CN203470360U - Penicillin bottle vacuum on-line detector - Google Patents
Penicillin bottle vacuum on-line detector Download PDFInfo
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- CN203470360U CN203470360U CN201320575025.5U CN201320575025U CN203470360U CN 203470360 U CN203470360 U CN 203470360U CN 201320575025 U CN201320575025 U CN 201320575025U CN 203470360 U CN203470360 U CN 203470360U
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- thumb wheel
- bottle
- laser detection
- detection system
- bottle outlet
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Abstract
The utility model discloses a penicillin bottle vacuum on-line detector. A rack assembly (13) is provided with a bottle charge mesh belt (1), a bottle charge shift wheel (3), a first laser detection system (6), a detection shift wheel (7), a second laser detection system (18), a bottle discharge transition shift wheel (8), a bottle discharge shift wheel (9), a waste product disc (10), a salable product disc (11), an operation system (12), an electric appliance control system (15) and a vacuum adsorption system. The utility model discloses the penicillin bottle vacuum on-line detector for detecting by lasers on line.
Description
Technical field
The utility model relates to a kind of low capacity bottle and detects online machine, particularly relates to a kind of cillin bottle vacuum and detects online machine.
Background technology
Cillin bottle freeze-drying, powder pin be filling roll and covered after, packing container leak check, mainly detects packing container internal vacuum, remaining oxygen and moisture.
The domestic main method for antibiotics medicine sealing propertytest has at present:
1, microorganism is immersed experiment, the sealing integrity of checking container.
Toward pour in product container culture medium and in the usual way tamponade roll lid, cooling standby after sterilizing.Cooled container is inverted and bottleneck is immersed in completely in the motility bacterium liquid of high concentration (being greater than 105/ml), thunder bacterium as husky in EHEC, pseudomonas aeruginosa or clayey is after 4 hours, container outer surface sterilized and cultivate, seeing if there is challenge bacterium and grow in container.
Can prepare some filling media samples more, under the storage requirement identical with product, store.Certain hour interval (as 12,24,36 and 48 months etc.) take out sample, detect as stated above, guarantee the validity of sealing system.Meanwhile, need to do positive control test, to confirm the long ability of cereobiogen of culture medium.
2, saturated salt water law experimental verification seal of vessel integrality.
Some product can be done salt solution immersion test: in vial, pour into water for injection, and sealing (tamponade, roll lid) according to a conventional method, after this, be inverted in one and filled in the pallet of saturated brine, plug and aluminium lid are all immersed.Put it into sterilizing installation sterilizing program sterilizing routinely, analyze content in bottle and whether contain sodium chloride to check sealing integrity.
3, methylene blue solution checking sealing integrity.
Get right quantity vial, pour into water for injection, tamponade according to a conventional method, roll lid.Actual production technique is preferably simulated in the processing of plug, aluminium lid and sample.Sample is inverted, is put into the container that finite concentration methylene blue solution is housed, make its complete submergence.Container is put into vacuum tank and vacuumize, maintain a period of time, vacuum tank returns to normal pressure, continues to maintain a period of time.Take out, outside water washing bottle, visual inspection.Methylene blue holds solution and must not infiltrate in bottle.
Three kinds of conventional methods of upper order all adopt sampling observation mode to carry out, and all can not adopt online laser detection, adopt the online laser detection mode that meets 2010 editions GMP requirements to carry out.
Utility model content
The cillin bottle vacuum that technical problem to be solved in the utility model is to provide a kind of online laser detection detects machine online.
In order to solve the problems of the technologies described above, the cillin bottle vacuum that the utility model provides detects machine online, comprise frame combination, in described frame combination, be provided with bottle feeding mesh-belt, bottle inlet thumb wheel, the first laser detection system, detect thumb wheel, the second laser detection system, bottle outlet transition thumb wheel, bottle outlet thumb wheel, waste product dish, certified products dish, operating system, electrical apparatus control system and vacuum suction system, the entrance point of the bottle inlet thumb wheel that described bottle feeding mesh-belt docking is described, the entrance point of the detection thumb wheel described in the port of export docking of described bottle inlet thumb wheel, the first described laser detection system and the second laser detection system align described detection thumb wheel, the entrance point of the port of export docking bottle outlet transition thumb wheel of described detection thumb wheel, the entrance point of the bottle outlet thumb wheel described in the port of export docking of described bottle outlet transition thumb wheel, described bottle outlet transition thumb wheel and bottle outlet thumb wheel are all equipped with described vacuum suction system, the described described waste product dish of bottle outlet transition thumb wheel docking, the described described certified products dish of bottle outlet thumb wheel docking, described operating system and described the first laser detection system, the second laser detection system and vacuum suction system adopt communication connection, the main motor of the bottle feeding mesh-belt motor of described electrical apparatus control system and described bottle feeding mesh-belt and described detection thumb wheel is electrically connected to.
