CN203798700U - Medicine percutaneous absorption experimental device - Google Patents
Medicine percutaneous absorption experimental device Download PDFInfo
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- CN203798700U CN203798700U CN201420220148.1U CN201420220148U CN203798700U CN 203798700 U CN203798700 U CN 203798700U CN 201420220148 U CN201420220148 U CN 201420220148U CN 203798700 U CN203798700 U CN 203798700U
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- percutaneous absorption
- pencil
- air pressure
- bottle
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Abstract
The utility model discloses a medicine percutaneous absorption experimental device which comprises a constant air pressure holding device, a percutaneous absorption device and a constant temperature stirring device. An air outlet of the constant air pressure holding device is connected and communicated with an air inlet of the percutaneous absorption device through a hose, and the percutaneous absorption device is fixedly connected with the constant temperature stirring device. The constant air pressure holding device comprises a compressed gas storing device, an air pressure buffering device and a gas diversion pipe. The compressed gas storing device is a gas cylinder, a pressure gauge is arranged on the gas cylinder, and the air pressure buffering device is a buffering bottle containing rational liquid. The gas diversion pipe is a transparent glass pipe provided with two or more ventilation pipes. The percutaneous absorption device comprises a mother liquid bottle, a liquid receiving bottle and a fixing device. The constant temperature stirring device comprises a magnetic rotor and a digital readout heating magnetic stirring device. According to the medicine percutaneous absorption experimental device, the experiment time can be shortened, the experiment temperature can be accurately controlled, obtained experiment data are accurate and reliable, and the comparability and reference are high.
Description
Technical field
The utility model relates to a kind of pharmacological experiment equipment, particularly Drug Percutaneous Absorption experimental provision.
Background technology
At present, development along with medical skill and cosmetics, people have carried out infiltrating research to the Transdermal absorption of medicine and cosmetics, and design the device Franz diffusion cell of simulation Transdermal absorption and the Franz diffusion cell of improvement version, for the test that sees through skin efficiency to preparation capable of permeating skin such as ointment, plaster, paint, lotion, film and aerosols.Transdermal absorption adopts Franz diffusion cell, surveyed skin samples is clipped between diffusion cell lid (administration body) and diffusion cell to the inside surface of skin between (being subject to medicine body) to be immersed in isotonic solution, with thermostat, keep diffusion cell under temperature constant state, to work, and adopt at the uniform velocity magnetic stirring apparatus to guarantee that isotonic solution is uniformly distributed.
Yet the experiment of traditional Transdermal absorption exists, and time consumption of experimental process is long, temperature is controlled the shortcomings such as poor and disperser is expensive, in addition, the experiment of tradition Transdermal absorption is because the mentality of designing in each laboratory is different, cause data comparability between laboratory to decline, and for some plasters, owing to being sticked on a certain position of health, effective constituent in plaster can be permeated skin under certain pressure, thus general traditional transdermal experiment cannot react comparatively approach see through skin efficiency.
Utility model content
For the deficiencies in the prior art, the purpose of this utility model be to provide can shorten the experiment used time, realize that temperature is accurately controlled, experimental provision is comparatively cheap and can simulate the Drug Percutaneous Absorption experimental provision that comparatively approaches medicine or the true service condition of cosmetic formulations.
