CN203929616U - A kind of flow cell with optical fiber interface - Google Patents
A kind of flow cell with optical fiber interface Download PDFInfo
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- CN203929616U CN203929616U CN201320832501.7U CN201320832501U CN203929616U CN 203929616 U CN203929616 U CN 203929616U CN 201320832501 U CN201320832501 U CN 201320832501U CN 203929616 U CN203929616 U CN 203929616U
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Abstract
A kind of flow cell with optical fiber interface, its body comprises middle liquid storage cavity and fluid input tube mouth and the fluid output tube mouth for fluid process, described fluid input tube mouth and fluid output tube mouth are communicated with described middle liquid storage cavity respectively, and be oppositely arranged at described middle liquid storage cavity two ends, it is characterized in that, at described middle liquid storage cavity both sides and fluid input tube mouth, middle liquid storage cavity, the direction that in fluid output tube mouth, fluid flow direction is vertical has two symmetrical windows, described window is communicated with middle liquid storage cavity and for mounted lens sleeve, described lens sleeve is for mounted lens O-ring seal, integrated echelon lens, lens position cover, supported flange and optic fibre switching head.The structural design of this flow cell is compact, flow cell inner chamber is followed with runner uniform cross section and is designed, flow resistance and additional volume have effectively been reduced, this integrated lens adopts stepped-style design, good seal performance can reduce liquid thickness between two lens as far as possible, makes maximum range improve 3～5 times, effectively suppress the flat peak that outrange causes, lenticular spacing is from adjusting within the specific limits simultaneously.
Description
Technical field
The utility model relates to process-scale chromatography chromatography pick-up unit, relates to particularly a kind of flow cell with optical fiber interface.
Background technology
Process-scale chromatography chromatography mainly refers to and from mixed solution, obtains purifying substance, is widely used in the commercial production of the products such as medicine, food additives.Flow cell collocation detects analytical equipment always for the final detection of the solution component concentration that obtains after chromatography.It is the important component part in whole chromatography process, directly affects correctness and the stability of component data acquisition.
On market, be flooded with multiple flow cell, what have is simple in structure, some complex structures, and from runner design, cardinal principle can be divided into through-type, U-shaped, Z-type and H type.
Patent CN200520097122.3 discloses a kind of flow cell and adopts opaque cavity, has avoided impurity and astigmatism, and light path is stable, but cavity design easily causes turbulent flow, can bring error to testing result; Patent CN200920175746.0 discloses a kind of flow cell flow and can reach 20-80ml/min especially, but because light beam causes stream steady not in the middle of being directly deep into stream, to testing result, brings interference.Patent CN201010586403.0 discloses a kind of flow cell and can regulate light path according to detected material concentration and absorbance difference especially, but optical glass contacts with rotating sealing clamp, when dismounting, more easily optical glass is damaged.
Separately there is patent CN200610039219.8, CN200420081014.2, CN200420021814.5, disclosed a kind of flow cell such as CN201220464843.3, its runner has U-shaped, Z-type and the design of H type.The runner of the disclosed flow cell of patent CN200610039219.8 adopts lucite pipe or glass tube especially, the flat window mouth region that optical channel is bending part, and window and runner, as one, have been avoided seepage and dead angle; The disclosed flow cell of patent CN200420081014.2 adopts full quartz construction especially, pond body and piezoid adopt transparent optical gluing knot, though avoided the problem of processing difficulties, but to the smooth finish of minute surface and avoid the resistivity of light disturbance greatly to weaken, do not meet the hygienic requirements of FDA to runner; Patent CN200420021814.5 especially, CN201220464843.3 adopts Z-type runner design, and light path overlaps with inclined flow passage, while there is bubble in stream, because bubble blocks light path, testing result is caused and is had a strong impact on.
In addition, existing flow cell is because the existence of lens fixing device makes two lens minute surfaces often can not lean on too closely, and light path can not be too little, and this may cause detecting device cannot detect some high concentration fluids, has limited detection range.
Therefore all there is the many disadvantages that is difficult to overcome in conventional flow cell, separately.
