CN203898319U - Biological fluid collecting device and biological fluid separating system - Google Patents

Biological fluid collecting device and biological fluid separating system Download PDF

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Publication number
CN203898319U
CN203898319U CN201420258664.3U CN201420258664U CN203898319U CN 203898319 U CN203898319 U CN 203898319U CN 201420258664 U CN201420258664 U CN 201420258664U CN 203898319 U CN203898319 U CN 203898319U
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CN
China
Prior art keywords
collecting device
biofluid
blood
flow channel
housing
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Expired - Lifetime
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CN201420258664.3U
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Chinese (zh)
Inventor
B·M·威尔金森
C·A·盖尔芬德
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Becton Dickinson and Co
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Becton Dickinson and Co
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150206—Construction or design features not otherwise provided for; manufacturing or production; packages; sterilisation of piercing element, piercing device or sampling device
    • A61B5/150213—Venting means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/14—Devices for taking samples of blood ; Measuring characteristics of blood in vivo, e.g. gas concentration within the blood, pH-value of blood
    • A61B5/1405—Devices for taking blood samples
    • A61B5/1411—Devices for taking blood samples by percutaneous method, e.g. by lancet
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    • A61B5/15142—Devices intended for single use, i.e. disposable
    • A61B5/15144—Devices intended for single use, i.e. disposable comprising driving means, e.g. a spring, for retracting the piercing unit into the housing
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    • A61B5/15188—Constructional features of reusable driving devices
    • A61B5/15192—Constructional features of reusable driving devices comprising driving means, e.g. a spring, for retracting the lancet unit into the driving device housing
    • A61B5/15198—Constructional features of reusable driving devices comprising driving means, e.g. a spring, for retracting the lancet unit into the driving device housing purely manually retracted
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    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
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    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
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    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
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    • B01L3/5021—Test tubes specially adapted for centrifugation purposes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
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  • Urology & Nephrology (AREA)
  • Medicinal Chemistry (AREA)
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  • Ecology (AREA)
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  • Anesthesiology (AREA)
  • Cardiology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • External Artificial Organs (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Centrifugal Separators (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)

Abstract

The utility model discloses a biological fluid collecting device and a biological fluid separating system for blood samples. The biological fluid separating system comprises the biological fluid collecting device used for receiving the blood samples and a centrifuge. The centrifuge is applicable to the biological fluid collecting device so as to separate plasma parts of the blood samples from cell parts of the blood samples through the biological fluid collecting device in the centrifuge and rotation acting force applied to the biological fluid collecting device. The biological fluid collecting device can only be arranged in the centrifuge with one orientation.

Description

Biofluid collecting device and biofluid piece-rate system
Technical field
The disclosure relates generally to equipment, assembly and the system used together with blood vessel access arrangement of being suitable for.More particularly, the disclosure relates to equipment, assembly and the system that is suitable for collection of biological sample.
Background technology
Blood sampling is a kind of relating in patient body to extract at least one routine physical examination process of bleeding out.Blood sample be generally by finger puncture, heel puncture or venipuncture take out in inpatient, home care patient and emergency room patient's body.Blood sample also can take out by duct of Arantius or arterial in patient body.Once complete collection, blood sample can be analyzed to obtain the medically Useful Information that comprises for example chemical composition, hematological indices or blood coagulation.
The physiology and chemistry state that patient is determined in blood count is disease, content of mineral substances, drug effectiveness and organ dysfunction for example.Blood count can complete or immediately complete at one's side patient in test section.A routine test that example is patient's blood sugar level of instant blood count, wherein relate to by finger puncture draw blood and by blood mechanical collection in diagnosis box.Subsequently, diagnosis box is analyzed blood sample and is provided the reading of patient's blood sugar level for clinician.Existing other equipment that can be used for analyzing vim and vigour electrolyte level, lithium level and ionized calcium level.Some other instant testing equipment identification is for the mark of acute coronary syndrome (ACS) and deep venous thrombosis/pulmonary infarction (DVT/PE).