Described frame combination is provided with the described bottle feeding mesh-belt of protection, bottle inlet thumb wheel, detects the protective door of thumb wheel, the first laser detection system, the second laser detection system, bottle outlet transition thumb wheel and bottle outlet thumb wheel.
The bottom of described frame combination is provided with lower margin and adjusts screw.
Adopt the cillin bottle vacuum of technique scheme to detect online machine, use laser absorption spectrum to carry out the detection of head space oxygen content to medicament packaging container, utilizing highly sensitive laser absorption technology---frequency modulation(PFM) spectroscope is measured the head space physical parameter of packing container, comprises gas concentration (oxygen and moisture) and head space gross pressure (vacuum).
Its measuring principle is as follows: the laser that diode emission wavelength and testing molecule absorbing wavelength (oxygen is that 760nm, water are 1400nm) match, makes it pass through container top.By accurate adjustment and signal processing technology, system obtains measurement result, and its sensitivity is 10000 times that standard NIR absorbs.
In sum, the utility model is that a kind of cillin bottle vacuum of online laser detection detects machine online.
Accompanying drawing explanation
Fig. 1 is front view of the present utility model.
Fig. 2 is top view of the present utility model.
Fig. 3 is left view of the present utility model.
The specific embodiment
Below in conjunction with accompanying drawing, the utility model is described in further detail.
Referring to Fig. 1, Fig. 2 and Fig. 3 are provided with bottle feeding mesh-belt 1 in frame combination 13, bottle inlet thumb wheel 3, the first laser detection system 6, detect thumb wheel 7, the second laser detection system 18, bottle outlet transition thumb wheel 8, bottle outlet thumb wheel 9, waste product dish 10, certified products dish 11, operating system 12, electrical apparatus control system 15 and vacuum suction system, vacuum suction system comprises piston type vacuum pump 16, the entrance point of bottle feeding mesh-belt 1 docking bottle inlet thumb wheel 3, the port of export docking of bottle inlet thumb wheel 3 detects the entrance point of thumb wheel 7, the first laser detection system 6 and the second laser detection system 18 align and detect thumb wheel 7, detect the entrance point of the port of export docking bottle outlet transition thumb wheel 8 of thumb wheel 7, the entrance point of the port of export docking bottle outlet thumb wheel 9 of bottle outlet transition thumb wheel 8, bottle outlet transition thumb wheel 8 and bottle outlet thumb wheel 9 are all equipped with vacuum suction system, bottle outlet transition thumb wheel 8 docking waste product dishes 10, bottle outlet thumb wheel 9 docking certified products dishes 11, in frame combination 13, main motor 4 is housed, main motor 4 is in transmission connection by main transmission 5 and detection thumb wheel 7, operating system 12 and the first laser detection system 6, the second laser detection system 18 and vacuum suction system adopt communication connection, and electrical apparatus control system 15 is electrically connected to the bottle feeding mesh-belt motor 2 of bottle feeding mesh-belt 1 and the main motor 4 of detection thumb wheel 7, and frame combination 13 is provided with protection bottle feeding mesh-belt 1, bottle inlet thumb wheel 3, detect thumb wheel 7, the first laser detection system 6, the second laser detection system 18, the protective door 14 of bottle outlet transition thumb wheel 8 and bottle outlet thumb wheel 9, the bottom of frame combination 13 is provided with lower margin and adjusts screw 17.
Referring to Fig. 1, Fig. 2 and Fig. 3, by bottle feeding mesh-belt 1 bottle inlet, drug bottle to be checked enters bottle inlet thumb wheel 3, bottle inlet thumb wheel 3 is sent into drug bottle to be checked to detect thumb wheel 7 as Fig. 2 shows counterclockwise rotation, detecting thumb wheel 7 as Fig. 2 shows and rotates clockwise twice of drug bottle to be checked through the first laser detection system 6 and the second laser detection system 18, when drug bottle to be checked is through the first laser detection system 6 and the second laser detection system 18, Ear Mucosa Treated by He Ne Laser Irradiation is on the top of drug bottle to be checked, laser detection system is according to oxygen in drug container to be checked, the wavelength that moisture transmitting matches the top that makes drug bottle to be checked are through laser detection system, opposite face at the laser detection system of drug bottle to be checked utilizes highly sensitive laser absorption technology, to drug bottle internal upper part to be checked by moisture content that laser irradiated, accurate computer software technology processing is carried out in the fluctuation of oxygen equal size, through contrast, obtain measurement result.After obtaining consequential signal, tested drug bottle is carried out to automatic analysis and judgment, thereby determine that tested drug bottle is certified products or waste product, last signal automatic transport is to electrical apparatus control system 15.Tested drug bottle is detecting on thumb wheel 7 through showing that as Fig. 2 clockwise direction rotates after certain station, detect thumb wheel 7 and tested drug bottle is transported to bottle outlet transition thumb wheel 8 places that show counter clockwise direction rotation as Fig. 2, as Fig. 2, showing the bottle outlet transition thumb wheel 8 and right handed bottle outlet thumb wheel 9 engagements of counterclockwise rotation, it is certified products or waste product that now electrical apparatus control system 15 meetings be differentiated tested drug bottle according to the testing result signal of the first laser detection system 6 and the second laser detection system 18, on bottle outlet transition thumb wheel 8 and bottle outlet thumb wheel 9, be all designed with vacuum suction system.When tested drug bottle is judged as certified products, bottle outlet thumb wheel 9 will adsorb tested drug bottle (vacuum at now bottle outlet transition thumb wheel 8 places disconnects), tested drug bottle is sent into sabot in certified products dish 11 to be collected, when tested drug bottle is waste product, bottle outlet transition thumb wheel (8) is sent the tested drug bottle of absorption into sabot in waste product dish 10 and is collected (now the vacuum system of bottle outlet thumb wheel 9 disconnects).
