CN203842074U - Graphene wound dressing - Google Patents
Graphene wound dressing Download PDFInfo
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- CN203842074U CN203842074U CN201420196616.6U CN201420196616U CN203842074U CN 203842074 U CN203842074 U CN 203842074U CN 201420196616 U CN201420196616 U CN 201420196616U CN 203842074 U CN203842074 U CN 203842074U
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Abstract
The utility model discloses a graphene wound dressing. The wound dressing comprises at least one substrate layer and an antibacterial layer, wherein the antibacterial layer is arranged on the substrate layer by a hot adhering method or a chemical binding method. The graphene wound dressing does not influence normal development and metabolism by adopting solid dispersed graphene, and bacteria cannot grow on graphene, so that the bacteriostatic effect of the wound dressing is very safe and effective; due to the structure arrangement of the substrate layer and the antibacterial layer, bacteria can be resisted effectively for a long time, and the wound dressing is prevented from aging; the wound dressing is soft and durable, and can be recycled; massive tissue secretion, pus, blood and other body fluids can be absorbed due to the huge specific surface area of the graphene, and the bond resistance of the graphene wound dressing cannot cause hard scar, and light scar can be easily separated, so that dressing change and treatment of the wound can be convenient.
Description
Technical field
This utility model relates to a kind of wound dressing, is specifically related to a kind of Graphene wound dressing.
Background technology
Wound dressing is commonly used to filling and binds up a wound, and generally raw materials such as gauze or cottons, consist of, and these raw materials itself is without bacteria resistance function.The wound dressing of mark of staining is easily bred antibacterial, causes wound infection, is difficult to healing.Wound exudate is adsorbed on wound dressing, the dry final and withered formation incrustation of wound, for subsequent treatment is brought difficulty, also for patient brings misery.
Graphene, a kind of sp2 hydridization, novel Two-dimensional Carbon nano material, it can be folded into the fullerene of zero dimension, is curled into the CNT of one dimension, is stacked to three-dimensional graphite [Rao, C.N.R.; Biswas, IC; Subrahmanyam, k S.; Govindaraj, A.Graphene, the new nanocarbon.Journal ofMaterials Chemistry 2009,19.].Discovery since Graphene, the whole world conducts in-depth research character such as the physical chemistry of Graphene, electricity, optics, machineries from the scientist of different field, and in fields such as Theoretical Physics, complex, the energy, catalysis, electronic device, optical detections, breakthrough [He, S. have been obtained; Song, B.; Li, D.; Zhu, C.; Qi, W.; Wen, Y.; Wang, L.; Song, S.; Fang, H.; Fan, C.A Graphene Nanoprobe for Rapid, Sensitive, and Multicolor Fluorescent DNA Analysis.Advanced Functional Materials 2010,20,453-459.].In recent years, researcher is to having carried out deep research in the synthetic method of Graphene, and Graphene mainly can be divided into three major types according to its chemical composition and synthetic method, is respectively: Graphene, graphene oxide and redox graphene.Graphene is a kind of Graphene of preparing with chemical gaseous phase depositing process, and it is elementary composition is all carbon atom, and this Graphene has large scale, the advantage such as conduct electricity very well, and [Li, X. are with a wide range of applications in fields such as electronic devices; Wang, X.; Zhang, L.; Lee, S.; Dai, H.Chemically Derived, Ultrasmooth Graphene Nanoribbon Semiconductors.Science 2008,319,1229-1232.].Graphene oxide (graphene oxide, Go) be a kind of to graphite by concentrated acid or strong oxidizer oxidation processes the containing oxygen derivative by a kind of Graphene of ultrasonic preparation, different because of oxidizing condition, the graphene oxide size obtaining generally arrives between hundreds of nanometer and even micron in ten nanometers.Graphene oxide has good aqueous dispersion ability and biocompatibility, and a large amount of aerobic active function groups is contained on its surface, as carboxyl, carbonyl, hydroxyl