CN204072058U - Multi-level microcirculating state monitoring device - Google Patents
Multi-level microcirculating state monitoring device Download PDFInfo
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Abstract
The utility model discloses a kind of multi-level microcirculating state monitoring device, comprising: light source controller, multi wave length illuminating source, the polarizer, optical fiber group, catoptric system, imaging optical path battery of lens, analyzer, detector, computer assisted image processing system and imaging optical path controller.Imaging optical path controller controls the imaging and focusing distance of imaging optical path battery of lens; Light source controller drives multi wave length illuminating source to launch the illuminating bundle of different wave length and power; Catoptric system controls the incident angle that polarized illumination beam projects tissue surface.The device that this utility model provides, changed by these four parameters of incident angle imaging and focusing distance, the wavelength of illuminating bundle and power, polarized illumination beam being projected to tissue surface, computer assisted image processing system just in real time, clearly can capture the multi-level microcirculating state information of the inner different depth of tissue.The invention also discloses a kind of multi-level microcirculating state monitoring method.
Description
Technical field
This utility model relates to Photobiology technical field of imaging, particularly relate to a kind of can in tissue the multi-level microcirculating state monitoring device of different depth and method.
Background technology
In blood circulation of human body system, microcirculation refers to the blood circulation between arteriole and venule, the most basic function of blood circulation carries out the mass exchange between blood and tissue, this function realizes in microcirculation part, the each organ of human body, each histiocyte all will provide oxygen, nutriment by microcirculation, transferring energy, gets rid of carbon dioxide and metabolic waste.Once the microcirculation generation obstacle of human body, its corresponding tissue system or internal organs will be affected and function of can not bringing into normal play, and just easily cause the generation of the exhaustion of human organ, the disorder of immunologic function and disease.How Real-Time Monitoring microcirculation situation, particularly quickly and easily monitor the microcirculation situation of critical patient, as early discovery shock (microcirculation failure) sign etc., very crucial for the survival rate improving critical patient.
There is limitation in the current microcirculation imaging device based on cross-polarization imaging, be mainly reflected in: on the one hand, the polarized light of single wavelength is adopted to project skin surface, make can only being transmitted to a specific degree of depth and maybe can only observing blood capillary in certain depth of polarized light, and microcirculation is the formal distribution with three-dimensional; On the other hand, the visual field of single adjustment microcirculation imaging device and numerical aperture, can only improve a microvascular visual field of certain depth and image resolution ratio, but cannot carry out careful observation to each state region of multi-level microcirculation distributed in three dimensions; Also have, for the patient under shock state, due to the microcirculation hypoperfusion in each organ-tissue, the perfusion state of observing each region of microcirculation in real time has important clinical meaning, common microcirculation imaging device is difficult to maybe to carry out depth judgement to the shock patient microcirculation image-forming information got, and also cannot carry out blur-free imaging to the multi-level microcirculating state of different depth.
Summary of the invention
Technical problem to be solved in the utility model is, a kind of multi-level microcirculating state monitoring device and method are provided, the microcirculation degree of depth level that will observe is set according to operator, imaging optical path battery of lens adjusts to applicable imaging and focusing distance, by control the wavelength of illuminating bundle, power and its project the incident angle of human tissue surface, illuminating bundle and imaging and focusing face are appeared in same level.Constantly adjust operator in the process of observing the degree of depth, multi-level microcirculating state monitoring device is changed these four parameters of incident angle that the wavelength of above-mentioned imaging and focusing distance, illuminating bundle and power, polarized illumination beam project human tissue surface automatically, and computer assisted image processing system just in real time, clearly can capture the multi-level microcirculating state information of the inner different depth of tissue.