Although immediately test and diagnosis has obtained fast progressively, it is relatively constant that blood collecting technology still keeps.Through conventional hypodermic needle or be attached to syringe needle or the vacuum tube of conduit tube component near-end is taken a blood sample.In some cases, clinician utilizes the syringe needle and the syringe that insert conduit from conduit tube component, to collect blood, to draw blood in patient body by the conduit inserting.These processes are used as intermediate equipment by syringe needle and vacuum tube, conventionally before test, from these intermediate equipments, extract the blood sample of collecting out.Therefore these processes are in obtaining, prepare and testing the process of blood sample, to use the intensive process of equipment of a plurality of equipment.Each optional equipment has increased time and the cost of test process.
Instant testing equipment is analyzed just permission test blood sample without blood sample being delivered to laboratory.Therefore, wish to create a kind of equipment, the instant test macro of described equipment utilization provides simply, safe, can reproduce and test process accurately.
Utility model content
The disclosure provides a kind of biofluid piece-rate system for example for the blood separation system of blood sample.Biofluid piece-rate system comprises that biofluid collecting device is for example suitable for receiving blood collecting equipment and the centrifuge of blood sample.Centrifuge is suitable for receiving biofluid collecting device, so that by being received in the biofluid collecting device and the turning effort power that is applied to biofluid collecting device in centrifuge, the blood plasma part of blood sample is separated with the cell part of blood sample.Biofluid collecting device can only be received in centrifuge with a kind of orientation.
Some advantages that biofluid collecting device of the present disclosure is compared with existing system with biofluid piece-rate system are that the disclosure is a kind of closed system that reduces blood sample exposure, and provide blood sample with the passive of sample stabilizing agent and mix fast.And blood sampling transmission equipment of the present disclosure has been integrated the concept of puncture, blood collecting and blood separation.
According to an embodiment of the present utility model, a kind of biofluid collecting device comprises housing, the serpentine flow channel that described housing has input port and is communicated with input port fluid.Described equipment also comprises that being arranged in being suitable in housing is activating piercing element mobile between front position and puncture position, in actuating front position, piercing element is retained in housing, extends through the input port of housing and set up to flow with serpentine flow channel to be communicated with at puncture position piercing element.
In some structure, when piercing element is during in puncture position, described biofluid collecting device is suitable for generating the vacuum being communicated with input port.Described equipment can also comprise the second flow channel being communicated with serpentine channel fluid, in the plane that wherein the second flow channel departs from the plane with limiting the flow axes of serpentine channel, is orientated.Described biofluid collecting device can also be suitable for receiving the multicomponent blood sample with cell part and blood plasma part.When applying turning effort power to described biofluid collecting device, can blood plasma part is partly separated by flow channel with cell.
In some structure, described equipment also comprises can and complete in initial setting up the indicator elment switching between setting.Indicator elment can automatically switch to setting when blood sample collection completes.Alternatively, piercing element is microneedle array.Housing can also comprise that the actuating of button and button can move to puncture position from activating front position by piercing element.In some structure, at least a portion of serpentine flow channel comprises sample stabilizing agent.Housing can also comprise electric contact, and described electric contact is for engaging with the corresponding electric contact of centrifuge.
According to another embodiment of the present utility model, a kind ofly for thering is the biofluid piece-rate system of cell part and blood plasma blood sample partly, comprise the biofluid collecting device that is suitable for receiving blood sample.Described blood collecting equipment comprises housing and is arranged in the piercing element in described housing, the flow channel that described housing has input port and is communicated with input port fluid.Described piercing element is suitable for moving between actuating front position and puncture position, and in actuating front position, piercing element is retained in housing, extends through the input port of housing and set up to flow with flow channel to be communicated with at puncture position piercing element.Described system also comprises the electric contact in the outer part that is arranged in housing.
In some structure, described system also comprises centrifuge, and described centrifuge has the receiving port that is suitable for receiving blood collecting equipment.The electric contact of biofluid collecting device engages with the corresponding part of centrifuge.Flow channel can be serpentine flow channel.In some structure, biofluid collecting device can only be received in centrifuge with a kind of orientation.When blood collecting equipment is received in while applying turning effort power in centrifuge and to blood collecting equipment, can the blood plasma part of blood sample and cell is partly separated by flow channel.