and epoxy radicals etc., make it be easy to carry out surface energy merit, thereby make graphene oxide at biomedical sector, have broad application prospects [He, S.; Song, B.; Li, D.; Zhu, C.; Qi, W.; Wen, Y.; Wang, L.; Song, S.; Fang, H.; Fan, C.A Graphene Nanoprobe for Rapid, Sensitive, and Multicolor Fluorescent DNA Analysis.Advanced Functional Materials 2010,20,453-459.:Yang, IC; Wan, J.; Zhang, S.; Tian, B.; Zhang, Y.; Liu Z.The influence of surface chemistry and size of nanoscale graphene oxide on photothermal therapy of cancer using ultra-low laser power.Biomaterials 2012,33,2206-2214.].By graphene oxide is reduced process can prepare a kind of on forming the redox graphene between Graphene and graphene oxide, this Graphene is similar to Graphene in the character of the aspects such as electronics transmission, but it has superiority compared with Graphene on preparation cost, this makes redox graphene be with a wide range of applications equally [Robinson, J.T.; Tabakman, S.M.; Liang, Y.; Wang, H.; Sanehez Casalongue, H.; Vinh, D.; Dal, H.Ultrasmall Reduced Graphene Oxide with High Near-Infrared Absorbance for Photothermal Therapy.Z Am.Chem.Soc.201 1,133,6825-683 1.].At present, other derivants of Graphene, graphene oxide and Graphene have been widely used in the research of biomedical sector, and in the conveying of biosensor, antitumor drug, photosensitizer, gene, breakthrough has been obtained in the photo-thermal therapy field of tumor.
Utility model content
The result of use that this utility model causes in order to solve the problems such as the easy breed bacteria of existing wound dressing, easy adhesion, provides a kind of Graphene wound dressing antibacterial, anti that has.
This utility model to achieve these goals, the technical solution adopting is: a kind of Graphene wound dressing, it is characterized in that: comprise at least one deck basal layer and one deck antibiotic layer, described antibiotic layer is arranged on basal layer by thermal bonding or chemical bond method, described basal layer is made by cotton, gauze or non-woven fabrics, and described antibiotic layer is made by Graphene.
Further, described nonwoven production fiber is a kind of of polypropylene, terylene, chinlon, viscose rayon, acrylon, polyethylene, polyvinyl chloride fibre.
Further, described Graphene adopts the solid dispersed graphite alkene of dry production.
Further, described solid dispersed graphite alkene main component is single-layer graphene or multi-layer graphene.
Further, described thermal bonding step is: the Graphene of dry production is crushed to 10～50um granule through ultrasonic grinder, and dry rear standby; Substrate layered material is set to size by wound dressing and cut out, be wrapped on spool, be placed on the sticky machine of spray; Graphene granule is loaded in feed bin, starts feed bin heater, temperature is controlled at above 5～8 ℃ of substrate material softening temperature; Start pay-off, the feeding speed that substrate layered material is set is 3～5cm/s; Open pneumatic Graphene material-spraying device simultaneously Graphene granule is vertically sprayed on to substrate layered material surface, material spray amount is controlled at more than 85%, to being stained with the basal layer of Graphene, in course of conveying, through the air-cooled Graphene that makes, firmly sticks at basal layer surface.
Further, described chemical bond method step is: the Graphene of dry production is crushed to 10～50um granule through ultrasonic grinder, is then made into content and is 0.5%～3% graphene solution; Add strong acid, oxidant, catalyst through heating and reacting, the ethylene linkage of Graphene to be opened, the organic compound that generates hydroxyl, carbonyl, carboxyl, ketone group and these oxygen-containing functional groups of oxo bridge base or add strong acid, oxidant, catalyst and contain amino, amido, imido grpup, sulfydryl, generates corresponding non-containing oxy functional groups through reaction; Reacted Graphene derivative solution is after adjusting pH, concentration, temperature, substrate layered material is immersed, through condensation, coupling, displacement, dehydration, be bonded to basal layer surface, when substrate layered material immerses Graphene derivative solution, part kind will add coupling agent.