For solving above technical problem, this utility model embodiment provides a kind of multi-level microcirculating state monitoring device, comprising: light source controller, multi wave length illuminating source, the polarizer, optical fiber group, catoptric system, imaging optical path battery of lens, analyzer, detector, computer assisted image processing system and imaging optical path controller;
Described light source controller, the monitoring human for setting according to operator organizes microcirculation depth requirements, drives described multi wave length illuminating source to launch the illuminating bundle of different wave length and power;
Described multi wave length illuminating source, for providing the illuminating bundle of many group different wave lengths and power;
The described polarizer, for changing the optical characteristics of described illuminating bundle, makes it become polarized illumination beam;
Described optical fiber group receives the polarized illumination beam from the described polarizer, and by described polarized illumination beam collimation for after parallel polarization illuminating bundle, imports to described catoptric system;
The light path part of described catoptric system is arranged on the end of device probe, by adjusting the rotational angle of described catoptric system inner counter mating plate, thus changes the angle that described parallel polarization illuminating bundle projects tissue;
It for gathering the polarized illumination beam that reflects from human tissue surface and the unpoiarized illumination light beam in the inner depolarization after Multiple Scattering of tissue, projects on described detector through described analyzer by described imaging optical path battery of lens;
The polarization direction of described analyzer is vertical with described polarizer polarization direction, effect is that the polarized illumination beam of being returned by tissue surface reflection is filtered, only allow unpoiarized illumination light beam depolarization occurring after Multiple Scattering at organization internal pass through, and project on described detector;
Described detector carries out opto-electronic conversion the unpoiarized illumination light beam of the carrier soma microcirculation information collected, and obtains electrical picture signal, and electrical picture signal is sent to described computer assisted image processing system;
Described computer assisted image processing system carries out real-time analysis, process, storage and feedback to described electrical picture signal;
Described imaging optical path controller, for adjusting the imaging and focusing distance of imaging optical path battery of lens;
Described computer assisted image processing system communicates with imaging optical path controller, light source controller, catoptric system according to image information, adjust described polarized illumination beam and be transmitted to degree of depth level in tissue, to obtain multi-level microcirculating state information clearly.
Further, described optical fiber group comprises polarization maintaining optical fibre and optical fiber collimator two parts;
Described polarization maintaining optical fibre, for keeping the polarization state of polarized illumination beam in transmission; The polarized illumination beam transmitted in polarization maintaining optical fibre can be collimated into parallel polarized illumination beam by described optical fiber collimator;
Preferably, the illuminating bundle wavelength that described multi wave length illuminating source sends is respectively 420nm, 550nm and 880nm, and respective tolerance scope is ± 10nm; Power is maximum is all no more than 3W;
Described catoptric system comprises controller, motor and reflecting piece;
Described controller, for controlling the running of described motor, by the running of described motor, drives the rotational angle changing described reflecting piece, thus can change the incident angle that described parallel polarization illuminating bundle projects human tissue surface's plane of incidence; Polarized illumination beam projects the incident angle of human tissue surface's plane of incidence can by adjustment between 0 degree to 85 degree;
Imaging optical path battery of lens is made up of focus groups, zoom group, compensating group and back focal length group; Wherein, described focus groups is used for adjusting as clear; Described zoom group is used for adjusting as size; Imaging clearly is kept when described compensating group is for changing focal length; Described back focal length group is used for will as moving a rear segment distance.
This utility model still further provides a kind of multi-level microcirculating state monitoring method, comprising:
Set the microcirculation degree of depth level that will observe according to operator, the imaging optical path battery of lens of multi-level microcirculating state monitoring device adjusts to applicable imaging and focusing distance;
Multi wave length illuminating source sends wavelength and the detection degree of depth matches and the illuminating bundle of power appropriateness;
Described illuminating bundle changed over the polarized illumination beam with certain polarization state and collimates as parallel output, and projecting human tissue surface with suitable incident angle;
Described multi-level microcirculating state monitoring device gathers the unpoiarized illumination light beam of carrier soma microcirculation information, carries out opto-electronic conversion and obtains microcirculation digital image information after process;
Fed back by microcirculation digital image information, adjustment polarized illumination beam incident angle and power, obtain the microcirculation digital image information of a certain degree of depth level clearly further;
When constantly adjusting the degree of depth of observation, imaging system just dynamically can export the multi-level microcirculating state information of different depth continuously.