Accompanying drawing explanation
With reference to the following explanation to disclosure embodiment, it is more apparent that the feature and advantage of above and other of the present disclosure and implementation thereof will become in conjunction with the drawings, and the disclosure self will be better understood, in the accompanying drawings:
Fig. 1 is according to the perspective view of the biofluid collecting device of this utility model embodiment.
Fig. 2 is according to the front view of the biofluid collecting device of this utility model embodiment.
Fig. 3 is according to the perspective view of the biofluid collecting device that is fixed to patient of this utility model embodiment.
Fig. 4 is according to the perspective view of the biofluid piece-rate system of this utility model embodiment.
Fig. 5 is according to the front view of the blood separation equipment of this utility model embodiment.
Fig. 6 is that wherein biofluid collecting device is received in the receiving port of blood separation equipment according to the front view of the blood separation equipment of this utility model embodiment.
Fig. 7 is according to the partial sectional view of the biofluid collecting device of this utility model embodiment.
Fig. 8 is that wherein piercing element is in puncture position according to the cutaway view of the biofluid collecting device in Fig. 3 of this utility model embodiment.
Fig. 9 is the cutaway view in the situation that blood sample is received in biofluid collecting device according to the biofluid collecting device in Fig. 3 of this utility model embodiment, and wherein piercing element is in activating front position.
Corresponding Reference numeral represents all the time corresponding parts in all views.The example of enumerating has herein provided one exemplary embodiment of the present disclosure, and these examples should not be read as restriction the scope of the present disclosure by any way.
The specific embodiment
Those skilled in the art provide the following description so that can complete and use for realizing above-described embodiment of the present utility model.But various modifications, equivalent way, modification and replacement scheme still keep it will be apparent to those skilled in the art.Any and whole such modification, modification, equivalent way and replacement schemes are all interpreted as dropping in essence of the present utility model and protection domain.
For explanation hereinafter, term " on ", D score, " right side ", " left side ", " vertically ", " level ", " top ", " bottom ", " laterally ", " longitudinally " and derivative thereof should be with the associated this utility model of its orientation in the accompanying drawings.But, unless it should be understood that separately there be contrary clearly stating, this utility model can adopt alternative modification and step order.The concrete equipment that should also be appreciated that shown in accompanying drawing and introduce in explanation subsequently and process are only one exemplary embodiment of the present utility model.Therefore, related concrete size and other physical features of embodiment disclosed herein should not be considered to restrictive.
Known in the art have a multiple different instant testing equipment.These instant testing equipments comprise test strip, microscope slide, diagnosis box or other testing equipments for testing and analyzing.Test strip, microscope slide and diagnosis box are the instant testing equipments that receives blood sample and biochemical state blood count biological for one or more.Existing multiple instant testing equipment is used framework based on box to analyze very small amount of blood and without sample is sent to laboratory analysis at bedside.So just saved the time that experience is obtained result for a long time, but compared and also brought a series of different challenges with the laboratory environment of height standard.The example of these testing cassetes comprises from Abbot group company testing cassete.Testing cassete for example testing cassete can be used to test various states, comprises chemicals and electrolytical existence, hematological indices, concentration of gas in blood, blood coagulation or myocardial injury markers.Use the test result of this testing cassete to be offered rapidly clinician.
But, the sample that offers this instant testing cassete is with the manual collection of open system and often to cause the manual mode of unstable result to transfer to instant testing cassete at present, or the fault of testing cassete can cause the repetition of sample collection and test process, offset thus the advantage of instant testing equipment.Therefore, to for collecting, transmission and test sample book provide safer, can reproduce and more the system of accurate result there is demand.
Fig. 1-9 show one exemplary embodiment of the present disclosure.Biofluid collecting device of the present disclosure for example blood collecting equipment 10 has been integrated the concept of puncture, blood collecting and blood separation.With reference to Fig. 1-9, blood collecting equipment 10 of the present disclosure is suitable for receiving the blood sample 12 with cell part 14 and blood plasma part 16.
