened is imported and derived, the utility model structure is simple, easy to use, suitable magneticstrength can be regulated to collect on slide glass by tumour cell according to different types of tumour cell, decrease the workload of medical personnel, improve working efficiency.
Description
Technical field
The utility model relates to technical field of medical instruments, particularly relates to a kind of novel tumor cell electromagnetic sieve screening device.
Background technology
The generation of tumour and the healthy impact of diffusion couple larger, day by day become one of life-threatening principal disease kind, relevant research confirms, the circulating tumor cell quantity occurred in the blood sample of patient and patient's early diagnosis and survival rate have very strong dependency, inspection early find the existence of tumour and spread condition very important to prophylactic treatment.Therefore, to the circulating tumor cell determination and analysis of the blood sample of patient, be the key improving tumor disease early discovery rate and personalized treatment.The current inspection to tumour cell generally adopts cytolgical examination and histological examination, clinically when carrying out cytology to patient and detecting film-making, in time, needs to extract sample with scraping ring mostly, then on slide glass, film-making is smeared, operate like this and extremely bother, waste time and energy, add great work difficulty to medical worker.
Utility model content
The utility model provides a kind of novel tumor cell electromagnetic sieve screening device, be mainly used in the clinical laboratory of the medical institutions such as hospital in the screening of tumour cell, the utility model is based on electro-magnet principle, electro-magnet case is connected with resistance box by electric wire, wherein, several by-pass cockes are provided with above resistance box, the turn on angle of solenoids different in electro-magnet case can be controlled respectively, and then regulate the intensity in magnetic field to screen tumour cell, the two ends of electro-magnet case are connected with clamp by spring, slide glass can be fixed on a surface of electro-magnet case by clamp, slide glass is closely placed on the upper surface of biochip, the upper surface of biochip is provided with a microchannel, by liquid-inlet pipe and drain pipe, fluid to be screened is imported and derived, the utility model structure is simple, easy to use, suitable magneticstrength can be regulated to collect on slide glass by tumour cell according to different types of tumour cell, decrease the workload of medical personnel, improve working efficiency.
For solving the problems of the technologies described above, the embodiment of the present application provides a kind of novel tumor cell electromagnetic sieve screening device, comprise resistance box, electric wire, electro-magnet case, solenoid, clamp, slide glass, biochip, liquid-inlet pipe, microchannel, drain pipe, display screen, the major portion compositions such as by-pass cock, it is characterized in that, several by-pass cockes are provided with above resistance box, a corresponding display screen below each by-pass cock, control the turn on angle of different solenoids respectively, electro-magnet case is connected with resistance box by electric wire, several solenoids are provided with side by side in electro-magnet case, the two ends of electro-magnet case are connected with clamp by spring, slide glass may be stuck on a surface of electro-magnet case, slide glass is closely placed on the upper surface of biochip, the upper surface of biochip is provided with a microchannel, the two ends of microchannel are communicated with liquid-inlet pipe and drain pipe respectively.
As the preferred embodiment of this programme, be provided with several by-pass cockes above described resistance box, below each by-pass cock, a corresponding display screen, controls the turn on angle of different solenoids respectively.
As the preferred embodiment of this programme, be provided with several solenoids side by side in described magnet case, each coil is for being connected in parallel.
As the preferred embodiment of this programme, the two ends of described electro-magnet case are connected with clamp by spring, and slide glass may be stuck on a surface of electro-magnet case.
As the preferred embodiment of this programme, the upper surface of described biochip is provided with a microchannel, and the two ends of microchannel are communicated with liquid-inlet pipe and drain pipe respectively.
The one or more technical schemes provided in the embodiment of the present application, at least have following technique effect or advantage:
Structure is simple, easy to use, suitable magneticstrength can be regulated to collect on slide glass by tumour cell according to different types of tumour cell, decrease the workload of medical personnel, improve working efficiency.
Accompanying drawing explanation
In order to be illustrated more clearly in the utility model embodiment or technical scheme of the prior art, be briefly described to the accompanying drawing used required in embodiment or description of the prior art below, apparently, accompanying drawing in the following describes is only embodiments more of the present utility model, for those of ordinary skill in the art, under the prerequisite not paying creative work, other accompanying drawing can also be obtained according to these accompanying drawings.
