CN203773372U - Hypoxia isolator - Google Patents
Hypoxia isolator Download PDFInfo
- Publication number
- CN203773372U CN203773372U CN201420170415.9U CN201420170415U CN203773372U CN 203773372 U CN203773372 U CN 203773372U CN 201420170415 U CN201420170415 U CN 201420170415U CN 203773372 U CN203773372 U CN 203773372U
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- China
- Prior art keywords
- air
- nitrogen
- isolator
- intake
- air inlet
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 206010021143 Hypoxia Diseases 0.000 title claims abstract description 13
- 230000007954 hypoxia Effects 0.000 title abstract 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims abstract description 132
- 229910052757 nitrogen Inorganic materials 0.000 claims abstract description 61
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims abstract description 52
- 239000001301 oxygen Substances 0.000 claims abstract description 52
- 229910052760 oxygen Inorganic materials 0.000 claims abstract description 52
- 239000007789 gas Substances 0.000 claims description 18
- 230000009467 reduction Effects 0.000 claims description 11
- 208000018875 hypoxemia Diseases 0.000 claims description 10
- 238000000034 method Methods 0.000 claims description 8
- 238000001914 filtration Methods 0.000 claims description 5
- 239000000203 mixture Substances 0.000 claims description 3
- 238000004519 manufacturing process Methods 0.000 abstract description 21
- 238000005303 weighing Methods 0.000 abstract description 12
- 238000001514 detection method Methods 0.000 abstract description 7
- 238000009423 ventilation Methods 0.000 abstract description 6
- 239000003814 drug Substances 0.000 description 14
- 230000000694 effects Effects 0.000 description 13
- 229910001873 dinitrogen Inorganic materials 0.000 description 10
- 238000006073 displacement reaction Methods 0.000 description 9
- 229940079593 drug Drugs 0.000 description 9
- 231100000086 high toxicity Toxicity 0.000 description 8
- 230000001276 controlling effect Effects 0.000 description 7
- 239000000463 material Substances 0.000 description 6
- 230000002146 bilateral effect Effects 0.000 description 5
- 230000008859 change Effects 0.000 description 5
- 230000003750 conditioning effect Effects 0.000 description 5
- 238000013461 design Methods 0.000 description 3
- 230000008569 process Effects 0.000 description 3
- 230000001105 regulatory effect Effects 0.000 description 3
- 238000012937 correction Methods 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 229940088597 hormone Drugs 0.000 description 2
- 239000005556 hormone Substances 0.000 description 2
- 238000012856 packing Methods 0.000 description 2
- 230000009183 running Effects 0.000 description 2
- 230000035945 sensitivity Effects 0.000 description 2
- 230000003068 static effect Effects 0.000 description 2
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 230000000118 anti-neoplastic effect Effects 0.000 description 1
- 230000000561 anti-psychotic effect Effects 0.000 description 1
- 230000000259 anti-tumor effect Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 238000003912 environmental pollution Methods 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 238000009434 installation Methods 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
- 125000006850 spacer group Chemical group 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
Landscapes
- Filtering Of Dispersed Particles In Gases (AREA)
- Ventilation (AREA)
Abstract
The utility model relates to a novel hypoxia isolator capable of adjusting oxygen concentration in a cabin. The hypoxia isolator comprises a box body, an air exhaust system, an air intake system and a control system; an efficient filter is adopted as the air exhaust system; a pipeline is provided with a pneumatic on-off valve; when leakage detection is performed on equipment, the pneumatic on-off valve is automatically closed; when the equipment is in a shutdown state, an air exhaust valve is closed, so that the box body can be prevented from contacting with the outside; the air flow mode of the air intake system is a turbulent flow mode and is divided into an air intake mode and a nitrogen intake mode which can be freely switched; an air intake port of the air intake system is provided with an manual butterfly valve used for adjusting the times of ventilation of the equipment; a nitrogen intake system is divided into two air-intake paths; air-intake flow can be adjusted and monitored through a flowmeter; when nitrogen intake is in a single-path air-intake state, a weighing mode is realized, and nitrogen flow enters the box body slowly and stately, and weighing will not be affected; and when nitrogen intake is a double-path air-intake state, a replacement mode is realized, oxygen content quickly drops and is below 5%. The isolator has oxygen concentration adjustment function in the turbulent flow mode, and is suitable for being applied to the production of highly-toxic or highly-active products requiring lower oxygen concentration.
