CN203489584U - Low-temperature vacuum freeze drier - Google Patents
Low-temperature vacuum freeze drier Download PDFInfo
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- CN203489584U CN203489584U CN201320426892.2U CN201320426892U CN203489584U CN 203489584 U CN203489584 U CN 203489584U CN 201320426892 U CN201320426892 U CN 201320426892U CN 203489584 U CN203489584 U CN 203489584U
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Abstract
The utility model relates to a low-temperature vacuum freeze drier. A refrigeration system is a three-stage cascade refrigerating system having a high-temperature stage, an intermediate-temperature stage and a low-temperature stage. The three-stage cascade refrigerating system is connected with a refrigerating coil of a refrigerating coil. A low-temperature ethyl alcohol outlet in the lower end of the vapor condenser is connected with an ethyl alcohol collector through a valve. The three-stage cascade refrigerating system cools the vapor condenser and makes the temperature of the vapor condenser in a range from 120 DEG C below zero to 125 DEG C below zero. The low-temperature vacuum freeze drier provided by the utility model can meet freeze-drying requirements for lyophilized products containing ethyl alcohol. The low-temperature vacuum freeze drier employs the three-stage cascade refrigerating system. The cascade of the high-temperature stage and the intermediate-temperature stage is used for cooling a drying box and making the temperature of the drying box in a range from 50 DEG C below zero to 60 DEG C below zero. The cascade of the high-temperature stage, the intermediate-temperature stage and the low-temperature-stage is used for cooling the vapor condenser and makes the temperature (which is adjustable and controllable) of the vapor condenser in a range from about 120 DEG C below zero to 125 DEG C below zero. The low-temperature ethyl alcohol collector is arranged below the vapor condenser. In this way, almost all ethyl alcohol in the lyophilized products can be collected after operation is repeated for several times in a freeze-drying process.
Description
Technical field
The utility model relates to a kind of vacuum freeze drier, especially a kind of cryogenic vacuum freeze drier.
Background technology
Vacuum freeze drier is generally comprised of two devices and seven systems, as shown in Figure 1.Two devices are drying box and water vessel, and seven systems are refrigeration system, vacuum system, hydraulic system, heat-exchange system, pneumatic system, control system, steam sterilizing (cleaning) system.
At present, the vacuum freeze drier drying box of domestic production generally can reach the temperature of-50 ℃ ~-60 ℃, and water vessel generally can reach-70 ℃ ~-80 ℃ temperature, and above temperature generally can meet the freeze-drying demand of most of goods.
But the above-mentioned water vessel temperature of the goods that contain alcohol equal solvent for some (most of is bulk drug, Chinese medicine etc.) can not meet the requirement of freeze-drying.
Reason is that alcohol solidification point is-117 ℃, domestic freeze dryer water vessel minimum temperature is-80 ℃ of left and right, alcohol gas can not all be trapped in water vessel, (now steam major part be cured in water vessel refrigeration coil surface) but part are evacuated in vavuum pump by vavuum pump group, can cause like this two consequences:
The one, have the vacuum oil of oil vacuum pump (general claim " oil pump ") destroyed cause vacuum can not reach predetermined value.
The 2nd, the seal in oil pump (many for rubber parts) and slide plate (non-metallic composite material) are corroded, and understanding after long-time affect the sealing of the pump housing, thereby affects the vacuum of complete machine.
In order to change above-mentioned situation, domestic freeze dryer user had following three helpless selections in the past:
First selection: when freeze-drying spirituosity goods, change frequently failed vacuum oil, termly vavuum pump is overhauled, adopt this kind of selection, alcohol is irretrievable, also can cause the rising of operating cost and overhaul the consequences such as frequent.
Second selection, when freeze-drying spirituosity goods, select to adopt oilless vacuum pump (general claim " dry pump "), insensitive to alcohol etc. without vacuum oil in dry pump vacuum chamber, but also has two problems to exist:
The one, the more expensive unit cost that makes of dry pump price rises, and the 2nd, alcohol cannot reclaim, and causes waste.
