CN203842683U - Full-automatic biologic sample treatment device - Google Patents
Full-automatic biologic sample treatment device Download PDFInfo
- Publication number
- CN203842683U CN203842683U CN201420216839.4U CN201420216839U CN203842683U CN 203842683 U CN203842683 U CN 203842683U CN 201420216839 U CN201420216839 U CN 201420216839U CN 203842683 U CN203842683 U CN 203842683U
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- China
- Prior art keywords
- elater
- microporous pipe
- base
- hand
- full
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- Expired - Lifetime
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- 241000676840 Elater Species 0.000 claims abstract description 42
- 238000000034 method Methods 0.000 claims description 19
- 230000008569 process Effects 0.000 claims description 19
- 238000012545 processing Methods 0.000 claims description 11
- 230000006978 adaptation Effects 0.000 claims description 3
- 238000013016 damping Methods 0.000 claims description 3
- 239000013013 elastic material Substances 0.000 claims description 3
- 238000010030 laminating Methods 0.000 claims description 3
- 230000008901 benefit Effects 0.000 abstract description 4
- 238000005054 agglomeration Methods 0.000 abstract 1
- 230000002776 aggregation Effects 0.000 abstract 1
- 230000010354 integration Effects 0.000 abstract 1
- 238000007885 magnetic separation Methods 0.000 abstract 1
- 230000000717 retained effect Effects 0.000 abstract 1
- 239000006249 magnetic particle Substances 0.000 description 8
- 239000000523 sample Substances 0.000 description 7
- 238000002474 experimental method Methods 0.000 description 5
- 238000010586 diagram Methods 0.000 description 3
- 230000009286 beneficial effect Effects 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 230000007812 deficiency Effects 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 238000000926 separation method Methods 0.000 description 2
- 239000013076 target substance Substances 0.000 description 2
- 108091005461 Nucleic proteins Proteins 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 239000006148 magnetic separator Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000000465 moulding Methods 0.000 description 1
- 102000039446 nucleic acids Human genes 0.000 description 1
- 108020004707 nucleic acids Proteins 0.000 description 1
- 150000007523 nucleic acids Chemical class 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 239000011435 rock Substances 0.000 description 1
- 239000012488 sample solution Substances 0.000 description 1
- 239000013077 target material Substances 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
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- Sampling And Sample Adjustment (AREA)
Abstract
The utility model discloses a full-automatic biologic sample treatment device which comprises a micropore tube, a micropore tube support disc, a treatment chamber and a treatment base, wherein the micropore tube is embedded into the treatment chamber; the treatment chamber is internally provided with an elater handle; an elater handle motor drives the elater handle to rotate for a certain angle and act at the outer wall of the micropore tube where a target biologic sample is located, so that the biologic sample inside a target micropore tube is uniformly mixed; an output shaft of a base motor on the treatment base is connected with a gear, a rotation ring is driven through the meshed gear, a magnetic block on the rotation ring is retained on the outer side of the target sample, and then agglomeration of magnetic grains on the side wall of the micropore tube is achieved. The full-automatic biologic sample treatment device achieves full-automatic uniform mixing operation and magnetic separation operation in a single station, has the advantages of simple and compact mechanical structure, smallness and flexibility, easiness in assembling and integration and the like, and can be widely applied to automatic treatment operation on biologic samples.
Description
Technical field
The utility model relates to a kind of biological specimen treating apparatus, and especially a kind of solution of automatically realizing mixes the treating apparatus separating with magnetic.
Background technology
In at present biological specimen being processed, be widely used magnetic-particle and carry out separating bio sample, it has following advantage: (1) separating rate is fast, efficiency is high, reusable; (2) simple device just can operate; (3) do not affect the activity of biological specimen.