Fig. 4-6 show one exemplary embodiment of the present disclosure.With reference to Fig. 4-6, biofluid piece-rate system for example in the disclosure blood separation system 20 for blood sample 12 comprise blood collecting equipment 10 and blood separation equipment or the centrifuge 22 that is suitable for receiving blood sample 12.Centrifuge 22 is suitable for receiving blood collecting equipment 10 so that by being received in the blood collecting equipment 10 and the turning effort power that is applied to blood collecting equipment 10 in centrifuge 22, and the blood plasma part 16 of blood sample 12 is separated with the cell part 14 of blood sample 12.Separated blood can be analyzed and without blood collecting equipment 10 is taken out from centrifuge 22 by centrifuge 22 subsequently.For example, blood separation system of the present disclosure can be used to determine packed cell volume value by centrifuging.Centrifuge 22 can be connected to computer system, and hand-held electronic equipment can be checked or be wirelessly transmitted to analysis result on the display screen of computer system.
Some advantages that blood collecting equipment of the present disclosure is compared with existing system with biofluid piece-rate system are that the disclosure is a kind of closed system that reduces blood sample exposure, and provide blood sample with the passive of sample stabilizing agent and mix fast.And biofluid sampling transmission equipment of the present disclosure has been integrated the concept of puncture, blood collecting and blood separation.
With reference to Fig. 1-9, blood collecting equipment 10 generally includes: the second container 42, piercing element junction surface 44, sample stabilizing agent 46, electric contact 48 and the indicator elment 56 that define housing 30 through centre bore 32 wherein, input port 34, input flow channel 35, the flow channel 36 being communicated with input port 34 fluids, the first container 38 being communicated with input port 34 fluids, the serpentine flow channel 40 being communicated with the first container 38 fluids, are communicated with serpentine flow channel 40 fluids.With reference to Fig. 8 and Fig. 9, blood collecting equipment 10 comprises the piercing element structure 70 of the centre bore 32 that is positioned at housing 30.Housing 30 comprises for piercing element structure 70 being fixed on to the piercing element junction surface 44 in the centre bore 32 of housing 30.In one embodiment, input flow channel 35 is communicated with serpentine flow channel 40 fluids and inputs in the plane that flow channel 35 departs from the plane of flow axes with restriction serpentine channel 40 and is orientated.In one embodiment, the housing 30 of blood collecting equipment 10 comprises the electric contact 48 for engaging with the corresponding electric contact of centrifuge 22.In one embodiment, a part for the housing 30 of blood collecting equipment 10 is transparent.For example, a part for housing 30 is transparent, allows thus user can see cell part 14 and the blood plasma part 16 in container 38,42 and flow channel 36,40.
Blood collecting equipment 10 is suitable for receiving the blood sample 12 with cell part 14 and blood plasma part 16.In one embodiment, indicator elment 56 can and complete between setting in initial setting up and switch and indicator elment 56 has automatically switched to setting when the collection of the interior blood sample 12 of blood collecting equipment 10 completes.
Blood collecting equipment 10 is suitable for comprising sample stabilizing agent 46 to provide blood sample with the passive of sample stabilizing agent 46 and to mix fast.Sample stabilizing agent 46 can be anticoagulant or be designed to retain for example material of RNA, protein analyte or other elements of element-specific in blood.In one embodiment, sample stabilizing agent 46 is arranged in a part of flow channel 36.In further embodiments, other regions that sample stabilizing agent 46 is arranged on housing 30 are for example in input port 34 or the first container 38.
In one embodiment, a part of flow channel 36 comprises that snakelike shape is to improve mixing and the separation efficiency of the blood sample 12 with cell part 14 and blood plasma part 16.As described below, centrifuge 22 provides and is applied to the turning effort power of blood collecting equipment 10 so that blood plasma part 16 is separated by flow channel 36 with cell part 14.In further embodiments, flow channel 36 comprises for improving the mixing of blood sample and other shapes of separation efficiency.
The top of housing 30 comprises that the bottom of dome-shaped surface 50 and housing 30 comprises bottom surface 52.With reference to Fig. 8 and Fig. 9, bottom surface 52 comprises binding agent 54 so that blood collecting equipment 10 can be fixed to will obtaining on the skin surface S of blood sample at this of patient.In one embodiment, the binding agent 54 of bottom surface 52 is similar to the peel ply protection of adhesive bandage, and peel ply is removed before will be on the skin surface S that blood collecting equipment 10 is placed into patient body.Can comprise that hydrogel layer or other layers think that bottom surface 52 provides certain thickness and helps improve the stability of adhesive seal.In addition, in one embodiment, binding agent 54 can comprise for building the chemical composition of better liquid-tight property sealing, be similar to japanning tape technology, wherein from paint, self moistening causes the chemical reaction with binding agent 54, thereby build better liquid-tight sexual isolation's layer, to prevent paint, leaks into adhesive tape below.