Utility model content
For overcoming the defect of above conventional flow cell, the utility model discloses a kind of small-sized flow cell with optical fiber interface, on the basis of the most of advantage of comprehensive conventional flow cell, and combination product practical service environment, selectively overcome its major defect, improve significantly it and detect performance.
The utility model provides a kind of flow cell with optical fiber interface, its body comprises middle liquid storage cavity and fluid input tube mouth and the fluid output tube mouth for fluid process, described fluid input tube mouth and fluid output tube mouth are communicated with described middle liquid storage cavity respectively, and be oppositely arranged at described middle liquid storage cavity two ends, it is characterized in that, at described middle liquid storage cavity both sides and fluid input tube mouth, middle liquid storage cavity, the direction that in fluid output tube mouth, fluid flow direction is vertical has two symmetrical windows, described window is communicated with middle liquid storage cavity and for mounted lens sleeve, described lens sleeve is for mounted lens O-ring seal, integrated echelon lens, lens position cover, supported flange and optic fibre switching head.
Preferably, described middle liquid storage cavity is column type cavity, and this cavity axis direction is opened taper reducing, and this reducing shape is used for guaranteeing that cross section of fluid channel is long-pending basically identical.Can make like this flow cell inner chamber follow the design of runner uniform cross section, effectively reduce flow resistance and additional volume, fluid is flowed steadily, accuracy of detection significantly improves.
Preferably, the deeply middle liquid storage cylinder body of described lens sleeve is divided into cylindrical cavity, and this cylindrical cavity end has integrated echelon lens installing port.
Preferably, the flange portion that described lens sleeve is stretched out middle liquid storage cavity adopts screw to be connected with flow cell body, and the middle O-ring seal that adopts seals.
Integrated echelon lens is housed in described lens sleeve, these lens combine (but these two parts are integrated formation) by one section of cylindrical plane lens and one side convex lens, these lens rely on lens position cover and flange screw, and liquid receiving end portion adopts the sealing of lens O-ring seal.Owing to having adopted the integrated echelon lens of this special construction, two lens can be drawn closer together, can reduce liquid thickness between two lens as far as possible, shorten light path, make detecting device maximum range improve 3～5 times, effectively suppress the flat peak that outrange causes.In addition, this special staircase structure also makes sealing be more prone to, and has improved sealing property.
Two integrated echelon lenses form optical channel along axis direction.
Optical channel mouth is left at two lens position cover centers.
Two supported flanges are separately installed with optic fibre switching head, for being connected with external fiber.Detecting device light source from a side through the optical fiber pond that circulates, optical fiber head is positioned at lens focus, through lens, transfer source of parallel light to and penetrate central fluid medium, and then return in an other optical fiber via a reverse process, final Returning detector carries out light intensity detection and contrast.
Optic fibre switching head is equipped with in the cavity outside of two supported flanges, is used separately as optical fiber entrance and outlet (being connected UV detecting device).Optic fibre switching head is fixed on supported flange, and can in supported flange, prolong optical path axis to carrying out distance adjustment, and optical fiber head is accurately positioned in lens focus.Supported flange is fixed on lens sleeve by flange face screw, supported flange coordinates with lens sleeve, axial compression lens position cover, integrated echelon lens, lens O-ring seal, form airtight lens cavity, its outer circumference surface is locating surface, guarantee light path coaxial, optic fibre switching head, lens position cover, lens O-ring seal all has light path through hole.Flow cell cavity two ends have fluid input tube mouth and the output mouth of pipe, and fluid to be checked is flowed into from one end, and the runner to be checked forming through two lens, then flows out from other one end.
The manufactured materials of this small-sized flow cell can be selected according to actual needs expediently by those skilled in the art.The flow cell using in fields such as medicine, food need to meet the particular requirement of various countries regulator (as U.S. FDA).For example, the flow cell using in fields such as medicine, food, its body preferably adopts the manufacture of polyethers ether copper (PEEK) material, and lens preferably adopt sapphire or artificial sapphire manufacture.Such benefit is that these materials have good processing characteristics and intensity, and acid-alkali-corrosive-resisting, meets the hygienic requirements of the relevant supervision structures such as FDA.
Each preferred aspect of the above the utility model can combine mutually.The various array modes of each preferred feature are all within scope of the present utility model.