The 3rd selection, to adopt liquid nitrogen refrigerating mode, liquid nitrogen evaporating temperature under an atmospheric pressure is about-196 ℃, after regulating, water vessel temperature can reach the low temperature of-120 ℃ of left and right, can catch alcohol gas, but due to liquid nitrogen refrigerating operating cost high (expense comprises that liquid nitrogen is bought, liquid nitrogen transports, liquid nitrogen under atmospheric pressure gasifies loss etc.), be approximately three times of left and right of compression-type refrigeration, user generally cannot bear.
Unique good method is: adopt compression-type refrigeration mode, and water vessel temperature is adjustable-110 ℃ ~-120 ℃ left and right, with all or overwhelming majority trapping alcohol, make alcohol on vavuum pump substantially without affecting, separately on water vessel, install an alcohol gathering-device additional, to collect alcohol.
But until 2012, domestic freeze dryer manufacturing enterprise there is no one and can produce this series products.
In international pharmaceutical machine exhibition, abroad Yao Ji enterprise has-110 ℃ of vacuum freeze driers to show, but price is high, is not that domestic general pharmacy corporation can bear.
Summary of the invention
The utility model is to be to provide a kind of cryogenic vacuum freeze drier, for meeting the requirement of spirituosity class freeze-dried products freeze-drying, and the feature such as this vacuum freeze drier has simple in structure, and cost is low, easy to use.
For achieving the above object, the technical solution of the utility model is: a kind of cryogenic vacuum freeze drier, comprise refrigeration system, water vessel, alcohol collector, be characterized in: refrigeration system is three grades of cascade refrigeration systems of high, medium and low temperature, three grades of cascade refrigeration systems of high, medium and low temperature are connected with the refrigeration coil of water vessel, and low temperature alcohol outlet in water vessel lower end connects alcohol collector by the first valve.
Refrigeration system is that in three grades of cascade refrigeration systems of high, medium and low temperature, cold-producing medium is respectively high temperature level R404a, middle temperature level R23, low temperature level R14.
Three grades of cascade refrigeration systems of high, medium and low temperature are-120 ℃ to-125 ℃ to water vessel cryogenic temperature.
Water vessel one end connects drying box, and the other end connects vavuum pump group.
The beneficial effects of the utility model are:
Cryogenic vacuum freeze drier of the present utility model, can meet the requirement of spirituosity class freeze-dried products freeze-drying, this vacuum freeze drier adopts three grades of cascade refrigeration systems, senior middle school's temperature level overlapping is responsible for drying box refrigeration to make it reach-50 ~-60 ℃ of temperature, senior middle school's low temperature overlapping is responsible for water vessel to freeze, make it reach-120 ℃ of left and right low temperature, minimum reaching-125 ℃ (and low temperature is adjustable, controlled).
Below water vessel, be equipped with low temperature alcohol gathering-device, like this in freeze-drying process, operation for several times repeatedly, just can collect the alcohol in whole freeze-dried products almost.
Vacuum freeze drier of the present utility model is filled up at the product in very low temperature region territory, has met the demand of vast pharmaceutical machine user to this type of freeze dryer.
In addition, the utlity model has simple in structure, the feature such as cost is low, easy to use.
Accompanying drawing explanation
Fig. 1 is vacuum freeze drier system diagram;
Fig. 2 is structural representation of the present utility model.
The specific embodiment
Below in conjunction with accompanying drawing and embodiment, the utility model is described in further detail.
As shown in Figure 2, cryogenic vacuum freeze drier of the present utility model, comprises refrigeration system, water vessel 1, alcohol collector 4 etc.
Refrigeration system is three grades of cascade refrigeration systems of high, medium and low temperature, and three grades of cascade refrigeration systems of high, medium and low temperature are connected with the refrigeration coil 2 of water vessel, and water vessel 1 lower end low temperature alcohol outlet connects alcohol collector 4 by the first valve 3.
Refrigeration system is that in three grades of cascade refrigeration systems of high, medium and low temperature, cold-producing medium is respectively high temperature level R404a, middle temperature level R23, low temperature level R14.
Three grades of cascade refrigeration systems of high, medium and low temperature are-120 ℃ to-125 ℃ to water vessel 1 cryogenic temperature.