The technical solution of the utility model is achieved in that Drug Percutaneous Absorption experimental provision, comprises that constant air pressure adds to hold device, Transdermal absorption device and constant temperature stirring apparatus, described constant air pressure adds the gas outlet of holding device and by flexible pipe, is connected conducting with the air intake opening of described Transdermal absorption device, and described Transdermal absorption device is fixedly connected with described constant temperature stirring apparatus, described constant air pressure adds to be held device and comprises compressed gas storage, atmospheric buffer device and drop-leg, described compressed gas storage is gas cylinder, on described gas cylinder, tensimeter is installed, described atmospheric buffer device is the surge flask that quantitative liquid is housed, and described drop-leg is the transparent glass tube with two snorkels, the gas outlet of described gas cylinder is connected conducting with the air intake opening of described surge flask by flexible pipe, a snorkel of the gas outlet of described surge flask and described drop-leg is connected conducting by flexible pipe, and another snorkel of described drop-leg is connected conducting with the air intake opening of described Transdermal absorption device by flexible pipe, described Transdermal absorption device comprises mother liquid multi-cavity bottle, be subject to liquid bottle and stationary installation, the body of described mother liquid multi-cavity bottle is provided with the first temperature measuring set arm and delivery tube is installed, the mouth of pipe place of described delivery tube is provided with the first convex edge of vertical described delivery tube axis, in described the first convex edge, be provided with mounting groove, described the first convex edge is provided with the first pilot hole, the described body of liquid bottle that is subject to is provided with the second temperature measuring set installation arm and is subject to pencil, the described mouth of pipe place that is subject to pencil is provided with the second convex edge that is subject to pencil axis described in vertical, on the end face of described the second convex edge, described in edge, gone out with described by pencil Axis Extension managed by the coaxial assembling of pencil, on described the second convex edge, offer the second pilot hole, described stationary installation comprises two positioning splints and bolt, described positioning splint is C template, on described positioning splint, offer the 3rd pilot hole, described assembling pipe extend in described mounting groove, described bolt through described the first pilot hole, described the second pilot hole with described the 3rd pilot hole and by described delivery tube with described in be subject to pencil relative fixing, described constant temperature stirring apparatus comprises magnet rotor and digital display heating magnetic stirring apparatus, described magnet rotor quantity is more than or equal to 2, described mother liquid multi-cavity bottle and described in be subject to respectively to put in liquid bottle a described magnet rotor, described digital display heating magnetic stirring apparatus is 2, described mother liquid multi-cavity bottle and described in be subject to liquid bottle under be placed with respectively a described digital display heating magnetic stirring apparatus.
Said medicine Transdermal absorption experimental provision, the external diameter of described mounting groove is greater than the internal diameter of described delivery tube and is less than or equal to the external diameter of described delivery tube, the sum of the length that is less than or equal to described assembling pipe of described mounting groove and the thickness of laboratory sample.
Said medicine Transdermal absorption experimental provision, is characterized in that, described delivery tube length is more than or equal to 1cm and is less than or equal to 2cm; The described length of pencil that is subject to is more than or equal to 1cm and is less than or equal to 2cm.
Said medicine Transdermal absorption experimental provision, described the first temperature measuring set and described the second temperature measuring set are temperature sensor.
Said medicine Transdermal absorption experimental provision, described magnet rotor is the magnet rotor that is provided with glass scuff-resistant coating.
The beneficial effects of the utility model are: the utility model not only can be realized the test operation of Franz diffusion cell Transdermal absorption completely, realize the test that medicine and cosmetic formulations is seen through to skin efficiency, also shortened the time of traditional Transdermal absorption experiment, and can realize the accurate control to experimental system temperature, and because experiment can be held air pressure in constant adding and carried out, air pressure, experimental situation temperature have improved comparability and the referential of experimental data comparatively accurately.
Accompanying drawing explanation
Fig. 1 is the structural representation of the utility model Drug Percutaneous Absorption test unit;
Fig. 2 is the structural representation of the mother liquid multi-cavity bottle of the utility model Drug Percutaneous Absorption test unit;
Fig. 3 is the structural representation that is subject to liquid bottle of the utility model Drug Percutaneous Absorption test unit;
Fig. 4 is the structural representation of the positioning splint of the utility model Drug Percutaneous Absorption experimental provision.