Herein to the description of any one parts, assembly, structure should not be considered as exhaustive, exclusiveness, each parts, assembly, structure may also contain not specifically mentioned other auxiliary component or supplementary structure herein.These auxiliary components or supplementary structure can be determined according to the existing knowledge and skills of those skilled in the art.
Having with next or many advantages of the small-sized flow cell with optical fiber interface of the present utility model:
1) structural design is tight, and number of components is few, be difficult for lens glass body to cause damage, so reliability is high, long service life in lens disassembly process.
2) optical mirror slip adopts integrated stepped design, has reduced optical path loss, and fluid thickness to be measured is reduced to below 1mm, and adjustable interval, has improved 3～5 times of maximum ranges (the minimum fluid thickness that allows of conventional plano lens is about 5mm) simultaneously; Improved sealing property simultaneously.
3) lenticular spacing, from adjusting within the specific limits, makes it easily adapt to various diversified demands, applied range.
4) flow cell inner chamber is followed and the design of runner uniform cross section, and fluid flows steadily, and accuracy of detection significantly improves.Below in conjunction with the drawings and specific embodiments, the utility model is further elaborated.
5) manufactured materials and structure meet the hygienic requirements of the relevant supervision structures such as FDA, and acid-alkali-corrosive-resisting, long service life.
Below in conjunction with the drawings and specific embodiments, the utility model is further elaborated.
Accompanying drawing explanation
Figure 1 shows that flow cell one-piece construction schematic diagram of the present utility model;
Figure 2 shows that sectional arrangement drawing of the present utility model;
Figure 3 shows that integrated echelon lens schematic diagram of the present utility model.
1. flow cell bodies in figure, 2. lens sleeve, 3. optic fibre switching head, 4, supported flange, 5. integrated echelon lens, 6. lens position cover, 7. lens sleeve O-ring seal, 8. lens O-ring seal, 9. fluid input tube mouth, 10. fluid output tube mouth.
Embodiment
Fig. 1～3 show the small-sized flow cell with optical fiber interface of the present utility model, and this flow cell has the flow cell body 1 of integrated design, and its internal cavity is class column type cavity (liquid storage cavity), these cavity two ends are symmetrically arranged with fluid input tube mouth 9 and fluid output tube mouth 10, these cavity both sides (i.e. the direction vertical with fluid flow direction) are symmetrically arranged with two circular ports (window), this circular port is for fit lens sleeve 2, the cylindrical cavity of this lens sleeve 2 gos deep in the middle liquid storage cavity of flow cell, lens sleeve 2 heads are equipped with integrated ladder convex lens 5, convex lens end is placed with lens O-ring seal 8, two lens coordinate with lens sleeve 2, coaxial installation relatively, centre is fluid course to be measured, lens 5 rear ends are fixed with supported flange 4 axial compression by lens position cover 6.Optic fibre switching head 3 can prolong axial adjustment in supported flange 4 the insides, to adapt to the focal length of lens 5, has adjusted rear dependence supported flange 4 screw thread jackscrew locking axial location above.Between lens sleeve 2 and flow cell body 1, rely on 7 sealings of lens sleeve O-ring seal, and profit is screwed.Meanwhile, as needs adjust two lenticular spacings from, only need between flow cell body 1 and lens sleeve 2, pad the ring washer of respective thickness or the thickness of increase lens O-ring seal 8 can be realized.
When the liquid-inlet 9 of liquid to be detected by flow cell flows into, circulate in the inner chamber body of pond, by be combined to form certain thickness detection runner by a pair of lens sleeve.The detection light of specific wavelength is injected in one end of optical fiber interface, detect light after lens reflection with parallel beam perpendicular to injecting fluid, light wave is after absorption of fluids, by an absorption of fluids part, residual ray is the reverse optical fiber of getting back to of device opposite side after testing, by detecting device, detect and analyze again, and then differentiate the content of test substance (for example albumen) in fluid.
The foregoing is only embodiment of the present utility model; not thereby limit the scope of the claims of the present utility model; every equivalent structure or conversion of equivalent flow process that utilizes the utility model instructions and accompanying drawing content to do; or be directly or indirectly used in other relevant technical fields, be all in like manner included in scope of patent protection of the present utility model.