Referring to figs. 1 through Fig. 9, blood collecting equipment 10 also comprises the piercing element structure 70 in the centre bore 32 that can be fixed on housing 30.Piercing element structure 70 generally includes the button 76 of first end 72, the second end 74, contiguous first end 72, piercing element 78 and the housing junction surface 80 of contiguous the second end 74.As shown in Figure 8 and Figure 9, the piercing element junction surface 44 that housing junction surface 80 engages housing 30 is for being fixed to piercing element structure 70 in the centre bore 32 of housing 30.Piercing element structure 70 comprises the piercing element 78 with cutting tip 82.Cutting tip 82 is suitable for patient's the skin surface S (Fig. 8) that punctures, and can limit tip, knife-edge or similar cutting mechanism.Cutting tip 82 can comprise preferred aligned orientation, for example, have the insert tip of aiming at specific orientation.In one embodiment, piercing element 78 comprises microneedle array.
Piercing element 78 is suitable for moving between actuating front position (Fig. 9) and puncture position (Fig. 8), comprise that the piercing element 78 of cutting tip 82 is retained in housing 30 activating front position, the input port 34 that extends through housing 30 at the cutting tip 82 of puncture position piercing element 78 is taken a blood sample and is set up to flow with flow channel 36 with puncture patient's skin surface S and is communicated with.In one embodiment, the actuating of button 76 moves to puncture position (Fig. 8) by piercing element 78 from activating front position (Fig. 9).
In one embodiment, when piercing element 78 is positioned at puncture position, blood collecting equipment 10 is suitable for generation and with help, in blood collecting equipment 10, takes a blood sample 12 with the vacuum that the input port 34 of the housing 30 of blood collecting equipment 10 is communicated with.
In one embodiment, the housing 30 of blood collecting equipment 10 can comprise and can allow outside lancet or piercing element to be received in removedly the self-sealing joint in housing 30.Outside lancet or piercing element can be integrated in packaged blood collecting equipment 10 or before using blood collecting equipment 10 of the present disclosure to be in advance introduced separately into by user.
With reference to Fig. 4 to Fig. 6, the blood separation system 20 for blood sample 12 in the disclosure comprises blood collecting equipment 10 and blood separation equipment or the centrifuge 22 that is suitable for receiving blood sample 12.Centrifuge 22 is suitable for receiving blood collecting equipment 10 so that by being received in the blood collecting equipment 10 and the turning effort power that is applied to blood collecting equipment 10 in centrifuge 22, and the blood plasma part 16 of blood sample 12 is separated with the cell part 14 of blood sample 12.Separated blood can be analyzed and without blood collecting equipment 10 is taken out from centrifuge 22 by centrifuge 22 subsequently.Centrifuge 22 can be connected to computer system, and hand-held electronic equipment can be checked or be wirelessly transmitted to analysis result on the display screen of computer system.
With reference to Fig. 4 to Fig. 6, blood separation equipment of the present disclosure or centrifuge 22 generally include the receiving port 120 that is suitable for receiving blood collecting equipment 10, so that by being received in the blood collecting equipment 10 and the turning effort power that is applied to blood collecting equipment 10 in centrifuge 22, the blood plasma part 16 of blood sample 12 is separated with the cell part 14 of blood sample 12.Centrifuge 22 comprise be suitable for receiving blood collecting equipment 10 receiving port 120, base or bottom 122, by articulated section 126, be connected to movably 122 top 124, bottom and be included in the turning effort power element 128 in bottom 122.Top 124 can be switched between open position and closed position, at open position, can as shown in Figure 6 blood collecting equipment 10 be placed in receiving port 120.By being received in the blood collecting equipment 10 in centrifuge 22, to blood collecting equipment 10, apply turning effort power so that blood plasma part 16 is separated with cell part 14.