The multi-level microcirculating state monitoring device that this utility model provides and method, there is following beneficial effect: utilize above-described multi-level microcirculating state monitoring device, the microcirculation degree of depth level that will observe is set according to operator, imaging optical path battery of lens adjusts to corresponding imaging and focusing distance, by control the wavelength of illuminating bundle, power and its project the incident angle of tissue surface, illuminating bundle and imaging and focusing face are appeared in same level.Constantly adjust operator in the process of observing the degree of depth, system is changed these four parameters of incident angle that above-mentioned imaging and focusing distance, the wavelength of illuminating bundle, the power of illuminating bundle, polarized illumination beam project tissue surface automatically, and computer assisted image processing system just in real time, clearly can capture the multi-level microcirculating state information of the inner different depth of tissue; The multi-level microcirculating state monitoring device that this utility model provides and method also have simple, convenient in practical operation, to human body noinvasive, harmless, and the feature of the many degree of depth of Real-Time Monitoring, multi-level microcirculating state.
Accompanying drawing explanation
Fig. 1 is the block diagram of an embodiment of the multi-level microcirculating state monitoring device that this utility model provides;
Fig. 2 is a structural representation of the multi-level microcirculating state monitoring device that Fig. 1 provides;
Fig. 3 is with oxygen hemoglobin, deoxyhemoglobin, water, the molar absorption coefficient figure of melanin under Different lightwave is long in tissue;
Fig. 4 is the incident angle of polarized illumination beam under P polarization and S polarization and reflectance relationship figure;
Fig. 5 is the schematic flow sheet of an embodiment of a kind of multi-level microcirculating state monitoring method that this utility model provides.
Detailed description of the invention
Below in conjunction with the accompanying drawing in this utility model embodiment, the technical scheme in this utility model embodiment is clearly and completely described.
See Fig. 1, it is the block diagram of an embodiment of the multi-level microcirculating state monitoring device that this utility model provides.
In the present embodiment, described multi-level microcirculating state monitoring device comprises: light source controller 101, multi wave length illuminating source 102, the polarizer 103, optical fiber group 104, catoptric system 105, imaging optical path battery of lens 106, analyzer 107, detector 108, computer assisted image processing system 109 and imaging optical path controller 110.
The basic functional principle of this multi-level microcirculating state monitoring device is: according to microcirculation target depth level in the tissue that will monitor, and first imaging optical path controller 110 can control imaging optical path battery of lens 106 according to depth information and adjust to applicable imaging and focusing distance; Light source controller 101 drives multi wave length illuminating source 102 to send the illuminating bundle of specific wavelength and power; Light, after the polarizer 103, becomes the polarized illumination beam with special polarization state; Described polarized illumination beam arrives catoptric system 105 by optical fiber group 104; Rotation based on the built-in reflecting piece of catoptric system 105 regulates, and light can project in tissue with specific incident angle; Imaging optical path battery of lens 106 gathers the loop light beam of returning through tissue reflection or scattering, and focuses on detector 108; In the way of loop beam propagation, the analyzer 107 that described loop light beam can be vertical with polarizer polarization direction through one piece of polarization direction, thus the light filtering of the microcirculation information of not carrying directly reflected from tissue surface; Detector 108 carries out opto-electronic conversion the received optical signal carrying microcirculation information, the signal of telecommunication obtained is input to computer assisted image processing system 109, and computer assisted image processing system 109 can image information real-time analysis, process, storage and feedback; Described image information is after process and analysis, command information can pass to light source controller 101 and catoptric system 106, respectively corresponding adjustment is made to the wavelength of illuminating bundle and power, the incident angle that projects tissue surface, obtain digital image information clearly; Observe in the process of the degree of depth at operator's continuous setup, computer assisted image processing system 109 can communicate with imaging optical path controller 110, light source controller 101, catoptric system 105 according to image information, change these four parameters of incident angle that the wavelength of imaging and focusing distance, illuminating bundle and power, polarized illumination beam project tissue surface respectively separately, computer assisted image processing system 109 just in real time, clearly can capture the multi-level microcirculating state information of different depth in tissue.
Referring to Fig. 2, it is a structural representation of the multi-level microcirculating state monitoring device that Fig. 1 provides.
Wherein, described light source controller 201, for setting microcirculation target depth level in the tissue that will monitor according to operator, drives described multi wave length illuminating source 202 to launch illuminating bundle with specific wavelength and power.During concrete enforcement, because the optical characteristics that the penetration depth of described illuminating bundle in tissue can be subject to multiple tissue affected, as absorption, scattering, transmission and reflection simultaneously.But have much different compositions, as erythrocyte, water and melanin in tissue; Each composition has their distinctive optical characteristics, polarized illumination beam itself also with certain optical characteristics, as luminous power, wavelength, polarization state; The distinctive absorption characteristic of erythrocyte is exactly the basis of the imaging function of described microcirculating state monitoring device.