Claims (7)
1. a flow cell with optical fiber interface, its body comprises middle liquid storage cavity and fluid input tube mouth (9) and the fluid output tube mouth (10) for fluid process, described fluid input tube mouth (9) and fluid output tube mouth (10) are communicated with described middle liquid storage cavity respectively, and be oppositely arranged at described middle liquid storage cavity two ends, it is characterized in that, at described middle liquid storage cavity both sides and fluid input tube mouth (9), middle liquid storage cavity, in fluid output tube mouth (10), the vertical direction of fluid flow direction has two symmetrical windows, described window is communicated with middle liquid storage cavity and for mounted lens sleeve (2), described lens sleeve (2) is for mounted lens O-ring seal (8), integrated echelon lens (5), lens position cover (6), supported flange (4) and optic fibre switching head (3).
2. flow cell as claimed in claim 1, is characterized in that, the flange portion that described lens sleeve (2) is stretched out middle liquid storage cavity adopts screw to be connected with flow cell body (1).
3. flow cell as claimed in claim 2, is characterized in that, described lens sleeve (2) is also provided with lens sleeve O-ring seal (7) between the flange portion of liquid storage cavity and described flow cell body (1) in the middle of stretching out.
4. flow cell as claimed in claim 1, is characterized in that, at described lens position cover (6) center, leaves optical channel mouth.
5. the flow cell as described in claim 1-4 any one, is characterized in that, described flow cell body (1) adopts polyethers ether copper product to manufacture, and described lens (5) adopt sapphire or artificial sapphire manufacture.
6. the flow cell as described in claim 1-4 any one, is characterized in that, the deeply middle liquid storage cylinder body of described lens sleeve (2) divides formation one cylindrical cavity.
7. flow cell as claimed in claim 6, is characterized in that, described integrated echelon lens (5) consists of integrated cylindrical plane lens that form and one side convex lens.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201320832501.7U CN203929616U (en) | 2013-12-18 | 2013-12-18 | A kind of flow cell with optical fiber interface |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201320832501.7U CN203929616U (en) | 2013-12-18 | 2013-12-18 | A kind of flow cell with optical fiber interface |
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| Publication Number | Publication Date |
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| CN203929616U true CN203929616U (en) | 2014-11-05 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201320832501.7U Expired - Fee Related CN203929616U (en) | 2013-12-18 | 2013-12-18 | A kind of flow cell with optical fiber interface |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107561034A (en) * | 2016-06-30 | 2018-01-09 | 株式会社堀场制作所 | Gas concentration measuring apparatus |
| CN110199189A (en) * | 2016-11-30 | 2019-09-03 | 通用电气健康护理生物科学股份公司 | Optical flow cell |
-
2013
- 2013-12-18 CN CN201320832501.7U patent/CN203929616U/en not_active Expired - Fee Related
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107561034A (en) * | 2016-06-30 | 2018-01-09 | 株式会社堀场制作所 | Gas concentration measuring apparatus |
| CN110199189A (en) * | 2016-11-30 | 2019-09-03 | 通用电气健康护理生物科学股份公司 | Optical flow cell |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| DD01 | Delivery of document by public notice |
Addressee: Li Yuntian Document name: Notification of Passing Examination on Formalities |
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| C56 | Change in the name or address of the patentee |
Owner name: YUANCHUANG JINGKE BIO-TECHNOLOGY (CHANGSHA) CO., L Free format text: FORMER NAME: CHANGSHA YUANCHUANG JINGKE BIOTECHNOLOGY CO., LTD. |
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| CP01 | Change in the name or title of a patent holder |
Address after: 410000 Hunan province Changsha Wenxuan High-tech Development Zone, Road No. 27 Building No. 101 Yuyuan Lu Valley A2 Patentee after: Biotechnology (Changsha) Co., Ltd of Yuan Chuanjing section Address before: 410000 Hunan province Changsha Wenxuan High-tech Development Zone, Road No. 27 Building No. 101 Yuyuan Lu Valley A2 Patentee before: CHANGSHA YUANCHUANG JINGKE BIOTECHNOLOGY CO., LTD. |
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| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20141105 Termination date: 20181218 |