With reference to Fig. 4, in one embodiment, centrifuge 22 comprises a plurality of receiving ports 120, and each is suitable for receiving independent blood collecting equipment 10.Like this, blood separation system 20 of the present disclosure can receive, minute a plurality of blood collecting equipment 10 of the analysis of variance.
Referring to figs. 1 through Fig. 6, blood collecting equipment 10 of the present disclosure can only be received in the receiving port 120 of centrifuge 22 with a kind of orientation.In one embodiment, the housing 30 of blood collecting equipment 10 has the exterior contour 60 that comprises key portion 62.The receiving port 120 of centrifuge 22 limits the in-profile 130 that comprises keyway portion 132.The exterior contour 60 of blood collecting equipment 10 and key portion 62 size and dimensions are confirmed as corresponding essentially to in-profile 130 and the keyway portion 132 of the receiving port 120 of centrifuge 22, so that blood collecting equipment 10 can only be received in the receiving port 120 of centrifuge 22 with a kind of orientation.Like this, blood collecting equipment 10 can only insert the receiving port 120 of centrifuge 22 in one way, and the electric contact 48 of guaranteeing to be thus arranged on blood collecting equipment 10 is correctly placed and engaged with the corresponding part of centrifuge 22.
Thereby can having, the in-profile 130 of the receiving port 120 of the exterior contour 60 of blood collecting equipment 10 and key portion 62 and centrifuge 22 and keyway portion 132 provide key portion and keyway portion only to allow blood collecting equipment 10 with a kind of orientation, to be received in the arbitrary shape in the receiving port 120 of centrifuge 22.
Referring to figs. 1 through Fig. 9, the existing use of introducing blood collecting equipment of the present disclosure.With reference to Fig. 3 and Fig. 9, when chosen position, clinician can bond to the binding agent on the bottom surface of housing 30 52 54 on patient's skin surface S, can on the sampling location of selecting, obtain blood sample thus.
Next, the button 76 on blood collecting equipment 10 is pressed or activates that piercing element 78 is moved to puncture position (Fig. 8) from activating front position (Fig. 9), thereby makes piercing element 78 puncture patients' skin surface S.In one embodiment, vacuum is applied simultaneously.Subsequently, blood sample 12 is drawn in microfluidic flow channels 36 by capillarity.Blood sample is exposed to the sample stabilizing agent 46 in flow channel 36 and mixes with it.Sample stabilizing agent 46 can be anticoagulant or be designed to retain for example material of RNA, protein analyte or other elements of element-specific in blood.
At indicator elment 56, transferred to and having arranged or when particular color that the collection of indication blood sample 12 has completed is for example red, user removes blood collecting equipment 10 from patient's arm.
With reference to Fig. 4 to Fig. 6, the next step of process relates to manually inserts specialized designs for blood separation equipment or the centrifuge 22 of blood collecting equipment 10 by blood collecting equipment 10.For example, blood collecting equipment 10 is transferred to " rotary vane type (spin chip) " blood separation equipment or the centrifuge 22 as small intelligent blood separation equipment.Blood collecting equipment 10 can only insert in one way the receiving port 120 of centrifuge 22 and correctly be placed and engage with the corresponding part of centrifuge 22 with the electric contact 48 of guaranteeing to be arranged on blood collecting equipment 10.
Centrifuge 22 is designed to be helped separating plasma and driven blood sample by the flow channel 36 of blood collecting equipment 10 by centrifugal force.By fast rotational and due to low capacity, in seconds the flow channel 36 by blood collecting equipment 10 is separated in centrifuge 22 for the blood sample 12 comprising in blood collecting equipment 10, and blood plasma part 16 is collected in the second container 42 of blood collecting equipment 10.
In one embodiment, centrifuge 22 is suitable for receiving blood collecting equipment 10 so that the blood plasma part 16 of blood sample 12 is separated with the cell part 14 of blood sample 12 with the turning effort power that is applied to blood collecting equipment 10 by the blood collecting equipment 10 being received in centrifuge 22.Separated blood can be analyzed and without blood collecting equipment 10 is taken out from centrifuge 22 by centrifuge 22 subsequently.Centrifuge 22 can be connected to computer system, and hand-held electronic equipment can be checked or be wirelessly transmitted to analysis result on the display screen of computer system.