But traditional magnetic separating device belongs to static-magnetic separator, microporous pipe bracket and permanent magnet are generally provided, such device only provides a kind of hold-down support that can make magnetic-particle enrichment.Cause like this in the time using such device to carry out experimental implementation, need between permanent magnet hold-down support and microporous pipe hold-down support, repeatedly carry out repeatedly artificial transfer microporous pipe work (for the appearing and subsiding of externally-applied magnetic field), this has brought a lot of inconvenience to experiment, has greatly increased the possibility of polluting simultaneously.The device of this type has only been realized the separation of biological specimen, but in the middle of specific experiment, need successively repeatedly use and mix operation and magnetic lock out operation is processed operation to biological specimen, the apparatus structure of publication cannot meet experiment demand at present, need in experimentation, use evenly mixing device and magnetic separating device, increase like this complexity of experiment, wasted energy and time.Particularly along with the continuous expansion of molecular biology research and experimental size demand, therefore more can automatically realize solution in the urgent need to the small and exquisite biological specimen flexibly of one treating apparatus and mix and the experimentations such as magnetic separating treatment, and just be integrated in the middle of the instrument of large instrument or miniaturization.This is also technical problem to be solved in the utility model.
Summary of the invention
Technical problem: the deficiency existing in order to overcome prior art, the utility model provides a kind of biological specimen treating apparatus, and this device can automatically realize that solution mixes and the processing such as magnetic separates.
Technical scheme: the full-automatic biological specimen treating apparatus of one of the present utility model is achieved through the following technical solutions: this device comprises microporous pipe, microporous pipe pallet, process chambers, processing base;
On described microporous pipe pallet, multiple installing holes are set, can place flexibly multiple microporous pipe, and microporous pipe pallet is provided with a pallet start bit; Described microporous pipe pallet laminating is placed on process chambers end face, and microporous pipe is embedded in process chambers; In described process chambers, be provided with an elater hand; Described elater hand is connected on elater torch machine by the rotating shaft of elater hand-screw; Described elater torch machine fixed placement is being processed on base.
On described processing base also fixed placement base electrical machinery, base electrical machinery output shaft connects a gear, engages driven rotary annulus by gear; On described rotating ring, be provided with the magnetic patch of a profile adaptation, rotating ring is placed on and is processed on base by ring-shaped guide rail.
Described ring-shaped guide rail fixed placement is being processed on base, and its appearance and size and rotating ring are suitable, and rotating ring can support ring-shaped guide rail and produce little damping and relatively rotate.
Described elater torch machine is placed on processes the circle centre position of base, and elater torch machine is identical with the microporous pipe array center of circle, and the length of elater hand makes with microporous pipe, slight bullet to occur in elater hand rotary course and hits.
Described elater hand getting elastic material, respectively there is a spherical terminal at two ends, and the deformation that can produce certain amplitude when elater hand is subject to resistance recovers shape after resistance disappears.
The material of each test tube plate of the present utility model and bedplate has no particular limits, and can be prepared by general moulding process by resin, or be processed into by metallic plate, and biological treatment device can integratedly be manufactured, and also can make by assembled.
Beneficial effect: compared with prior art, the technical solution of the utility model has following beneficial effect:
(1) the utility model has overcome many deficiencies that existing magnetic separating device exists, increase biological specimen has been mixed to operating function, automatically realized to target sample optionally solution mix and the processing such as magnetic separates, make up technological gap, low cost of manufacture, difficulty of processing are low, are easy to the advantages such as assembling.
(2) microporous pipe that the utility model contains magnetic-particle solution in the whole course of work is still on microporous pipe bracket all the time, having realized single station magnetic separates, so both save working space and made the effect that device is small and exquisite, ensured separation, can avoid again the interference between microporous pipe, greatly prevent cross pollution.
(3) by changing different microporous pipe brackets, thereby go for the microporous pipe of multiple volume, improved the versatility of magnetic separating device, realized " one multiplex ", reduced use cost.
(4) practical, this device is Open architecture, there is frame for movement simple, small and exquisite flexibly and be easy to the features such as realization, can be integrated on the devices such as large-scale biochemical analyzer, also can independently use as the magnetic separating device of miniaturization, such device will meet the actual demand realizing widely.
Brief description of the drawings
Below in conjunction with drawings and Examples, the utility model is further illustrated.
Fig. 1 is the entirety blast organigram of the utility model device.
Fig. 2 is the configuration state schematic diagram that installs initialization position after hiding process chambers.