In figure, 1-gas cylinder, 2-surge flask, 3-drop-leg, 4-rain glass, 5-mother liquid multi-cavity bottle, 6-is subject to liquid bottle, 7-positioning splint, 8-the first temperature measuring set, 9-the first temperature measuring set is installed arm, 10-delivery tube, 11-the first convex edge, 12-mounting groove, 13-the first pilot hole, 14-the second temperature measuring set, 15-the second temperature measuring set is installed arm, 16-is subject to pencil, 17-the second convex edge, 18-the second pilot hole, 19-assembles pipe, 20-the 3rd pilot hole, 21-magnet rotor, 22-digital display heating magnetic stirring apparatus, 23-laboratory sample.
Embodiment
As shown in Figure 1, the utility model Drug Percutaneous Absorption experimental provision, comprises that constant air pressure adds to hold device, Transdermal absorption device and constant temperature stirring apparatus, described constant air pressure adds the gas outlet of holding device and by flexible pipe, is connected conducting with the air intake opening of described Transdermal absorption device, described Transdermal absorption device is fixedly connected with described constant temperature stirring apparatus, wherein said constant air pressure adds to be held device and provides the air pressure higher than standard atmospheric pressure for Drug Percutaneous Absorption experimental system, can not only simulate transdermal absorption formulation practical service environment, but also can shorten experiment flow, described Transdermal absorption device plays the effect of Franz diffusion cell, the skin efficiency that sees through to certain preparation capable of permeating skin is tested, described constant temperature stirring apparatus stirs power and heating and temperature maintenance for described Transdermal absorption device provides.
As shown in Figure 1, described constant air pressure adds holds device, comprise compressed gas storage, atmospheric buffer device and drop-leg 3, described compressed gas storage is gas cylinder 1, on described gas cylinder 1, tensimeter 4 is installed, described atmospheric buffer device is the surge flask 2 that quantitative liquid is housed, described drop-leg 3 is for having the transparent glass tube of two snorkels, when snorkel is not used on described drop-leg 3, can the flexible pipe on described snorkel be closed by its blow vent with hemostatic forceps gripping sleeve, the described drop-leg 3 that is provided with a plurality of described snorkels can make described gas cylinder 1 and described surge flask 2 for a plurality of described Transdermal absorption devices and test to provide the air pressure higher than standard atmospheric pressure, the gas outlet of described gas cylinder 1 is connected conducting with the air intake opening of described surge flask 2 by flexible pipe, a snorkel of the gas outlet of described surge flask 2 and described drop-leg 3 is connected conducting by flexible pipe, and another snorkel of described drop-leg 3 is connected conducting with the air intake opening of described Transdermal absorption device by flexible pipe.
The utility model according to Franz diffusion cell designs the utility model diffusion cell used, i.e. described Transdermal absorption device.As Figure 1-4, described Transdermal absorption device, comprise mother liquid multi-cavity bottle 5, be subject to liquid bottle 6 and stationary installation, on the body of described mother liquid multi-cavity bottle 5, offer the first temperature measuring set arm 9 and delivery tube 10 are installed, the mouth of pipe place of described delivery tube 10 is provided with the first convex edge 11 of vertical described delivery tube 10 axis, in described the first convex edge 11, be provided with mounting groove 12, described the first convex edge is provided with the first pilot hole 13, on the described body that is subject to liquid bottle 6, offering the second temperature measuring set installs arm 15 and is subject to pencil 16, described pencil 16 mouth of pipe places that are subject to are provided with the second convex edge 17 that is subject to pencil 16 axis described in vertical, on the end face of described the second convex edge 17, described in edge, gone out and the described coaxial assembling pipe 19 of pencil 16 that is subject to by pencil 16 Axis Extensions, on described the second convex edge, offer the second pilot hole 18, described stationary installation comprises two positioning splints 7 and bolt, described positioning splint 7 is C template, on described positioning splint 7, offer the 3rd pilot hole 20, described assembling pipe 19 extend in described mounting groove 12, described bolt through described the first pilot hole 13, described the second pilot hole 18 with described the 3rd pilot hole 20 and by described delivery tube 10 with described in be subject to pencil 16 relative fixing.Wherein, in order can described laboratory sample 23 to be tightly pressed on the diapire of described mounting groove 12 with described assembling pipe 19, the degree of depth of described mounting groove 12 equals the sum of the length of described assembling pipe 19 and the thickness of laboratory sample 23.