This equipment be mainly used in cillin bottle freeze-drying, powder pin filling roll covered after, packing container leak check, main packing container internal vacuum, remaining oxygen and the water content of detecting, current this series products at home market is blank project, has in the world the product of quantity several companies specialty research and development the type seldom.
Claims (3)
1. a cillin bottle vacuum detects machine online, comprise frame combination (13), it is characterized in that: in described frame combination (13), be provided with bottle feeding mesh-belt (1), bottle inlet thumb wheel (3), the first laser detection system (6), detect thumb wheel (7), the second laser detection system (18), bottle outlet transition thumb wheel (8), bottle outlet thumb wheel (9), waste product dish (10), certified products dish (11), operating system (12), electrical apparatus control system (15) and vacuum suction system, the entrance point of the bottle inlet thumb wheel (3) that described bottle feeding mesh-belt (1) docking is described, the entrance point of the detection thumb wheel (7) described in the port of export docking of described bottle inlet thumb wheel (3), described the first laser detection system (6) and the second laser detection system (18) align described detection thumb wheel (7), the entrance point of the port of export docking bottle outlet transition thumb wheel (8) of described detection thumb wheel (7), the entrance point of the bottle outlet thumb wheel (9) described in the port of export docking of described bottle outlet transition thumb wheel (8), described bottle outlet transition thumb wheel (8) and bottle outlet thumb wheel (9) are all equipped with described vacuum suction system, the described described waste product dish (10) of bottle outlet transition thumb wheel (8) docking, the described described certified products dish (11) of bottle outlet thumb wheel (9) docking, described operating system (12) and described the first laser detection system (6), the second laser detection system (18) and vacuum suction system adopt communication connection, the main motor (4) of the bottle feeding mesh-belt motor (2) of described electrical apparatus control system (15) and described bottle feeding mesh-belt (1) and described detection thumb wheel (7) is electrically connected to.
2. cillin bottle vacuum according to claim 1 detects machine online, it is characterized in that: described frame combination (13) is provided with the described bottle feeding mesh-belt (1) of protection, bottle inlet thumb wheel (3), detects thumb wheel (7), the first laser detection system (6), the second laser detection system (18), bottle outlet transition thumb wheel (8), bottle outlet thumb wheel (9), protective door (14).
3. cillin bottle vacuum according to claim 1 and 2 detects machine online, it is characterized in that: the bottom of described frame combination (13) is provided with lower margin and adjusts screw (17).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201320575025.5U CN203470360U (en) | 2013-09-17 | 2013-09-17 | Penicillin bottle vacuum on-line detector |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201320575025.5U CN203470360U (en) | 2013-09-17 | 2013-09-17 | Penicillin bottle vacuum on-line detector |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN203470360U true CN203470360U (en) | 2014-03-12 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201320575025.5U Expired - Lifetime CN203470360U (en) | 2013-09-17 | 2013-09-17 | Penicillin bottle vacuum on-line detector |
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| Country | Link |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103464382A (en) * | 2013-09-17 | 2013-12-25 | 湖南正中制药机械有限公司 | Online vacuum detector for penicillin bottle |
| CN105292626A (en) * | 2015-11-30 | 2016-02-03 | 成都三可实业有限公司 | Lollipop discharge device for lollipop packaging machine |
-
2013
- 2013-09-17 CN CN201320575025.5U patent/CN203470360U/en not_active Expired - Lifetime
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103464382A (en) * | 2013-09-17 | 2013-12-25 | 湖南正中制药机械有限公司 | Online vacuum detector for penicillin bottle |
| CN105292626A (en) * | 2015-11-30 | 2016-02-03 | 成都三可实业有限公司 | Lollipop discharge device for lollipop packaging machine |
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| GR01 | Patent grant | ||
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Granted publication date: 20140312 |
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| CX01 | Expiry of patent term |