Referring to Fig. 3, be with oxygen hemoglobin, deoxyhemoglobin, water, the molar absorption coefficient figure of melanin under Different lightwave is long in tissue.
As shown in Figure 3, in the absorption spectrum being with oxygen hemoglobin and deoxyhemoglobin, the absworption peaks such as wavelength is 420 nm, 550 nm and 880 nm are, by the understanding to erythrocyte light absorption frequency spectrum, can help to select the illuminating bundle with suitable wavelength, therefore the illuminating bundle wavelength that multi wave length illuminating source 102 sends is preferably 420nm, 550nm and 880nm respectively, and respective tolerance scope is ± 10nm.Because tissue interior edema divides the ratio that account for about 70%, the multi-level microcirculating state of different depth be observed, understand the absorption spectrum of water and just to seem particular importance.
In addition, melanin is also the important component affecting illuminating bundle transmission depth in tissue, in the polarized illumination beam of above-mentioned 3 kinds of wavelength, melanin is that the polarized illumination beam absorbance of 420nm is the highest to wavelength, and melanin is that the polarized illumination beam absorbance of 880nm is minimum to wavelength.
Preferably, the polarized illumination beam that light source controller 201 can be 420nm according to practical situation wavelength observes the microcirculating state in shallow-layer tissue, observe the microcirculating state in the tissue of middle level with the polarized illumination beam that wavelength is 550nm, observe the microcirculating state in deep layer tissue with the polarized illumination beam that wavelength is 880nm.
In addition, luminous power is also affect the factor of light in organization internal transmission depth, and light exists relation in the size of organization internal transmission depth and luminous power:
（1）
In formula (1),
i(
z) represent the illuminating bundle power arriving and organize needed for the internal object degree of depth,
i 0represent and just can enter in-house initial illumination light beam power, α represents absorptance, and z represents the in-house degree of depth.Therefore, polarized illumination beam be made to reach the degree of depth of organization internal darker, required polarized illumination beam power is larger.Particularly, in actual applications, the illuminating bundle that light source controller 201 pairs of multi wave length illuminating sources 202 send adjusts flexibly, and the mode mainly through changing voltage or electric current changes the power of illuminating bundle, and illuminating bundle power is maximum is no more than 3W.Adjust the effect of polarized illumination beam in the tissue internal transmission degree of depth compared to change illuminating bundle wavelength, change illuminating bundle power and mainly play the polarized illumination beam effect that transmission depth is finely tuned in tissue.
In the present embodiment, light source controller 201 according to the observation degree of depth of operator's setting, by comprehensively analyzing required illuminating bundle wavelength and power, control multi wave length illuminating source 202 and selecting to send applicable wavelength and the illuminating bundle of power.
Described multi wave length illuminating source 202, for providing the illuminating bundle of many group different wave lengths and power.Particularly, described multi wave length illuminating source 202 sends three groups of illuminating bundles, and three groups of illuminating bundle wavelength are respectively 420 nm, 550 nm and 880 nm, and respective tolerance scope is ± 10 nm; Three groups of illuminating bundles can be sent respectively by three different light emitting diodes, or also can be sent by tunable laser (tunable laser).
Preferably, described multi wave length illuminating source 202 select three emission wavelengths be respectively 420 nm, 550 nm, 880 nm light emitting diode as luminescent device.
The described polarizer 203 is arranged on the direction of advance of the illuminating bundle that described multi wave length illuminating source 202 sends, and for changing the optical characteristics of illuminating bundle, makes it become polarized illumination beam with certain polarization state; The polarization state of polarized illumination beam that the polarizer 203 is changed, includes but not limited to P polarization, S polarization, also can be the mixed polarization states of P polarization and S polarization.
Preferably, the polarization state of the polarized illumination beam that the polarizer 203 described in the present embodiment deflects away from is P polarization, but is not limited to P polarization.
Described optical fiber group receives the polarized illumination beam from the described polarizer 203, and polarized illumination beam is imported to described catoptric system.Particularly, optical fiber group comprises polarization maintaining optical fibre 204 and optical fiber collimator 205 two parts.