In addition for guarantee delivery tube 10 and described in can under the stirring of stirring apparatus, flow by the liquid in pencil 16, described delivery tube 10 preferred lengths are more than or equal to 1cm and are less than or equal to the delivery tube of 2cm, described in be subject to pencil 16 preferred lengths to be more than or equal to 1cm and be less than or equal to the pencil that is subject to of 2cm.
As shown in Figure 1, described constant temperature stirring apparatus, comprise magnet rotor 21 and digital display heating magnetic stirring apparatus 22, wherein said magnet rotor 21 is more than or equal to 2 for being provided with the magnet rotor quantity of glass scuff-resistant coating, described mother liquid multi-cavity bottle 5 and described in be subject to respectively to put in liquid bottle 6 a described magnet rotor 21, described digital display heating magnetic stirring apparatus is 2, described mother liquid multi-cavity bottle 5 and described in be subject to liquid bottle 6 under be placed with respectively a described digital display heating magnetic stirring apparatus 22.Described magnet rotor 21 is for being provided with the magnet rotor of glass scuff-resistant coating.And because described digital display heating magnetic stirring apparatus 22 need to pass through temperature measuring set measured temperature electric signal, so described the first temperature measuring set 8 and described the second temperature measuring set 14 are temperature sensor.
In the present embodiment, while using the utility model, only need each instrument to assemble according to Fig. 1, then start Transdermal absorption experiment.
Above-described embodiment is only for the invention example is clearly described, and the not restriction to the invention embodiment.For those of ordinary skill in the field, can also make other changes in different forms on the basis of the above description.Here exhaustive without also giving all embodiments.All any apparent variations of being extended out within spirit of the present utility model and principle or change are still among the protection domain in the invention claim.
Claims (5)
1. Drug Percutaneous Absorption experimental provision, is characterized in that, comprises that constant air pressure adds to hold device, Transdermal absorption device and constant temperature stirring apparatus, described constant air pressure adds the gas outlet of holding device and by flexible pipe, is connected conducting with the air intake opening of described Transdermal absorption device, and described Transdermal absorption device is fixedly connected with described constant temperature stirring apparatus, described constant air pressure adds to be held device and comprises compressed gas storage, atmospheric buffer device and drop-leg (3), described compressed gas storage is gas cylinder (1), tensimeter (4) is installed on described gas cylinder (1), described atmospheric buffer device is the surge flask (2) that quantitative liquid is housed, and described drop-leg (3) is for having the transparent glass tube of two snorkels, the gas outlet of described gas cylinder (1) is connected conducting with the air intake opening of described surge flask (2) by flexible pipe, a snorkel of the gas outlet of described surge flask (2) and described drop-leg (3) is connected conducting by flexible pipe, and another snorkel of described drop-leg (3) is connected conducting with the air intake opening of described Transdermal absorption device by flexible pipe, described Transdermal absorption device comprises mother liquid multi-cavity bottle (5), be subject to liquid bottle (6) and stationary installation, the body of described mother liquid multi-cavity bottle (5) is provided with the first temperature measuring set arm (9) and delivery tube (10) is installed, the mouth of pipe place of described delivery tube (10) is provided with first convex edge (11) of vertical described delivery tube (10) axis, in described the first convex edge (11), be provided with mounting groove (12), described the first convex edge (11) is provided with the first pilot hole (13), the described body of liquid bottle (6) that is subject to is provided with the second temperature measuring set installation arm (15) and is subject to pencil (16), the described mouth of pipe place that is subject to pencil (16) is provided with the second convex edge (17) that is subject to pencil (16) axis described in vertical, on the end face of described the second convex edge (17), described in edge, gone out and the described coaxial assembling pipe (19) of pencil (16) that is subject to by pencil (16) Axis Extension, on described the second convex edge (17), offer the second pilot hole (18), described stationary installation comprises two positioning splints (7) and bolt, described positioning splint (7) is C template, on described positioning splint (7), offer the 3rd pilot hole (20), described assembling pipe (19) extend in described mounting groove (12), described bolt through described the first pilot hole (13), described the second pilot hole (18) with described the 3rd pilot hole (20) and by described delivery tube (10) with described in be subject to pencil (16) relative fixing, described constant temperature stirring apparatus comprises magnet rotor (21) and digital display heating magnetic stirring apparatus (22), described magnet rotor (21) quantity is more than or equal to 2, described mother liquid multi-cavity bottle (5) and described in be subject to respectively to put in liquid bottle (6) a described magnet rotor (21), described digital display heating magnetic stirring apparatus (22) is 2, described mother liquid multi-cavity bottle (5) and described in be subject to liquid bottle (6) under be placed with respectively a described digital display and heat magnetic stirring apparatus (22).