The beneficial effect that this utility model produces is: owing to adopting solid dispersed graphite alkene not exert an influence to human body cell normal development, metabolism, antibacterial cannot grow and make wound dressing fungistatic effect fool proof effectively on Graphene; The structural configuration of basal layer and antibiotic layer can be permanently effective antibacterial, prevent that wound dressing is aging, soft wear-resisting, and can reuse; Because Graphene has huge specific surface area, can absorb the body fluid such as a large amount of tissue secretion things, pus, blood, and its resistance to bond causes and can not form hard crust, slight incrustation is easy to separation, makes site of injury change dressings, process very convenient.
Accompanying drawing explanation
Below in conjunction with drawings and Examples, this utility model is further elaborated.
Fig. 1 is structural representation of the present utility model.
In figure: 1, basal layer; 2, antibiotic layer.
The specific embodiment
A kind of Graphene wound dressing as shown in Figure 1, it is characterized in that: comprise at least one deck basal layer and one deck antibiotic layer, described antibiotic layer is arranged on basal layer by thermal bonding or chemical bond method, described basal layer is made by cotton, gauze or non-woven fabrics, and described antibiotic layer is made by Graphene.
Further, described nonwoven production fiber is a kind of of polypropylene (PP), terylene (PET), chinlon (PA), viscose rayon, acrylon, polyethylene (HDPE), polyvinyl chloride fibre (PVC).
Further, described Graphene adopts the solid dispersed graphite alkene of dry production.
Further, described solid dispersed graphite alkene main component is single-layer graphene or multi-layer graphene.
embodiment 1
1, the Graphene powder of dry production is crushed to 10～50 submicron size particles through high-power ultrasonics pulverizer again, dry rear standby.
2, by wound dressing, need dimension width to cut out the polypropylene non-woven fabric cloth for the preparation of wound dressing.Be wrapped on suitable spool.And material loading is on the sticky machine cloth conveying axis of spray.
3, each 1000g Graphene powder is loaded on respectively in former and later two feed bins, starts feed bin heater, start air blowing heater simultaneously, temperature is controlled at 155～158 ℃.
4, start non-woven fabrics pay-off, making non-woven fabrics feeding speed is 3～5cm/s.Start pneumatic Graphene material-spraying device simultaneously Graphene powder is vertically sprayed on to nonwoven design on fabric surface from corresponding both direction.The Graphene that material spray amount is controlled at more than 85% firmly sticks at nonwoven surface.
5,, when gluing the non-woven fabrics of Graphene and carry, can firmly stick at nonwoven surface through the air-cooled Graphene that makes downwards.By sticking not firm Graphene, blow off simultaneously.
6, the Graphene cloth of finished product is bundled through spool coiling, then packs.
embodiment 2
1, the Graphene powder of dry production is crushed to 50 submicron size particles through high-power ultrasonics pulverizer again, is made into Graphene content and is 3% solution.
2, add 50%HNO
3, 40%H
2sO
4be warmed to 80 ℃ of reaction 2h, the ethylene linkage of Graphene is opened, generate the oxygen-containing functional groups such as hydroxyl, carbonyl, carboxyl, ketone group and oxo bridge base.
3, by this solution dilution, to Graphene content, be 0.5%, adding NaOH adjustment pH is 3, and polypropylene-base non-woven fabrics fabric is immersed to solution, and by coupling agent N, N mono-methylene-bisacrylamide adds, and concentration is 0.1%, normal temperature crosslinked 2h.
4, the fabric after crosslinked is through being washed to neutral dry for standby.
5, the fabric after processing is cut into arbitrary size, the wound dressing of shape, encapsulation after sterilization, packing.
embodiment 3
1, the Graphene powder of dry production is crushed to 10 submicron size particles through high-power ultrasonics pulverizer again, is made into Graphene content and is 0.5% solution.