Fig. 3 installs the magnetic-particle reunion of target sample at the configuration state schematic diagram of microporous pipe sidewall after hiding process chambers.
Fig. 4 is overall appearance schematic diagram of the present utility model.
Fig. 5 is the schematic internal view of process chambers.
In figure, have: microporous pipe 101, microporous pipe pallet 102, process chambers 103, processes base 104, pallet start bit 105, magnetic patch 201, elater hand 202, elater hand-screw rotating shaft 203, elater torch machine 204, gear 205, base electrical machinery 206, rotating ring 207, ring-shaped guide rail 208.
Detailed description of the invention
Below with reference to accompanying drawing, preferred embodiment of the present utility model is elaborated, understands the purpose of this utility model, feature and advantage so that clearer.It should be understood that embodiment shown in the drawings is not the restriction to the utility model scope, and just for the connotation of technical solutions of the utility model is described.Hereinafter, the identical Reference numeral of identical with similar element numeral.
As shown in Figures 1 to 5, full-automatic biological specimen treating apparatus of the present utility model comprises microporous pipe 101, microporous pipe pallet 102, process chambers 103, processing base 104.On described microporous pipe pallet 102, multiple installing holes are set, can place flexibly multiple microporous pipe 101, and microporous pipe pallet 102 is provided with a pallet start bit 105; Described microporous pipe pallet 102 laminatings are placed on process chambers 103 end faces, and microporous pipe 101 is embedded in process chambers 103; In described process chambers 103, be provided with an elater hand 202; Described elater hand 202 is connected on elater torch machine 204 by elater hand-screw rotating shaft 203, and elater hand 202 adopts elastic material, and respectively there is a spherical terminal at two ends, and the deformation that can produce certain amplitude when elater hand 202 is subject to resistance recovers shape after resistance disappears; Described elater torch machine 204 fixed placement are being processed the circle centre position of base 104, elater torch machine 204 is also relative with the microporous pipe 101 array centers of circle, and elater hand 202 length make with microporous pipe 101, slight bullet to occur in elater hand 202 rotary courses and hit, under the drive of elater torch machine 204, elater hand can make the biological specimen in target microporous pipe 101 mix like this.
On described processing base 104 also fixed placement base electrical machinery 206, base electrical machinery 206 output shafts connect a gear 205, engage driven rotary annulus 207 by gear; On described rotating ring 207, be provided with the magnetic patch of a profile adaptation, rotating ring 207 is placed on and is processed on base 104 by ring-shaped guide rail 208.Described ring-shaped guide rail 208 fixed placement are being processed on base 104, and its appearance and size and rotating ring 207 are suitable, and rotating ring 207 can support ring-shaped guide rail 208 and produce little damping and relatively rotate.
This device, under the drive of base electrical machinery 206, can automatically rotate rotating ring 207, makes magnetic patch 201 rest on the outside of target sample, thereby magnetic-particle is reunited at microporous pipe 101 sidewalls.
The full-automatic concrete course of work of biological specimen treating apparatus is described below:
(1) work is initial, the microporous pipe 101 filling with the magnetic-particle solution of biological specimen to be separated (as the biomolecule such as nucleic acid, protein or cell etc.) specific bond is placed on microporous pipe pallet 102, pallet start bit 105 is right against magnetic patch 201, this timer is in original state, as shown in Figure 2, the interior magnetic-particle solution of microporous pipe 101 is in dispersity.
(2) target organism sample solution mix operation, as shown in Figure 3, elater torch machine 204 drives elater hand 202 to turn an angle, microporous pipe 101 outer wall generation elastic collisions with target organism sample place, making target microporous pipe 101 produce certain amplitude rocks, cause the interior biological specimen of target microporous pipe 101 to mix, accelerated course of reaction.
(3) the magnetic lock out operation of target organism sample, as shown in Figure 3, under the drive of base electrical machinery 206, rotating ring 207 turns an angle, make magnetic patch 201 rest on the outside of target organism sample microporous pipe 101, thereby the target substance that makes magnetic-particle in solution carry combination is adsorbed to sidewall, has realized sidewall reunion; Remaining liq can siphon away by modes such as pipettors, can realize target material and the separating of non-target substance, complete biological specimen processing.