2. according to the Drug Percutaneous Absorption experimental provision described in claim 1 or 3, it is characterized in that, the degree of depth of described mounting groove (12) equals the sum of the length of described assembling pipe (19) and the thickness of laboratory sample (23).
3. according to the Drug Percutaneous Absorption experimental provision described in claim 3 or 5, it is characterized in that, described delivery tube (10) length is more than or equal to 1cm and is less than or equal to 2cm; The described length of pencil (16) that is subject to is more than or equal to 1cm and is less than or equal to 2cm.
4. according to the Drug Percutaneous Absorption experimental provision described in claim 1 or 3, it is characterized in that, described the first temperature measuring set (8) and described the second temperature measuring set (14) are temperature sensor.
5. according to the Drug Percutaneous Absorption experimental provision described in claim 1 or 4, it is characterized in that, described magnet rotor (21) is for being provided with the magnet rotor of glass scuff-resistant coating.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201420220148.1U CN203798700U (en) | 2014-05-02 | 2014-05-02 | Medicine percutaneous absorption experimental device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201420220148.1U CN203798700U (en) | 2014-05-02 | 2014-05-02 | Medicine percutaneous absorption experimental device |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN203798700U true CN203798700U (en) | 2014-08-27 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201420220148.1U Expired - Fee Related CN203798700U (en) | 2014-05-02 | 2014-05-02 | Medicine percutaneous absorption experimental device |
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| Country | Link |
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| CN (1) | CN203798700U (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105018339A (en) * | 2015-01-21 | 2015-11-04 | 中国人民解放军军事医学科学院附属医院 | Double-cavity cell resistance impedance chip |
| CN109612898A (en) * | 2018-11-12 | 2019-04-12 | 禄根仪器(镇江)有限公司 | A kind of suspending agent flowing release test flowing lumen |
| CN110045071A (en) * | 2019-04-19 | 2019-07-23 | 禄根仪器(镇江)有限公司 | A kind of absorption pool structure of drug absorption sampling system |
-
2014
- 2014-05-02 CN CN201420220148.1U patent/CN203798700U/en not_active Expired - Fee Related
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105018339A (en) * | 2015-01-21 | 2015-11-04 | 中国人民解放军军事医学科学院附属医院 | Double-cavity cell resistance impedance chip |
| CN109612898A (en) * | 2018-11-12 | 2019-04-12 | 禄根仪器(镇江)有限公司 | A kind of suspending agent flowing release test flowing lumen |
| CN109612898B (en) * | 2018-11-12 | 2021-06-04 | 禄根仪器(镇江)有限公司 | Flowable release test circulation cavity for suspending agent |
| CN110045071A (en) * | 2019-04-19 | 2019-07-23 | 禄根仪器(镇江)有限公司 | A kind of absorption pool structure of drug absorption sampling system |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20140827 Termination date: 20160502 |