Wherein, described polarization maintaining optical fibre 204 comprises high birefringence optical fiber and low birefringent fiber two kinds of making forms, and described polarization maintaining optical fibre 204 is for keeping the polarization state of polarized illumination beam in transmission; Described optical fiber collimator 205 is accurately located by tail optical fiber and GRIN Lens and is formed, and the transmission polarized illumination beam in polarization maintaining optical fibre 204 can be transformed into parallel polarized illumination beam by described optical fiber collimator 205.
The light path part of described catoptric system is arranged on the end of device probe, by changing the controling parameters of described catoptric system, can change the incident angle of described parallel polarization illumination beam to human tissue surface's plane of incidence; The incident angle changing polarized illumination beam can change the reflectance of polarized illumination beam human tissue surface.
The polarized illumination beam of S polarization state meets following relation at the reflectance of human tissue surface:
（2）
The polarized illumination beam of P polarization state meets following relation at the reflectance of human tissue surface:
（3）
In formula (2), formula (3), n
1for the refractive index of air, n
2for the refractive index of tissue, incidence angle θ
ifor polarized illumination beam to project the angle of human tissue surface from air, R
sfor the polarized illumination beam of S polarization state is at the reflectance of human tissue surface, R
pfor the polarized illumination beam of P polarization state is at the reflectance of human tissue surface.
The absorbance of polarized illumination beam in tissue of S polarization state equals 1 and deducts R
s; The absorbance of polarized illumination beam in tissue of P polarization state equals 1 and deducts R
p; Therefore can change the absorbance of polarized illumination beam in tissue by the incident angle changing polarized illumination beam, make polarized illumination beam can arrive degree of depth levels different in tissue.
Referring to Fig. 4, be the incident angle of polarized illumination beam under P polarization and S polarization and reflectance relationship figure; As can be seen from the figure the polarized illumination beam of P polarization is adopted can to obtain absorbance maximum in tissue.
Particularly, described catoptric system comprises controller 206, motor 207 and reflecting piece 208.
Wherein, described controller 206, for controlling the running of described motor 207, analyzes polarized illumination beam at the incident angle information of human tissue surface and related communication; Described reflecting piece 208 is the slice structure of a lever rotation, and fixed by the fulcrum in the middle part of described reflecting piece 208, described reflecting piece 208 one end is connected by spring, and the other end is connected to described motor 207 by rope; Pull rope to change the rotational angle of described reflecting piece 208 by described motor 207 running, thus the incident angle that described parallel polarization illuminating bundle projects human tissue surface's plane of incidence can be changed; Polarized illumination beam projects the incident angle of human tissue surface's plane of incidence can by adjustment between 0 degree to 85 degree.
It for gathering the polarized illumination beam that returns from tissue surface and the unpoiarized illumination light beam in organization internal depolarization after Multiple Scattering, projects on described detector through described analyzer by described imaging optical path battery of lens 209; Particularly, imaging optical path battery of lens 209 is made up of focus groups, zoom group, compensating group and back focal length group.Wherein, described focus groups is used for adjusting as clear; Described zoom group is used for adjusting as size; Imaging clearly is kept when described compensating group is for changing focal length; Described back focal length group is used for will as moving a rear segment distance.
Described imaging optical path controller 210 for adjusting the imaging and focusing distance of imaging optical path battery of lens 209, thus changes over the multiplying power of picture, numerical aperture, visual field and resolution; The imaging and focusing distance that the microcirculating state of different degree of depth levels has it corresponding, described imaging optical path controller 210 sets the tissue microcirculation degree of depth level that will observe according to operator, control described imaging optical path battery of lens and adjust to corresponding imaging and focusing distance.
Described analyzer 211 is arranged on the rear end of imaging optical path battery of lens, polarization direction is vertical with polarizer polarization direction, the polarized illumination beam of returning from tissue surface reflection is filtered, only allow unpoiarized illumination light beam depolarization occurring after Multiple Scattering at organization internal pass through, and project on described detector 212.