Water vessel 1 one end connects drying box, and the other end connects vavuum pump group.
The utlity model has following two features:
(1), refrigeration system adopts three grades of cascade refrigerations, cold-producing medium is respectively high temperature level R404a, middle temperature level R23, low temperature level R14, every grade of cooling is 50 ℃ of left and right, and senior middle school's temperature level overlapping is responsible for drying box 1 refrigeration to make it reach-50 ~-60 ℃ of temperature, and senior middle school's low temperature overlapping is responsible for water vessel 1 refrigeration, make it reach-120 ℃ of left and right low temperature, minimum reaching-125 ℃ (and low temperature is adjustable, controlled).
(2), be equipped with low temperature alcohol gathering-device
When freeze-drying, water vessel 1 cryogenic temperature is adjustable, air-flow (water vapour, alcohol gas, some incoagulable gas) from drying box, flow in water vessel 1, under vacuum and low temperature condition, water vapour is cured on the interior refrigeration coil 2 of water vessel 1, under freeze-drying vacuum condition, below generally-50 ℃, alcohol gas liquefy, starts to drip from refrigeration coil 2, when approaching-117 ℃ of temperature, almost all liquefaction, drops to water vessel 1 bottom.Water vessel 1 bottom design has certain gradient, liquid alcohol can flow in alcohol collector 4, and in this process, the first valve 3 is opened, the second valve 5 is closed, when alcohol is full of after alcohol collector 4 substantially, close the first valve 3, open second valve 5, liquid alcohol can be emitted alcohol collector 4 and be flow in machine outer container through putting alcohol mouth 6, like this in freeze-drying process, operation for several times repeatedly, just can collect the alcohol in whole freeze-dried products almost.
Above-mentioned cryogenic vacuum freeze drier, makes domestic vacuum freeze drier be filled up at the product in very low temperature region territory, has met the demand of vast pharmaceutical machine user to this type of freeze dryer.
Claims (4)
1. a cryogenic vacuum freeze drier, comprise refrigeration system, water vessel (1), alcohol collector (4), it is characterized in that: described refrigeration system is three grades of cascade refrigeration systems of high, medium and low temperature, three grades of cascade refrigeration systems of high, medium and low temperature are connected with the refrigeration coil (2) of water vessel, and low temperature alcohol outlet in water vessel (1) lower end connects alcohol collector (4) by the first valve (3).
2. cryogenic vacuum freeze drier according to claim 1, is characterized in that: described refrigeration system is that in three grades of cascade refrigeration systems of high, medium and low temperature, cold-producing medium is respectively high temperature level R404a, middle temperature level R23, low temperature level R14.
3. cryogenic vacuum freeze drier according to claim 1, is characterized in that: described water vessel (1) one end connects drying box, and the other end connects vavuum pump group.
4. cryogenic vacuum freeze drier according to claim 1 and 2, is characterized in that: three grades of cascade refrigeration systems of described high, medium and low temperature are-120 ℃ to-125 ℃ to water vessel (1) cryogenic temperature.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201320426892.2U CN203489584U (en) | 2013-07-18 | 2013-07-18 | Low-temperature vacuum freeze drier |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201320426892.2U CN203489584U (en) | 2013-07-18 | 2013-07-18 | Low-temperature vacuum freeze drier |
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| Publication Number | Publication Date |
|---|---|
| CN203489584U true CN203489584U (en) | 2014-03-19 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201320426892.2U Expired - Fee Related CN203489584U (en) | 2013-07-18 | 2013-07-18 | Low-temperature vacuum freeze drier |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103335491A (en) * | 2013-07-18 | 2013-10-02 | 上海千山远东制药机械有限公司 | Low-temperature vacuum freeze drier |
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2013
- 2013-07-18 CN CN201320426892.2U patent/CN203489584U/en not_active Expired - Fee Related
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103335491A (en) * | 2013-07-18 | 2013-10-02 | 上海千山远东制药机械有限公司 | Low-temperature vacuum freeze drier |
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| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20140319 Termination date: 20180718 |
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| CF01 | Termination of patent right due to non-payment of annual fee |