The conversion of above-mentioned several duties can be realized by control system, in conjunction with liquid-transfering device, automatized magnetic separating experiment can be realized.
Last institute should be noted that; above-described embodiment is preferably embodiment of the utility model; but embodiment of the present utility model is not restricted to the described embodiments; wherein structure, the connected mode etc. of each parts all can change to some extent; other any do not deviate from equivalents, improvement, the modification done under Spirit Essence of the present utility model and principle, substitutes, combination, simplify; all should be equivalent substitute mode, within being included in protection domain of the present utility model.
Claims (4)
1. a full-automatic biological specimen treating apparatus, is characterized in that this device comprises microporous pipe (101), microporous pipe pallet (102), process chambers (103), processing base (104);
On described microporous pipe pallet (102), multiple installing holes are set, can place flexibly multiple microporous pipe (101), and microporous pipe pallet (102) is provided with a pallet start bit (105); Described microporous pipe pallet (102) laminating is placed on process chambers (103) end face, and microporous pipe (101) is embedded in process chambers (103); In described process chambers (103), be provided with an elater hand (202); Described elater hand (202) is connected on elater torch machine (204) by elater hand-screw rotating shaft (203); Described elater torch machine (204) fixed placement is being processed base (104) above,
Described processing base (104) is upper has gone back fixed placement base electrical machinery (206), and base electrical machinery (206) output shaft connects a gear (205), engages driven rotary annulus (207) by gear; On described rotating ring (207), be provided with the magnetic patch (201) of a profile adaptation, rotating ring (207) is placed on and is processed on base (104) by ring-shaped guide rail (208).
2. full-automatic biological specimen treating apparatus according to claim 1, it is characterized in that, described ring-shaped guide rail (208) fixed placement is being processed on base (104), its appearance and size and rotating ring (207) are suitable, and rotating ring (207) can support ring-shaped guide rail (208) and produce little damping and relatively rotate.
3. full-automatic biological specimen treating apparatus according to claim 1, it is characterized in that, described elater torch machine (204) is placed on the circle centre position of processing base (104), elater torch machine (204) is identical with microporous pipe (101) the array center of circle, and the length of elater hand (202) makes with microporous pipe (101), slight bullet to occur in elater hand (202) rotary course and hits.
4. full-automatic biological specimen treating apparatus according to claim 1, it is characterized in that, described elater hand (202) adopts elastic material, respectively there is a spherical terminal at two ends, the deformation that elater hand (202) can produce certain amplitude while being subject to resistance recovers shape after resistance disappears.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201420216839.4U CN203842683U (en) | 2014-04-29 | 2014-04-29 | Full-automatic biologic sample treatment device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201420216839.4U CN203842683U (en) | 2014-04-29 | 2014-04-29 | Full-automatic biologic sample treatment device |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN203842683U true CN203842683U (en) | 2014-09-24 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201420216839.4U Expired - Lifetime CN203842683U (en) | 2014-04-29 | 2014-04-29 | Full-automatic biologic sample treatment device |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN203842683U (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103949341A (en) * | 2014-04-29 | 2014-07-30 | 东南大学 | Full-automatic biological sample processing device |
| CN108927285A (en) * | 2018-05-23 | 2018-12-04 | 齐齐哈尔医学院 | The micro- magnetic ball fast desorption device of nanometer |
-
2014
- 2014-04-29 CN CN201420216839.4U patent/CN203842683U/en not_active Expired - Lifetime
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103949341A (en) * | 2014-04-29 | 2014-07-30 | 东南大学 | Full-automatic biological sample processing device |
| CN108927285A (en) * | 2018-05-23 | 2018-12-04 | 齐齐哈尔医学院 | The micro- magnetic ball fast desorption device of nanometer |
| CN108927285B (en) * | 2018-05-23 | 2020-03-24 | 齐齐哈尔医学院 | Nano micro magnetic ball quick desorption device |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CX01 | Expiry of patent term | ||
| CX01 | Expiry of patent term |
Granted publication date: 20140924 |