Described detector 212 is a kind of sensors, the optical signal of spatial domain is converted into the signal of telecommunication of spatial domain, as charge coupled cell imageing sensor or cmos image sensor etc.; Described detector 212 is sent to described computer assisted image processing system 213 the signal of telecommunication, it is electrical picture signal that the unpoiarized illumination light beam of the carrier soma microcirculation information collected is carried out opto-electronic conversion, and electrical picture signal is sent to described computer assisted image processing system 213.
Described computer assisted image processing system 213 carries out real-time analysis, process, storage and feedback to described electrical picture signal, can communicate according to the controller 206 of image information with imaging optical path controller 210, light source controller 201, catoptric system simultaneously, make illuminating bundle and imaging and focusing face appear in same level; Further, described computer assisted image processing system 213 pairs of images carry out quantitative analysis, calculate the relevant information of microcirculating state, as blood flow rate, microvessel density etc., export multi-level microcirculating state digital image information.
In the present embodiment, when adopting described multi-level microcirculating state monitoring device to carry out the multi-level microcirculating state of Real-Time Monitoring different depth, its specific works process is: the microcirculating state will observing a certain degree of depth level according to operator's setting, first imaging optical path controller 210 can control imaging optical path battery of lens 209 according to depth information and adjust to applicable imaging and focusing distance, light source controller 201 can send wavelength according to depth information control multi wave length illuminating source 202 simultaneously and the monitoring degree of depth matches and the illuminating bundle of power appropriateness, illuminating bundle can pass through the polarizer 203, the illuminating bundle that multi wave length illuminating source 202 sends is changed over the polarized illumination beam with certain polarization state by the polarizer 203, polarized illumination beam collimates the reflecting piece 208 of rear arrival catoptric system by the transmission of polarization maintaining optical fibre 204 and optical fiber collimator 205, catoptric system controls its inner counter mating plate 208, with moderate incident angle, polarized illumination beam is projected human tissue surface.Imaging optical path battery of lens 209 gathers the polarized illumination beam that returns from tissue surface reflection and the unpoiarized illumination light beam in organization internal carrier soma microcirculation information of depolarization after Multiple Scattering; All illuminating bundles that imaging optical path battery of lens 209 collects all can be vertical with polarizer polarization direction through one piece of polarization direction analyzer 211, thus the polarized illumination beam filtering of the microcirculation information of not carrying directly reflected from tissue surface; Detector 212 is converted to the signal of telecommunication the optical signal carrying microcirculation information by analyzer 211, and the signal of telecommunication be converted to is sent to computer assisted image processing system 213; Computer assisted image processing system 213 pairs of signals of telecommunication carry out quantitative analysis, calculate microcirculatory image state, output digital image information.
Digital image information can be fed back to controller 206 and the light source controller 201 of catoptric system by computer assisted image processing system 213 in real time; The controller 206 of catoptric system projects the incident angle of human tissue surface's plane of incidence by adjustment polarized illumination beam, illuminating bundle is made to reach target depth level more exactly, then light source controller 201 is again by the power of adjustment illuminating bundle, illuminating bundle is made more accurately to reach target depth level, appear in same level with imaging and focusing distance, thus make computer assisted image processing system 213 can obtain the microcirculating state digital image information of a certain level clearly.
Be transmitted in the adjustment order of the tissue degree of depth at change polarized illumination beam, the adjustment of polarized illumination beam wavelength is had precedence over the adjustment of polarized illumination beam at tissue surface incident angle, polarized illumination beam is had precedence over to the adjustment of polarized illumination beam power in the adjustment of tissue surface incident angle.
Therefore, when operator wants the multi-level microcirculating state of different depth in observer soma, by the microcirculation degree of depth level that the adjustment of operator's continuous print will be observed, the imaging and focusing distance of imaging optical path controller 210 meeting continuous print adjustment imaging optical path battery of lens 209, each degree of depth level has corresponding imaging and focusing distance, and the tissue internal depth that imaging and focusing distance is reached with polarized illumination beam all the time matches.Then, the adjustment illuminating bundle wavelength that the controller 206 of light source controller 201 and catoptric system moves in circles by above-mentioned workflow, power and at human tissue surface's incident angle, make polarized illumination beam appear in same level all the time in the transmission depth of tissue and imaging and focusing distance, this device just can continuously dynamically and export multi-level microcirculating state digital image information clearly.
On the other hand, this utility model additionally provides a kind of multi-level microcirculating state monitoring method.