Some advantages that blood collecting equipment of the present disclosure is compared with existing system with blood separation system are that the disclosure is a kind of closed system that reduces blood sample exposure, and provide blood sample with the passive of sample stabilizing agent and mix fast.And blood sampling transmission equipment of the present disclosure has been integrated the concept of puncture, blood collecting and blood separation.
Although the disclosure has been described to have exemplary design, the disclosure can be revised further in this disclosed spirit and scope.Therefore the application has been interpreted as containing any variations, purposes or the modification of its cardinal principle of use of the present disclosure.And the application is interpreted as having contained within the scope of the known or conventional practice that drops on field under the disclosure drawing according to the disclosure and falls into these changes in claims limited field.

Claims (15)

1. a biofluid collecting device, comprising:
Housing, the serpentine flow channel that described housing has input port and is communicated with input port fluid; And
Be arranged in described housing and be suitable for activating piercing element mobile between front position and puncture position, at piercing element described in described actuating front position, be retained in described housing, at piercing element described in described puncture position, extend through the described input port of described housing and set up mobile connection with described serpentine flow channel.
2. biofluid collecting device as claimed in claim 1, wherein, when described piercing element is during in described puncture position, described biofluid collecting device is suitable for producing the vacuum being communicated with described input port.
3. biofluid collecting device as claimed in claim 1, further comprises the second flow channel being communicated with described serpentine channel fluid, in the plane that described the second flow channel departs from the plane with limiting the flow axes of described serpentine flow channel, is orientated.
4. biofluid collecting device as claimed in claim 1, wherein said biofluid collecting device is suitable for receiving has cell part and blood plasma multicomponent blood sample partly.
5. biofluid collecting device as claimed in claim 4, wherein, when applying turning effort power to described biofluid collecting device, described blood plasma part is partly separated by described serpentine flow channel with described cell.
6. biofluid collecting device as claimed in claim 4, further comprises and can and complete in initial setting up the indicator elment switching between setting, described in wherein said indicator elment automatically switches to when blood sample collection completes, completes setting.
7. biofluid collecting device as claimed in claim 1, wherein said piercing element comprises microneedle array.
8. biofluid collecting device as claimed in claim 1, wherein said housing comprises button, the actuating of wherein said button moves to described puncture position by described piercing element from described actuating front position.
9. biofluid collecting device as claimed in claim 1, at least a portion of wherein said serpentine flow channel comprises sample stabilizing agent.
10. biofluid collecting device as claimed in claim 1, wherein said housing comprises electric contact, described electric contact is for engaging with the corresponding electric contact of centrifuge.
11. 1 kinds for having the biofluid piece-rate system of cell part and blood plasma blood sample partly, comprising:
Be suitable for receiving the biofluid collecting device of described blood sample, described biofluid collecting device comprises:
Housing, the flow channel that described housing has input port and is communicated with described input port fluid;
Be arranged in described housing and be suitable for activating piercing element mobile between front position and puncture position, at piercing element described in described actuating front position, be retained in described housing, at piercing element described in described puncture position, extend through the described input port of described housing and set up mobile connection with described flow channel; And
Be arranged in the electric contact in the outer part of described housing.
12. biofluid piece-rate systems as claimed in claim 11, further comprise centrifuge, described centrifuge has the receiving port that is suitable for receiving described biofluid collecting device, and the described electric contact of wherein said biofluid collecting device engages with the corresponding part of described centrifuge.
13. biofluid piece-rate systems as claimed in claim 11, wherein said flow channel is serpentine flow channel.
14. biofluid piece-rate systems as claimed in claim 11, wherein said biofluid collecting device can only be received in described centrifuge with a kind of orientation.
15. biofluid piece-rate systems as claimed in claim 11, wherein, when described biofluid collecting device is received in while applying turning effort power in described centrifuge and to described biofluid collecting device, the blood plasma part of described blood sample is partly separated by described flow channel with described cell.
CN201420258664.3U 2013-04-15 2014-04-15 Biological fluid collecting device and biological fluid separating system Expired - Lifetime CN203898319U (en)

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