Description
Technical field
The utility model belongs to isolator instrument field, relate to isolator, the novel isolator of especially adjustable isolator cabin body oxygen concentration, isolator has the ergonomics of meeting, and is applicable to oxygen concentration to require lower high toxicity or the Production requirement of high activity product.
Background technology
Recently, in advance, kinds of Diseases and generation develop variation to relevant research finder group age of onset, and therefore, increasing antineoplastic, hormone drugs, antipsychotic similar drug, biotechnology similar drug are are constantly researched and developed, and progressively put in actual production.Thereby the isolator matching with it is also extensively put in actual production.Because the high-activity drugs such as antitumor medicine, hormone drugs, biotechnology similar drug exist serious harmfulness in the production operation process of medicine, by domestic and international expert, regarded as excessive risk production operation.Be directed to this, in these high-activity drug production runes, need to equip isolator, to protection medicine, prevent that medicine from leaking and cross pollution; And protection production operation personnel, prevent production run due to suck or contact objectionable impurities cause personnel health or spiritual aspect injury; And protection of the environment, prevent that medicine from leaking or the excessive environmental pollution causing.
In view of China's high activity pharmaceutical production present situation, long-term in exposed open production environment, thus cause the high-activity drug production equipment facility matching with it to fall behind.Thereby exploitation can meet isolation and Sealing Technology requirement in high-activity drug production, can meet oxygen concentration lower in casing again simultaneously, use oxygen concentration is required to lower high toxicity or the production of high activity product, by contributing to promote the progress of China's isolator industry, have compared with Great significance.
Widely used protection type isolator in existing market, mainly plays mechanicalness protection, can not regulate the oxygen concentration in isolator casing, thereby is not suitable for oxygen concentration to require lower high toxicity or the production of high activity product.Nitrogen have safety, price low, be easy to the advantages such as acquisition, widespread use in pharmacy and commercial production.Present inventor, plan provides a kind of hypoxemia isolator, the isolator of especially adjustable isolator cabin body oxygen concentration, take into full account and overcome existing isolator cannot adjusting cabin body in the defect of oxygen concentration, further expand isolator product type, meet the Production requirement of dissimilar product.
Utility model content
The purpose of this utility model is to provide a kind of hypoxemia isolator, the isolator of especially adjustable isolator cabin body oxygen concentration, and this isolator has the ergonomics of meeting, and is applicable to oxygen concentration to require lower high toxicity or the Production requirement of high activity product.
In isolator of the present utility model, utilize nitrogen to participate in circulation dynamic adjustments isolator box house oxygen concentration, nitrogen also has and has certain explosion-proof ability simultaneously, can, for there being the occasion of potential safety hazard, be a kind of specialities for requiring low oxygen concentration condition to produce.
Concrete, the isolator of the especially adjustable isolator of a kind of hypoxemia isolator of the present utility model cabin body oxygen concentration, is characterized in that, it is by casing, exhaust system, gas handling system and composition of the control system; Described exhaust system adopts high efficiency particulate air filter, and pneumatic on-off valve is set on pipeline, in equipment leak detection, automatically closes, and equipment is exhaust valve closure under stopped status, avoids casing to contact with extraneous; The flow pattern of gas handling system system is Turbulent Models, is divided into air inlet and nitrogen intake method, can freely switch; The air inlet port arrangement Hand-operated butterfly valve of air inlet system is for the rate of ventilation of conditioning equipment; Nitrogen gas handling system is divided into two-way air inlet, by flowmeter, is regulated charge flow rate and is monitored charge flow rate, and nitrogen air inlet is weighing pattern when single channel air inlet, now stream of nitrogen gas enters casing gently, do not affect weighing, be displacement patterns when bilateral air agreement, and oxygen content is down to below 5% rapidly.
In the utility model, nitrogen operation valve 1,2 is for controlling the break-make of nitrogen air inlet; Air inlet valve 3, for controlling the break-make of air inlet; Vent valve 4 is for controlling the break-make of gas exhaust piping; Efficient bucket 5 is installed high efficiency particulate air filter, and can change safely filtrator; Blower fan 6 produces negative pressure; Oxygen content instrument 7 detects oxygen content (range: 0-25%, the precision: ± 1%) of box house; Pressure difference transmitter 8 detects external pressure reduction (range: 0-125pa, the precision: ± 1%) of box house; Discharge filter 9 exhaust gas filter (grades: H14); Air intake filter 10 inlet air filtration (grades: H14); Nitrogen flow meter 11 regulates the flow of nitrogen pipeline 1; Nitrogen flow meter 12 regulates the flow of nitrogen pipeline 2.