Referring to Fig. 5, it is the schematic flow sheet of an embodiment of a kind of multi-level microcirculating state monitoring method that this utility model provides.
In the present embodiment, utilize the multi-level microcirculating state monitoring device in above-described embodiment, monitor the multi-level microcirculating state of different depth, its concrete monitoring step comprises:
Set the microcirculation degree of depth level that will observe according to operator, the imaging optical path battery of lens of multi-level microcirculating state monitoring device adjusts to applicable imaging and focusing distance; Multi wave length illuminating source sends wavelength and the detection degree of depth matches and the illuminating bundle of power appropriateness; Described illuminating bundle changed over the polarized illumination beam of certain polarization state and collimate as parallel output, and projecting human tissue surface with suitable incident angle;
Described multi-level microcirculating state monitoring device gathers the unpoiarized illumination light beam of carrier soma microcirculation information, carries out opto-electronic conversion and obtains microcirculation digital image information after process; Fed back by microcirculation digital image information, adjustment polarized illumination beam incident angle and power, obtain the microcirculation digital image information of a certain degree of depth level clearly further; When constantly adjusting the degree of depth of observation, imaging system just dynamically can export the multi-level microcirculating state information of different depth continuously.
Particularly, the multi-level microcirculating state monitoring method that this utility model embodiment provides can be subdivided into following steps:
Step S301: imaging optical path battery of lens adjusts to applicable imaging and focusing distance by the microcirculation degree of depth level of monitoring.
Step S302: multi wave length illuminating source sends the illuminating bundle of wavelength coincidence detection depth requirements and power appropriateness.Particularly, multi wave length illuminating source provides the illuminating bundle of many group different wave lengths and power.As preferred value, described wavelength is respectively 3 fixed values of 420nm, 550nm and 880nm, and respective tolerance scope is ± 10nm; Described power is maximum is all no more than 3W.
Step S303: illuminating bundle changed over the polarized illumination beam with certain polarization state and collimates as parallel output, and projecting human tissue surface with suitable incident angle.Wherein incident angle controls between 0 degree to 85 degree.
Step S304: the unpoiarized illumination light beam gathering carrier soma microcirculation information, carries out opto-electronic conversion and obtains microcirculation digital image information after process.
Step S305: fed back by microcirculation digital image information, adjustment polarized illumination beam incident angle and power, obtain the microcirculation digital image information of a certain degree of depth level clearly further.
Step S306: when constantly adjusting the degree of depth of observation, imaging system just dynamically can export the multi-level microcirculating state information of different depth continuously.
The multi-level microcirculating state monitoring method that this utility model provides, utilize above-described multi-level microcirculating state monitoring device, the microcirculation degree of depth level that will observe is set according to operator, imaging optical path battery of lens adjusts to corresponding imaging and focusing distance, by control the wavelength of illuminating bundle, power and its project the incident angle of tissue surface, illuminating bundle and imaging and focusing face are appeared in same level.Constantly adjust operator in the process of observing the degree of depth, system is changed these four parameters of incident angle that above-mentioned imaging and focusing distance, the wavelength of illuminating bundle, the power of illuminating bundle, polarized illumination beam project tissue surface automatically, and computer assisted image processing system just in real time, clearly can capture the multi-level microcirculating state information of the inner different depth of tissue.
The above is preferred implementation of the present utility model; it should be pointed out that for those skilled in the art, under the prerequisite not departing from this utility model principle; can also make some improvements and modifications, these improvements and modifications are also considered as protection domain of the present utility model.