Fig. 1 is the structural representation that the application implements;
Fig. 2 is the electro-magnet box structure schematic diagram that the application implements;
Fig. 3 is the by-pass cock structural representation that the application implements;
In Fig. 1,1, resistance box, 2, electric wire, 3, electro-magnet case, 4, solenoid, 5, clamp, 6, slide glass, 7, biochip, 8, liquid-inlet pipe, 9, microchannel, 10, drain pipe, 11, display screen, 12, by-pass cock, 13, spring.
Embodiment
The utility model provides a kind of novel tumor cell electromagnetic sieve screening device, be mainly used in the clinical laboratory of the medical institutions such as hospital in the screening of tumour cell, the utility model is based on electro-magnet principle, electro-magnet case is connected with resistance box by electric wire, wherein, several by-pass cockes are provided with above resistance box, the turn on angle of solenoids different in electro-magnet case can be controlled respectively, and then regulate the intensity in magnetic field to screen tumour cell, the two ends of electro-magnet case are connected with clamp by spring, slide glass can be fixed on a surface of electro-magnet case by clamp, slide glass is closely placed on the upper surface of biochip, the upper surface of biochip is provided with a microchannel, by liquid-inlet pipe and drain pipe, fluid to be screened is imported and derived.
In order to better understand technique scheme, below in conjunction with Figure of description and concrete embodiment, technique scheme is described in detail.
As shown in Figure 1-Figure 3, a kind of novel tumor cell electromagnetic sieve screening device, comprise resistance box 1, electric wire 2, electro-magnet case 3, solenoid 4, clamp 5, slide glass 6, biochip 7, liquid-inlet pipe 8, microchannel 9, drain pipe 10, display screen 11, the major portion compositions such as by-pass cock 12, it is characterized in that, resistance box 1 is provided with several by-pass cockes 12 above, each by-pass cock 12 is a corresponding display screen 11 below, control the turn on angle of different solenoids 4 respectively, electro-magnet case 3 is connected with resistance box 1 by electric wire 2, several solenoids 4 are provided with side by side in electro-magnet case 3, the two ends of electro-magnet case 3 are connected with clamp 5 by spring 13, slide glass 6 may be stuck on a surface of electro-magnet case 3, slide glass 6 is closely placed on the upper surface of biochip 7, the upper surface of biochip 7 is provided with a microchannel 9, the two ends of microchannel 9 are communicated with liquid-inlet pipe 8 and drain pipe 10 respectively.
Wherein in actual applications, described resistance box 1 is provided with several by-pass cockes 12 above, each by-pass cock 12 is a corresponding display screen 11 below, control the turn on angle of different solenoids 4 respectively, the magnetism intensity that each magnet coil 4 produces can calculate according to its size of current, and shown by the display screen 11 of below, thus achieve the vernier control of magnetism intensity, more accurate to screened cell.
Wherein in actual applications, several solenoids 4 are provided with side by side in described magnet case 3, each coil is for being connected in parallel, can according to the intensity of the solenoid 4 of the Auto-regulating System of Density of Heavy Medium different positions of collection cell aggregation, magnetism intensity as the solenoid 4 near liquid-inlet pipe 8 place is slightly little, increase successively subsequently, prevent the cell transition collected from concentrating with this, collection is impacted.
Wherein in actual applications, the two ends of described electro-magnet case 3 are connected with clamp 5 by spring 13, and slide glass 6 may be stuck on a surface of electro-magnet case 3, thus slide glass 6 can freely be changed, and fixation, prevent from coming off.
Wherein in actual applications, the upper surface of described biochip 7 is provided with a microchannel 9, and the two ends of microchannel 9 are communicated with liquid-inlet pipe 8 and drain pipe 10 respectively, make screening process convenient.
First in blood sample, magnetic nano-particle is put into during use, magnetic nano-particle surface is with antibody, be adsorbed on target cell, because the antigen molecule number of different types of tumor cell surface is different, the nano particle number adsorbed is also different, thus be certain value for the magneticstrength required for specific target cell, above-mentioned sample liquid is passed into by liquid-inlet pipe 8 in the microchannel of biochip 7, slide glass 6 is placed on the clamp 5 at electro-magnet case 3 two ends, and make the clamp 5 at two ends clamp slide glass 6 by spring 13, biochip 7 is abutted against the surface of slide glass 6, by-pass cock 12 after making opening power on regulating resistance case 1 is to change the size of current of solenoid 4, thus after changing its magnetism intensity to particular value, cell is screened, selected cell is adhered on the surface of slide glass 6, remaining liq is by drain pipe 10 outflow system.