In the utility model, described exhaust system adopts high efficiency particulate air filter, and in embodiment of the present utility model, exhaust system adopts the high efficiency particulate air filter (filtration efficiency: 99.993%) that filter-grade is H14, and by blower fan (static pressure: 600pa, flow: > 100m
3/ h) get rid of to outdoor, pneumatic on-off valve is set on pipeline, in equipment leak detection, automatically close, equipment is exhaust valve closure under stopped status, can avoid casing to contact with extraneous;
In the utility model, there is the function that under Turbulent Models, oxygen concentration regulates, be applicable to oxygen concentration to require the production of lower high toxicity or high activity product.
In the utility model, the flow pattern of gas handling system adopts Turbulent Models, is divided into air inlet and nitrogen intake method, can freely switch; Wherein, the air inlet port arrangement Hand-operated butterfly valve of air inlet system is for the rate of ventilation of conditioning equipment; Nitrogen gas handling system is divided into two-way air inlet, by flowmeter, regulate charge flow rate and monitor charge flow rate, nitrogen air inlet is weighing pattern when single channel air inlet, now stream of nitrogen gas enters casing gently, do not affect weighing, when bilateral air agreement, be displacement patterns, air that can Rapid replacement box house, is down to below 5% rapidly oxygen content.
Described gas handling system system is divided into air inlet and two kinds of modes of nitrogen air inlet, can freely switch; The air inlet port arrangement Hand-operated butterfly valve of air inlet system is for the rate of ventilation of conditioning equipment; Nitrogen air inlet is divided into two-way air inlet, when single channel air inlet, is weighing pattern, and now stream of nitrogen gas enters casing gently, does not affect weighing, when bilateral air agreement, is displacement patterns, and oxygen content is down to below 5% rapidly.
In the utility model, the design of the nitrogen of two-way can make casing Rapid replacement and slowly displacement, is applicable to different technological requirements.
In the utility model, described nitrogen operation valve 1,2, two-way is for controlling the break-make of nitrogen air inlet, and the difference by two-way coordinates, and can effectively control nitrogen air inflow and intake velocity;
In the utility model, described air inlet valve is controlled the break-make of air inlet, and then controls inlet and the speed of air;
In the utility model, described efficient bucket installation high efficiency particulate air filter, and can change safely filtrator;
Oxygen content instrument of the present utility model, oxygen content that can Real-time and Dynamic Detection box house, feeds back in time casing oxygen concentration to PLC, thereby regulates in time air inlet valve 3, controls the break-make of air inlet.
The utility model nitrogen flow meter, nitrogen flow that can Real-time and Dynamic Detection box house,, thereby regulating in time two-way nitrogen operation valve 1,2, the difference by two-way coordinates, and can effectively control nitrogen air inflow and intake velocity.
In the utility model, adopt the pressure reduction of pid algorithm opertaing device, can make the quick realize target value of pressure reduction and higher stability.
During the practical operation of the utility model isolator, its equipment has two kinds of air inlet patterns: nitrogen air inlet pattern, is applicable to the material to oxygen concentration sensitivity; Air inlet pattern, is applicable to common material; Nitrogen air inlet pattern: after startup work, oxygen content instrument detect oxygen content higher than setting value after, 1,2,4,6 open, 3 close, start the air in casing to replace, after waiting for that 7 detected value is lower than setting value, 1 closes, 3 close, retain 2,4,6 runnings, equipment enters slow air-flow displacement patterns, now can weigh, the work such as packing, in whole process, 8 participate in carrying out the adjusting feedback of casing to external differential, keep the stable of casing pressure reduction.Air inlet pattern: after startup work, 1,2 close, and 3,4,6 open, and enter the circulation pattern of air, 7 now do not participate in work, and 8 participate in the constant control of pressure reduction.
Result demonstration, isolator of the present utility model has the function that under Turbulent Models, oxygen concentration regulates, and is applicable to oxygen concentration to require lower high toxicity or the production of high activity product.
The beneficial effects of the utility model are, oxygen concentration in the body of adjustable isolator cabin:
1. the selection of oxygen and two kinds of mode of operations of nitrogen, the oxygen concentration in can free adjustment isolator cabin body, makes the range of application of isolator more wide.
2. nitrogen participates in circulation and replacement of oxygen, makes the certain explosion-proof ability of having of box house, can have for some the occasion of potential safety hazard.
3. the design of the nitrogen of two-way can make casing Rapid replacement and slowly displacement, is applicable to different technological requirements.
4. the control of the pressure reduction of equipment has adopted pid algorithm, makes the quick realize target value of pressure reduction and higher stability.