2, add 50%HNO
3, 40%H
2sO
4be warmed to 80 ℃ of reaction 2h, the ethylene linkage of Graphene is opened, generate the oxygen-containing functional groups such as hydroxyl, carbonyl, carboxyl, ketone group and oxo bridge base.
3, by this solution dilution, to Graphene content, be 0.1%, adding NaOH adjustment pH is 3, and cotton, linen are immersed to solution, and by coupling agent N, N mono-methylene-bisacrylamide adds, and concentration is 0.1%, normal temperature crosslinked 2h.
4, the fabric after crosslinked is through being washed to neutral dry for standby.
5, the fabric after processing can be cut into arbitrary size, the wound dressing of shape, encapsulation after sterilization, packing.
Above-mentioned explanation is not to restriction of the present utility model; this utility model is also not limited in above-mentioned giving an example; the variation that those skilled in the art make in essential scope of the present utility model, remodeling, interpolation or replacement, also should belong to protection domain of the present utility model.
Claims (4)
1. a Graphene wound dressing, it is characterized in that: comprise at least one deck basal layer and one deck antibiotic layer, described antibiotic layer is arranged on basal layer by thermal bonding or chemical bond method, and described basal layer is made by cotton, gauze or non-woven fabrics, and described antibiotic layer is made by Graphene.
2. Graphene wound dressing according to claim 1, is characterized in that: described nonwoven production fiber is a kind of of polypropylene, terylene, chinlon, viscose rayon, acrylon, polyethylene, polyvinyl chloride fibre.
3. Graphene wound dressing according to claim 1, is characterized in that: described Graphene adopts the solid dispersed graphite alkene of dry production.
4. Graphene wound dressing according to claim 3, is characterized in that: described solid dispersed graphite alkene main component is single-layer graphene or multi-layer graphene.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201420196616.6U CN203842074U (en) | 2014-04-22 | 2014-04-22 | Graphene wound dressing |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201420196616.6U CN203842074U (en) | 2014-04-22 | 2014-04-22 | Graphene wound dressing |
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| CN203842074U true CN203842074U (en) | 2014-09-24 |
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| CN201420196616.6U Expired - Fee Related CN203842074U (en) | 2014-04-22 | 2014-04-22 | Graphene wound dressing |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103920179A (en) * | 2014-04-22 | 2014-07-16 | 楚立云 | Graphene wound dressing |
| DE102016115370A1 (en) * | 2016-08-18 | 2018-02-22 | Linkwin Technology Co., Ltd. | METHOD OF USE OF A CARBONIZED MATERIAL TO INHIBIT BACTERIA |
| CN109125783A (en) * | 2018-09-20 | 2019-01-04 | 合肥巧织纺织科技有限公司 | A kind of absorbing sweat antibacterial movement bandage |
| WO2019085190A1 (en) * | 2017-10-31 | 2019-05-09 | 江苏工程职业技术学院 | Method for preparing high-water-retention bacteriostatic facial mask base cloth with graphene oxide |
-
2014
- 2014-04-22 CN CN201420196616.6U patent/CN203842074U/en not_active Expired - Fee Related
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103920179A (en) * | 2014-04-22 | 2014-07-16 | 楚立云 | Graphene wound dressing |
| CN103920179B (en) * | 2014-04-22 | 2015-12-09 | 楚立云 | A kind of Graphene wound dressing |
| DE102016115370A1 (en) * | 2016-08-18 | 2018-02-22 | Linkwin Technology Co., Ltd. | METHOD OF USE OF A CARBONIZED MATERIAL TO INHIBIT BACTERIA |
| WO2019085190A1 (en) * | 2017-10-31 | 2019-05-09 | 江苏工程职业技术学院 | Method for preparing high-water-retention bacteriostatic facial mask base cloth with graphene oxide |
| CN109125783A (en) * | 2018-09-20 | 2019-01-04 | 合肥巧织纺织科技有限公司 | A kind of absorbing sweat antibacterial movement bandage |
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| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20140924 Termination date: 20150422 |
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| EXPY | Termination of patent right or utility model |