The above, it is only preferred embodiment of the present utility model, not any pro forma restriction is done to the utility model, although the utility model discloses as above with preferred embodiment, but and be not used to limit the utility model, any those skilled in the art, do not departing within the scope of technical solutions of the utility model, make a little change when the technology contents of above-mentioned announcement can be utilized or be modified to the Equivalent embodiments of equivalent variations, in every case be the content not departing from technical solutions of the utility model, according to any simple modification that technical spirit of the present utility model is done above embodiment, equivalent variations and modification, all still belong in the scope of technical solutions of the utility model.
Claims (5)
1. a novel tumor cell electromagnetic sieve screening device, comprise resistance box (1), electric wire (2), electro-magnet case (3), solenoid (4), clamp (5), slide glass (6), biochip (7), liquid-inlet pipe (8), microchannel (9), drain pipe (10), display screen (11), the major portion compositions such as by-pass cock (12), it is characterized in that, resistance box (1) is provided with several by-pass cockes (12) above, each by-pass cock (12) is a corresponding display screen (11) below, control the turn on angle of different solenoids (4) respectively, electro-magnet case (3) is connected with resistance box (1) by electric wire (2), several solenoids (4) are provided with side by side in electro-magnet case (3), the two ends of electro-magnet case (3) are connected with clamp (5) by spring (13), slide glass (6) may be stuck on a surface of electro-magnet case (3), slide glass (6) is closely placed on the upper surface of biochip (7), the upper surface of biochip (7) is provided with a microchannel (9), the two ends of microchannel (9) are communicated with liquid-inlet pipe (8) and drain pipe (10) respectively.
2. a kind of novel tumor cell electromagnetic sieve screening device according to claim 1, it is characterized in that, described resistance box (1) is provided with several by-pass cockes (12) above, each by-pass cock (12) is a corresponding display screen (11) below, controls the turn on angle of different solenoids (4) respectively.
3. a kind of novel tumor cell electromagnetic sieve screening device according to claim 1, it is characterized in that, be provided with several solenoids (4) side by side in described magnet case (3), each coil is for being connected in parallel.
4. a kind of novel tumor cell electromagnetic sieve screening device according to claim 1, it is characterized in that, the two ends of described electro-magnet case (3) are connected with clamp (5) by spring (13), and slide glass (6) may be stuck on a surface of electro-magnet case (3).
5. a kind of novel tumor cell electromagnetic sieve screening device according to claim 1, it is characterized in that, the upper surface of described biochip (7) is provided with a microchannel (9), and the two ends of microchannel (9) are communicated with liquid-inlet pipe (8) and drain pipe (10) respectively.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201420567663.7U CN204111767U (en) | 2014-09-29 | 2014-09-29 | A kind of novel tumor cell electromagnetic sieve screening device |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201420567663.7U CN204111767U (en) | 2014-09-29 | 2014-09-29 | A kind of novel tumor cell electromagnetic sieve screening device |
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| CN204111767U true CN204111767U (en) | 2015-01-21 |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104805011A (en) * | 2015-04-28 | 2015-07-29 | 中国科学院半导体研究所 | Microfluidic chip and circulating tumor cell capture method using same |
| CN107233941A (en) * | 2017-04-24 | 2017-10-10 | 深圳无微华斯生物科技有限公司 | A kind of multiple near-infrared fluorescent enhancing biochip screening circulating tumor cell method |
| CN110004106A (en) * | 2018-04-12 | 2019-07-12 | 苏州天际创新纳米技术有限公司 | A kind of many cells magnetic separating method and system |
-
2014
- 2014-09-29 CN CN201420567663.7U patent/CN204111767U/en not_active Expired - Fee Related
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104805011A (en) * | 2015-04-28 | 2015-07-29 | 中国科学院半导体研究所 | Microfluidic chip and circulating tumor cell capture method using same |
| CN107233941A (en) * | 2017-04-24 | 2017-10-10 | 深圳无微华斯生物科技有限公司 | A kind of multiple near-infrared fluorescent enhancing biochip screening circulating tumor cell method |
| CN110004106A (en) * | 2018-04-12 | 2019-07-12 | 苏州天际创新纳米技术有限公司 | A kind of many cells magnetic separating method and system |
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| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20150121 Termination date: 20150929 |
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| EXPY | Termination of patent right or utility model |