5. exhaust efficiently adopts double layer design, effectively removes high toxicity and high activity material in working environment, makes the gas of discharge cleaner, reduces the pollution to environment.
6. the software systems of equipment can automatically detect the leakage rate of casing and can automatically start emergency mode, avoid outside personnel to be subject to the threat that material leaks.
For the ease of understanding, below the accompanying drawing by concrete and implementation example are described in detail of the present utility model.It needs to be noted, instantiation and accompanying drawing are only in order to illustrate, obviously those of ordinary skill in the art can be according to explanation herein, in scope of the present utility model, the utility model is made to various corrections and change, these corrections and change are also included in scope of the present utility model.
Accompanying drawing explanation
Fig. 1 is the utility model spacer structures schematic diagram,
Wherein, 1,2 is nitrogen operation valve, and 3 is air inlet valve, and 4 is vent valve, and 5 is efficient bucket, and 6 is blower fan, and 7 is oxygen content instrument, and 8 is pressure difference transmitter, and 9 is discharge filter, and 10 is air intake filter, and 11 is nitrogen flow meter, and 12 is nitrogen flow meter.
Fig. 2: the utility model isolator outboard profile.
Fig. 3: the utility model isolator vertical view,
Wherein, 1,2 is nitrogen operation valve, and 3 is air inlet valve, and 4 is vent valve, and 5 is efficient bucket, and 6 is blower fan, and 7 is oxygen content instrument, and 8 is pressure difference transmitter, and 11 is nitrogen flow meter, and 12 is nitrogen flow meter.
Embodiment
Embodiment 1
Prepare the utility model isolator, it is by casing, exhaust system, gas handling system and composition of the control system; Described exhaust system adopts high efficiency particulate air filter, and pneumatic on-off valve is set on pipeline, in equipment leak detection, automatically closes, and equipment is exhaust valve closure under stopped status, avoids casing to contact with extraneous; The flow pattern of gas handling system system is Turbulent Models, is divided into air inlet and nitrogen intake method, can freely switch; The air inlet port arrangement Hand-operated butterfly valve of air inlet system is for the rate of ventilation of conditioning equipment; Nitrogen gas handling system is divided into two-way air inlet, by flowmeter, is regulated charge flow rate and is monitored charge flow rate, and nitrogen air inlet is weighing pattern when single channel air inlet, now stream of nitrogen gas enters casing gently, do not affect weighing, be displacement patterns when bilateral air agreement, makes oxygen content be down to rapidly below 5%; Wherein, nitrogen operation valve 1,2 is for controlling the break-make of nitrogen air inlet; Air inlet valve 3, for controlling the break-make of air inlet; Vent valve 4 is for controlling the break-make of gas exhaust piping; Efficient bucket 5 is installed high efficiency particulate air filter, and can change safely filtrator; Blower fan 6 produces negative pressure; Oxygen content instrument 7 detects oxygen content (range: 0-25%, the precision: ± 1%) of box house; Pressure difference transmitter 8 detects external pressure reduction (range: 0-125pa, the precision: ± 1%) of box house; Discharge filter 9 exhaust gas filter (grades: H14); Air intake filter 10 inlet air filtration (grades: H14); Nitrogen flow meter 11 regulates the flow of nitrogen pipeline 1; Nitrogen flow meter 12 regulates the flow of nitrogen pipeline 2.
In the present embodiment, exhaust system adopts the high efficiency particulate air filter that filter-grade is H14 (filtration efficiency: 99.993%), and pass through blower fan (static pressure: 600pa, flow: > 100m
3/ h) get rid of to outdoor, pneumatic on-off valve is set on pipeline, in equipment leak detection, automatically close, equipment is exhaust valve closure under stopped status, can avoid casing to contact with extraneous.
Embodiment 2
Adopt this isolator to regulate isolator cabin body oxygen concentration, equipment includes two kinds of air inlet patterns: nitrogen air inlet pattern, is applicable to the material to oxygen concentration sensitivity; Air inlet pattern, is applicable to common material.Nitrogen air inlet pattern: after startup work, oxygen content instrument detect oxygen content higher than setting value after, nitrogen operation valve 1, 2, vent valve 4, blower fan 6 is opened, air inlet valve 3 cuts out, start the air in casing to replace, the detected value of waiting for oxygen content instrument 7 lower than setting value after, nitrogen operation valve 1 is closed, air inlet valve 3 cuts out, retained nitrogen gas control valve 2, vent valve 4, blower fan 6 runnings, equipment enters slow air-flow displacement patterns, now can weigh, the work such as packing, in whole process, pressure difference transmitter 8 participates in carrying out the adjusting feedback of casing to external differential, keep the stable of casing pressure reduction, air inlet pattern: after startup work, nitrogen operation valve 1,2 is closed, and air inlet valve 3, vent valve 4, vent valve 6 are opened, and enter the circulation pattern of air, oxygen content instrument 7 does not now participate in work, and pressure difference transmitter 8 participates in the constant control of pressure reduction.