Claims (5)
1. a multi-level microcirculating state monitoring device, it is characterized in that, comprising: light source controller, multi wave length illuminating source, the polarizer, optical fiber group, catoptric system, imaging optical path battery of lens, analyzer, detector, computer assisted image processing system and imaging optical path controller;
Described light source controller, the monitoring human for setting according to operator organizes microcirculation depth requirements, drives described multi wave length illuminating source to launch the illuminating bundle of different wave length and power;
Described multi wave length illuminating source, for providing the illuminating bundle of many group different wave lengths and power;
The described polarizer, for changing the optical characteristics of described illuminating bundle, makes it become polarized illumination beam;
Described optical fiber group receives the polarized illumination beam from the described polarizer, and by described polarized illumination beam collimation for after parallel polarization illuminating bundle, imports to described catoptric system;
The light path part of described catoptric system is arranged on the end of device probe, by adjusting the rotational angle of described catoptric system inner counter mating plate, thus changes the angle that described parallel polarization illuminating bundle projects tissue;
It for gathering the polarized illumination beam that reflects from human tissue surface and the unpoiarized illumination light beam in the inner depolarization after Multiple Scattering of tissue, projects on described detector through described analyzer by described imaging optical path battery of lens;
The polarization direction of described analyzer is vertical with described polarizer polarization direction, effect is that the polarized illumination beam of being returned by tissue surface reflection is filtered, only allow unpoiarized illumination light beam depolarization occurring after Multiple Scattering at organization internal pass through, and project on described detector;
Described detector carries out opto-electronic conversion the unpoiarized illumination light beam of the carrier soma microcirculation information collected, and obtains electrical picture signal, and electrical picture signal is sent to described computer assisted image processing system;
Described computer assisted image processing system carries out real-time analysis, process, storage and feedback to described electrical picture signal;
Described imaging optical path controller, for adjusting the imaging and focusing distance of imaging optical path battery of lens;
Described computer assisted image processing system communicates with imaging optical path controller, light source controller, catoptric system according to image information, adjust described polarized illumination beam and be transmitted to degree of depth level in tissue, to obtain multi-level microcirculating state information clearly.
2. multi-level microcirculating state monitoring device as claimed in claim 1, it is characterized in that, described optical fiber group comprises polarization maintaining optical fibre and optical fiber collimator two parts;
Described polarization maintaining optical fibre, for keeping the polarization state of polarized illumination beam in transmission; The polarized illumination beam transmitted in polarization maintaining optical fibre can be collimated into parallel polarized illumination beam by described optical fiber collimator.
3. multi-level microcirculating state monitoring device as claimed in claim 2, it is characterized in that, many groups illuminating bundle power that described multi wave length illuminating source sends is maximum is all no more than 3W.
4. multi-level microcirculating state monitoring device as claimed in claim 3, it is characterized in that, described catoptric system comprises controller, motor and reflecting piece;
Described controller, for controlling the running of described motor, by the running of described motor, drives the rotational angle changing described reflecting piece, thus can change the incident angle that described parallel polarization illuminating bundle projects human tissue surface's plane of incidence; Polarized illumination beam projects the incident angle of human tissue surface's plane of incidence can by adjustment between 0 degree to 85 degree.
5. multi-level microcirculating state monitoring device as claimed in claim 4, it is characterized in that, imaging optical path battery of lens is made up of focus groups, zoom group, compensating group and back focal length group;
Described focus groups is used for adjusting as clear;
Described zoom group is used for adjusting as size;
Imaging clearly is kept when described compensating group is for changing focal length;
Described back focal length group is used for will as moving a rear segment distance.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201420604639.6U CN204072058U (en) | 2014-10-20 | 2014-10-20 | Multi-level microcirculating state monitoring device |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104224135A (en) * | 2014-10-20 | 2014-12-24 | 广州医软智能科技有限公司 | Multilevel microcirculation condition monitoring device and method |
| CN106725345A (en) * | 2017-01-24 | 2017-05-31 | 青岛大学 | Device for detecting human body microvascular ultrastructure by circular polarization lateral flow dark field imaging technology |
| CN107505270A (en) * | 2017-07-07 | 2017-12-22 | 广州医软智能科技有限公司 | Microcirculation imaging method and device |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104224135A (en) * | 2014-10-20 | 2014-12-24 | 广州医软智能科技有限公司 | Multilevel microcirculation condition monitoring device and method |
| CN106725345A (en) * | 2017-01-24 | 2017-05-31 | 青岛大学 | Device for detecting human body microvascular ultrastructure by circular polarization lateral flow dark field imaging technology |
| CN106725345B (en) * | 2017-01-24 | 2023-08-11 | 青岛大学 | Device for detecting human microvascular ultrastructure by using circular polarization sidestream dark field imaging technology |
| CN107505270A (en) * | 2017-07-07 | 2017-12-22 | 广州医软智能科技有限公司 | Microcirculation imaging method and device |
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