In the present embodiment, the flow pattern of gas handling system adopts Turbulent Models, is divided into air inlet and nitrogen intake method, can freely switch; Wherein, the air inlet port arrangement Hand-operated butterfly valve of air inlet system is for the rate of ventilation of conditioning equipment; Nitrogen gas handling system is divided into two-way air inlet, by flowmeter, regulate charge flow rate and monitor charge flow rate, nitrogen air inlet is weighing pattern when single channel air inlet, now stream of nitrogen gas enters casing gently, do not affect weighing, when bilateral air agreement, be displacement patterns, air that can Rapid replacement box house, is down to below 5% rapidly oxygen content.
Test findings demonstration, isolator of the present utility model has the function that under Turbulent Models, oxygen concentration regulates, is applicable to oxygen concentration to require lower high toxicity or the production of high activity product, and safety, environmental protection.
Claims (6)
1. a hypoxemia isolator, is characterized in that, it is by casing, exhaust system, gas handling system and composition of the control system; Described exhaust system adopts high efficiency particulate air filter, and pneumatic on-off valve is set on pipeline, and the flow pattern of described gas handling system is Turbulent Models, is divided into air inlet and nitrogen intake method, can freely switch; The air inlet port arrangement Hand-operated butterfly valve of described air inlet system.
2. by hypoxemia isolator claimed in claim 1, it is characterized in that, in gas handling system, by nitrogen operation valve 1,2, control the break-make of nitrogen air inlet.
3. by hypoxemia isolator claimed in claim 1, it is characterized in that, in gas handling system, by air inlet valve 3, control the break-make of air inlet.
4. by hypoxemia isolator claimed in claim 1, it is characterized in that, in exhaust system, by vent valve 4, control the break-make of gas exhaust piping.
5. by hypoxemia isolator claimed in claim 1, it is characterized in that, in exhaust system, efficient bucket 5 is installed high efficiency particulate air filter.
6. by hypoxemia isolator claimed in claim 1, it is characterized in that, in described isolator, by blower fan 6, produce negative pressure; Oxygen content instrument 7 detects the oxygen content of box house, range: 0-25%, precision: ± 1%); Pressure difference transmitter 8 detects the external pressure reduction of box house, range: 0-125pa, precision: ± 1%; Discharge filter 9 exhaust gas filters, grade: H14; Air intake filter 10 inlet air filtrations, grade: H14; Nitrogen flow meter 11 regulates the flow of nitrogen pipeline 1; Nitrogen flow meter 12 regulates the flow of nitrogen pipeline 2.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201420170415.9U CN203773372U (en) | 2014-04-09 | 2014-04-09 | Hypoxia isolator |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201420170415.9U CN203773372U (en) | 2014-04-09 | 2014-04-09 | Hypoxia isolator |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN203773372U true CN203773372U (en) | 2014-08-13 |
Family
ID=51290540
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201420170415.9U Expired - Lifetime CN203773372U (en) | 2014-04-09 | 2014-04-09 | Hypoxia isolator |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN203773372U (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104977948A (en) * | 2014-04-09 | 2015-10-14 | 上海核创制药系统工程有限公司 | Low-oxygen isolator |
-
2014
- 2014-04-09 CN CN201420170415.9U patent/CN203773372U/en not_active Expired - Lifetime
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104977948A (en) * | 2014-04-09 | 2015-10-14 | 上海核创制药系统工程有限公司 | Low-oxygen isolator |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C41 | Transfer of patent application or patent right or utility model | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20160119 Address after: Tan Zhen Ningxiang County, Hunan province 410600 Changsha Yu Xin Kang Road No. 1 Patentee after: TRUKING TECHNOLOGY Ltd. Address before: 201109, Shanghai, Minhang District Hongmei Road South Lane 23 No. 4999 in the bottom of the middle side Patentee before: SHANGHAI H+C PHARMACEUTICAL SYSTEM ENGINEERING CO.,LTD. |
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| CX01 | Expiry of patent term |
Granted publication date: 20140813 |
|
| CX01 | Expiry of patent term |